Family Search for PF09949 (APP1_cat)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF09949

PF09949 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

APP1_YEAST / P53933 Phosphatidate phosphatase APP1; PAP; Actin patch protein 1; EC 3.1.3.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
Aligns to 276:426 / 587 (25.7%), covers 100.0% of PF09949, 174.5 bits

• function: Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches (PubMed:23071111, PubMed:23335564). Can also utilize diacylglycerol pyrophosphate and lyso-PA as substrates with specificity constants 4- and 7-fold lower, respectively, when compared with PA (PubMed:23335564).
  catalytic activity: a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn- glycerol + phosphate (RHEA:27429)
  catalytic activity: 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2- di-(9Z-octadecenoyl)-sn-glycerol + phosphate (RHEA:43244)
  cofactor: Mg(2+)
  subunit: Monomer (PubMed:23335564). Interacts with ABP1 (PubMed:14737190).

YNK4_SCHPO / Q9HGP1 Uncharacterized protein C29B5.04c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 291:441 / 605 (25.0%), covers 100.0% of PF09949, 138.7 bits

Q9XXT5 phosphatidate phosphatase (EC 3.1.3.4) from Caenorhabditis elegans (see paper)
Aligns to 554:692 / 794 (17.5%), covers 76.8% of PF09949, 28.6 bits

Or search for genetic data about PF09949 in the Fitness Browser