Family Search for PF08878 (HamA)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF08878 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

AbpA / b2628 CP4-57 prophage; anti-bacteriophage protein from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ABPA_ECOLI / P52127 Anti-bacteriophage protein A from Escherichia coli (strain K12) (see 2 papers)
Aligns to 294:520 / 538 (42.2%), covers 99.6% of PF08878, 142.3 bits

• function: Part of an antiviral system composed of AbpA and AbpB; when both are expressed from a plasmid they confer resistance to phages T2, T4, T7 and lambda but not RB32 or RB69. Resistance is temperature dependent, it can be seen at 30 degrees Celsius but not at 37 or 42 degrees Celsius. The system impairs phage but not bacterial DNA synthesis (shown for T4, T7 and lambda). Partially suppressed by mutations in T4 gene 41, a replicative helicase.
  subunit: Interacts with AbpB.
  disruption phenotype: About 20% increase in T4 progeny; the phenotype is the same in a double abpA-abpB deletion.

HAMA_BACCE / P0DW39 Hachiman protein HamA from Bacillus cereus (see paper)
Aligns to 45:235 / 271 (70.5%), covers 73.0% of PF08878, 55.9 bits

• function: Component of antiviral defense system Hachiman, composed of HamA and HamB. Expression of Hachiman in B.subtilis (strain BEST7003) confers resistance to phages phi105, phi29, phi3T, rho14, SBSphiJ, SpBeta and SPR.
  disruption phenotype: When this gene is missing the Hachiman system does not confer SpBeta resistance in B.subtilis.

Or search for genetic data about PF08878 in the Fitness Browser