Family Search for PF08768 (THAP4_heme-bd)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF08768

PF08768 hits 27 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

NB_ARATH / O64527 Peroxynitrite isomerase Rv2717c; Ferric Arabidopsis thaliana nitrobindin; At-Nb(III); EC 5.99.-.- from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 19:165 / 166 (88.6%), covers 99.3% of PF08768, 173.7 bits

• function: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively) (PubMed:32295384). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo (PubMed:32295384, PubMed:19938152).
  catalytic activity: peroxynitrite = nitrate (RHEA:63116)
  cofactor: heme b (Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.)
  subunit: Homodimer.

THAP4_HUMAN / Q8WY91 Peroxynitrite isomerase THAP4; Ferric Homo sapiens nitrobindin; Hs-Nb(III); THAP domain-containing protein 4; EC 5.99.-.- from Homo sapiens (Human) (see 3 papers)
Aligns to 421:574 / 577 (26.7%), covers 99.3% of PF08768, 168.7 bits

• function: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N- terminal region.
  catalytic activity: peroxynitrite = nitrate (RHEA:63116)
  cofactor: heme b (Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.)
  subunit: Homodimer.

NB1_MYCTU / P9WFG7 Peroxynitrite isomerase 1; Ferric Mycobacterium tuberculosis nitrobindin; Mt-Nb(III); EC 5.99.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 8:162 / 164 (94.5%), covers 99.3% of PF08768, 165.7 bits

• function: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). In M.tuberculosis, could be part of the pool of proteins required to scavenge RNS and ROS produced by the host during the immunity response. Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
  catalytic activity: peroxynitrite = nitrate (RHEA:63116)
  cofactor: heme b (Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.)
  subunit: Homodimer.

NB2_MYCTU / P9WFG9 Peroxynitrite isomerase 2; Ferric nitrobindin; Nb(III); EC 5.99.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 64:223 / 226 (70.8%), covers 99.3% of PF08768, 137.6 bits

• function: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
  catalytic activity: peroxynitrite = nitrate (RHEA:63116)
  cofactor: heme b (Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.)
  subunit: Homodimer.

MAB7_CAEEL / Q95Q39 Protein male abnormal 7 from Caenorhabditis elegans (see paper)
Aligns to 124:277 / 287 (53.7%), covers 86.8% of PF08768, 33.4 bits

• function: Plays an important role in determining body shape and sensory ray morphology, possibly by acting as a signaling molecule outside the expressing cell.

Or search for genetic data about PF08768 in the Fitness Browser