Family Search for PF09313 (DUF1971)
PF09313 hits 20 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
APL_1350 tellurite resistance protein TehB-like protein from Actinobacillus pleuropneumoniae L20
Aligns to 8:88 / 290 (27.9%), covers 100.0% of PF09313, 120.7 bits
TEHB_HAEIN / P45134 Probable S-adenosyl-L-methionine-dependent methyltransferase TehB; Tellurite resistance protein TehB homolog; EC 2.1.1.- from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
HI1275 tellurite resistance protein (tehB) from Haemophilus influenzae Rd KW20
Aligns to 9:89 / 286 (28.3%), covers 100.0% of PF09313, 114.4 bits
- function: Probable S-adenosyl-L-methionine-dependent methyltransferase. Plays a role in both resistance to oxidative damage and heme uptake/utilization. Also protects H.influenzae from tellurite exposure in vitro; however, since H.influenzae grows only in humans, it is unlikely to encounter tellurite in its natural environment, and it is thus probable that tellurite resistance does not represent a biologically relevant role of TehB (By similarity).
- Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance
Earl, EMBO molecular medicine 2015 - “...responses such as iron uptake (HI0994), biofilm formation (HI1344), stress response (HI0628) and antimicrobial resistance (HI1275) as well as the yfe operon ( HI0359HI0362 ), which encodes an ABC transporter putatively involved in metal ion uptake and previously implicated in H.influenzae virulence regulation, adherence to host...”
- “...qRTPCR: the mRNA levels of five up-regulated genes ( HI0075 , HI0095 , HI0628 , HI1275 and HI1677 ) and four down-regulated genes ( HI0127 , HI0811 , HI1177 and HI1431 ) (Fig 2D ). The ratios of the transcripts from samples determined by RNA-seq to...”
- Characterization of the Haemophilus influenzae tehB gene and its role in virulence
Whitby, Microbiology (Reading, England) 2010 - “...9 January 2010 The Haemophilus influenzae ORF designated HI1275 in the Rd KW20 genomic sequence encodes a putative S-adenosyl methyltransferase with significant...”
- “...influenzae tehB and its role in virulence designated HI1275, encodes a putative protein with a high degree of similarity to a previously described S-adenosyl...”
- The iron/heme regulated genes of Haemophilus influenzae: comparative transcriptional profiling as a tool to define the species core modulon
Whitby, BMC genomics 2009 - “...-3.60 HI1218 4.67 33.45 3.58 17.21 ns 11.58 HI1224 -1.66 -1.2 -1.68 -1.93 ns 1.13 HI1275 -2.01 1.07 -1.37 1.01 -3.34 -5.77 HI1305 ns 2.29 1.68 2.29 ns 1.71 HI1356 ns -1.83 -2.25 -1.83 -1.82 -2.15 HI1366 -1.66 -1.08 -1.59 -1.60 ns -1.42 HI1368 ns 2.24...”
- Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions
Deslandes, BMC genomics 2007 - “...ap1666 valS valyl-tRNA synthetase 1.22 Cellular processes ap0168 napC transformation locus protein OrfG 1.62 ap1505 HI1275 tellurite resistance protein TehB 1.61 ap1606 apxIC RTX-1 toxin determinant 1.57 ap0688 ftsK cell division protein FtsK 1.27 ap0025 ftsA cell division protein FtsA 1.22 Cell envelope ap0486 mreB similar...”
- “...hypothetical protein ap1738 exbD 1187 biopolymer transport protein ap0286 nagB 875 conserved hypothetical protein ap1505 HI1275 656 tellurite resistance protein TehB ap1363 fldA 353 flavodoxin Down-Regulated genes ap0108 nrfA 1792 nitrate reductase cytochrome c552 ap1470 ap1698 dcuB1 dcuB2 1434 anaerobic C4-dicarboxylate membrane transporter ap0169-ap0173 aopA, nqrBCDE...”
- Transcriptional profile of Haemophilus influenzae: effects of iron and heme
Whitby, Journal of bacteriology 2006 - “...ansB pckA genX pdxH iga1 tbp1, tbp2 HI1217 HI1227 HI1228 HI1275 HI1349 HI13563HI1360 HI13683HI1369 1 1 1 1 1 5 2 hup uraA upp tehB HI1398 HI1427 HI1564...”
NTHI1895 tellurite resistance protein TehB from Haemophilus influenzae 86-028NP
Aligns to 9:89 / 286 (28.3%), covers 100.0% of PF09313, 113.4 bits
TEHB_HAEI1 / E1X791 Probable S-adenosyl-L-methionine-dependent methyltransferase TehB; Tellurite resistance protein TehB homolog; EC 2.1.1.- from Haemophilus influenzae (strain 10810) (see paper)
Aligns to 9:89 / 286 (28.3%), covers 100.0% of PF09313, 111.6 bits
- function: Probable S-adenosyl-L-methionine-dependent methyltransferase. Plays a role in both resistance to oxidative damage and heme uptake/utilization, and is important for virulence of this organism in an animal model of invasive disease. Also protects H.influenzae from tellurite exposure in vitro; however, since H.influenzae grows only in humans, it is unlikely to encounter tellurite in its natural environment, and it is thus probable that tellurite resistance does not represent a biologically relevant role of TehB.
disruption phenotype: Deletion of tehB leads to an increase in sensitivity both to tellurite and to the oxidizing agents cumene hydroperoxide, tert-butyl hydroperoxide and hydrogen peroxide. The tehB mutant additionally shows a significantly reduced ability to utilize free heme as well as several heme-containing moieties including heme- human serum albumin, hemoglobin and hemoglobin-haptoglobin, to support aerobic growth. Virulence of the mutant strain is reduced compared to the wild-type strain in the infant rat.
ECA0900 SAM-dependent methyltransferase TehB from Pectobacterium atrosepticum SCRI1043
ECA0900 putative tellurite resistance protein from Erwinia carotovora subsp. atroseptica SCRI1043
Aligns to 8:88 / 286 (28.3%), covers 100.0% of PF09313, 107.5 bits
YPTB1947 putative tellurite resistance protein from Yersinia pseudotuberculosis IP 32953
YPO1949 putative tellurite resistance protein from Yersinia pestis CO92
Aligns to 16:96 / 295 (27.5%), covers 100.0% of PF09313, 106.0 bits
SAG1558 tellurite resistance protein TehB from Streptococcus agalactiae 2603V/R
Aligns to 11:91 / 291 (27.8%), covers 100.0% of PF09313, 104.9 bits
- Genetic islands of Streptococcus agalactiae strains NEM316 and 2603VR and their presence in other Group B streptococcal strains
Herbert, BMC microbiology 2005 - “...( cyl operon) , sag0825, sag1190 ( pavA ) , sag1283, sag1417, sag1442, sag1472, sag1510, sag1558, sag1603, sag1675, sag1772, and sag2043 ( cfb ) Genes highlighted in bold have a known or likely role in virulence. Table 3 Strains employed for PCR and CGH analysis. Serotype...”
ZY05719_06620 SAM-dependent methyltransferase TehB from Streptococcus suis
Aligns to 8:88 / 286 (28.3%), covers 100.0% of PF09313, 101.5 bits
SP_RS04845 SAM-dependent methyltransferase TehB from Streptococcus pneumoniae TIGR4
Aligns to 8:88 / 286 (28.3%), covers 100.0% of PF09313, 99.6 bits
- Streptococcus pneumoniae metal homeostasis alters cellular metabolism
Burcham, Metallomics : integrated biometal science 2020 - “...CbpA SP_RS11185 choline binding protein A 1.3 SP1804 SP_RS08955 Alkaline shock protein, YloU 4.8 TehB SP_RS04845 tellurite resistance protein (S-adenosylmethionine-dep methyltransferase) 5.4 SP0923 SP_RS04565 Cof family protein, phosphatase (hydrolase) 7.4 SP2028 SP_RS10255 phosphotyrosine protein phosphatase...”
spr0880 Tellurite resistance from Streptococcus pneumoniae R6
Aligns to 10:90 / 288 (28.1%), covers 100.0% of PF09313, 99.5 bits
- Reactive Oxygen Species Contribute to the Bactericidal Effects of the Fluoroquinolone Moxifloxacin in Streptococcus pneumoniae
Ferrándiz, Antimicrobial agents and chemotherapy 2016 - “...(hrcA-grpE-dnaK-dnaJ) spr0692 (gor) spr1723c-1722 (groES-groEL) spr0844 (gidA) spr0880 (tehB) 2.3 3.4 2.6 3.6 2.2 2.6 spr0816 (cad) spr0284 (xylS) spr0673...”
- Pneumococcal gene complex involved in resistance to extracellular oxidative stress
Andisi, Infection and immunity 2012 - “...spr0369 spr0374 spr0426 spr0427 spr0576 spr0648 spr0880 spr0974 spr1052 spr1181 spr1353 NP_357860.1 NP_357963.1 NP_357968.1 NP_358020.1 NP_358021.1 NP_358170.1...”
