Family Search for PF08719 (DUF1768)
PF08719.11 hits 16 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
AWN65_RS00880 NADAR family protein from Flavobacterium columnare
Aligns to 16:175 / 178 (89.9%), covers 99.4% of PF08719, 193.4 bits
- Comparative Analysis of the Flavobacterium columnare Genomovar I and II Genomes
Kumru, Frontiers in microbiology 2017 - “...hypothetical protein 185330-185518 AWN65_RS00865 Hypothetical protein 185635-186198 AWN65_RS00870 Hypothetical protein 186284-187126 AWN65_RS00875 Crystallin J1 187123-187659 AWN65_RS00880 Hypothetical protein 187656-188486 AWN65_RS00885 Phosphoribosylpyrophosphate synthetase 188909-189601 AWN65_RS00890 NUDIX hydrolase Flavobacterium columnare ATCC 49512 Region I 1241010-1241513 FCOL_RS05470 Chromosome partitioning protein ParB 1241510-1242790 FCOL_RS05475 Phosphoadenosine phosphosulfate sulfurtransferase 1242787-1244013 FCOL_RS05310 Hypothetical...”
FCOL_RS13285 NADAR family protein from Flavobacterium columnare ATCC 49512
Aligns to 16:175 / 177 (90.4%), covers 99.4% of PF08719, 191.3 bits
- Comparative Analysis of the Flavobacterium columnare Genomovar I and II Genomes
Kumru, Frontiers in microbiology 2017 - “...2-phosphotransferase 3029802-3030464 FCOL_RS13270 Hypothetical protein 3030527-3031030 FCOL_RS13275 RNase III inhibitor 3031196-3031753 FCOL_RS13280 Hypothetical protein 3031753-3032286 FCOL_RS13285 Hypothetical protein 3032283-3033113 FCOL_RS13290 Phosphoribosylpyrophosphate synthetase 3033491-3034183 FCOL_RS13295 NUDIX hydrolase The F. columnare 94-081 genome contains one incomplete phage cluster of 13.8 kb with 16 genes, two of which have...”
DR_1263 NADAR family protein from Deinococcus radiodurans R1
Aligns to 9:157 / 159 (93.7%), covers 100.0% of PF08719, 170.5 bits
DR1263 conserved hypothetical protein (NCBI ptt file) from Deinococcus radiodurans R1
Aligns to 72:220 / 222 (67.1%), covers 100.0% of PF08719, 169.1 bits
RIBX_NOSP7 / B2J4E5 N-glycosidase Npun_R5314; Riboflavin biosynthesis intermediates N-glycosidase; EC 3.2.2.- from Nostoc punctiforme (strain ATCC 29133 / PCC 73102) (see paper)
Aligns to 4:146 / 156 (91.7%), covers 100.0% of PF08719, 140.6 bits
- function: Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose.
catalytic activity: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate (RHEA:23436)
catalytic activity: 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6- diaminouracil + D-ribose 5-phosphate (RHEA:55020)
TTHERM_00486130 swarming motility protein ybiA from Tetrahymena thermophila SB210
Aligns to 59:200 / 204 (69.6%), covers 100.0% of PF08719, 129.4 bits
- Proteomic analysis of the ventral disc of Giardia lamblia
Lourenço, BMC research notes 2012 - “...marneffei ] 6 79 15571 -.VIEALLQFTNDIEKQSFQVLHK.D K.DVVVILQR.I R.IAVESQLDSR.D R.IAVESQLDSRDVYSLEEGFK.A R.DVYSLEEGFK.A 2D 9 XP_001032825.1 Hypothetical protein TTHERM_00486130 [ Tetrahymena thermophila SB210] 6 63 18838 K.DAGRQISILVLGK.M R.QISILVLGK.M R.QISILVLGKMPEEFFDIGK.K 2D 10 AAK32143.1 giardin delta chain [Giardia intestinalis] 147 30969 R.VTDFHEDFKR.Q K.IAQEHDDLLESIR.Y K.TSAEESFGAFIGNLTNER.N R.ADREQSIDEYLR.D K.VLAGVVAELIATR.K Table with isolated ventral disc...”
A1S_0598 hypothetical protein (RefSeq) from Acinetobacter baumannii ATCC 17978
Aligns to 1:103 / 105 (98.1%), covers 60.9% of PF08719, 127.8 bits
- Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing
Camarena, PLoS pathogens 2010 - “...4.5 4-hydroxyphenylpyruvate dioxygenase, COG3185 A1S_1031 2.1 Protease La Repressed Genes A1S_0520 0.46 Putative dehydrogenase, COG0644 A1S_0598 0.42 Hypothetical protein, DUF1768 A1S_0661 0.5 Phage integrase family protein, P-4 like integrase A1S_0669 0.44 Putative arsenite efflux permease, COG0798 A1S_0923 0.51 Malate:quinone oxidoreductase A1S_1174 0.32 DNA polymerase V, UmuD...”
W8SSB7 N-glycosidase YbiA from Escherichia coli
Aligns to 7:146 / 149 (94.0%), covers 98.8% of PF08719, 126.4 bits
- Label-Free Proteomic Approach to Study the Non-lethal Effects of Silver Nanoparticles on a Gut Bacterium
Domingo, Frontiers in microbiology 2019 - “...1a1b All AgNPs treatments 2-methylcitrate synthase (N3MZ53; log2FC = 2.98, 3.06, 3.21) GTP cyclohydrolase II (W8SSB7; log2FC = 3.32, 3.21, 3.21) Glyoxalase I (T9A3H1; log2FC = 4.57, 4.44, 4.43) ABC transporter-binding protein MlaB (N2GWD3; log2FC = -5.95, 5.68, 5.84) 1-Acylglycerol-3-phosphate O -acyltransferase (X7PK56; log2FC = 4.74,...”
YbiA / b0798 N-glycosidase YbiA from Escherichia coli K-12 substr. MG1655 (see 3 papers)
RIBX_ECOLI / P30176 N-glycosidase YbiA; Riboflavin biosynthesis intermediates N-glycosidase; EC 3.2.2.- from Escherichia coli (strain K12) (see 2 papers)
ybiA / P30176 N-glycosidase YbiA from Escherichia coli (strain K12) (see 3 papers)
ybiA / ECOCYC|EG11579-MONOMER swarming motility protein ybiA from Escherichia coli K12 (see 6 papers)
b0798 hypothetical protein (NCBI) from Escherichia coli str. K-12 substr. MG1655
Aligns to 18:157 / 160 (87.5%), covers 98.8% of PF08719, 126.1 bits
- function: Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose (PubMed:25431972). Is Required for swarming motility (PubMed:17122336).
catalytic activity: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate (RHEA:23436)
catalytic activity: 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6- diaminouracil + D-ribose 5-phosphate (RHEA:55020)
disruption phenotype: Strongly represses cell swarming but no effect on cell swimming (PubMed:17122336). Cells lacking this gene show significantly reduced FAD and FMN levels (both by 13%) (PubMed:25431972). - Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A
Hong, Antimicrobial agents and chemotherapy 2003 - “...ylcD (b0574) entE (b0594) ybfC (b0704) rh1E (b0797) ybiA (b0798) ybiX (b0804) -- (b0817) -- (b0872) csgD (b1040) pin (b1158) ychK (b1234) -- (b1364) ydbA...”
RIBXA_VIBVY / Q7MGG3 Riboflavin biosynthesis protein VVA0006; EC 3.2.2.-; EC 3.5.4.25 from Vibrio vulnificus (strain YJ016) (see paper)
Aligns to 22:161 / 367 (38.1%), covers 100.0% of PF08719, 123.3 bits
- function: Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Has no activity against GTP, nucleoside monophosphates or ADP- ribose.
function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
catalytic activity: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate (RHEA:23436)
catalytic activity: 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6- diaminouracil + D-ribose 5-phosphate (RHEA:55020)
catalytic activity: GTP + 3 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)- pyrimidine + diphosphate + formate + 2 H(+) (RHEA:23704)
cofactor: Zn(2+) (Binds 1 zinc ion per subunit.)
RIBRX_MAIZE / K7WIZ6 Riboflavin biosynthesis protein PYRR, chloroplastic; EC 1.1.1.193; EC 3.2.2.- from Zea mays (Maize) (see 2 papers)
Aligns to 456:610 / 623 (24.9%), covers 98.8% of PF08719, 114.7 bits
- function: Pyrimidine reductase involved in the riboflavin biosynthesis pathway. Has also a non-functional N-terminal deaminase domain that lacks the catalytically essential zinc-binding residues. 39% activity when NADH replaces NADPH. No evidence for a phosphatase activity conferred by the N-terminal domain.
function: Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Has no activity against GTP, nucleoside monophosphates or ADP- ribose.
catalytic activity: 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5- amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH (RHEA:17845)
catalytic activity: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate (RHEA:23436)
catalytic activity: 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6- diaminouracil + D-ribose 5-phosphate (RHEA:55020)
disruption phenotype: Lethal when homozygous. Required for both endosperm and embryo formation in the seed.
PyrR / F4JBI5 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) from Arabidopsis thaliana (see paper)
Aligns to 427:583 / 596 (26.3%), covers 98.8% of PF08719, 111.5 bits
YP_009345041 hypothetical protein from Xinzhou nematode virus 1
Aligns to 1074:1228 / 2708 (5.7%), covers 98.8% of PF08719, 82.5 bits
- RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages
Morozov, PeerJ 2017 - “..._***_ Hubei virga-like virus 2 6e47 42 YP_009337412 _***_ Xinzhou nematode virus 1 1e30 36 YP_009345041 _***_ Xingshan nematode virus 2 1e30 35 YP_009345038 Tischeria quercitella (Tischeriidae) Hubei virga-like virus 1 2e40 38 YP_009337423 _***_ Hubei virga-like virus 2 9e40 38 YP_009337412 _***_ Lodeiro virus 1e27...”
- “..._***_ Hubei virga-like virus 2 1e44 39 YP_009337412 _***_ Xinzhou nematode virus 1 3e32 39 YP_009345041 _***_ Broad bean necrosis virus 2e29 35 NP_740761 Ostrinia nubilalis (Crambidae) Hubei virga-like virus 1 7e45 41 YP_009337423 _***_ Hubei virga-like virus 2 2e41 41 YP_009337412 _***_ Xinzhou nematode virus...”
RIBRX_ARATH / Q9STY4 Riboflavin biosynthesis protein PYRR, chloroplastic; EC 1.1.1.193; EC 3.2.2.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
AT3G47390 cytidine/deoxycytidylate deaminase family protein (RefSeq) from Arabidopsis thaliana
Aligns to 434:586 / 599 (25.5%), covers 64.6% of PF08719, 75.8 bits
- function: Pyrimidine reductase involved in the riboflavin biosynthesis pathway. Has also a non-functional N-terminal deaminase domain that lacks the catalytically essential zinc-binding residues.
function: Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. Has no activity against GTP, nucleoside monophosphates or ADP-ribose.
catalytic activity: 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5- amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH (RHEA:17845)
catalytic activity: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate (RHEA:23436)
catalytic activity: 5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6- diaminouracil + D-ribose 5-phosphate (RHEA:55020) - Gene Expression Profiling of Iron Deficiency Chlorosis Sensitive and Tolerant Soybean Indicates Key Roles for Phenylpropanoids under Alkalinity Stress
Waters, Frontiers in plant science 2018 - “...II 5.0 4.1 1.1 0.9 1.2 0.9 At4g20960 PYRD MU51870 Medtr4g119220 Glyma.07G071800 Diaminohydroxyphosphoribosylaminopyrimidine deaminase 4.3 AT3G47390 PHS1,PYRR MELO3C010048 Medtr7g080120 Glyma.18G242600 Cytidine/Deoxycytidylate deaminase family protein 4.3 3.3 AT3G47390 PHS1,PYRR MELO3C010049 Medtr7g080120 Glyma.18G242600 Cytidine/Deoxycytidylate deaminase family protein 2.7 AT2G44050 COS1 MU59012 contig_50382_2 Glyma.08G087500 COS1 (COI1 SUPPRESSOR1); 6,7-dimethyl-8-ribityllumazine synthase...”
- Alkaline stress and iron deficiency regulate iron uptake and riboflavin synthesis gene expression differently in root and leaf tissue: implications for iron deficiency chlorosis
Hsieh, Journal of experimental botany 2016 - “...Csa6M003430 MU51870 AT4G20960 Diaminohydroxyphosphoribosylamino- pyrimidine deaminase 369 505 1.4 415 394 0.9 PHS1 Csa1M655920 Melo3C010048 AT3G47390 Pyrimidine reductase 177 1670 9.4 27 25 1.0 DMRLs Csa6M366300 MU59012 AT2G44050 Dimethyl-8-ribityllumazine synthase 1838 6234 3.4 1690 1142 0.7 RIBC Csa6M128550 MU45607 AT2G20690 Riboflavin synthase chain 220 385 1.8...”
- Identification and characterization of the missing pyrimidine reductase in the plant riboflavin biosynthesis pathway
Hasnain, Plant physiology 2013 (PubMed)- “...deaminase domain, and that the Arabidopsis PyrR gene (At3g47390) is coexpressed with riboflavin synthesis genes. These observations imply that PyrR is a...”
- “...this inference, Arabidopsis or maize (Zea mays) PyrR (At3g47390 or GRMZM2G090068) restored riboflavin prototrophy to an E. coli ribD deletant strain when...”
YP_001661452 ORF1ab replicase polyprotein pp1ab from Gill-associated virus
Aligns to 5820:5963 / 6673 (2.2%), covers 94.4% of PF08719, 46.8 bits
- Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes
Nga, PLoS pathogens 2011 - “...NP_828863, WBV: YP_803213, GAV: YP_001661453), RNA-dependent RNA polymerase (EAV: NP_705590, SARS-CoV: NP_828869, WBV: YP_803213, GAV: YP_001661452), superfamily 1 helicase (EAV: NP_705591, SARS-CoV: NP_828870, WBV: YP_803213, GAV: YP_001661452), exoribonuclease (SARS-CoV: NP_828871, WBV: YP_803213), N7-methyltransferase (SARS-CoV: NP_828871), uridylate-specific endonuclease (EAV: NP_705592, SARS-CoV: NP_828872, WBV: YP_803213) and 2-O-methyltransferase (SARS-CoV:...”
YP_009345038 RdRp from Xingshan nematode virus 2
Aligns to 1077:1232 / 2722 (5.7%), covers 94.4% of PF08719, 42.8 bits
Or search for genetic data about PF08719 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory