Family Search for PF09755 (DUF2046)

PF09755 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

XP_006514339 coiled-coil domain-containing protein 6 isoform X1 from Mus musculus
Aligns to 25:330 / 412 (74.3%), covers 95.7% of PF09755, 513.0 bits

• Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity.
  Leone, Oncotarget 2015
  • GeneRIF: Ccdc6-ex2 knock-in mice developed thyroid hyperplasia associated with an enhanced CREB1 activity and an increased expression of the CREB-1 regulated genes.

NP_001414302 coiled-coil domain containing 6 from Rattus norvegicus
Aligns to 26:330 / 470 (64.9%), covers 95.7% of PF09755, 512.3 bits

• Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.
  Wang, Acta biochimica Polonica 2023 (PubMed)
  • GeneRIF: Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.

CCDC6_HUMAN / Q16204 Coiled-coil domain-containing protein 6; Papillary thyroid carcinoma-encoded protein; Protein H4 from Homo sapiens (Human) (see paper)
NP_005427 coiled-coil domain-containing protein 6 from Homo sapiens
Aligns to 42:337 / 474 (62.4%), covers 95.7% of PF09755, 505.5 bits

• CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
  Qiu, Proceedings of the National Academy of Sciences of the United States of America 2024
  • GeneRIF: CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.
• RET rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients.
  Khonrak, Pathology oncology research : POR 2023
  • GeneRIF: RET rearrangements are relevant to histopathologic subtypes and clinicopathological features in Thai papillary thyroid carcinoma patients.
• Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.
  Wang, Acta biochimica Polonica 2023 (PubMed)
  • GeneRIF: Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.
• The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells.
  Zhang, Molecular and cellular biochemistry 2022 (PubMed)
  • GeneRIF: The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells.
• Suppression of CCDC6 sensitizes tumor to oncolytic virus M1.
  Liu, Neoplasia (New York, N.Y.) 2021
  • GeneRIF: Suppression of CCDC6 sensitizes tumor to oncolytic virus M1.
• MicroRNA-146b-5p as an oncomiR promotes papillary thyroid carcinoma development by targeting CCDC6.
  Jia, Cancer letters 2019 (PubMed)
  • GeneRIF: Results demonstrate that CCDC6 is a direct target of miR-146b which downregulates CCDC6 expression in papillary thyroid cancer (PTC). Also, CCDC6 expression correlates with clinicopathological parameters and exerts significant diagnostic and prognostic value in patients with PTC.
• CCDC6 and USP7 expression levels suggest novel treatment options in high-grade urothelial bladder cancer.
  Morra, Journal of experimental & clinical cancer research : CR 2019
  • GeneRIF: The identification of two clusters of patients based on CCDC6 and USP7 expession can possibly indicate the use of PARP-inhibitor drugs.
• Analysis of CCDC6 as a novel biomarker for the clinical use of PARP1 inhibitors in malignant pleural mesothelioma.
  Morra, Lung cancer (Amsterdam, Netherlands) 2019 (PubMed)
  • GeneRIF: we propose CCDC6 as a biomarker of drugs sensitivity for MPMs. In case of MPMs expressing low levels of CCDC6 the addition of olaparib to cisplatinum and pemetrexed is expected to be highly beneficial. In case of MPMs expressing normal CCDC6 levels the sensitivity to olaparib can be restored by the addition of P5091.
• More
• Tracing the pathways and mechanisms involved in medicinal uses of flaxseed with computational methods and bioinformatics tools
  Joshi, Frontiers in chemistry 2023
  • “...ELE1 , and RFG P03372 ESR1 ESR1 , ESR , and NR3A1 Q9NWZ3 IRAK4 IRAK4 Q16204 CCDC6 CCDC6 , D10S170 , and TST1 A6NNY8 UBP27 USP27X , USP22L , and USP27 Q04609 FOLH1 FOLH1 , FOLH , NAALAD1 , PSM PSMA , and GIG27 O75340 PDCD6...”
• dBMHCC: A comprehensive hepatocellular carcinoma (HCC) biomarker database provides a reliable prediction system for novel HCC phosphorylated biomarkers
  Chu, PloS one 2020
  • “...S k S cm 2289 Q13451 FKBP5 8.00 4.29 7175 P12270 TPR 7.40 4.26 8030 Q16204 CCDC6 6.00 4.69 83667 P58004 SESN2 6.00 4.53 55367 Q9HB75 PIDD1 6.00 4.53 64065 Q96FX8 PERP 6.00 4.53 55256 Q9BV57 ADI1 6.00 4.49 27430 Q9NZL9 MAT2B 6.00 4.49 2069 O14944...”
• Ginsenoside Rh2 activates α-catenin phosphorylation to inhibit lung cancer cell proliferation and invasion.
  Zhang, Experimental and therapeutic medicine 2020
  • “...1226.3796 3 S159 P35221 CTNNA1 Catenin -1 100693 5.95 R.TPEELDDSDFETEDFDVR.S 98 9.50E-09 1120.2859 2 S641 Q16204 CCDC6 Coiled-coil domain-containing protein 6 53429 6.87 K.LDQPVSAPPSPR.D 38 0.0045 712.4462 2 S240, S244 Q9UPQ0 LIMCH1 LIM and calponin homology domains-containing protein 1 122818 6.1 K.SPEPEATLTFPFLDK.M 52 0.0031 886.3337 2...”
• β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells
  Vergara, Frontiers in physiology 2017
  • “...7 70.8 SAFB Scaffold attachment factor B1 Q15424 9 16.6 CCDC6 Coiled-coil domain-containing protein 6 Q16204 7 17.7 FSCN1 Fascin Q16658 16 41.2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 Q32MZ4 10 17 MYH14 Myosin-14 Q7Z406 42 28 KTN1 Kinectin Q86UP2 46 41.9 NMD3 60S ribosomal export...”

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