- Activation of yeaR-yoaG operon transcription by the nitrate-responsive regulator NarL is independent of oxygen- responsive regulator Fnr in Escherichia coli K-12
Lin, Journal of bacteriology 2007 - “...YPTB1947 in Y. pseudotuberculosis IP32953 and locus tag spr0880 in S. pneumoniae R6). Consequently, the YeaR protein itself has been designated "TehB" or "TehB"...”
- An unstable competence-induced protein, CoiA, promotes processing of donor DNA after uptake during genetic transformation in Streptococcus pneumoniae
Desai, Journal of bacteriology 2006 - “...(Fig. 2B) (46). Expression of its upstream neighbor gene, spr0880, is invariant in response to CSP, and a terminator was identified between spr0884 and spr0885...”
- Genome of the bacterium Streptococcus pneumoniae strain R6
Hoskins, Journal of bacteriology 2001 - “...ABC-NBD&MSP spr0144 Conserved hypothetical spr0610 spr0875 spr0880 ABC-NBD/truncation pmrA tehB spr0971 spr1023 spr1052 mefE ABC-MSP MATE spr1183 spr1203...”
SMU_1645 SAM-dependent methyltransferase TehB from Streptococcus mutans UA159
Aligns to 14:94 / 293 (27.6%), covers 100.0% of PF09313, 96.3 bits
STM1808 putative cytoplasmic protein from Salmonella typhimurium LT2
Aligns to 14:94 / 113 (71.7%), covers 100.0% of PF09313, 93.0 bits
- Stress response, amino acid biosynthesis and pathogenesis genes expressed in Salmonella enterica colonizing tomato shoot and root surfaces
Han, Heliyon 2020 - “...shock protein 5.7 0.012 8.0 0.008 STM1513 STM1513 Stress-induced bacterial acidophilic repeat motif 3.3 0.002 STM1808 STM1808 Putative cytoplasmic protein; NsrR regulon 0.008 STM1851 STM1851 hypothetical protein 1.3 0.003 1.6 0.003 STM05615 STM05615 hypothetical protein 2.2 0.002 2.0 0.003 STM4271 STM4271 murein hydrolase regulator LrgA 1.4...”
- “...yoaG DUF1869 domain-containing protein; NsrR regulon gene ygbA Nitrous oxide-stimulated promoter; NsrR regulon 3.5 3.5 STM1808 Putative cytoplasmic protein; NsrR regulon - yfhH DNA-binding transcriptional regulator; possible NsrR binding site in E.coli 1.0 1.2 soxR Redox-sensitive transcriptional activatorSoxR 3.1 1.9 yqhD Alcohol dehydrogenase; induced under chlorine-based...”
- Salmonella enterica Elicits and Is Restricted by Nitric Oxide and Reactive Oxygen Species on Tomato
Ferelli, Frontiers in microbiology 2020 - “...tomato leaves and roots identified multiple up-regulated NsrR regulon genes, ygbA , ytfE , yoaG STM1808 and yfhH (Han et al., unpublished), which in E. coli is known to offer an NsrR binding site ( Partridge et al., 2009 ). Supporting this, we assayed two genes...”
- Salmonella Establishment in Agricultural Soil and Colonization of Crop Plants Depend on Soil Type and Plant Species
Jechalke, Frontiers in microbiology 2019 - “...Additionally, expression of genes associated with infection and host-pathogen interaction was increased ( feoB , STM1808, STM0082), as well as genes associated with biofilm formation ( yaiC, luxS ). Interestingly, sulA , which is associated with filamentation and downregulation of SPI-1 as well as celC ,...”
- “...( Kim H. et al., 2013 ). Further genes upregulated in response to LM, were: STM1808, which was reported to support the growth of Salmonella during systemic infection of mice ( Karlinsey et al., 2012 ) and STM0082, also referred to as gene srfN , which...”
- Deciphering nitric oxide stress in bacteria with quantitative modeling
Robinson, Current opinion in microbiology 2014 - “...reduced viability in murine macrophages. [ 8 ] S . Typhimurium hmp, xth, nfo, ytfE, STM1808 Mutants lacking hmp exhibited reduced survival in human macrophages [ 25 ] and attenuated virulence in mice [ 26 ]. Mutations in base excision repair ( xth and nfo )...”
