Family Search for PF08924 (Rv2525c_GlyHyd-like)

PF08924 hits 16 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

FADG_BACSU / O34320 Uncharacterized protein FadG from Bacillus subtilis (strain 168) (see paper)
Aligns to 303:489 / 576 (32.5%), covers 99.0% of PF08924, 180.7 bits

LYS25_MYCTU / I6XEI5 Putative peptidoglycan hydrolase Rv2525c; EC 3.2.1.17 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
Aligns to 52:231 / 240 (75.0%), covers 99.0% of PF08924, 163.9 bits

• function: May function as a peptidoglycan hydrolase with glycosidase activity (PubMed:25260828). In vitro, displays esterase activity toward p-nitrophenyl esters of various acyl chain length (C4 to C16), with a preference for p-nitrophenyl butyrate (C4) (PubMed:25869294).
  catalytic activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
  disruption phenotype: Cells lacking this gene display an increase in susceptibility to some beta-lactam antibiotics and, despite slower growth in vitro, enhanced virulence in both cellular and murine models of tuberculosis. No detectable difference in the lipid profiles.

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