Family Search for PF09323 (DUF1980)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF09323 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TCMPA_STRMU / Q8DUY4 Putative two-component membrane permease complex subunit SMU_746c from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see paper)
Aligns to 2:102 / 271 (37.3%), covers 100.0% of PF09323, 113.4 bits

• function: Could be part of a two-component membrane permease system responsible for amino acid transport under low pH. Involved in acidogenesis, biofilm formation and low-pH survival.
  subunit: Interacts with SMU_747c.
  disruption phenotype: SMU_746c-SMU_747c deletion affects biofilm formation in a medium- and pH-dependent manner. Mutants show a reduced ability to grow in acidified medium, but they survive both short-term or long-term acid stress. Mutants have lower glycolytic activity. Deletion does not affect membrane proton permeability.

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