Family Search for PF09740 (DUF2043)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF09740 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

UVSSA_HUMAN / Q2YD98 UV-stimulated scaffold protein A from Homo sapiens (Human) (see 4 papers)
Aligns to 497:603 / 709 (15.1%), covers 98.1% of PF09740, 139.5 bits

• function: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II- blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Also facilitates transfer of TFIIH to RNA polymerase II (PubMed:32142649). Not involved in processing oxidative damage (PubMed:22466612).
  subunit: Interacts with the elongating form of RNA polymerase II (RNA pol IIo) during transcription stress (PubMed:22466611, PubMed:32142649). Interacts with the TFIIH complex during transcription stress (PubMed:32142649). Interacts with ERCC6 (PubMed:22466612). Interacts with ERCC8 (PubMed:22466612). Interacts with USP7 (PubMed:22466612, PubMed:22466611).

Or search for genetic data about PF09740 in the Fitness Browser