- The NsrR regulon in nitrosative stress resistance of Salmonella enterica serovar Typhimurium
Karlinsey, Molecular microbiology 2012 - “...Typhimurium 14028s using transcriptional microarray, qRT-PCR and in silico methods. A novel NsrR-regulated gene designated STM1808 has been identified, along with hmp , hcp-hcr , yeaR-yoaG , ygbA and ytfE . STM1808 and ygbA are important for S. Typhimurium growth during nitrosative stress, and the hcp-hcr...”
- “...metalloprotein, with histidine residues H32 and H82 required for NO resistance and zinc binding. Moreover, STM1808 and ytfE promote Salmonella growth during systemic infection of mice. Collectively, these findings demonstrate that NsrR-regulated genes in addition to hmp are important for NO detoxification, nitrosative stress resistance and...”
Swit_5202 hypothetical protein from Sphingomonas wittichii RW1
Aligns to 8:82 / 92 (81.5%), covers 98.8% of PF09313, 89.3 bits
3bb6C / P64488 Crystal structure of the p64488 protein from e.Coli (strain k12). Northeast structural genomics consortium target er596
Aligns to 12:96 / 113 (75.2%), covers 100.0% of PF09313, 79.7 bits
c2204 Hypothetical protein yeaR from Escherichia coli CFT073
Aligns to 12:96 / 119 (71.4%), covers 100.0% of PF09313, 79.5 bits
YeaR / b1797 DUF1971 domain-containing protein YeaR from Escherichia coli K-12 substr. MG1655 (see 4 papers)
NP_416311 DUF1971 domain-containing protein YeaR from Escherichia coli str. K-12 substr. MG1655
UTI89_C1995 hypothetical protein YeaR from Escherichia coli UTI89
b1797 hypothetical protein from Escherichia coli str. K-12 substr. MG1655
Z2839 No description from Escherichia coli O157:H7 EDL933
ECs2506 hypothetical protein from Escherichia coli O157:H7 str. Sakai
Aligns to 12:96 / 119 (71.4%), covers 100.0% of PF09313, 79.5 bits
- Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters.
Squire, The Biochemical journal 2009 (PubMed)- GeneRIF: DNase I footprinting studies identified Fis-binding sites that overlap the yeaR promoter NarL site at position -43.5, and the ogt promoter NarL site at position -78.5, and suggest that Fis represses both promoters by displacing NarL.
- Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis
Conover, mBio 2016 - “...chuT 5.365860462 Putative periplasmic binding protein with FepB/HutB regions UTI89_C1122 iroB 5.215178967 Putative glucosyl transferase UTI89_C1995 yeaR 4.653666496 Hypothetical protein UTI89_C0599 ybdB 4.367933273 Paal_thioesterasetetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for PA, phenylacetic acid PA degradation in bacteria UTI89_C0587...”
- 18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
, Haematologica 2013 - Global gene expression profiling of the asymptomatic bacteriuria Escherichia coli strain 83972 in the human urinary tract
Roos, Infection and immunity 2006 - “...Gene Code c1686 b1476 b1226 b1796 b4209 b1223 ECs5443 b1797 Z2001 b1541 Z0893 b1227 b1225 b4013 b2941 b2552 c4141 b1475 b0873 b3240 b3556 b2732 b3437 b3242...”
- “...up-regulation in all patients (Table 1). The yeaR gene (b1797) has been shown to be induced by nitrate, together with the yoaG gene (b1796) (15), which also...”
- Hierarchical control of anaerobic gene expression in Escherichia coli K-12: the nitrate-responsive NarX-NarL regulatory system represses synthesis of the fumarate-responsive DcuS-DcuR regulatory system
Goh, Journal of bacteriology 2005 - “...not defined. These apparently activated genes were yeaR-yoaG (b1797 and b1796), and the apparently repressed genes were yegE (b2067) and yeiTA (b2146 and...”
- Disruption of rcsB by a duplicated sequence in a curli-producing Escherichia coli O157:H7 results in differential gene expression in relation to biofilm formation, stress responses and metabolism
Sharma, BMC microbiology 2017 - “...2.0E-04 ydeF Z2308 Unknown +2.83 2.7E-06 Z2421 Unknown +1.79 0.03 yoaG Z2838 Unknown +2.54 0.02 Z2839 Unknown +2.36 0.04 Z2893 Unknown 1.61 0.01 rcnB Z3275 Putative nickel/cobalt efflux protein 1.61 0.02 ypeC Z3656 Unknown 23.74 1.9E-17 ypfG Z3722 Unknown 4.58 9.0E-09 Z3965 Unknown 2.33 1.5E-03 Z4126...”
- Gene expression induced in Escherichia coli O157:H7 upon exposure to model apple juice
Bergholz, Applied and environmental microbiology 2009 - “...ECs2283 ECs2289 ECs2292 ECs2303 ECs2392 ECs2449 ECs2505 ECs2506 ECs2536 ECs2544 ECs2558 ECs2581 ECs2614 ECs2622 ECs2623 ECs2692 ECs2714 ECs2737 ECs2758 ECs2759...”
- Inversions over the terminus region in Salmonella and Escherichia coli: IS200s as the sites of homologous recombination inverting the chromosome of Salmonella enterica serovar typhi
Alokam, Journal of bacteriology 2002 - “...inversion of 870 kb (including the genes ECs1667 to ECs2506) (Fig. 2B). The order of most genes of EDL933, an independent wild-type strain of E. coli O157:H7,...”
NMB1617 putative tellurite resistance protein from Neisseria meningitidis MC58
Aligns to 16:91 / 289 (26.3%), covers 98.8% of PF09313, 65.0 bits
- The Hfq regulon of Neisseria meningitidis
Huis, FEBS open bio 2017 - “...acid metabolism 2.4 2.7 NMB0881 cysT f Sulfate transport system permease Membrane components 7.3 2.2 NMB1617 tehB Tellurite resistance protein/methyltransferase Response to tellurium ion 3.0 2.1 NMB1934 atpD ATP synthase subunit beta Oxidative phosphorylation 1.7 1.8 2.2 NMB1935 atpG ATP synthase gamma chain Oxidative phosphorylation 1.8...”
- Role of Hfq in iron-dependent and -independent gene regulation in Neisseria meningitidis
Mellin, Microbiology (Reading, England) 2010 - “...cysK Cysteine synthase 2.72 2.65 1.66 1.15 NMB0993 Rubredoxin ETC protein 9.13 5.25 2.46 2.10 NMB1617 TehB Methyltransferase 2.98 2.65 1.65 1.56 NMB1934 atpD ATP synthase 1.79 3.11 1.04 1.11 Hypothetical: NMB0986 Hypothetical protein 2.3 2.5 1.4 1.2 Table 3. Hfq-regulated IG regions identified my microarray...”
NGO1161 hypothetical protein from Neisseria gonorrhoeae FA 1090
Aligns to 16:91 / 289 (26.3%), covers 98.8% of PF09313, 64.8 bits
- Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae
Isabella, BMC genomics 2011 - “...B (HSP- F84.1) RpoH, MtrR recX NGO1053 3.6 2.8 RecX-family regulator of RecA function tehB NGO1161 2.6 4.0 Tellurite resistance protein hsp33 NGO1189 6.1 5.2 Heat shock protein HSP-33 chaperonin MtrR NGO1245 4.0 8.5 ABC-type multidrug transport system, ATPase/permease hit NGO1273 2.3 5.5 Protein Kinase C...”
- “...anaerobically, including those encoding glutaredoxin, Grx3, cytochrome C peroxidase, CCP (NGO1769), tellurite resistance protein, TehB (NGO1161), and nitroreductase-like protein, NtrA (NGO1702, Table 1 , Figure 2E ). CCP was shown to protect gonococci from hydrogen peroxide mediated damage, but not to be involved in protection from...”
SGRAN_3396 DUF1971 domain-containing protein from Sphingopyxis granuli
Aligns to 19:94 / 103 (73.8%), covers 88.8% of PF09313, 45.9 bits
lpp2599 hypothetical protein from Legionella pneumophila str. Paris
Aligns to 23:91 / 298 (23.2%), covers 77.5% of PF09313, 45.8 bits
- High precision multi-genome scale reannotation of enzyme function by EFICAz
Arakaki, BMC genomics 2006 - “...lpf lpl2377 16390437 2.7.3.- 2.7.3.- 3 Bacteria lpp lpp2524 16390437 2.7.3.- 2.7.3.- 3 Bacteria lpp lpp2599 11053398 2.1.1.- 2.1.1.- 3 Archaea mja MJ0883 15165845 2.1.1.31 2.1.1.- 3 Archaea pho PH1035 15737605 2.4.1.- 2.4.1.- 3 Archaea pho PH1915 16260766 2.1.1.- 2.1.1.- 3 Archaea pho PH1948 16245322 2.1.1.-...”
Or search for genetic data about PF09313 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory