Family Search for PF09922 (LiaF-like_C)
Running HMMer for PF09922
PF09922 hits 33 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
lmo1020 similar to B. subtilis YvqF protein from Listeria monocytogenes EGD-e
Aligns to 122:234 / 237 (47.7%), covers 100.0% of PF09922, 130.2 bits
lin1019 similar to B. subtilis YvqF protein from Listeria innocua Clip11262
Aligns to 122:234 / 237 (47.7%), covers 100.0% of PF09922, 129.3 bits
EF2913 conserved hypothetical protein from Enterococcus faecalis V583
OG1RF_12213 cell wall-active antibiotics response protein LiaF from Enterococcus faecalis OG1RF
Aligns to 128:240 / 243 (46.5%), covers 100.0% of PF09922, 125.2 bits
SSU0386 membrane protein from Streptococcus suis P1/7
Aligns to 115:228 / 231 (49.4%), covers 100.0% of PF09922, 124.7 bits
LSA1371 Hypothetical membrane protein from Lactobacillus sakei subsp. sakei 23K
Aligns to 137:249 / 252 (44.8%), covers 100.0% of PF09922, 122.6 bits
- Global transcriptome response in Lactobacillus sakei during growth on ribose
McLeod, BMC microbiology 2011 - “...GNAT family -0.5 LSA1365 lsa1365 Hypothetical protein -0.5 -0.7 LSA1368 lsa1368 Hypothetical protein 0.9 0.6 LSA1371 lsa1371 Hypothetical membrane protein 0.6 LSA1395 lsa1395 Putative zinc-containing alcohol dehydrogenase (oxidoreductase) 0.9 LSA1427 lsa1427 Putative hydrolase, haloacid dehalogenase 1.3 0.6 LSA1472 lsa1472 Putative N-acetyl transferase, GNAT family 0.6 LSA1535...”
LIAF_BACSU / O32199 Protein LiaF from Bacillus subtilis (strain 168) (see 6 papers)
NP_391190 membrane component associated to the LiaRS two-component system from Bacillus subtilis subsp. subtilis str. 168
Aligns to 126:238 / 241 (46.9%), covers 100.0% of PF09922, 122.1 bits
spr0342 Conserved hypothetical protein from Streptococcus pneumoniae R6
SPD_0350 hypothetical protein from Streptococcus pneumoniae D39
SPV_0350 cell wall-active antibiotics response protein LiaF from Streptococcus pneumoniae
Aligns to 114:229 / 232 (50.0%), covers 100.0% of PF09922, 117.6 bits
- Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae
El, Scientific reports 2017 - “...1.00 1.00 1.58 spr0307 clpL ATP-dependent protease ATP-binding subunit 2.16 spr0311 hypothetical protein 1.32 2.04 spr0342 hypothetical protein 1.25 spr0343 hk03 sensor histidine kinase 1.29 spr0441 pgk phosphoglycerate kinase 1.11 1.26 1.11 1.18 spr0453 hrcA heat-inducible transcription repressor 1.31 1.36 1.87 spr0454 grpE heat shock protein...”
- VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus
Boyle-Vavra, Antimicrobial agents and chemotherapy 2013 - “...SS7213T_08747 SLGD_01043 STAWA0001_0601 SPSINT_1638 LMOf2365_104 HMPREF0352_0461 spr0342 BA_1455 GYO_3616 aa positions of TM helices psi BLAST e value...”
- The pneumococcal cell envelope stress-sensing system LiaFSR is activated by murein hydrolases and lipid II-interacting antibiotics
Eldholm, Journal of bacteriology 2010 - “...the pneumococcal system also contains a third component (spr0342) corresponding to LiaF. Our results show that CbpD, together with LytA and LytC, activates the...”
- “...a promoter deletion analysis. Promoter fragments upstream of spr0342 were transcriptionally fused to lacZ, using the promoter-probe vector pPPP2 (14) (see Table...”
- The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance
De, PLoS pathogens 2024 - “...SPD_0279 celB cellobiose PTS transporter subunit 5.05 2.97 SPD_0308 clpL ATP-dependent protease subunit 13.7 9.55 SPD_0350 vraT cell wall-active antibiotic response protein 2.19 2.62 SPD_0351 vraS two-component system histidine kinase 2.29 2.74 SPD_0352 vraR two-component system response regulator 2.31 2.70 SPD_0353 alkD degenerate DNA alkylation repair...”
- Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae
Zhang, mBio 2021 - “...0.008 SPD_0201 rpmC 50S ribosomal protein L29 0.65 0.046 SPD_0267 NCS2 family permease 0.63 0.012 SPD_0350 vraT Cell wall-active antibiotic response protein 0.82 0.013 SPD_0351 vraS Sensor histidine kinase 0.94 0.002 SPD_0354 DNA alkylation repair protein 1.16 0.032 SPD_0378 fabM Enoyl-CoA hydratase 1.66 0.000 SPD_0380 fabH...”
- Refining the Pneumococcal Competence Regulon by RNA Sequencing
Slager, Journal of bacteriology 2019 - “...of a VraR-binding motif (VRM), we combined upstream regions of pneumococcal genes spxA2 (SPV_0178), vraT (SPV_0350), and SPV_0803 with those of six Lactococcus lactis genes that were reported to be regulated by the close VraR homolog CesR ( 15 , 95 ) as follows: llmg_0165, llmg_0169,...”
WP_011054833 cell wall-active antibiotics response protein LiaF from Streptococcus pyogenes
SpyM3_1368 conserved hypothetical protein from Streptococcus pyogenes MGAS315
Aligns to 115:227 / 230 (49.1%), covers 100.0% of PF09922, 116.8 bits
SM12261_RS07670 cell wall-active antibiotics response protein LiaF from Streptococcus mitis NCTC 12261
Aligns to 114:229 / 232 (50.0%), covers 100.0% of PF09922, 115.5 bits
- Human Serum Supplementation Promotes Streptococcus mitis Growth and Induces Specific Transcriptomic Responses
Wei, Microbiology spectrum 2023 - “...family protein 43 SM12261_RS06925 2.45 DUF3953 domain-containing protein 44 SM12261_RS07665 liaS 1.62 Sensor histidine kinase SM12261_RS07670 liaF 1.59 Transporter 45 SM12261_RS08265 2.54 50S ribosomal protein L28 46 SM12261_RS08730 2.44 Membrane protein 47 SM12261_RS08845 2.14 Hypothetical protein 48 SM12261_RS08925 1.65 Glycosyltransferase a PTS, phosphotransferase system. TABLE3 Genes...”
- “...system (2CS), CiaRH ( ciaR : SM12261_RS03850; ciaH : SM12261_RS03855), and liaFS ( liaF : SM12261_RS07670; liaS : SM12261_RS07665), which are part of the three-component system (3CS) LiaFSR, are downregulated, as well as genes that are predicted to be regulated by these systems. LiaFSR is conserved...”
SP_0385 hypothetical protein from Streptococcus pneumoniae TIGR4
Aligns to 114:229 / 232 (50.0%), covers 100.0% of PF09922, 115.0 bits
- Multi-omic profiling to assess the effect of iron starvation in Streptococcus pneumoniae TIGR4
Jiménez-Munguía, PeerJ 2018 - “...4/4 Upregulated 38508 SP_0202, SP_0203 2/2 Upregulated 38509 SP_0204, SP_0205, SP_0206, SP_0207 4/4 Upregulated 38541 SP_0385, SP_0386 2/3 Upregulated 38567 SP_0515, SP_0516 2/2 Upregulated 38588 SP_0599, SP_0600, SP_0601 3/4 Upregulated 38589 SP_0603, SP_0604 2/2 Upregulated 38594 SP_0622, SP_0623, SP_0624 3/4 Upregulated 38595 SP_0627, SP_0628 2/3 Upregulated...”
