Family Search for PF09740 (DUF2043)

Running HMMer for PF09740

PF09740 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

UVSSA_HUMAN / Q2YD98 UV-stimulated scaffold protein A from Homo sapiens (Human) (see 4 papers)
XP_016863982 UV-stimulated scaffold protein A isoform X2 from Homo sapiens
Aligns to 497:603 / 709 (15.1%), covers 98.1% of PF09740, 139.5 bits

• function: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II- blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Also facilitates transfer of TFIIH to RNA polymerase II (PubMed:32142649). Not involved in processing oxidative damage (PubMed:22466612).
  subunit: Interacts with the elongating form of RNA polymerase II (RNA pol IIo) during transcription stress (PubMed:22466611, PubMed:32142649). Interacts with the TFIIH complex during transcription stress (PubMed:32142649). Interacts with ERCC6 (PubMed:22466612). Interacts with ERCC8 (PubMed:22466612). Interacts with USP7 (PubMed:22466611, PubMed:22466612).
• The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics
  Llerena, Nature communications 2024
  • “...comprising the amino acid sequences of the human TC-NER subunits (UniProt accession numbers: Q13216, Q03468, Q2YD98, Q9BW61, Q93009 and Q16531). Default parameters were applied, including carbamidomethylation of cysteine and oxidation of methionine set as fixed and variable modifications, respectively. BS3 was selected as the crosslinker. Four...”
• Transcription coupled DNA repair protein UVSSA binds to DNA and RNA: Mapping of nucleic acid interaction sites on human UVSSA.
  Mistry, Archives of biochemistry and biophysics 2023 (PubMed)
  • GeneRIF: Transcription coupled DNA repair protein UVSSA binds to DNA and RNA: Mapping of nucleic acid interaction sites on human UVSSA.
• Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein.
  Mistry, International journal of biological macromolecules 2023 (PubMed)
  • GeneRIF: Structural characterization of transcription-coupled repair protein UVSSA and its interaction with TFIIH protein.
• The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.
  Kordon, Proceedings of the National Academy of Sciences of the United States of America 2022
  • GeneRIF: The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling.
• The UVSSA complex alleviates MYC-driven transcription stress.
  Sato, The Journal of cell biology 2021
  • GeneRIF: The UVSSA complex alleviates MYC-driven transcription stress.
• USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.
  Zhu, Cell cycle (Georgetown, Tex.) 2020
  • GeneRIF: USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage.
• The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.
  van, Nature communications 2020
  • GeneRIF: TCR is initiated by RNAPIIo-bound CSB, which recruits CSA through a newly identified CSA-interaction motif (CIM); once recruited, CSA facilitates the association of UVSSA with stalled RNAPIIo; in addition, UVSSA is the key factor that recruits the TFIIH complex in a manner that is stimulated by CSB and CSA
• FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER.
  Wienholz, Nucleic acids research 2019
  • GeneRIF: FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates transcription-coupled nucleotide excision repair.
• UV-sensitive syndrome: Whole exome sequencing identified a nonsense mutation in the gene UVSSA in two consanguineous pedigrees from Pakistan.
  Ijaz, Journal of dermatological science 2019 (PubMed)
  • GeneRIF: Study reports nine UV-sensitive syndrome cases from two Pakistani families with a novel homozygous nonsense mutation, (c.1040 G > A [p.(Trp347*)]) in exon 6 of the UVSSA gene.
• More

NP_505012 UV-stimulated scaffold protein A homolog from Caenorhabditis elegans
Aligns to 388:493 / 582 (18.2%), covers 99.1% of PF09740, 128.3 bits

• A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA.
  Babu, DNA repair 2016
  • GeneRIF: functional homolog of the human UVSSA gene in the nematode Caenorhabditis elegans

AT3G61800 hypothetical protein from Arabidopsis thaliana
Aligns to 409:512 / 664 (15.7%), covers 97.2% of PF09740, 99.8 bits

• Arabidopsis RAD16 Homologues Are Involved in UV Tolerance and Growth
  Alrayes, Genes 2023
  • “...1 (SALK_025534 in At5g21900), ddb2 - 1 (SALK_040408 in At5g58760), uvssa - 2 (SALK_061538 in At3g61800), and csb - 1 (SALK_000799 in At2g18760), rad23b - 1 (SALK_076360 in At1g79650). All insertion mutant lines were genotyped using allele-specific primers, along with the T-DNA-specific primer LBb1.3 ( Table...”
• UVSSA, UBP12, and RDO2/TFIIS Contribute to Arabidopsis UV Tolerance
  Al, Frontiers in plant science 2019
  • “...significance. Results In this study we identify the Arabidopsis UVSSA homolog. Arabidopsis UVSSA (encoded by At3g61800) is 39% and 28% identical to rice and human UVSSA, respectively. Clear UVSSA homologs are found throughout the animal and plant kingdoms including angiosperms, gymnosperms, ferns, and moss. One million...”
  • “...Analysis of CHR8 and UVSSA alleles. (A) Map of CHR8 ( At2g18760 ) and UVSSA (At3g61800) genes. Lines indicate introns and boxes exons, with coding regions shaded light gray and untranslated regions dark gray. For CHR8 , transcript At2g18760.4 is shown because it is the best...”

8b3dc / Q2YD98 Structure of the pol ii-tcr-elof1 complex.
Aligns to 118:197 / 264 (30.3%), covers 46.2% of PF09740, 80.0 bits

• Ligand: zinc ion (8b3dc)

Or search for genetic data about PF09740 in the Fitness Browser