Family Search for PF09767 (DUF2053)

PF09767 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

TM147_CANLF / A0A8I3MKU8 BOS complex subunit TMEM147; Transmembrane protein 147 from Canis lupus familiaris (Dog) (Canis familiaris) (see paper)
7tm36 / A0A8C0RUW0 7tm36 (see paper)
Aligns to 2:158 / 224 (70.1%), covers 100.0% of PF09767, 230.2 bits

• function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261528). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261528). Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity). Regulates LBR localization to the nucleus inner membrane (By similarity).
  subunit: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO1 and TMEM147 (PubMed:36261528). The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO1 and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:36261528). The MPT complex associates with the SEC61 complex (PubMed:36261528). Interacts with CHRM3, CHRM1 and AVPR2 (By similarity). Interacts with LBR; promoting LBR localization to the nucleus inner membrane (By similarity). Interacts with DHCR7 (By similarity).
• Ligand: rna (7tm36)

TM147_CAPHI / I6VSD2 BOS complex subunit TMEM147; Transmembrane protein 147 from Capra hircus (Goat) (see paper)
Aligns to 2:158 / 224 (70.1%), covers 100.0% of PF09767, 230.2 bits

• function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.
  function: (Microbial infection) Involved in the immunomodulatory effects exerted by H.contortus GAL-1 on host peripheral blood mononuclear cells to down-regulate host immune response.
  subunit: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Interacts with CHRM3, CHRM1 and AVPR2. Interacts with LBR; promoting LBR localization to the nucleus inner membrane. Interacts with DHCR7.
  subunit: (Microbial infection) Interacts with H.contortus GAL-1 (via domain galectin 2).

TM147_HUMAN / Q9BVK8 BOS complex subunit TMEM147; Protein NIFIE 14; Transmembrane protein 147 from Homo sapiens (Human) (see 6 papers)
Aligns to 2:158 / 224 (70.1%), covers 100.0% of PF09767, 230.2 bits

• function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (PubMed:21056967). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (PubMed:21056967). Regulates LBR localization to the nucleus inner membrane (PubMed:32694168).
  subunit: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147 (PubMed:20538592, PubMed:36261522). The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47) (PubMed:32820719, PubMed:36261522). The MPT complex associates with the SEC61 complex (PubMed:32820719, PubMed:36261522). Interacts with CHRM3, CHRM1 and AVPR2 (PubMed:21056967). Interacts with LBR; promoting LBR localization to the nucleus inner membrane (PubMed:32694168). Interacts with DHCR7 (PubMed:32694168).

TM147_MOUSE / Q9CQG6 BOS complex subunit TMEM147; Transmembrane protein 147 from Mus musculus (Mouse) (see paper)
Aligns to 2:158 / 224 (70.1%), covers 100.0% of PF09767, 230.2 bits

• function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.
  subunit: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Interacts with CHRM3, CHRM1 and AVPR2. Interacts with LBR; promoting LBR localization to the nucleus inner membrane. Interacts with DHCR7.

CG5861 uncharacterized protein from Drosophila melanogaster
Aligns to 2:160 / 227 (70.0%), covers 100.0% of PF09767, 208.1 bits

• Misexpression screen delineates novel genes controlling Drosophila lifespan
  Paik, Mechanisms of ageing and development 2012
  • “...(PPP1R12A) 55.9 83.0 (387) 47.2 78.0 (350) 0.84 < 0.001 < 0.001 < 0.001 GX8400 CG5861 Transmembrane protein (TMEM147) 40.3 66.0 (347) 37.3 62.0 (324) 0.93 < 0.001 < 0.001 < 0.001 GX47642 CG10916 Zinc ion binding 32.0 62.0 (361) 40.8 78.0 (293) 1.28 < 0.001...”
• A comparative genomic analysis of two distant diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae
  Bolshakov, Genome research 2002
  • “...lace BG:DS07108.2 CycE beat-B beat BG:DS02740.4 Cyp303a1 heix CG5861 Sed5 cni cact I(2)35Fe BG:DS09218.4 BG:DS09218.5 46-76 79 80 48-53 47-63 88 84 55-76 82...”
  • “...microsyntenic. The latter include two adjacent genes (the CG5861 and Sed5 orthologs) that map to the 31C cytogenetic cluster. The 29C cytogenetic cluster...”

AT1G47640 hypothetical protein from Arabidopsis thaliana
Aligns to 2:164 / 228 (71.5%), covers 98.1% of PF09767, 202.2 bits