HSISS4_01346 cell wall-active antibiotics response protein LiaF from Streptococcus salivarius
Aligns to 115:229 / 232 (49.6%), covers 100.0% of PF09922, 110.7 bits
SAOUHSC_02100 hypothetical protein from Staphylococcus aureus subsp. aureus NCTC 8325
SA1702 hypothetical protein from Staphylococcus aureus subsp. aureus N315
SAV1886 hypothetical protein from Staphylococcus aureus subsp. aureus Mu50
SAUSA300_1867 hypothetical protein from Staphylococcus aureus subsp. aureus USA300_FPR3757
MW1826 conserved hypothetical protein from Staphylococcus aureus subsp. aureus MW2
NWMN_1824 hypothetical protein from Staphylococcus aureus subsp. aureus str. Newman
USA300HOU_1882 hypothetical membrane protein from Staphylococcus aureus subsp. aureus USA300_TCH1516
SAR1976 putative membrane protein from Staphylococcus aureus subsp. aureus MRSA252
SACOL1944 hypothetical protein from Staphylococcus aureus subsp. aureus COL
Aligns to 119:230 / 233 (48.1%), covers 100.0% of PF09922, 106.6 bits
- Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein
Shang, Microbiology spectrum 2022 - “...2.07 Membrane protein, putative Uncharacterized protein SAOUHSC_02458 0.26 DUF3885 domain-containing protein SAOUHSC_02436 2.68 Uncharacterized protein SAOUHSC_02100 2.03 DUF2154 domain-containing protein SAOUHSC_01966 2.22 Uncharacterized protein SAOUHSC_00030 2.20 Uncharacterized protein SAOUHSC_01475 4.20 Uncharacterized protein SAOUHSC_02689 0.29 Uncharacterized protein SAOUHSC_00052 0.48 Uncharacterized lipoprotein SAOUHSC_00061 4.92 Uncharacterized protein SAOUHSC_00146 2.31...”
- Association between cell growth and vancomycin resistance in clinical community-associated methicillin-resistant Staphylococcus aureus
Yamaguchi, Infection and drug resistance 2019 - “...- 21, 22 SA0017 walR ( vicR ) DNA-binding response regulator None - 21, 22 SA1702 yvqF Hypothetical protein None - 21 SA1701 vraS Sensor histidine kinase None - 21, 22 SA1700 vraR DNA-binding response regulator None - 21 SA0616 vraF ABC transporter ATP-binding protein T721388C...”
- Novel single-nucleotide variations associated with vancomycin resistance in vancomycin-intermediate Staphylococcus aureus
Lin, Infection and drug resistance 2018 - “...P327S) 9 , 20 SA1095 xerC 12411471242043 Site-specific recombinase XerC homolog Transcriptome analysis data 16 SA1702 SA1702 19484011949102 Conserved hypothetical protein SNP (E56G, L86I, Q136H) 9 Acknowledgments We thank Dr Chao-Hung Lee for editing the manuscript. This work was supported by grants from Chang Gung Memorial...”
- Characterization of genetic changes associated with daptomycin nonsusceptibility in Staphylococcus aureus
Ma, PloS one 2018 - “...cis/trans isomerase Originally identified in JH6 [ 34 ] JH1/JH4, JH1/JH5 1948612 Nonsynonymous H164R a SA1702 Conserved hypothetical protein Originally identified in JH2 [ 34 ] JH1/JH4, JH1/JH5 2307851 Nonsynonymous G152D rplC/SA2047 50S ribosomal protein L3 JH1/JH4, JH1/JH5 2307876 Nonsynonymous G144S rplC/SA2047 50S ribosomal protein L3...”
- Dissecting vancomycin-intermediate resistance in staphylococcus aureus using genome-wide association
Alam, Genome biology and evolution 2014 - “...Katayama et al. (2009) ; Cui et al. (2009) ; Gardete et al. (2012) yvqF SA1702 Uncharacterized protein Y220C Gardete et al. (2012) agrA SA1844 Accessory gene regulator A a The list consists of gene identified by comparative whole-genome and candidate gene sequencing studies. For a...”
- “...and ntree = 10,000. From this result, six significant features (rpoB H481, SA0017, SA1659, SA0617, SA1702, and SA1700) were selected for a second iteration of the classifier, using mytry = 4 and ntree = 10,000 parameters. The second classifier ( etest_rf_pred2 ) was then used to...”
- VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus
Boyle-Vavra, Antimicrobial agents and chemotherapy 2013 - “...SAUSA300_1865 SAUSA300_1866 SAUSA300_1867 SAUSA300_1868 SAUSA300_0362 SA1700 SA1701 SA1702 SA1703 SA0349 Kuroda et al. (9) Kuroda et al. (9) Kuroda et al....”
- Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus
Cameron, The Journal of infectious diseases 2012 - “...including the ABC transporter permease vraG [32]; yvqF (SA1702) [7], which is a member of the vraSR operon; and the DNA-dependent RNA polymerase subunit...”
- “...transporter permease ABC transporter, defense 633 SNP Ala580Val SA1702 SA2047 yvqF rplC Protein of the VraSR operon 50S ribosomal protein L3 Cell wall/outer...”
- Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate Staphylococcus aureus
Hafer, Antimicrobial agents and chemotherapy 2012 - “...and VISA candidate genesa Genotype based on: Gene vraS SA1702 SA1703 graR* graS* rpoB walK walR MLST VISA isolates MLST VISA isolates MLST VISA isolates MLST...”
- Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300
Gardete, PLoS pathogens 2012 - “...+ + 4 T 2027986 C 2027986 Y 220 C 220 (non - synonymous) USA300HOU_1882 SA1702 yvqF Conserved hypothetical protein. Part of the vraSR operon [22] + + 5 Deletion T 2027914 Frameshift mutation. Premature stop codon at 234 aa USA300HOU_1881 SA1701 vraS Two-component sensor histidine...”
- More
- Genome wide structural prediction of ABC transporter systems in <i>Bacillus subtilis</i>
Mahendran, Frontiers in microbiology 2024 - “...belonging to the type IV exporter class adopt a fold similar to the founding member Sav1886 from Staphylococcus aureus ( Dawson and Locher, 2006 ), and display 12 long transmembrane helices that extend well into the cytosol where they engage the NBDs ( Figure 4 )....”
- “...of B. subtilis type IV transporters are highly similar to classical ABC transporters such as Sav1886 or MsbA ( Dawson and Locher, 2006 ; Mi et al., 2017 ). These transporters all display domain swapping of transmembrane helixes 4 and 5 across the dimer interface, and...”
- Non-aureus Staphylococci and Bovine Udder Health: Current Understanding and Knowledge Gaps
De, Frontiers in veterinary science 2021 - “...simulans CHL, TET, PIR, ERY, PEN, MDR tetK (3), tetL (3), tetM (3) norA (100), Sav1886 (100). ( 82 ) S. xylosus CHL, TET, CLI, PIR, ERY, AMP, PEN, MDR msrA (14), tetK (19) norA (100), norB (100), sav1886 (100) S. arlettae bla ARL ( 103...”
- Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases
Kim, Journal of molecular biology 2021 - “...first structure of a bacterial multidrug ABC exporter was determined in 2006. This structure captured Sav1886, which mediates the efflux of verapamil, tetraphenylphosphochloride, and Hoechst 33342 from Staphylococcus aureus , in an outward-facing conformation [ 130 ] ( Fig. 6a ). In this state, the two...”
- “...general transport mechanism of mediating drug resistance. (a) Representative structures of bacterial ABC exporter including Sav1886 with ADP bound (pink; PDB ID: 2HYD), TM287/288 with AMP-PNP bound (orange; PDB ID: 3QF4), McjD with AMP-PNP bound (orange; PDB ID: 4PL0), MsbA with LPS bound (green; PDB ID:...”
- A multidrug ABC transporter with a taste for GTP
Orelle, Scientific reports 2018 - “...exhibited similar sequence identities with Sav1866 and MsbA (about 30% for each Pat protein with Sav1886, and 27 and 31% for PatA and PatB, respectively, with MsbA), but due to higher atomic resolution (3.4 versus 3.7), the Sav1866 structure 2ONJ was proposed to be the unique...”
- Two ABCB4 point mutations of strategic NBD-motifs do not prevent protein targeting to the plasma membrane but promote MDR3 dysfunction
Degiorgio, European journal of human genetics : EJHG 2014 - “...a homodimeric bacterial transporter. Both MDR3 and Sav1886 show significant homology of sequence (35% identical residues, spanning 578 amino-acid positions) and...”
- “...molecules present in the bacterial multidrug ABC transporter Sav1886 from S. aureus (PDB: 2hyd).3 The multiple sequence alignment of amino-acid stretches from...”
- VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus
Boyle-Vavra, Antimicrobial agents and chemotherapy 2013 - “...tag Staphylococcus aureus (Mu50) NP_372410.1 SAV1886 Staphylococcus haemolyticus JCSC1435 Staphylococcus epidermidis (M23864:W1) Staphylococcus simiae CCM 7213...”
