Family Search for PF08593 (DUF1773)

PF08593 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MUG2_SCHPO / Q9URV3 Meiotically up-regulated gene 2 protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
SPBC106.08c DUF1773 family protein 1 from Schizosaccharomyces pombe
Aligns to 204:278 / 296 (25.3%), covers 97.6% of PF08593, 70.7 bits

• function: Has a role in meiosis.
• The global transcriptional response of fission yeast to hydrogen sulfide
  Jia, PloS one 2011
  • “...meiosis-specific cyclin Rem1 meu10 2.76 up conserved fungal family nep2 3.68 up nedd8 protease Nep2 SPBC106.08c 0.49 down DUF1773 family protein 1 SPACUNK4.19 0.43 down sequence orphan Cellular amide metabolic process car1 2.34 up arginase Car1 (PMID 7985419) SPCC794.01c 3.13 up glucose-6-phosphate 1-dehydrogenase (predicted) SPBC8E4.03 2.23...”
• Schizosaccharomyces pombe essential genes: a pilot study
  Decottignies, Genome research 2003
  • “...SPBC106.04 SPBC106.05c SPBC106.06 SPBC106.07c SPBC106.08c SPBC106.09/cut4 SPBC106.10/pka1 SPBC106.11c SPBC106.12c SPBC106.13 SPBC106.14c SPBC106.15 SPBC106.16...”
• Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe
  Watanabe, Nucleic acids research 2001
  • “...five other Meu23-like proteins (SPCC330.04cp, SPCC569.8, SPBC337.02c, SPBC106.08c Nucleic Acids Research, 2001, Vol. 29, No. 11 2331 Table 1. Characterization...”

YQO3_SCHPO / Q9Y7S2 UPF0612 protein C569.003 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 287:363 / 375 (20.5%), covers 97.6% of PF08593, 68.1 bits

SPCC569.01c DUF1773 family protein 5 from Schizosaccharomyces pombe
Aligns to 235:310 / 323 (23.5%), covers 97.6% of PF08593, 67.4 bits

• Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination
  Garg, Nucleic acids research 2022
  • “...antagonizes precocious 3-processing/termination during prt lncRNA synthesis. ADS-2 also has an incidental missense mutation in SPCC569.01c (encoding an inessential 323-aa protein of unknown function) and a missense mutation in SPBC20F10.02c (encoding an inessential 600-aa protein of unknown function) (Figure 1C ). rad24 encodes a 270-aa protein...”
• Global effects on gene expression in fission yeast by silencing and RNA interference machineries
  Hansen, Molecular and cellular biology 2005
  • “...alone in some chromosomal regions (e.g., SPBC337.02c, SPCC569.01c, SPCC794.06, and SPAC1B3.17). Effects of silencing factors in telomeric and subtelomeric...”

SPCC613.11c DUF1773 family protein 2 from Schizosaccharomyces pombe
Aligns to 166:240 / 254 (29.5%), covers 97.6% of PF08593, 66.5 bits

• Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe
  Ohtaka, Cell division 2007
  • “...coiled-coil protein meu1 SPAC1556.06 776 middle meiotic expression upregulated meu18 SPBC409.11 553 middle NLS meu23 SPCC613.11C 254 middle B13958 domain spn5/mde9/meu28 SPAC24C9.15C 464 middle septin mde4 SPBC6B1.04 421 middle mei4 dependent protein mcp2 SPCC1682.08C 703 late RNA-binding protein mcp1 SPAC1687.10 661 late meiosis specific coiled-coil protein...”

MU135_SCHPO / O74876 Meiotically up-regulated gene 135 protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
mug135 protein mug135 from Schizosaccharomyces pombe
Aligns to 266:341 / 357 (21.3%), covers 96.3% of PF08593, 60.8 bits

• function: Has a role in meiosis.
• Restarted replication forks are error-prone and cause CAG repeat expansions and contractions
  Gold, PLoS genetics 2021
  • “...flanked by 434 bp and 478 bp of sequence homology to the 3UTR of the mug135 gene. The Spe1-Sph1 restriction fragment was transformed into YC13 (containing the RTS1 -RFB) and YC6 (without the RTS1 -RFB) to integrate repeats 6.7 Kb away from the RFB. To integrate...”
• Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance
  Iglesias, Molecular cell 2020
  • “...+ reporter gene inserted in place of the ura4 + gene between pmp20 + and mug135 + genes. Thin arrows indicate primer locations for ChIP-qPCR analyses in H and I panels. G , Silencing assays of 10XtetO-ade6 + on low-adenine medium lacking tetracycline (Low Ade -...”
• Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription
  Jih, Nature 2017
  • “...loss of H3K9me2 at the 10xtetO-ade6 + reporter gene ( a ) and the adjacent mug135 + gene ( b ) upon the release of tethered TetR-Clr4-I by the addition of tetracycline ( tet versus + tet). c, ChIP-qPCR analysis showing loss of H3K9me2 at pericentromeric...”
  • “...c, H3K9me2 ChIP-seq reads mapped to the 10xtetO-ade6 + region. Both 10xtetO-ade6 + (green) and mug135 + (black dash) located 5 kb upstream of 10xtetO-ade6 + were used for ChIP-qPCR analysis (see Extended Data Fig. 10 ). d, Same as c , but after 24 hours...”
• The impact of local genome sequence on defining heterochromatin domains
  Wheeler, PLoS genetics 2009
  • “...C spcc330.06 2723 0.570.10 14 0.002 ade6 340 0.670.05 13 0.000 D tDNAgly 4535 E mug135 4943 0.480.08 8 0.001 F CC330.03 7819 0.900.20 17 0.628 G CC330.19 9984 0.660.03 8 0.008 H rhp7 10902 1.080.15 4 0.731 1 mlo3 6 10609 0.830.09 5 0.172 2...”

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