Family Search for PF08818 (DUF1801)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

PF08818 hits 12 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Sca_1935 hypothetical protein from Staphylococcus carnosus subsp. carnosus TM300
SCA_1935 DUF1801 domain-containing protein from Staphylococcus carnosus subsp. carnosus TM300
Aligns to 20:118 / 198 (50.0%), covers 100.0% of PF08818, 73.5 bits

• Transcriptomic analysis of staphylococcal sRNAs: insights into species-specific adaption and the evolution of pathogenesis
  Broach, Microbial genomics 2016
  • “...< SCA_1913 832.99 SCAs052 jacL-52 1929303..1929527 SCA_1921 < SCA_1922 84.17 SCAs053 jacL-53 1941508..1941755 opuCA < SCA_1935 515.79 SCAs054 jacL-54 2031863..2032724 SCA_2018 > SCA_2019 7319.06 SCAs055 jacL-55 2088262..2088525 SCA_2075 > SCA_2076 761.4 SCAs056 jacL-56 2199217..2199338 SCA_2172 < SCA_2173 1628.55 SCAs057 jacL-57 2224729..2224907 SCA_2191 < SCA_2192 848.25 SCAs058...”
• Transcriptomic analysis of staphylococcal sRNAs: insights into species-specific adaption and the evolution of pathogenesis
  Broach, Microbial genomics 2016
  • “...< SCA_1913 832.99 SCAs052 jacL-52 1929303..1929527 SCA_1921 < SCA_1922 84.17 SCAs053 jacL-53 1941508..1941755 opuCA < SCA_1935 515.79 SCAs054 jacL-54 2031863..2032724 SCA_2018 > SCA_2019 7319.06 SCAs055 jacL-55 2088262..2088525 SCA_2075 > SCA_2076 761.4 SCAs056 jacL-56 2199217..2199338 SCA_2172 < SCA_2173 1628.55 SCAs057 jacL-57 2224729..2224907 SCA_2191 < SCA_2192 848.25 SCAs058...”

lin1206 similar to B. subtilis YdeI protein from Listeria innocua Clip11262
Aligns to 20:117 / 197 (49.7%), covers 100.0% of PF08818, 70.6 bits

• Listeria monocytogenes {sigma}B has a small core regulon and a conserved role in virulence but makes differential contributions to stress tolerance across a diverse collection of strains
  Oliver, Applied and environmental microbiology 2010
  • “...YdgH protein) B. subtilis YdeI protein homolog lin1206 Uncharacterized conserved protein, PhnB family CAC3689 Highly similar to methylene tetrahydrofolate...”

lmo1242 similar to B. subtilis YdeI protein from Listeria monocytogenes EGD-e
Aligns to 20:117 / 197 (49.7%), covers 100.0% of PF08818, 69.6 bits

• Protein level identification of the Listeria monocytogenes sigma H, sigma L, and sigma C regulons
  Mujahid, BMC microbiology 2013
  • “...lmo0813 Energy metabolism Sugars Lmo0930 1.88 hypothetical protein lmo0930 Unclassified Role category not yet assigned Lmo1242 1.59 hypothetical protein lmo1242 Hypothetical proteins Conserved Lmo1254 2.10 alpha-phosphotrehalase lmo1254 Energy metabolism Biosynthesis and degradation of polysaccharides Lmo1348 2.42 glycine cleavage system T protein gcvT Energy metabolism Amino acids...”
• Listeria monocytogenes {sigma}B has a small core regulon and a conserved role in virulence but makes differential contributions to stress tolerance across a diverse collection of strains
  Oliver, Applied and environmental microbiology 2010
  • “...lmo0929 lmo0995 lmo1037 lmo1064 lmo1072 lmo1121 lmo1226 lmo1242 lmo1243 lmo1360 lmo1388 lmo1421 lmo1426 lmo1427 lmo1527 lmo1534 lmo1571 lmo1580 lmo1622 lmo1635...”