- Structural evolution of the ABC transporter subfamily B
Flanagan, Evolutionary bioinformatics online 2007 - “...amino acid sequences including the eukaryotic ABC transporter subfamily B and bacterial orthologs of the Sav1886 protein from S. aureus were used in this analysis. Eukaryotic sequences were downloaded from the National Center for Biotechnology Informations Homologene database ( www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=homologene ). Clusters of homologous protein sequences...”
- “...B6, 83488; B7, 3175; B8, 5203; B9, 10491; B10, 6474; B11, 74509. Bacterial orthologs of Sav1886 were identified in the IMG database ( http://img.jgi.doe.gov/ ) ( Markowitz et al. 2006 ) of pre-computed clusters of best pair-wise BLAST alignments (ortholog cluster 7683, 37 sequences). The sequence...”
- Short and Robust Anti-Infective Lipopeptides Engineered Based on the Minimal Antimicrobial Peptide KR12 of Human LL-37
Lakshmaiah, ACS infectious diseases 2021 - “...SAUSA300_1037 pheS Phenylalanyl-tRNA synthetase subunit alpha 1.6 Yes SAUSA300_1503 Putative competence protein ComGB 3.1 No SAUSA300_1867 Conserved hypothetical protein 3.1 No SAUSA300_1097 pyrF orotidine 5'-phosphate decarboxylase 3.1 No 1 Mutants found previously in response to human cathelicidin LL-37 and its major antimicrobial peptides GF-17 and 17BIPHE2...”
- Resistome of Staphylococcus aureus in Response to Human Cathelicidin LL-37 and Its Engineered Antimicrobial Peptides
Golla, ACS infectious diseases 2020 - “...-0645, graS -0646, vraF -0647, and mprF -1255), (2) two-component system ( vraR -1865 and SAUSA300_1867), (3) transporters ( trkA -0988 and znuB -1515), (4) lipoprotein export ( lspA -1089), (5) RNA biogenesis (SAUSA300 _ 1036 and 1336), (6) biosynthesis and metabolism ( argC -0186, lipA...”
- “...abolishes daptomycin bactericidal activity against vancomycin-resistant E. faecalis 40 . We found that, although the SAUSA300_1867 mutant is less effective in biofilm formation, it remained infective in the wax moth model similar to S. aureus USA300 LAC. S. aureus also contains multiple K + uptake systems,...”
- Inactivation of the Monofunctional Peptidoglycan Glycosyltransferase SgtB Allows Staphylococcus aureus To Survive in the Absence of Lipoteichoic Acid
Karinou, Journal of bacteriology 2019 - “...protease, was observed in one strain ( Table 1 ). Finally, a mutation in vraT (SAUSA300_1867), coding for the membrane protein VraT and forming part of the VraRST three-component system, was identified. Using our standard genome sequence analysis workflow, an unusually large number (>300) of zero-coverage...”
- “...SAUSA300_1855; monofunctional glycosyltransferase SgtB Leu173* ANG3717 (S7- vraT ): 2027736 SNV A C 100 38.8 SAUSA300_1867; membrane protein Yvfq/VraT Leu71* ANG3718 (S8- sgtB ): 2018107 INS T 92.6 38.6 SAUSA300_1855; monofunctional glycosyltransferase SgtB Ser39fs a Suppressor strains S1, S2, S7, and S8 were derived from strain...”
- VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus
Boyle-Vavra, Antimicrobial agents and chemotherapy 2013 - “...operon vra operon Membrane transport SAUSA300_1865 SAUSA300_1866 SAUSA300_1867 SAUSA300_1868 SAUSA300_0362 SA1700 SA1701 SA1702 SA1703 SA0349 Kuroda et al. (9)...”
- New Antimicrobial Resistance Strategies: An Adaptive Resistance Network Conferring Reduced Glycopeptide Susceptibility in VISA
Aguglia, Antibiotics (Basel, Switzerland) 2023 - “...Charge of the cell envelope Phosphatidylglycerol lysyl-transferase MprF MI-nsSNPs Thr345Ala Leu538Phe Regulators of Vancomycin-Intermediate Resistance MW1826 Methicillin resistance and activation of vraSR TCRS VraT MI-nsSNPs Ala59Glu Glycopeptide--Lactams Resistant-Related Genes MW0014 -lactams and/or glycopeptide cross-resistance GdpP MI-nsSNPs Ile186Met Metabolic Substrate Transporters MW2304 Proton/sodium-glutamate symport GltT MI-nsSNPs Val232Glu...”
- Balancing the Virulence and Antimicrobial Resistance in VISA DAP-R CA-MRSA Superbug
Salemi, Antibiotics (Basel, Switzerland) 2022 - “...MW1054 Exfoliative toxin A Leu47Ile MW1080 Pseudouridine synthase Glu294Val MW1664 Peroxiredoxin osmotic stress-related protein Asn87Lys MW1826 DUF2154 domain-containing protein VraT Ala59Glu MW2107 D-ornithine--citrate ligase SfnaD Leu195Trp MW2286 Malate:quinone oxidoreductase 1 Val280Glu MW2393 D-histidine (S)-2-aminobutanoyltransferase CntL Glu31Leu MW2533 HTH-type transcriptional regulator Gly41Asp MW0131 Capsular polysaccharide synthesis enzyme...”
- Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16
Mensa, Antimicrobial agents and chemotherapy 2014 - “...regulated drp35 vraS NWMN_2332 mgt vraR NWMN_2405 NWMN_1824 proP NWMN_2211 NWMN_1835 NWMN_1621 NWMN_2331 NWMN_1732 NWMN_1825 NWMN_2404 tcaA ctpA murZ NWMN_0931...”
- A mutation in the PP2C phosphatase gene in a Staphylococcus aureus USA300 clinical isolate with reduced susceptibility to vancomycin and daptomycin
Passalacqua, Antimicrobial agents and chemotherapy 2012 - “...mutation was Pro174Ser replacement in a hypothetical gene (USA300HOU_1882) that is located just upstream of, and potentially in an operon with, the regulatory...”
- Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300
Gardete, PLoS pathogens 2012 - “...[70] + + 4 T 2027986 C 2027986 Y 220 C 220 (non - synonymous) USA300HOU_1882 SA1702 yvqF Conserved hypothetical protein. Part of the vraSR operon [22] + + 5 Deletion T 2027914 Frameshift mutation. Premature stop codon at 234 aa USA300HOU_1881 SA1701 vraS Two-component sensor...”
- Staphylococcal phenotypes induced by naturally occurring and synthetic membrane-interactive polyphenolic β-lactam resistance modifiers
Palacios, PloS one 2014 - “...CGC ATT TCT AGC TGC GAA TC GAC TAG CAC GAG AAC TTC AC vraT SAR1976 ACC GGC AAT ATA ACC TGC AC ACA TGG AAT TGG CGA CCT AC vraX SAR0584 ATC AAC ATG AAG GCG CAC CA CGT CTT GTA ATA AAG AGA GC...”
- “...0.86 vraS/yvqE SAR1975 two-component sensor histidine kinase 2.20* 0.65 1.51* 4.95* 2.41* 11.01* 0.92 vraT/yvqF SAR1976 response regulator 2.93* 0.97 2.24* 3.10* 2.90* 5.81* 0.91 mreC SAR1729 cell shape determining protein MreC 1.08 1.11 0.85 0.65* 0.45* 0.99 0.55* mprF/fmtC SAR1372 phosphatidylglycerol lysyltransferase 2.23* 1.59 2.26*...”
- Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2
Bernal, The Journal of biological chemistry 2010 - “...mechanism SAR1975 SA1701 vraS Sensor histidine kinase 8.05 2.5 8.7 10.4 9.57 Signal transduction mechanism SAR1976 SA1702 yvpF Conserved hypothetical protein 6.57 2.60 8.1 7.1 Function unknown SAR1977 SA1703 Hypothetical protein 6.8 3.1 Up Function unknown SAR0204 SA0205 Peptidase domain protein 2 4.5 Up Cell envelope...”
- BACTERIAL VACCINE COMPONENTS FROM STAPHYLOCOCCUS AUREUS AND USES THEREOF
MALOUIN, 2011 - Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications
Howden, Clinical microbiology reviews 2010 - “...of California, Berkeley SACOL1777 SACOL1897 SACOL1932 SACOL1943 SACOL1944 SACOL1945 SACOL1956 SACOL2116 Function 103 104 HOWDEN ET AL. CLIN. MICROBIOL. REV....”
- Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia
Howden, BMC microbiology 2008 - “...number of these cell wall genes were also down regulated in pair 5 (SACOL1066, SACOL1943, SACOL1944, SACOL2116, SACOL2571). Figure 2 Heat map analysis of cell wall genes . Heat map analysis of "core cell wall genes" and additional cell wall genes which have been commonly shown...”
SMU_485 cell wall-active antibiotics response protein LiaF from Streptococcus mutans UA159
Aligns to 115:228 / 231 (49.4%), covers 100.0% of PF09922, 104.9 bits
SERP1424 hypothetical protein from Staphylococcus epidermidis RP62A
Aligns to 119:230 / 233 (48.1%), covers 100.0% of PF09922, 101.8 bits
BJK46_008080 cell wall-active antibiotics response protein LiaF from Staphylococcus pseudintermedius
Aligns to 119:230 / 233 (48.1%), covers 100.0% of PF09922, 101.6 bits
- Erythritol alters gene transcriptome signatures, cell growth, and biofilm formation in Staphylococcus pseudintermedius
Fujii, BMC veterinary research 2023 - “...that is required to drive the PTS. Moreover, the other four genes ( URGs2 ), BJK46_008080 ( vraT ), BJK46_008075 ( vraS ), BJK46_008070 ( vraR ), and BJK46_008015 ( sgtB ) were predicted to belong to the same group. The vraTSR genes belonging to a...”
- “...process 0.63 GO:0000160 phosphorelay signal transduction system 0.58 GO:0006355 regulation of transcription, DNA-templated 4.14 2.29E-274 BJK46_008080 transporter vraT 0.69 Transporter yvqF 4.1 5.04E-252 BJK46_008075 sensor histidine kinase vraS 0.89 Sensor protein VraS 0.68 GO:0018106 peptidyl-histidine phosphorylation 0.63 GO:0000160 phosphorelay signal transduction system 4.1 5.40E-246 BJK46_000760 DUF1002...”
SH1069 hypothetical protein from Staphylococcus haemolyticus JCSC1435
Aligns to 119:230 / 233 (48.1%), covers 100.0% of PF09922, 99.6 bits
SPy1623 conserved hypothetical protein from Streptococcus pyogenes M1 GAS
Aligns to 132:228 / 228 (42.5%), covers 82.5% of PF09922, 97.8 bits
llmg_1650 putative secreted protein from Lactococcus lactis subsp. cremoris MG1363
Aligns to 81:188 / 191 (56.5%), covers 78.9% of PF09922, 59.3 bits
- Refining the Pneumococcal Competence Regulon by RNA Sequencing
Slager, Journal of bacteriology 2019 - “...close VraR homolog CesR ( 15 , 95 ) as follows: llmg_0165, llmg_0169, llmg_1115, llmg_1155, llmg_1650, and llmg_2164. Cappable-seq ( 60 ) was used to identify L. lactis TSSs (S. B. van der Meulen and O. P. Kuipers, unpublished data). Importantly, we did not use the...”
- Efficient overproduction of membrane proteins in Lactococcus lactis requires the cell envelope stress sensor/regulator couple CesSR
Pinto, PloS one 2011 - “...protein; Regulation of lysozyme resistance 5.60 5.3*10 7 llmg_1156/yneG Putative transcriptional repressor 5.79 6.2*10 5 llmg_1650 Putative membrane protein 3.08 9.4*10 7 llmg_1649/cesS Two-component system sensor (histidine kinase) 2.35 5.0*10 5 llmg_1648/cesR Two-component system regulator 2.75 8.5*10 7 llmg_1647 Putative hydrolase from the Cof-subfamily 2.04 2.1*10...”
K7S1Q8 Uncharacterized protein from Acidipropionibacterium acidipropionici (strain ATCC 4875 / DSM 20272 / JCM 6432 / NBRC 12425 / NCIMB 8070 / 4)
Aligns to 100:199 / 216 (46.3%), covers 64.9% of PF09922, 42.4 bits
Bovatus_RS21370 LiaF domain-containing protein from Bacteroides ovatus
Aligns to 164:255 / 264 (34.8%), covers 57.0% of PF09922, 41.7 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...bp-TATACT Spirochaetes Bacteroides thetaiotaomicron Btheta7330_RS19915 Btheta7330_RS19920 TCCGGTATTCA-11bp-ACCGGAAATCA 11 bp TGTA-19 bp-TATCTTTG Bacteroidia Bacteroides ovatus Bovatus_RS21375 Bovatus_RS21370 TCCGGCATTCA-11 bp-ACCGTAAATCA 11 bp TGTG-19 bp-TATCTTTG Bacteroidia Activation of the BrsRM LRS is intimately connected with purine metabolism As mentioned previously, little is known about the environmental and/or cellular signals...”
Btheta7330_RS19920 LiaI-LiaF-like domain-containing protein from Bacteroides thetaiotaomicron
Aligns to 163:253 / 264 (34.5%), covers 58.8% of PF09922, 39.5 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...Bacilli Treponema bryantii SAMN04487977_102124 SAMN04487977_102123 ACCACTTAT-11 bp-GCCACTTAT 10 bp CACACA-17 bp-TATACT Spirochaetes Bacteroides thetaiotaomicron Btheta7330_RS19915 Btheta7330_RS19920 TCCGGTATTCA-11bp-ACCGGAAATCA 11 bp TGTA-19 bp-TATCTTTG Bacteroidia Bacteroides ovatus Bovatus_RS21375 Bovatus_RS21370 TCCGGCATTCA-11 bp-ACCGTAAATCA 11 bp TGTG-19 bp-TATCTTTG Bacteroidia Activation of the BrsRM LRS is intimately connected with purine metabolism As mentioned...”
- “.... Residues shown in red represent a putative cleavable signal sequence. G) Predicted topology of Btheta7330_RS19920 from Bacteroides thetaiotaomicron . (TIF) Click here for additional data file. S4 Fig Insertion sites of brsRM-activating transposon mutations. Red arrows mark the locations of transposon insertions resulting in activation...”
cg0706 hypothetical protein from Corynebacterium glutamicum ATCC 13032
Aligns to 249:350 / 357 (28.6%), covers 85.1% of PF09922, 36.2 bits
- HyCas9-12aGEP: an efficient genome editing platform for Corynebacterium glutamicum
Zhang, Frontiers in bioengineering and biotechnology 2024 - “...D ). Thus, only cg0703-0706 remained unevaluated. Finally, crRNA11 was employed to target esrI ( cg0706 ) and facilitate the deletion of cg0703-0706 , resulting in the strain 912cg0703-0706 ( Supplementary Figure S8D ), which exhibited a milder version of the phenotype compared to the 29.86kb...”
- Abasy Atlas v2.2: The most comprehensive and up-to-date inventory of meta-curated, historical, bacterial regulatory networks, their completeness and system-level characterization
Escorcia-Rodríguez, Computational and structural biotechnology journal 2020 - “...the cell envelope stress response of C.glutamicum [53] . Interestingly, the integral membrane protein EsrI (Cg0706) acts as an inhibitor of EsrSR under non-stress conditions. The resulting three-component system EsrISR directly regulates a broad set of genes, including the esrI - esrSR locus itself, and genes...”
- A secretion biosensor for monitoring Sec-dependent protein export in Corynebacterium glutamicum
Jurischka, Microbial cell factories 2020 - “...not in the strain producing the signal peptide-less AmyE variant. Three of these genes, esrI (cg0706), cg1325, and rsmP (cg3264), belong to envelope stress response (Esr) regulon that is regulated by the EsrISR three component system. The Esr regulon is induced under conditions that threaten the...”
- “...b Average mRNA ratio NrpE-cutinase overproduction c cg0998 htrA HtrA protease homologue 1.24 4.22 4.40 cg0706 esrI EsrI, inhibitor of the EsrSR two-component system 0.99* 2.31 0.80* cg1325 Putative stress responsive transcriptional regulator 1.13* 3.69 0.96* cg3264 rsmP RsmP, conserved cytoskeletal protein 0.61 2.67 0.96* Significant...”
- Physiology and Transcriptional Analysis of (p)ppGpp-Related Regulatory Effects in Corynebacterium glutamicum
Ruwe, Frontiers in microbiology 2019 - “...synthase (NADPH), large chain 1.42 1.30696E08 cg0230 gltD glutamate synthase (NADPH), small chain 1.38 3.24867E08 cg0706 putative membrane protein 1.14 6.41725E63 cg1325 hypothetical protein 1.25 1.64564E61 cg1665 putative secreted protein 1.09 6.95957E12 cg1784 ocd putative ornithine cyclodeaminase 1.44 5.2046E16 cg2543 glcD putative (S)-2-hydroxy-acid oxidase 1.66 1.09228E47...”