• RLPredictiOme, a Machine Learning-Derived Method for High-Throughput Prediction of Plant Receptor-like Proteins, Reveals Novel Classes of Transmembrane Receptors
  Silva, International journal of molecular sciences 2022
  • “...expressed AT1G16170 0.0 0.33333333 1 4 expressed protein AT5G03345 0.0 0.33333333 1 4 expressed protein AT1G47640 0.0 0.33333333 1 4 SSA2-2S albumin seed storage family protein precursor, putative, expressed AT5G52420 0.0 0.33333333 1 4 expressed protein BPA1 0.30818366 0.51898734 6 2 RNA recognition motif containing protein,...”
• The FLA4-FEI Pathway: A Unique and Mysterious Signaling Module Related to Cell Wall Structure and Stress Signaling
  Seifert, Genes 2021
  • “...0.145 0.112 0.1 AT3G28220 TRAF-like fam. unknown FEI1 [ 84 ] cp 0.074 0.01 -0.2 AT1G47640 seven transmembrane domain fam. receptor-like FEI1, FEI2 [ 84 ] PM, apopl. 0.07 0.17 0.19 AT2G31360 acyl-CoA desaturase like enzyme FEI1 [ 84 ] ER 0.06 0.06 0.42 AT5G47530 auxin-responsive...”
• Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)
  Pizzio, Frontiers in plant science 2017
  • “...protein Protein-fragment complementation assay (PCA) Jones et al., 2014 n.n. AT1G07860 Putative protein kinase n.n. AT1G47640 Hypothetical protein n.n. AT3G66654 Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein n.n. AT1G34640 Peptidase Data extracted from BIOGRID. n.n., no-name . Protein phosphorylation is a fundamental mechanism through which protein function...”
• Identification of rice cornichon as a possible cargo receptor for the Golgi-localized sodium transporter OsHKT1;3
  Rosas-Santiago, Journal of experimental botany 2015 (no snippet)
• Identification of two novel type 1 peroxisomal targeting signals in Arabidopsis thaliana
  Ramirez, Acta histochemica 2014
  • “...domain-containing protein AT2G26920 Ubiquitin-associated/translation elongation factor AT5G12120 Ubiquitin-associated/translation elongation factor AT4G35270 NLP2: NIN-like protein 2 AT1G47640 unknown...”
• WikiPathways for plants: a community pathway curation portal and a case study in rice and arabidopsis seed development networks
  Hanumappa, Rice (New York, N.Y.) 2013
  • “...rice MADS57 and its homolog AGL44 (circled in pink). However, rice SSA2 and its homolog AT1G47640 (circled in purple), and rice GP-alpha-1/XA7 and its homolog GPA1 (circled in blue) display conserved diurnal rhythmic expression. A similar gene expression analysis of Arabidopsis genes in the network was...”
  • “...rice MADS57 and its homolog AGL44 (circled in pink). However, rice SSA2 and its homolog AT1G47640 (circled in purple), and rice MADS56 and its homolog AGL19 (circled in blue) display conserved diurnal rhythmic expression. (PPTX 485 KB) Additional file 8: Diurnal expression of some rice genes....”
• Transcriptomic profiling during the post-harvest of heat-treated Dixiland Prunus persica fruits: common and distinct response to heat and cold
  Lauxmann, PloS one 2012
  • “...superfamily protein. At1g68300 R32 JK845796 XM_003538309 Uncharacterized protein LOC100783844 ( G. max ). Unknown protein. At1g47640 R33 JK845797 XM_002275701 Uncharacterized LOC100263264 ( V. vinifera ). Protein of unknown function (DUF544). At4g11860 R34 JK845798 XM_002267027 Putative vesicle-associated membrane protein 726-like( V. vinifera ). VAMP721 (Vesicle-Associated Membrane Protein...”

DDB_G0293704 seven transmembrane domain protein from Dictyostelium discoideum AX4
Aligns to 2:160 / 235 (67.7%), covers 100.0% of PF09767, 173.0 bits

• Sociogenomics of self vs. non-self cooperation during development of Dictyostelium discoideum
  Li, BMC genomics 2014
  • “...n.a. U box domain-containing protein; putative E3 ubiquitin-protein ligase DDB_G0279681 n.a. Calcium-binding EF-hand domain-containing protein DDB_G0293704 n.a Seven transmembrane domain protein DDB_G0276965 gltA Citrate synthase DDB_G0290527 n.a. DDB_G0283091 n.a. FNIP repeat-containing protein DDB_G0289549 n.a. DDB_G0280865 n.a. DDB_G0293522 ponA Actin binding protein; ponticulin DDB_G0283089 n.a. DDB_G0275439 cad2...”

TGME49_026270 hypothetical protein from Toxoplasma gondii ME49
Aligns to 2:161 / 258 (62.0%), covers 100.0% of PF09767, 153.9 bits

• Identifying novel cell cycle proteins in Apicomplexa parasites through co-expression decision analysis
  Butler, PloS one 2014
  • “...Loop/tail addition). An example of matching protein topology is the pair of proteins, T. gondii TGME49_026270 and P. falciparum PF10_0070 ( Fig. 4C Topology match), whereas the disordered profiles of proteins T. gondii TGME49_091150 and P. falciparum PFL0360c poorly match ( Fig. 4C Minimal match). Experimental...”

NP_001229526 BOS complex subunit TMEM147 isoform 2 from Homo sapiens
Aligns to 1:109 / 175 (62.3%), covers 70.0% of PF09767, 141.6 bits

• TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma.
  Cheng, Analytical cellular pathology (Amsterdam) 2023
  • GeneRIF: TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma.
• A biallelic loss-of-function variant in TMEM147 causes profound intellectual disability and spasticity.
  Ghorashi, Neurogenetics 2023 (PubMed)
  • GeneRIF: A biallelic loss-of-function variant in TMEM147 causes profound intellectual disability and spasticity.
• Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huët anomaly.
  Thomas, American journal of human genetics 2022
  • GeneRIF: Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huet anomaly.
• Regulation of ER Composition and Extent, and Putative Action in Protein Networks by ER/NE Protein TMEM147.
  Maimaris, International journal of molecular sciences 2021
  • GeneRIF: Regulation of ER Composition and Extent, and Putative Action in Protein Networks by ER/NE Protein TMEM147.
• Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.
  Dettmer, The Journal of biological chemistry 2010
  • GeneRIF: TMEM147 is a novel core component of the Nicalin-NOMO complex, further emphasizing its similarity with gamma-secretase.

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