RSAU_002289 YdeI family protein from Staphylococcus aureus subsp. aureus 6850
Aligns to 20:118 / 199 (49.7%), covers 100.0% of PF08818, 68.1 bits

• Identification of a Novel LysR-Type Transcriptional Regulator in Staphylococcus aureus That Is Crucial for Secondary Tissue Colonization during Metastatic Bloodstream Infection
  Groma, mBio 2020
  • “...acid permease family protein RSAU_000994 5.58 4.08E07 typA RSAU_000042 5.59 2.28E04 Dienelactone hydrolase family protein RSAU_002289 5.60 1.96E04 rpsP RSAU_001080 5.62 7.42E04 rluD RSAU_002278 5.70 4.86E04 cycA RSAU_000062 5.76 3.24E05 67-kDa myosin-cross-reactive antigen RSAU_001145 5.77 2.91E04 proS RSAU_001630 5.84 7.83E04 Mannosyl-glycoprotein endo-beta- N -acetylglucosaminidase protein RSAU_000638...”

SA2238 hypothetical protein from Staphylococcus aureus subsp. aureus N315
Aligns to 20:118 / 199 (49.7%), covers 100.0% of PF08818, 66.6 bits

• Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover
  Anderson, FEMS immunology and medical microbiology 2010
  • “...* 3.1 5 stable rplC SA2239 50S ribosomal protein L3 sa_c4880s4187_at 4.0 5 30 rplD SA2238 50S ribosomal protein L4 sa_c4848s4156_at * 2.8 15 stable rplE SA2227 50S ribosomal protein L5 sa_c9951s8647_at * 2.8 15 stable rplF SA2224 50S ribosomal protein L6 sa_c7621s6634_a_at * 3.1 5...”

SAUSA300_2394 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
Aligns to 20:118 / 199 (49.7%), covers 100.0% of PF08818, 66.6 bits

• A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis
  Cassat, Cell host & microbe 2013
  • “...4.0000 4.0000 0.0403 Putative uncharacterized protein; SAUSA300_2257 Q2FE49|Q2FE49_STAA3 0.0000 3.3333 3.3333 0.0155 Putative uncharacterized protein; SAUSA300_2394 Q2FK61|Q2FK61_STAA3 0.0000 2.3333 2.3333 0.0279 Putative lipoprotein; SAUSA300_0203 1 UniprotKB nomenclature ( www.uniprot.org ) 2 Ratio of mean LAC spectra divided by mean LAC sae / aur spectra. If mean...”

LBJ_RS09455 DUF1801 domain-containing protein from Leptospira borgpetersenii serovar Hardjo-bovis str. JB197
Aligns to 30:122 / 133 (69.9%), covers 97.6% of PF08818, 64.6 bits

• Distinct transcriptional profiles of Leptospira borgpetersenii serovar Hardjo strains JB197 and HB203 cultured at different temperatures
  Putz, PLoS neglected tropical diseases 2021
  • “...family transposase 4.65E-32 -12.55137177 48 LBJ_RS05835 flagellar basal body M-ring protein FliF 3.3E-31 4.219471408 49 LBJ_RS09455 hypothetical protein 4.84E-31 -3.272227444 50 LBJ_RS16285 hypothetical protein 1.05E-30 -4.593857724 10.1371/journal.pntd.0009320.t005 Table 5 The forty-one significantly differentially expressed genes between HB203 grown at 29C and 37C. All genes are relative...”

EF1737 hypothetical protein from Enterococcus faecalis V583
Aligns to 19:137 / 155 (76.8%), covers 97.6% of PF08818, 62.9 bits

• Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalis
  Gilmore, mBio 2020
  • “...of genes that become important to fitness upon antibiotic exposure include a group of genes (EF1737, EF1741, EF1743, EF1745, EF1748, EF1758, and EF1769) that lie on either side of the recently described liaXYZ operon (EF1753EF1751) ( 68 ). These genes have no discernible impact on daptomycin...”

YP_002005759 hypothetical protein from Cupriavidus taiwanensis
Aligns to 18:114 / 138 (70.3%), covers 98.8% of PF08818, 60.8 bits

• Plant-bacteria association and symbiosis: are there common genomic traits in alphaproteobacteria?
  Pini, Genes 2011
  • “...YP_001177947 2654 Adenylate cyclase YP_932132 YP_002008552 2734 ABC transporter YP_001175837 YP_002237478 YP_001177423 YP_002239806 2737 Unknown YP_002005759 2774 Endoribonuclease l-psp YP_931980 YP_002008711 YP_001178228 YP_002237662 YP_002008874 YP_002238064 2791 Phosphoesterase 2853 Electron transfer flavoprotein, beta subunit YP_001796225 2898 Unknown YP_002236173 2908 Electron transfer flavoprotein, alpha subunit YP_001796224 2912 Methyltransferase...”

BH2032 hypothetical protein from Bacillus halodurans C-125
Aligns to 16:111 / 123 (78.0%), covers 100.0% of PF08818, 57.7 bits

• Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from Thermus thermophilus
  Doni, International journal of molecular sciences 2024
  • “...additional members, the DUF1801 domain-containing protein from Lactobacillus paracasei (PDB.ID: 2I8D chain A) and the BH2032 protein (PDB.ID: 2KL4 chain A) from Bacillus halodurans. To further explore the structural similarities between Nqo15 and representatives of FXN-like folds, we used the Dali server to obtain a similarity...”

FRA_BACSU / Q797E6 Intracellular iron chaperone frataxin; Fra; Iron channeling protein frataxin from Bacillus subtilis (strain 168) (see 4 papers)
BSU05750 hypothetical protein from Bacillus subtilis subsp. subtilis str. 168
Aligns to 16:111 / 123 (78.0%), covers 100.0% of PF08818, 57.0 bits

• function: Plays an essential role in iron intracellular trafficking to iron cofactor biogenesis systems including iron-sulfur cluster (Fe-S) or heme assembly (PubMed:21744456, PubMed:25826316). Promotes the biosynthesis of iron-sulfur clusters by delivering Fe to the complex composed of the cysteine desulfurase SufS and the zinc-dependent sulfurtransferase SufU (PubMed:27382962). Also plays a critical role in coproporphyrin-dependent heme b biogenesis and thus provides an essential function for the bacterial global metabolism.
  cofactor: Fe(2+) (Binds 1.0 Fe(2+) (PubMed:20087498) to 1.5 to 3.2 Fe(2+) per monomer (PubMed:21744456).)
  subunit: Homodimer, upon Fe(2+) binding (PubMed:20087498). Interacts with the SufS/SufU complex (PubMed:27382962). Interacts with CpfC (PubMed:25826316).
  disruption phenotype: Reduced growth in rich medium, unable to grow in minimal medium. Reduced activity of Fe-S-dependent aconitase (citB). Reactive oxygen species are drastically reduced. No bacillibactin (BB), an endogenous siderophore, produced. 20% higher intracellular iron concentrations.
• The Blueprint of a Minimal Cell: MiniBacillus
  Reuß, Microbiology and molecular biology reviews : MMBR 2016
  • “...No BSU03950 No BSU32670 BSU32680 BSU32700 BSU32690 BSU32710 BSU05750 BSU32220 Yes Yes Yes Yes Yes No No BSU28390 Yes Metals and iron-sulfur clusters Sodium...”

LS25_1609 DUF1801 domain-containing protein from Latilactobacillus sakei subsp. sakei LS25
Aligns to 16:109 / 114 (82.5%), covers 91.7% of PF08818, 40.6 bits

• Effects of glucose availability in Lactobacillus sakei; metabolic change and regulation of the proteome and transcriptome
  McLeod, PloS one 2017
  • “...-0.73 0.72 0.74 0.68 LCA_0743 LS25_0799 Putative S-adenosylmethionine-dependent-methyltransferase 0.75 1.90 -0.74 0.73 0.72 0.68 LCA_1526 LS25_1609 Hypothetical protein 0.59 1.47 -0.83 0.82 0.79 0.79 3 LCA_0202 LS25_0208 Ribokinase ( rbsK ) -0.65 -0.89 0.67 -0.67 -0.63 -0.68 4 LCA_0217 LS25_0262 Putative thiosulfate sulfurtransferase with a ArsR-HTH...”

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