LBA0404 hypothetical protein from Lactobacillus acidophilus NCFM
Aligns to 151:249 / 252 (39.3%), covers 63.2% of PF09922, 35.2 bits
cg0580 hypothetical protein from Corynebacterium glutamicum ATCC 13032
Aligns to 154:260 / 266 (40.2%), covers 90.4% of PF09922, 33.1 bits
D819_07614, SMU41_RS00715 hdrR negative regulator HdrM from Streptococcus mutans 2VS1
SmuNN2025_0283 hypothetical protein from Streptococcus mutans NN2025
Aligns to 127:225 / 228 (43.4%), covers 67.5% of PF09922, 31.9 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SMU108_RS00450 SMU108_RS08330 SMU108_RS08335 SMU108_RS04130 SMU108_RS04135 SMU108_RS02300 SMU108_RS02295 2VS1 SMU41_RS02780 SMU41_RS02785 SMU41_RS02285 SMU41_RS02290 SMU41_RS09195 SMU41_RS09190 SMU41_RS00710 SMU41_RS00715 SMU41_RS08205 SMU41_RS08210 24 SMU99_RS01810 SMU99_RS01805 SMU99_RS04370 SMU99_RS04365 SMU99_RS06740 SMU99_RS06745 SMU99_06753 SMU99_06748 SMU99_RS03985 SMU99_RS03990 NMT4863 SMU57_RS00640 SMU57_RS00635 SMU57_RS03960 SMU57_RS03955 SMU57_RS08545 SMU57_RS08540 SMU57_06768 SMU57_06773 SMU57_RS06355 SMU57_RS06360 * NLML1 SMU89_RS00770 SMU89_RS00775 SMU89_RS03240 SMU89_RS03245...”
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing
Song, BMC genomics 2013 - “...D820_09650 D821_09748 D822_05851 D823_03191 HdrM high density responsive membrane protein SMU.1855 GI|290579809 D816_08353 D817_08543 D818_08143 D819_07614 D820_08345 D821_08319 D822_08240 D823_08222 HdrR high density responsive regulator SMU.1854 GI|290579810 D816_08348 D817_08538 D818_08138 D819_07609 D820_08340 D821_08314 - - BrsM SMU.2081 GI|290581347 D816_09358 D817_09538 D818_09198 D819_08671 D820_09275 D821_09348 - -...”
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SMUGS5_RS04780 SMUGS5_RS04775 SMUGS5_08350 SMUGS5_08355 SMUGS5_RS09430 SMUGS5_RS09435 * NN2025 SMUNN2025_RS08570 SMUNN2025_RS08565 SmuNN2025_1529 SmuNN2025_1528 SMUNN2025_RS05005 SMUNN2025_RS05010 SmuNN2025_0284 SmuNN2025_0283 SMUNN2025_RS09370 SMUNN2025_RS09375 PKUSS-LG01 PLG01_00262 PLG01_00263 PLG01_RS0109205 PLG01_RS07225 PLG01_RS04590 PLG01_RS04595 PLG01_01702 PLG01_01703 PLG01_01917 PLG01_01918 NLML8 SMU88_07197 SMU88_07202 SMU88_RS06890 SMU88_RS06895 SMU88_RS04905 SMU88_RS04910 SMU88_00375 SMU88_00380 SMU88_RS05640 SMU88_RS05635 15VF2 SMU40_07796 SMU40_07791 SMU40_RS08320 SMU40_RS08315 SMU40_RS03775...”
SMU77_07686 hdrR negative regulator HdrM from Streptococcus mutans NV1996
Aligns to 127:225 / 228 (43.4%), covers 65.8% of PF09922, 31.1 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SMU40_RS08315 SMU40_RS03775 SMU40_RS03770 SMU40_07636 SMU40_07641 SMU40_RS06735 SMU40_RS06730 NV1996 SMU77_09132 SMU77_09137 SMU77_RS04625 SMU77_RS04620 SMU77_RS08555 SMU77_RS08560 SMU77_07681 SMU77_07686 SMU77_RS03320 SMU77_RS03325 S1B SMU102_05654 SMU102_05649 SMU102_RS03520 SMU102_RS03515 SMU102_RS07325 SMU102_RS07330 SMU102_09448 SMU102_09453 SMU102_RS05585 SMU102_RS05590 5SM3 SMU50_08366 SMU50_08361 SMU50_RS07800 SMU50_RS07795 SMU50_RS01165 SMU50_RS01170 SMU50_07866 SMU50_07861 SMU50_RS02940 SMU50_RS02935 NVAB SMU53_09635 SMU53_09640 SMU53_RS05955 SMU53_RS05950 SMU53_01385...”
D817_08543, SMU_1855 hdrR negative regulator HdrM from Streptococcus mutans KK21
Aligns to 127:225 / 228 (43.4%), covers 65.8% of PF09922, 31.1 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...are part of the core genome. Strain SMU_294 SMU_295 SMU_433 SMU_434 SMU_1070c SMU_1069c SMU_1854 (HdrR) SMU_1855 (HdrM) SMU_2080 (BrsR) SMU_2081 (BrsM) GS-5 SMUGS5_RS01270 SMUGS5_RS01275 SMUGS5_RS01975 SMUGS5_RS01980 SMUGS5_RS04780 SMUGS5_RS04775 SMUGS5_08350 SMUGS5_08355 SMUGS5_RS09430 SMUGS5_RS09435 * NN2025 SMUNN2025_RS08570 SMUNN2025_RS08565 SmuNN2025_1529 SmuNN2025_1528 SMUNN2025_RS05005 SMUNN2025_RS05010 SmuNN2025_0284 SmuNN2025_0283 SMUNN2025_RS09370 SMUNN2025_RS09375 PKUSS-LG01 PLG01_00262...”
- “...BUB90_RS22585 from Anaerosporobacter mobilis (E-value e = 2.2 x 10 6 ). D) Comparison of SMU_1855 (HdrM) with ERS095036_10318 from Chlamydia trachomatis (E-value e = 9 x 10 6 ). Residues shown in red represent a putative cleavable signal sequence. E) Comparison of SMU_2081 (BrsM) with...”
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing
Song, BMC genomics 2013 - “...D818_00020 D819_09056 D820_09650 D821_09748 D822_05851 D823_03191 HdrM high density responsive membrane protein SMU.1855 GI|290579809 D816_08353 D817_08543 D818_08143 D819_07614 D820_08345 D821_08319 D822_08240 D823_08222 HdrR high density responsive regulator SMU.1854 GI|290579810 D816_08348 D817_08538 D818_08138 D819_07609 D820_08340 D821_08314 - - BrsM SMU.2081 GI|290581347 D816_09358 D817_09538 D818_09198 D819_08671 D820_09275 D821_09348...”
D816_08353, PLG01_01703, SMU102_09453, SMU107_RS01185, SMU108_RS04135, SMU40_07641, SMU57_06773, SMU68_RS09280, SMU76_RS00955, SMU80_RS03030, SMU88_00380, SMU97_RS01115 hdrR negative regulator HdrM from Streptococcus mutans NFSM1
Aligns to 127:225 / 228 (43.4%), covers 65.8% of PF09922, 31.1 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SmuNN2025_1528 SMUNN2025_RS05005 SMUNN2025_RS05010 SmuNN2025_0284 SmuNN2025_0283 SMUNN2025_RS09370 SMUNN2025_RS09375 PKUSS-LG01 PLG01_00262 PLG01_00263 PLG01_RS0109205 PLG01_RS07225 PLG01_RS04590 PLG01_RS04595 PLG01_01702 PLG01_01703 PLG01_01917 PLG01_01918 NLML8 SMU88_07197 SMU88_07202 SMU88_RS06890 SMU88_RS06895 SMU88_RS04905 SMU88_RS04910 SMU88_00375 SMU88_00380 SMU88_RS05640 SMU88_RS05635 15VF2 SMU40_07796 SMU40_07791 SMU40_RS08320 SMU40_RS08315 SMU40_RS03775 SMU40_RS03770 SMU40_07636 SMU40_07641 SMU40_RS06735 SMU40_RS06730 NV1996 SMU77_09132 SMU77_09137 SMU77_RS04625 SMU77_RS04620 SMU77_RS08555...”
- “...SMU77_RS04620 SMU77_RS08555 SMU77_RS08560 SMU77_07681 SMU77_07686 SMU77_RS03320 SMU77_RS03325 S1B SMU102_05654 SMU102_05649 SMU102_RS03520 SMU102_RS03515 SMU102_RS07325 SMU102_RS07330 SMU102_09448 SMU102_09453 SMU102_RS05585 SMU102_RS05590 5SM3 SMU50_08366 SMU50_08361 SMU50_RS07800 SMU50_RS07795 SMU50_RS01165 SMU50_RS01170 SMU50_07866 SMU50_07861 SMU50_RS02940 SMU50_RS02935 NVAB SMU53_09635 SMU53_09640 SMU53_RS05955 SMU53_RS05950 SMU53_01385 SMU53_01380 SMU53_RS00300 SMU53_RS00305 SMU53_RS06530 SMU53_RS06535 SF12 SMU105_RS01360 SMU105_RS01355 SMU105_RS07335 SMU105_RS07330 SMU105_RS08645...”
- “...SMU26_RS07140 SMU26_08772 SMU26_08767 SMU26_09654 not annotated * R221 SMU107_RS02805 SMU107_RS02800 SMU107_RS06685 SMU107_RS06680 SMU107_RS01840 SMU107_RS01845 SMU107_RS01190 SMU107_RS01185 SMU107_00213 SMU107_00208 OMZ175 SMU109_RS09430 SMU109_RS09425 SMU109_RS02930 SMU109_RS02925 SMU109_RS08705 SMU109_RS08710 SMU109_07636 SMU109_07641 SMU109_RS01905 SMU109_RS01900 * M230 SMU108_RS03395 SMU108_RS03400 SMU108_RS00445 SMU108_RS00450 SMU108_RS08330 SMU108_RS08335 SMU108_RS04130 SMU108_RS04135 SMU108_RS02300 SMU108_RS02295 2VS1 SMU41_RS02780 SMU41_RS02785 SMU41_RS02285 SMU41_RS02290...”
- “...SMU109_RS08705 SMU109_RS08710 SMU109_07636 SMU109_07641 SMU109_RS01905 SMU109_RS01900 * M230 SMU108_RS03395 SMU108_RS03400 SMU108_RS00445 SMU108_RS00450 SMU108_RS08330 SMU108_RS08335 SMU108_RS04130 SMU108_RS04135 SMU108_RS02300 SMU108_RS02295 2VS1 SMU41_RS02780 SMU41_RS02785 SMU41_RS02285 SMU41_RS02290 SMU41_RS09195 SMU41_RS09190 SMU41_RS00710 SMU41_RS00715 SMU41_RS08205 SMU41_RS08210 24 SMU99_RS01810 SMU99_RS01805 SMU99_RS04370 SMU99_RS04365 SMU99_RS06740 SMU99_RS06745 SMU99_06753 SMU99_06748 SMU99_RS03985 SMU99_RS03990 NMT4863 SMU57_RS00640 SMU57_RS00635 SMU57_RS03960 SMU57_RS03955 SMU57_RS08545...”
- “...SMU88_RS06895 SMU88_RS04905 SMU88_RS04910 SMU88_00375 SMU88_00380 SMU88_RS05640 SMU88_RS05635 15VF2 SMU40_07796 SMU40_07791 SMU40_RS08320 SMU40_RS08315 SMU40_RS03775 SMU40_RS03770 SMU40_07636 SMU40_07641 SMU40_RS06735 SMU40_RS06730 NV1996 SMU77_09132 SMU77_09137 SMU77_RS04625 SMU77_RS04620 SMU77_RS08555 SMU77_RS08560 SMU77_07681 SMU77_07686 SMU77_RS03320 SMU77_RS03325 S1B SMU102_05654 SMU102_05649 SMU102_RS03520 SMU102_RS03515 SMU102_RS07325 SMU102_RS07330 SMU102_09448 SMU102_09453 SMU102_RS05585 SMU102_RS05590 5SM3 SMU50_08366 SMU50_08361 SMU50_RS07800 SMU50_RS07795 SMU50_RS01165...”
- “...SMU99_RS04365 SMU99_RS06740 SMU99_RS06745 SMU99_06753 SMU99_06748 SMU99_RS03985 SMU99_RS03990 NMT4863 SMU57_RS00640 SMU57_RS00635 SMU57_RS03960 SMU57_RS03955 SMU57_RS08545 SMU57_RS08540 SMU57_06768 SMU57_06773 SMU57_RS06355 SMU57_RS06360 * NLML1 SMU89_RS00770 SMU89_RS00775 SMU89_RS03240 SMU89_RS03245 SMU89_RS06550 SMU89_RS06555 SMU89_04914 SMU89_04919 SMU89_RS02570 SMU89_RS02575 N66 SMU76_08650 SMU76_08645 SMU76_RS00735 SMU76_RS00740 SMU76_RS06520 SMU76_RS06525 SMU76_RS00960 SMU76_RS00955 SMU76_00800 SMU76_00805 NFSM1 SMU68_RS00360 SMU68_RS00355 SMU68_RS04130 SMU68_RS04135...”
- “...SMU76_RS00740 SMU76_RS06520 SMU76_RS06525 SMU76_RS00960 SMU76_RS00955 SMU76_00800 SMU76_00805 NFSM1 SMU68_RS00360 SMU68_RS00355 SMU68_RS04130 SMU68_RS04135 SMU68_RS01560 SMU68_RS01555 SMU68_RS09285 SMU68_RS09280 SMU68_RS03260 SMU68_RS03255 NLML5 SMU70_RS00900 SMU70_RS00895 SMU70_RS08165 SMU70_RS08160 SMU70_RS02155 SMU70_RS02150 SMU70_RS05295 SMU70_RS05300 SMU70_08278 SMU70_08283 SM4 SMU97_08152 SMU97_08157 SMU97_RS01095 SMU97_RS01100 SMU97_RS07460 SMU97_RS07455 SMU97_RS01120 SMU97_RS01115 SMU97_RS01790 SMU97_RS01785 LJ23 SMULJ23_1676 SMULJ23_1675 SMULJ23_RS07900 SMULJ23_RS07895 SMULJ23_RS05010...”
- “...SMU89_RS03245 SMU89_RS06550 SMU89_RS06555 SMU89_04914 SMU89_04919 SMU89_RS02570 SMU89_RS02575 N66 SMU76_08650 SMU76_08645 SMU76_RS00735 SMU76_RS00740 SMU76_RS06520 SMU76_RS06525 SMU76_RS00960 SMU76_RS00955 SMU76_00800 SMU76_00805 NFSM1 SMU68_RS00360 SMU68_RS00355 SMU68_RS04130 SMU68_RS04135 SMU68_RS01560 SMU68_RS01555 SMU68_RS09285 SMU68_RS09280 SMU68_RS03260 SMU68_RS03255 NLML5 SMU70_RS00900 SMU70_RS00895 SMU70_RS08165 SMU70_RS08160 SMU70_RS02155 SMU70_RS02150 SMU70_RS05295 SMU70_RS05300 SMU70_08278 SMU70_08283 SM4 SMU97_08152 SMU97_08157 SMU97_RS01095 SMU97_RS01100 SMU97_RS07460...”
- “...APQ13_RS02945 APQ13_RS02950 not annotated APQ13_RS09135 APQ13_RS08050 APQ13_RS08045 SF1 SMU80_RS05505 SMU80_RS05500 SMU80_RS07445 SMU80_RS07440 SMU80_RS04625 SMU80_RS04630 SMU80_RS03035 SMU80_RS03030 SMU80_RS06900 SMU80_RS06905 Genes are listed by their NCBI Gene Locus Tag designations. *Indicates a frameshift mutation is present LRS are autoregulatory due to a positive feedback loop encoded within their...”
- “...PLG01_RS07225 PLG01_RS04590 PLG01_RS04595 PLG01_01702 PLG01_01703 PLG01_01917 PLG01_01918 NLML8 SMU88_07197 SMU88_07202 SMU88_RS06890 SMU88_RS06895 SMU88_RS04905 SMU88_RS04910 SMU88_00375 SMU88_00380 SMU88_RS05640 SMU88_RS05635 15VF2 SMU40_07796 SMU40_07791 SMU40_RS08320 SMU40_RS08315 SMU40_RS03775 SMU40_RS03770 SMU40_07636 SMU40_07641 SMU40_RS06735 SMU40_RS06730 NV1996 SMU77_09132 SMU77_09137 SMU77_RS04625 SMU77_RS04620 SMU77_RS08555 SMU77_RS08560 SMU77_07681 SMU77_07686 SMU77_RS03320 SMU77_RS03325 S1B SMU102_05654 SMU102_05649 SMU102_RS03520 SMU102_RS03515 SMU102_RS07325...”
- “...SMU70_RS08160 SMU70_RS02155 SMU70_RS02150 SMU70_RS05295 SMU70_RS05300 SMU70_08278 SMU70_08283 SM4 SMU97_08152 SMU97_08157 SMU97_RS01095 SMU97_RS01100 SMU97_RS07460 SMU97_RS07455 SMU97_RS01120 SMU97_RS01115 SMU97_RS01790 SMU97_RS01785 LJ23 SMULJ23_1676 SMULJ23_1675 SMULJ23_RS07900 SMULJ23_RS07895 SMULJ23_RS05010 SMULJ23_RS05015 SMULJ23_0305 SMULJ23_0304 SMULJ23_1824 SMULJ23_1825 NG8 APQ13_RS06435 APQ13_RS06430 APQ13_RS05775 APQ13_RS05770 APQ13_RS02945 APQ13_RS02950 not annotated APQ13_RS09135 APQ13_RS08050 APQ13_RS08045 SF1 SMU80_RS05505 SMU80_RS05500 SMU80_RS07445 SMU80_RS07440...”
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing
Song, BMC genomics 2013 - “...D817_09913 D818_00020 D819_09056 D820_09650 D821_09748 D822_05851 D823_03191 HdrM high density responsive membrane protein SMU.1855 GI|290579809 D816_08353 D817_08543 D818_08143 D819_07614 D820_08345 D821_08319 D822_08240 D823_08222 HdrR high density responsive regulator SMU.1854 GI|290579810 D816_08348 D817_08538 D818_08138 D819_07609 D820_08340 D821_08314 - - BrsM SMU.2081 GI|290581347 D816_09358 D817_09538 D818_09198 D819_08671 D820_09275...”
SMU89_04919 hdrR negative regulator HdrM from Streptococcus mutans NLML1
Aligns to 127:225 / 228 (43.4%), covers 65.8% of PF09922, 31.1 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SMU57_RS08545 SMU57_RS08540 SMU57_06768 SMU57_06773 SMU57_RS06355 SMU57_RS06360 * NLML1 SMU89_RS00770 SMU89_RS00775 SMU89_RS03240 SMU89_RS03245 SMU89_RS06550 SMU89_RS06555 SMU89_04914 SMU89_04919 SMU89_RS02570 SMU89_RS02575 N66 SMU76_08650 SMU76_08645 SMU76_RS00735 SMU76_RS00740 SMU76_RS06520 SMU76_RS06525 SMU76_RS00960 SMU76_RS00955 SMU76_00800 SMU76_00805 NFSM1 SMU68_RS00360 SMU68_RS00355 SMU68_RS04130 SMU68_RS04135 SMU68_RS01560 SMU68_RS01555 SMU68_RS09285 SMU68_RS09280 SMU68_RS03260 SMU68_RS03255 NLML5 SMU70_RS00900 SMU70_RS00895 SMU70_RS08165 SMU70_RS08160 SMU70_RS02155...”
SMULJ23_0304 hdrR negative regulator HdrM from Streptococcus mutans LJ23
Aligns to 127:225 / 228 (43.4%), covers 65.8% of PF09922, 31.0 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SMU97_RS01100 SMU97_RS07460 SMU97_RS07455 SMU97_RS01120 SMU97_RS01115 SMU97_RS01790 SMU97_RS01785 LJ23 SMULJ23_1676 SMULJ23_1675 SMULJ23_RS07900 SMULJ23_RS07895 SMULJ23_RS05010 SMULJ23_RS05015 SMULJ23_0305 SMULJ23_0304 SMULJ23_1824 SMULJ23_1825 NG8 APQ13_RS06435 APQ13_RS06430 APQ13_RS05775 APQ13_RS05770 APQ13_RS02945 APQ13_RS02950 not annotated APQ13_RS09135 APQ13_RS08050 APQ13_RS08045 SF1 SMU80_RS05505 SMU80_RS05500 SMU80_RS07445 SMU80_RS07440 SMU80_RS04625 SMU80_RS04630 SMU80_RS03035 SMU80_RS03030 SMU80_RS06900 SMU80_RS06905 Genes are listed by their...”
SMU50_07861 hdrR negative regulator HdrM from Streptococcus mutans 5SM3
Aligns to 127:225 / 228 (43.4%), covers 65.8% of PF09922, 30.1 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SMU102_RS03515 SMU102_RS07325 SMU102_RS07330 SMU102_09448 SMU102_09453 SMU102_RS05585 SMU102_RS05590 5SM3 SMU50_08366 SMU50_08361 SMU50_RS07800 SMU50_RS07795 SMU50_RS01165 SMU50_RS01170 SMU50_07866 SMU50_07861 SMU50_RS02940 SMU50_RS02935 NVAB SMU53_09635 SMU53_09640 SMU53_RS05955 SMU53_RS05950 SMU53_01385 SMU53_01380 SMU53_RS00300 SMU53_RS00305 SMU53_RS06530 SMU53_RS06535 SF12 SMU105_RS01360 SMU105_RS01355 SMU105_RS07335 SMU105_RS07330 SMU105_RS08645 SMU105_RS08640 SMU105_RS00340 SMU105_RS00335 SMU105_07142 SMU105_07137 3SN1 SMU26_RS06535 SMU26_RS06540 SMU26_RS04770 SMU26_RS04775 SMU26_RS07145...”
D822_08240 LiaF domain-containing protein from Streptococcus ratti FA-1 = DSM 20564
Aligns to 131:219 / 234 (38.0%), covers 65.8% of PF09922, 30.1 bits
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing
Song, BMC genomics 2013 - “...D823_03191 HdrM high density responsive membrane protein SMU.1855 GI|290579809 D816_08353 D817_08543 D818_08143 D819_07614 D820_08345 D821_08319 D822_08240 D823_08222 HdrR high density responsive regulator SMU.1854 GI|290579810 D816_08348 D817_08538 D818_08138 D819_07609 D820_08340 D821_08314 - - BrsM SMU.2081 GI|290581347 D816_09358 D817_09538 D818_09198 D819_08671 D820_09275 D821_09348 - - BrsR SMU.2080 GI|290581346...”
APQ13_RS09135, D818_08143, D820_08345, D821_08319, SMU105_RS00335, SMU109_07641, SMU26_08767, SMU53_RS00305, SMU70_RS05300, SMU99_06748, SMUGS5_08355, WP_002268420 hdrR negative regulator HdrM from Streptococcus mutans NCTC 11060
Aligns to 127:225 / 228 (43.4%), covers 65.8% of PF09922, 30.1 bits
- LytTR Regulatory Systems: A potential new class of prokaryotic sensory system
Zou, PLoS genetics 2018 - “...SMULJ23_RS05010 SMULJ23_RS05015 SMULJ23_0305 SMULJ23_0304 SMULJ23_1824 SMULJ23_1825 NG8 APQ13_RS06435 APQ13_RS06430 APQ13_RS05775 APQ13_RS05770 APQ13_RS02945 APQ13_RS02950 not annotated APQ13_RS09135 APQ13_RS08050 APQ13_RS08045 SF1 SMU80_RS05505 SMU80_RS05500 SMU80_RS07445 SMU80_RS07440 SMU80_RS04625 SMU80_RS04630 SMU80_RS03035 SMU80_RS03030 SMU80_RS06900 SMU80_RS06905 Genes are listed by their NCBI Gene Locus Tag designations. *Indicates a frameshift mutation is present LRS...”
- “...SMU53_RS05950 SMU53_01385 SMU53_01380 SMU53_RS00300 SMU53_RS00305 SMU53_RS06530 SMU53_RS06535 SF12 SMU105_RS01360 SMU105_RS01355 SMU105_RS07335 SMU105_RS07330 SMU105_RS08645 SMU105_RS08640 SMU105_RS00340 SMU105_RS00335 SMU105_07142 SMU105_07137 3SN1 SMU26_RS06535 SMU26_RS06540 SMU26_RS04770 SMU26_RS04775 SMU26_RS07145 SMU26_RS07140 SMU26_08772 SMU26_08767 SMU26_09654 not annotated * R221 SMU107_RS02805 SMU107_RS02800 SMU107_RS06685 SMU107_RS06680 SMU107_RS01840 SMU107_RS01845 SMU107_RS01190 SMU107_RS01185 SMU107_00213 SMU107_00208 OMZ175 SMU109_RS09430 SMU109_RS09425 SMU109_RS02930...”
- “...SMU107_RS06680 SMU107_RS01840 SMU107_RS01845 SMU107_RS01190 SMU107_RS01185 SMU107_00213 SMU107_00208 OMZ175 SMU109_RS09430 SMU109_RS09425 SMU109_RS02930 SMU109_RS02925 SMU109_RS08705 SMU109_RS08710 SMU109_07636 SMU109_07641 SMU109_RS01905 SMU109_RS01900 * M230 SMU108_RS03395 SMU108_RS03400 SMU108_RS00445 SMU108_RS00450 SMU108_RS08330 SMU108_RS08335 SMU108_RS04130 SMU108_RS04135 SMU108_RS02300 SMU108_RS02295 2VS1 SMU41_RS02780 SMU41_RS02785 SMU41_RS02285 SMU41_RS02290 SMU41_RS09195 SMU41_RS09190 SMU41_RS00710 SMU41_RS00715 SMU41_RS08205 SMU41_RS08210 24 SMU99_RS01810 SMU99_RS01805 SMU99_RS04370 SMU99_RS04365...”
- “...SMU105_RS07330 SMU105_RS08645 SMU105_RS08640 SMU105_RS00340 SMU105_RS00335 SMU105_07142 SMU105_07137 3SN1 SMU26_RS06535 SMU26_RS06540 SMU26_RS04770 SMU26_RS04775 SMU26_RS07145 SMU26_RS07140 SMU26_08772 SMU26_08767 SMU26_09654 not annotated * R221 SMU107_RS02805 SMU107_RS02800 SMU107_RS06685 SMU107_RS06680 SMU107_RS01840 SMU107_RS01845 SMU107_RS01190 SMU107_RS01185 SMU107_00213 SMU107_00208 OMZ175 SMU109_RS09430 SMU109_RS09425 SMU109_RS02930 SMU109_RS02925 SMU109_RS08705 SMU109_RS08710 SMU109_07636 SMU109_07641 SMU109_RS01905 SMU109_RS01900 * M230 SMU108_RS03395 SMU108_RS03400...”
- “...SMU50_RS07795 SMU50_RS01165 SMU50_RS01170 SMU50_07866 SMU50_07861 SMU50_RS02940 SMU50_RS02935 NVAB SMU53_09635 SMU53_09640 SMU53_RS05955 SMU53_RS05950 SMU53_01385 SMU53_01380 SMU53_RS00300 SMU53_RS00305 SMU53_RS06530 SMU53_RS06535 SF12 SMU105_RS01360 SMU105_RS01355 SMU105_RS07335 SMU105_RS07330 SMU105_RS08645 SMU105_RS08640 SMU105_RS00340 SMU105_RS00335 SMU105_07142 SMU105_07137 3SN1 SMU26_RS06535 SMU26_RS06540 SMU26_RS04770 SMU26_RS04775 SMU26_RS07145 SMU26_RS07140 SMU26_08772 SMU26_08767 SMU26_09654 not annotated * R221 SMU107_RS02805 SMU107_RS02800 SMU107_RS06685...”
- “...SMU68_RS04135 SMU68_RS01560 SMU68_RS01555 SMU68_RS09285 SMU68_RS09280 SMU68_RS03260 SMU68_RS03255 NLML5 SMU70_RS00900 SMU70_RS00895 SMU70_RS08165 SMU70_RS08160 SMU70_RS02155 SMU70_RS02150 SMU70_RS05295 SMU70_RS05300 SMU70_08278 SMU70_08283 SM4 SMU97_08152 SMU97_08157 SMU97_RS01095 SMU97_RS01100 SMU97_RS07460 SMU97_RS07455 SMU97_RS01120 SMU97_RS01115 SMU97_RS01790 SMU97_RS01785 LJ23 SMULJ23_1676 SMULJ23_1675 SMULJ23_RS07900 SMULJ23_RS07895 SMULJ23_RS05010 SMULJ23_RS05015 SMULJ23_0305 SMULJ23_0304 SMULJ23_1824 SMULJ23_1825 NG8 APQ13_RS06435 APQ13_RS06430 APQ13_RS05775 APQ13_RS05770 APQ13_RS02945...”
- “...SMU41_RS02290 SMU41_RS09195 SMU41_RS09190 SMU41_RS00710 SMU41_RS00715 SMU41_RS08205 SMU41_RS08210 24 SMU99_RS01810 SMU99_RS01805 SMU99_RS04370 SMU99_RS04365 SMU99_RS06740 SMU99_RS06745 SMU99_06753 SMU99_06748 SMU99_RS03985 SMU99_RS03990 NMT4863 SMU57_RS00640 SMU57_RS00635 SMU57_RS03960 SMU57_RS03955 SMU57_RS08545 SMU57_RS08540 SMU57_06768 SMU57_06773 SMU57_RS06355 SMU57_RS06360 * NLML1 SMU89_RS00770 SMU89_RS00775 SMU89_RS03240 SMU89_RS03245 SMU89_RS06550 SMU89_RS06555 SMU89_04914 SMU89_04919 SMU89_RS02570 SMU89_RS02575 N66 SMU76_08650 SMU76_08645 SMU76_RS00735 SMU76_RS00740...”
- “...(HdrR) SMU_1855 (HdrM) SMU_2080 (BrsR) SMU_2081 (BrsM) GS-5 SMUGS5_RS01270 SMUGS5_RS01275 SMUGS5_RS01975 SMUGS5_RS01980 SMUGS5_RS04780 SMUGS5_RS04775 SMUGS5_08350 SMUGS5_08355 SMUGS5_RS09430 SMUGS5_RS09435 * NN2025 SMUNN2025_RS08570 SMUNN2025_RS08565 SmuNN2025_1529 SmuNN2025_1528 SMUNN2025_RS05005 SMUNN2025_RS05010 SmuNN2025_0284 SmuNN2025_0283 SMUNN2025_RS09370 SMUNN2025_RS09375 PKUSS-LG01 PLG01_00262 PLG01_00263 PLG01_RS0109205 PLG01_RS07225 PLG01_RS04590 PLG01_RS04595 PLG01_01702 PLG01_01703 PLG01_01917 PLG01_01918 NLML8 SMU88_07197 SMU88_07202 SMU88_RS06890 SMU88_RS06895...”
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing
Song, BMC genomics 2013 - “...D819_09056 D820_09650 D821_09748 D822_05851 D823_03191 HdrM high density responsive membrane protein SMU.1855 GI|290579809 D816_08353 D817_08543 D818_08143 D819_07614 D820_08345 D821_08319 D822_08240 D823_08222 HdrR high density responsive regulator SMU.1854 GI|290579810 D816_08348 D817_08538 D818_08138 D819_07609 D820_08340 D821_08314 - - BrsM SMU.2081 GI|290581347 D816_09358 D817_09538 D818_09198 D819_08671 D820_09275 D821_09348 -...”
- “...D821_09748 D822_05851 D823_03191 HdrM high density responsive membrane protein SMU.1855 GI|290579809 D816_08353 D817_08543 D818_08143 D819_07614 D820_08345 D821_08319 D822_08240 D823_08222 HdrR high density responsive regulator SMU.1854 GI|290579810 D816_08348 D817_08538 D818_08138 D819_07609 D820_08340 D821_08314 - - BrsM SMU.2081 GI|290581347 D816_09358 D817_09538 D818_09198 D819_08671 D820_09275 D821_09348 - - BrsR...”
- “...D822_05851 D823_03191 HdrM high density responsive membrane protein SMU.1855 GI|290579809 D816_08353 D817_08543 D818_08143 D819_07614 D820_08345 D821_08319 D822_08240 D823_08222 HdrR high density responsive regulator SMU.1854 GI|290579810 D816_08348 D817_08538 D818_08138 D819_07609 D820_08340 D821_08314 - - BrsM SMU.2081 GI|290581347 D816_09358 D817_09538 D818_09198 D819_08671 D820_09275 D821_09348 - - BrsR SMU.2080...”
- The hdrRM operon of Streptococcus mutans encodes a novel regulatory system for coordinated competence development and bacteriocin production.
Okinaga, Journal of bacteriology 2010 - GeneRIF: The authors created an hdrR overexpression strain and showed that it could reproduce each of the hdrM competence and mutacin phenotypes, indicating that HdrM acts as a negative regulator of HdrR activity.
Or search for genetic data about PF09922 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory