Family Search for PF09740 (DUF2043)

PF09740.9 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

UVSSA_HUMAN / Q2YD98 UV-stimulated scaffold protein A from Homo sapiens (Human) (see 3 papers)
XP_016863982 UV-stimulated scaffold protein A isoform X1 from Homo sapiens
Aligns to 497:603 / 709 (15.1%), covers 98.1% of PF09740, 133.3 bits

• function: Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
  subunit: Interacts with the elongating form of RNA polymerase II (RNA pol IIo). Interacts with ERCC6, ERCC8 and USP7.
• The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.
  van, Nature communications 2020
  • GeneRIF: TCR is initiated by RNAPIIo-bound CSB, which recruits CSA through a newly identified CSA-interaction motif (CIM); once recruited, CSA facilitates the association of UVSSA with stalled RNAPIIo; in addition, UVSSA is the key factor that recruits the TFIIH complex in a manner that is stimulated by CSB and CSA
• FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.
  Wienholz, Nucleic acids research 2019
  • GeneRIF: FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates transcription-coupled nucleotide excision repair.
• UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan.
  Ijaz, Journal of dermatological science 2019 (PubMed)
  • GeneRIF: Study reports nine UV-sensitive syndrome cases from two Pakistani families with a novel homozygous nonsense mutation, (c.1040 G > A [p.(Trp347*)]) in exon 6 of the UVSSA gene.
• Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.
  Higa, The FEBS journal 2018 (PubMed)
  • GeneRIF: UVSSA is mono-ubiquitinated in vitro. Lys(414) is the target of ubiquitination. Lys(414) was also modified by poly-ubiquitin chains in vivo. The substitution of Lys(414) by Arg of UVSSA inhibited its degradation and thereby suppressed the deficiency in transcription-coupled nucleotide excision repair.
• Common TFIIH recruitment mechanism in global genome and transcription-coupled repair subpathways.
  Okuda, Nucleic acids research 2017
  • GeneRIF: Data suggest that a common TFIIH subunit p62 recruitment mechanism is shared by UV-stimulated scaffold protein A (UVSSA) in transcription-coupled repair (TCR) and xeroderma pigmentosum, complementation group C protein (XPC) in global genome repair (GGR).
• Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair.
  Higa, The Journal of biological chemistry 2016
  • GeneRIF: stabilization of UVSSA by interaction with USP7 is essential for Transcription-coupled Nucleotide Excision Repair
• [Molecular cloning and characterisation of UVSSA, the responsible gene for UV-sensitive syndrome].
  Ogi, Seikagaku. The Journal of Japanese Biochemical Society 2013 (PubMed)
  • GeneRIF: Human UVSSA protein is required for the ubiquitination of RNA polymerase and DNA repair after light-induced DNA damage [review].
• UVSSA and USP7, a new couple in transcription-coupled DNA repair.
  Schwertman, Chromosoma 2013
  • GeneRIF: UVSSA together with USP7 is implicated in regulating transcription-coupled DNA repair.[review]
• More

NP_505012 UV-stimulated scaffold protein A homolog from Caenorhabditis elegans
Aligns to 388:493 / 582 (18.2%), covers 99.1% of PF09740, 130.7 bits

• A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA.
  Babu, DNA repair 2016
  • GeneRIF: functional homolog of the human UVSSA gene in the nematode Caenorhabditis elegans

AT3G61800 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 409:512 / 664 (15.7%), covers 97.2% of PF09740, 93.9 bits

• UVSSA, UBP12, and RDO2/TFIIS Contribute to Arabidopsis UV Tolerance
  Al, Frontiers in plant science 2019
  • “...significance. Results In this study we identify the Arabidopsis UVSSA homolog. Arabidopsis UVSSA (encoded by At3g61800) is 39% and 28% identical to rice and human UVSSA, respectively. Clear UVSSA homologs are found throughout the animal and plant kingdoms including angiosperms, gymnosperms, ferns, and moss. One million...”
  • “...Analysis of CHR8 and UVSSA alleles. (A) Map of CHR8 ( At2g18760 ) and UVSSA (At3g61800) genes. Lines indicate introns and boxes exons, with coding regions shaded light gray and untranslated regions dark gray. For CHR8 , transcript At2g18760.4 is shown because it is the best...”

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