Family Search for PF08590 (DUF1771)
PF08590 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
CNAG_05769 cytoplasmic protein from Cryptococcus neoformans var. grubii H99
Aligns to 138:201 / 313 (20.4%), covers 100.0% of PF08590, 74.5 bits
CNBF2620 hypothetical protein from Cryptococcus neoformans var. neoformans B-3501A
Aligns to 133:196 / 308 (20.8%), covers 100.0% of PF08590, 73.5 bits
YLL3_SCHPO / Q9UTP4 Smr domain-containing protein C11H11.03c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPAC11H11.03c SMR and DUF1771 domain protein (RefSeq) from Schizosaccharomyces pombe
Aligns to 4:67 / 206 (31.1%), covers 100.0% of PF08590, 73.0 bits
YP199_YEAST / Q08954 Smr domain-containing protein YPL199C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
NP_015125, YPL199C Ypl199cp (RefSeq) from Saccharomyces cerevisiae
Aligns to 26:89 / 240 (26.7%), covers 100.0% of PF08590, 69.9 bits
- A Multi-Perspective Proximity View on the Dynamic Head Region of the Ribosomal 40S Subunit.
Schmitt, International journal of molecular sciences 2021 - “...(iii) mRNA surveillance and vesicular transport (Smy2, Syh1), (iv) degradation of mRNA (endo- and exonucleases Ypl199c and Xrn1, respectively), (v) autophagy (Psp2, Vps30, Ykt6), and (vi) kinase signaling (Ste20). Additionally, they must be harmonized with translation initiation factors (eIF3, cap-binding protein Cdc33, eIF2A) and mRNA-binding/ribosome-charging proteins...”
- “...found proximal to the hr40S in our previous BioID experiments [ 3 , 18 ]. Ypl199c is another protein of this group. The Smr domain containing proteins Ypl199c and Cue2 are homologs of the Caenorhabditis elegans endonuclease NONU-1, and they have recently been shown to redundantly...”
- Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae
Vélez-Segarra, G3 (Bethesda, Md.) 2020 - “..., Egd2p , Gtt1p , Msa1p , Ras2p , Tma7p , Yck1p , Yck2p , Ypl199c , Zeo1p ) and 5 protein interactors for Wsc3p ( Bmh1p , Cpr1p , Egd2p , Yck1p , and Zeo1p ) ( Figure 2 and Table 1 ) of which...”
- “...glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication. YPL199C YPL199C WSC2P Putative protein of unknown function; predicted to be palmitoylated. ZEO1 YOL109W WSC2P,WSC3P Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated...”
- NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance
Glover, Cell reports 2020 - “...processing RNA. Homologs of NONU-1 include the recently identified S. cerevisiae CUE2 and the uncharacterized YPL199C , which we show function redundantly in nonstop mRNA decay. Our results identify a critical component of the translation surveillance machinery in two model organisms and suggest why this factor...”
- “...). We performed a homology search and identified two candidate homologs in S. cerevisiae : YPL199C and CUE2 . Of the two, CUE2 was recently identified as a factor involved in no-go mRNA decay ( DOrazio et al., 2019 ), but the relationship of YPL199C to...”
- Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of Saccharomyces cerevisiae
Santiago-Cartagena, G3 (Bethesda, Md.) 2019 - “...sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication viable YPL199C YPL199C MID2 Putative protein of unknown function, predicted to be palmitoylated viable YPL238C YPL238C WSC1/MID2 Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and...”
- “...ssb1 Wt Wt S Wt sso2 Wt Wt Wt Wt yck1 Wt Wt Wt Wt ypl199c Wt Wt Wt Wt zeo1 Wt Wt Wt Wt atx1mid2 S S grx1mid2 S S ras2mid2 S S ras2wsc1 S S zeo1mid2 Wt zeo1wsc1 S cof1 , fas1 , fba1...”
- Progress toward Understanding Protein S-acylation: Prospective in Plants
Li, Frontiers in plant science 2017 - “...are also S-acylated by Akr1 are Meh1, Sna4 and the unknown function proteins such as Ypl199c, Ykl047w, and Ypl236c (Roth et al., 2006 ). Therefore, Akr1 alone can S-acylate at least 9 substrate proteins in yeast. It was noted that Akr1 prefers hydrophilic proteins that tether...”
- “...Substrates of yeast PATs . PATs Substrates References Akr1 Lcb4, Yck1, Yck2, Yck3, Meh1, Sna4, Ypl199c, Ykl047w, Ypl236c, Vac8 Roth et al., 2002 ; Babu et al., 2004 ; Kihara et al., 2005 ; Roth et al., 2006 , 2011 Erf2 (shr5) Ras1, Ras2, Rho2, Rho3,...”
- tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding
Rezgui, Proceedings of the National Academy of Sciences of the United States of America 2013 - “...and translation, we quantified the stability of Cms1 and Ypl199c in wild-type and urm1 cells after blocking translation by cycloheximide (Fig. 3 E and F and...”
- “...0 20 40 60 80 Time (min) 100 120 Discussion Ypl199c 100 80 0 U34 Modifications Stabilize Binding of Cognate tRNAs to the A-Site and Promote Peptide Bond...”
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB
Van, Proceedings of the National Academy of Sciences of the United States of America 2012 - “...charged precursor) of the Heat shock factor protein YPL199C (1MNNAANTGTTNESNVSDAPR20) demonstrate this to be a genuine yNatB substrate N termini as it was found...”
- Structure and Function of the Small MutS-Related Domain
Fukui, Molecular biology international 2011 - “...Neisseria gonorrhoeae NGO0880 (YP_207992) Pseudomonas aeruginosa Hypothetical protein (AAG_05064) Saccharomyces cerevisiae CUE2 protein (EEU_05137) Ypl199cp (NP_015125) 2 Caenorhabditis elegans Hypothetical protein (NP_498004) Hypothetical protein (NP_494494) Hypothetical protein (NP_494390) Drosophila melanogaster CG7139, isoform A (NP_649378) 3 Mus musculus N4BP2 (NP_001020088) 4 Homo sapiens N4BP2 (NP_060647) 1 Numbers...”
- More
- PalmPred: an SVM based palmitoylation prediction method using sequence profile information.
Kumari, PloS one 2014 - “...$ , 10 $ 9, 10 10 9, 10 TLG2 Q08144 317, 325 316 YPL199C Q08954 235 233, 235 SAM3 Q08986 268, 321 321 YPL236C Q12003 13*, 14*, 15* 14, 15 13, 14, 159 13, 14, 15 PIN2 Q12057 35, 41, 53 66, 79, 81,82, 84...”
- CSS-Palm 2.0: an updated software for palmitoylation sites prediction
Ren, Protein engineering, design & selection : PEDS 2008 - “...Q00245 P25349 Q07800 Q07949 Q02205 P53139 Q12003 P42951 Q08954 P36090 P38216 Q12057 Q07549 P39106 Q07895 P32047 P48525 P08466 P32867 P39926 Q12241 Q08144 P50108...”
CID7_ARATH / O64843 Polyadenylate-binding protein-interacting protein 7; PABP-interacting protein 7; Poly(A)-binding protein-interacting protein 7; PAM2-containing protein CID7; Protein CTC-INTERACTING DOMAIN 7 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT2G26280 CID7; ATP binding / damaged DNA binding / protein binding (RefSeq) from Arabidopsis thaliana
Aligns to 408:471 / 567 (11.3%), covers 100.0% of PF08590, 66.2 bits
NP_001020088 NEDD4-binding protein 2 from Mus musculus
Aligns to 1527:1590 / 1678 (3.8%), covers 100.0% of PF08590, 62.9 bits
- Structure and Function of the Small MutS-Related Domain
Fukui, Molecular biology international 2011 - “...protein (NP_494494) Hypothetical protein (NP_494390) Drosophila melanogaster CG7139, isoform A (NP_649378) 3 Mus musculus N4BP2 (NP_001020088) 4 Homo sapiens N4BP2 (NP_060647) 1 Numbers in parenthesis indicate accession numbers. 2 Ypl199cp also contains DUF1771. 3 CG7139 shows amino acid sequence similarity to mammalian N4BP2-like proteins. The highly...”
N4BP2_HUMAN / Q86UW6 NEDD4-binding protein 2; N4BP2; BCL-3-binding protein; EC 3.-.-.- from Homo sapiens (Human) (see paper)
NP_060647 NEDD4-binding protein 2 isoform 1 from Homo sapiens
Aligns to 1619:1682 / 1770 (3.6%), covers 100.0% of PF08590, 61.9 bits
- function: Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.
subunit: Binds NEDD4 (By similarity). Binds BCL3 and CREBBP. - Structure and Function of the Small MutS-Related Domain
Fukui, Molecular biology international 2011 - “...Drosophila melanogaster CG7139, isoform A (NP_649378) 3 Mus musculus N4BP2 (NP_001020088) 4 Homo sapiens N4BP2 (NP_060647) 1 Numbers in parenthesis indicate accession numbers. 2 Ypl199cp also contains DUF1771. 3 CG7139 shows amino acid sequence similarity to mammalian N4BP2-like proteins. The highly conserved domain, DUF1771, is adjacent...”
- Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression
Fukui, The Journal of biological chemistry 2008 - “...JOURNAL OF BIOLOGICAL CHEMISTRY binding protein 2 (N4BP2) (NP_060647). The location of the secondary structure elements is shown above the sequence of ttSmr663....”
Y5872_ARATH / O65573 SMR domain-containing protein At5g58720; PRL1-interacting protein PIPC from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT5G58720 PRLI-interacting factor, putative (RefSeq) from Arabidopsis thaliana
Aligns to 356:419 / 519 (12.3%), covers 100.0% of PF08590, 56.2 bits
CG7139, NP_649378 uncharacterized protein from Drosophila melanogaster
Aligns to 808:871 / 969 (6.6%), covers 95.3% of PF08590, 48.0 bits
- Structure and Function of the Small MutS-Related Domain
Fukui, Molecular biology international 2011 - “...(NP_015125) 2 Caenorhabditis elegans Hypothetical protein (NP_498004) Hypothetical protein (NP_494494) Hypothetical protein (NP_494390) Drosophila melanogaster CG7139, isoform A (NP_649378) 3 Mus musculus N4BP2 (NP_001020088) 4 Homo sapiens N4BP2 (NP_060647) 1 Numbers in parenthesis indicate accession numbers. 2 Ypl199cp also contains DUF1771. 3 CG7139 shows amino acid...”
- “...mammalian N4BP2-like proteins. The highly conserved domain, DUF1771, is adjacent to the Smr domain in CG7139. 4 DUF1771 is adjacent to the Smr domains in mammalian N4BP2. 5 Organisms that possess a family 3 Smr domain do not have a family 1 Smr domain [ 11...”
- “...elegans Hypothetical protein (NP_498004) Hypothetical protein (NP_494494) Hypothetical protein (NP_494390) Drosophila melanogaster CG7139, isoform A (NP_649378) 3 Mus musculus N4BP2 (NP_001020088) 4 Homo sapiens N4BP2 (NP_060647) 1 Numbers in parenthesis indicate accession numbers. 2 Ypl199cp also contains DUF1771. 3 CG7139 shows amino acid sequence similarity to...”
- Heterochromatic genes in Drosophila: a comparative analysis of two genes
Schulze, Genetics 2006 - “...(http://www.genome.gov/11008080) for this region. The ortholog of CG7139 in D. melanogaster, which encodes a conserved function in DNA repair (Eisen 1998),...”
- “...is exhibited by the conservation of the arrangement of CG7139 and CG14561 in both species. A large Ulysses retrotransposon is downstream of DvDbp80 in the...”
- Analysis of Ras-induced overproliferation in Drosophila hemocytes
Asha, Genetics 2003 - “...CG18228 CG17219 CG13162 CG10420 CG3362 CG12065 CG9576 CG4880 CG3238 CG7139 uzip Average SLR 1.89 3.38 2.7 2.62 1.78 2.53 1.75 1.68 1.61 3.04 1.88 Genes that are...”
AT5G23520 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 243:306 / 435 (14.7%), covers 93.8% of PF08590, 48.0 bits
- A willow sex chromosome reveals convergent evolution of complex palindromic repeats
Zhou, Genome biology 2020 - “...of P. trichocarpa best hit Palindromes W.P1 and W.P2 SMR 4 [a] Manually annotated Chr19 AT5G23520 SMR (Small MutS Related) domain-containing protein) Potri.T013000 90.70 RR 4 Sapur.15WG073500 Chr19 AT3G56380 ARR17 (type A cytokinin response regulator) Potri.019G133600 92.81 Sapur.15WG073900 Sapur.15WG074000 Sapur.15WG075200 R1 4 [a] Sapur.15WG073800 Chr15Z AT4G27220...”
SDE5_ARATH / Q9LUQ3 Putative nuclear RNA export factor SDE5; Protein SILENCING DEFECTIVE 5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT3G15390 SDE5 (silencing defective 5) (RefSeq) from Arabidopsis thaliana
Aligns to 328:391 / 490 (13.1%), covers 95.3% of PF08590, 47.3 bits
- function: Involved in sense transgene post-transcriptional gene silencing (S-PTGS). Not involved in repeat-induced transgene silencing (IR-PTGS). Essential component of the trans-acting short interfering RNA (tasiRNA) pathway. Required for the production of tasiRNAs (PubMed:17397509, PubMed:20798330). Acts together with RDR6 in generating double-stranded RNA from specific single-stranded RNAs. May be involved in the transport of RNA molecules that are converted into a double-stranded form by RDR6. Involved in virus-induced silencing. Not involved in the biogenesis of microRNAs and 24 nt siRNAs produced by DCL3 (PubMed:17397509).
disruption phenotype: Elongated and curled downward leaves. Upon infection, over-accumulation of cucumber mosaic virus (CMV) RNA and enhanced susceptibility to CMV. - DNA Methylation Level Changes in Transgenic Chinese Cabbage (Brassica rapa ssp. pekinensis) Plants and Their Effects on Corresponding Gene Expression Patterns.
Park, Genes 2021 - “...3 CHG CHH Hyper CT001_A08284340 Bra034540 - - TCD 4 CHG CHH Hypo CT001_A05184770 Bra027247 AT3G15390 Putative nuclear RNA export factor SDE5 isoform X1 TCD 5 CHG CHH Hypo CT001_A07260420 Bra004227 AT1G67480 F-box/kelch-repeat protein TCD 6 CG CHH Hypo CT001_A07264360 Bra016068 AT1G72300 Tyrosine-sulfated glycopeptide receptor 1...”
CNF02090 cytoplasm protein (RefSeq) from Cryptococcus neoformans var. neoformans JEC21
Aligns to 23:62 / 174 (23.0%), covers 59.4% of PF08590, 40.8 bits
Or search for genetic data about PF08590 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory