Family Search for PF09982 (LpxR)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF09982 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
HMU07990 hypothetical protein from Helicobacter mustelae 12198
Aligns to 7:343 / 343 (98.3%), covers 94.4% of PF09982, 304.2 bits
Vca1114GL_01026 lipid A deacylase LpxR family protein from Vibrio campbellii
Aligns to 5:325 / 325 (98.8%), covers 98.8% of PF09982, 288.9 bits
- Popmarker: Identifying Phylogenetic Markers at the Population Level
Ke, Evolutionary bioinformatics online 2017 - “...(eg, Vca1114GL_00502), glutathione-dependent formaldehyde-activating enzyme (Vca1114GL_03935), helicase IV (Vca1114GL_04071), glutamate cysteine ligase (Vca1114GL_02510), and exonuclease (Vca1114GL_01026). It would be interesting to study the function of the first protein with an unknown function so far. Although the application of phylogenetic markers other than 16S ribosomal RNA has...”
HPG27_RS03360 lipid A deacylase LpxR family protein from Helicobacter pylori G27
Aligns to 4:336 / 336 (99.1%), covers 99.4% of PF09982, 248.1 bits
jhp0634 putative Outer membrane protein from Helicobacter pylori J99
Aligns to 3:336 / 336 (99.4%), covers 99.4% of PF09982, 246.2 bits
- Helicobacter pylori diversification during chronic infection within a single host generates sub-populations with distinct phenotypes
Jackson, PLoS pathogens 2020 - “...jhp0336 Unknown 19 5.07 1 1 jhp1097 glnP_2 ABC transporter permease 5 4.63 1 1 jhp0634 Unknown 7 4.29 1 1 jhp1102 Guanine permease 9 4.26 1 1 jhp0833 babA Outer membrane protein 15 4.16 2 4 jhp0662 sabA Outer membrane protein 13 4.12 4 5...”
- Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation
Gaddy, mBio 2015 - “...acyltransferase, LpxL (Jhp0265), a 4-phosphatase, LpxF (Jhp1486), and an outer membrane 3- O -deacylase, LpxR (Jhp0634) ( 23 ). The predominant peak from the CP-treated H.pylori lipid A is at m/z 1546.8, consistent with the [M-H] ion of the wild-type structure of H.pylori lipid A (predicted...”
- Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa
Cullen, PLoS pathogens 2011 - “...unmodified hydroxyl group, followed by removal of the 3- O -linked acyl chains by LpxR (Jhp0634) resulting in a tetra-acylated lipid A. Following transport of core-lipid A across the inner membrane, the first four modification reactions occur at the periplasmic face of the inner membrane. The...”
- “...Kan R , Cam R This study J99 lpxR J99 with chloramphenicol resistance cassette in jhp0634, Cam R [21] B128 lpxF B128 with kanamycin resistance cassette in jhp1487, Kan R This study B128 lpxF, lpxF + B128 lpxF with jhp1487 in rdxA , Kan R ,...”
- Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface
Stead, Molecular microbiology 2010 - “...et al., 2008 ). Plasmid pET634comp was digested with BamHI and EcoRI to remove the jhp0634 insert and gel purified, leaving the rdxA flanking regions intact. Hp0580 (primers F580comp and R580comp) and hp0579 - hp0580 (primers F580comp and R579comp) plus approximately 100 base pairs of upstream...”
- “...SK (+) containing hp0579-80 flanking regions with a chloramphenicol resistance cassette insert This work pET634comp jhp0634 complemrnt plasmid ( Stead et al., 2008 ) pET580comp pEThp0954 with hp0580 inserted in hp0954 This work pET579-80comp pEThp0954 with hp0579-80 inserted in hp0954 This work pPhoA pET21a containing phoA...”
- Deciphering the unusual acylation pattern of Helicobacter pylori lipid A
Stead, Journal of bacteriology 2008 - “...lipid A species of H. pylori that is tetra-acylated. Jhp0634 was identified as an outer membrane deacylase that removes the 3-linked acyl chains of H. pylori...”
- “...lipid A minor species is also identified as Jhp0634. * Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, The University...”
lpxR / O25401 lipid A 3'-O-acyloxyacylase from Helicobacter pylori (strain ATCC 700392 / 26695) (see 2 papers)
O25401 Lipid A deacylase LpxR family protein from Helicobacter pylori (strain ATCC 700392 / 26695)
HP0694 hypothetical protein from Helicobacter pylori 26695
Aligns to 4:257 / 257 (98.8%), covers 75.5% of PF09982, 182.5 bits
- Structural and functional aspects of the Helicobacter pylori secretome
Zanotti, World journal of gastroenterology 2014 - “...O25091 O25166 O25218 O25222 O25230 O25231 O25355 O25382 O25401 O25410 O25414 3BGH 3CWX, 3CWY 4G0H, 4DVY, 4DVZ, 3IEC Q7X2J9 P55969 O25556 O25570 O25571 O25580...”
- Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization
Marcus, Helicobacter 2018 - “...0.08 1.17 0.03 0.05 1.57 0.07 0.03 outer membrane protein HefG other omp genes HPG27_RS03360 HP0694 1.53 0.07 0.04 1.67 0.06 0.02 1.98 0.05 0.00 outer membrane protein HPG27_RS03515 HP0726 1.54 0.03 0.00 1.51 0.03 0.00 1.48 0.06 0.03 outer membrane protein HPG27_RS03830 HP0785 1.70 0.16...”
- Helicobacter pylori: expect the unexpected
Suarez, Molecular microbiology 2014 - “...resistance to antibiotics. Hexa-acylated H. pylori lipid A then becomes tetra-acylated by the activity of Hp0694, a homolog of LpxR, which removes 3'-O-linked acyl chains. This five-step modification (1'-dephosphorylation, addition of phosphoethanolamine, removal of a Kdo subunit, 4'-dephosphorylation, and deacylation) renders H. pylori lipid A a...”
- Whole-genome sequencing of clarithromycin resistant Helicobacter pylori characterizes unidentified variants of multidrug resistant efflux pump genes
Iwamoto, Gut pathogens 2014 - “...54 18 1 G 739962 739963 HP0688 hypothetical protein 45 19 1 T 745341 745342 HP0694 hypothetical protein 84 20 1 T 745352 745353 86 21 1 A 745389 745390 95 22 1 T 745429 745430 97 23 2 AG 773423 773424 HP0719 hypothetical protein 55...”
- Structural and functional aspects of the Helicobacter pylori secretome
Zanotti, World journal of gastroenterology 2014 - “...(Omp13) y HP0671 Outer membrane protein (Omp14) b', y HP0694 Putative outer membrane protein b', y HP0706 Outer membrane protein (Omp15) b', z HP0710 Outer...”
- Colonize, evade, flourish: how glyco-conjugates promote virulence of Helicobacter pylori
Rubin, Gut microbes 2013 - “...removal of the 3'-linked acyl chains by LpxR (Hp0694), producing the final tetra-acylated lipid A structure characteristic of the H. pylori outer membrane (Fig....”
- “...by LpxF (Hp1580). Finally, the outer-membrane -barrel LpxR (Hp0694) catalyzes removal of the 3'-linked acyl chains, generating the final lipid A structure in...”
- Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface
Stead, Molecular microbiology 2010 - “...position. The final step involves the removal of the 3- O -linked acyl chains by Hp0694 (LpxR), resulting in a tetra-acylated lipid A. Fig. 2 In vitro assay of Kdo hydrolase candidate proteins, Hp0579 and Hp0580, heterologously expressed in E. coli Hp0579, Hp0580 and Hp0579-Hp0580 were...”
- Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen
O'Toole, BMC genomics 2010 - “...No significant homologues No HMU07990 343 39,155 AENL -FAF 42.9% in 233 aa overlap with HP0694 No HMU10040 167 18,839 -EGK 50.9% in 163 aa overlap with HP1546 No HMU01230 232 24,626 ANTN -YKF 44.5% in 236 aa overlap with HH_0525 No Predicted by SignalP 2.0...”
- Deciphering the unusual acylation pattern of Helicobacter pylori lipid A
Stead, Journal of bacteriology 2008 - “...DNA. Construction of H. pylori 26695 and J99 3-O-deacylase (hp0694 and jhp0634) defective mutants. In a comparison of the gene sequences of H. pylori lpxR...”
- “...found in the microbial database, the 26695 homolog (hp0694) was determined to have a truncation of 237 nucleotides. However, sequencing data using genomic DNA...”
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DA88_30375, DC23_03830, E2348C_0684, EDL933_0859, EDL933_RS04255 lipid A deacylase LpxR family protein from Escherichia coli
ECs0814 putative outer membrane protein from Escherichia coli O157:H7 str. Sakai
Aligns to 9:319 / 319 (97.5%), covers 98.4% of PF09982, 136.8 bits
- Genomic Island-Encoded Histidine Kinase and Response Regulator Coordinate Mannose Utilization with Virulence in Enterohemorrhagic Escherichia coli
Yang, mBio 2023 - “...ATP binding protein LmuX EDL933_RS02035 EDL933_0405 424286 423204 423542 1.39 2.8 Transcriptional repressor LacI EDL933_RS04255 EDL933_0859 898620 897661 898688 1.64 2.3 Lipid A deacylase LpxR family protein EDL933_RS05865 EDL933_1192 1203785 1202697 1203894 1.26 2.4 Porin OmpF EDL933_RS07100 EDL933_1438 1406552 1408060 1406890 1.79 2.5 Sodium/proline symporter PutP...”
- “...transporter ATP binding protein LmuX EDL933_RS02035 EDL933_0405 424286 423204 423542 1.39 2.8 Transcriptional repressor LacI EDL933_RS04255 EDL933_0859 898620 897661 898688 1.64 2.3 Lipid A deacylase LpxR family protein EDL933_RS05865 EDL933_1192 1203785 1202697 1203894 1.26 2.4 Porin OmpF EDL933_RS07100 EDL933_1438 1406552 1408060 1406890 1.79 2.5 Sodium/proline symporter...”
- Comparative Transcriptomics of Shiga Toxin-Producing and Commensal Escherichia coli and Cytokine Responses in Colonic Epithelial Cell Culture Infections
Harrison, Frontiers in cellular and infection microbiology 2020 - “...enterohemolysin A 5.32 2.27 2.16 2.25 DA88_29555 DC23_13320 mobC plasmid mobilization 7.57 4.73 3.12 2.64 DA88_30375 DC23_03830 lpxR lipid A 3-O-deacylase 9.22 24.09 35.96 11.48 DA88_31020 DC23_01930 repA IncFII plasmid replication initiation 2.13 3.26 2.24 5.15 Genes encoding potential novel virulence factors are shown in bold...”
- “...A 5.32 2.27 2.16 2.25 DA88_29555 DC23_13320 mobC plasmid mobilization 7.57 4.73 3.12 2.64 DA88_30375 DC23_03830 lpxR lipid A 3-O-deacylase 9.22 24.09 35.96 11.48 DA88_31020 DC23_01930 repA IncFII plasmid replication initiation 2.13 3.26 2.24 5.15 Genes encoding potential novel virulence factors are shown in bold font....”
- Microarray analysis of the Ler regulon in enteropathogenic and enterohaemorrhagic Escherichia coli strains
Bingle, PloS one 2014 - “...protein E2348C_0523 9 pagP palmitoyl transferase for Lipid A E2348C_0683 4 - hypothetical protein PP2 E2348C_0684 21 - SfpA (systemic factor protein A)-like protein PP2 E2348C_1040 2 - T3SS secreted effector NleI/NleG homolog PP4 E2348C_1442 13 - T3SS secreted effector NleA/EspI homolog PP6 E2348C_1444 2 -...”
- “...protein E2348C_0523 15 pagP palmitoyl transferase for Lipid A E2348C_0683 3 - hypothetical protein PP2 E2348C_0684 35 - SfpA (systemic factor protein A)-like protein PP2 E2348C_0685 2 - predicted late gene regulator PP2 E2348C_0718 2 - T3SS secreted effector NleH homolog PP2 E2348C_0723 3 - T3SS...”
- Microarray analysis of the Ler regulon in enteropathogenic and enterohaemorrhagic Escherichia coli strains
Bingle, PloS one 2014 - “...a porin involved in systemic disease in Yersinia enterocolitica [42] . A homologue of sfpA (ECs0814) in the Sakai strain of EHEC was previously observed to be Ler regulated [36] . The rcsA gene, which encodes a positive regulator of the serotype-specific group I K (capsular)...”
- Global regulation by horizontally transferred regulators establishes the pathogenicity of Escherichia coli
Abe, DNA research : an international journal for rapid publication of reports on genes and genomes 2008 - “...espF-U/tccP . Finally, class L1 included three unknown O157-specific genes in an S-loop, ECs0355, ECs0356, ECs0814, and the plasmid-born gene tagA . In addition, the transcription levels of three genes common to EHEC O157:H7 and K-12 in the E. coli backbone chromosome were regulated in close...”
- “...seem to belong to the same operon and are transcribed in the opposite direction from ECs0814, which belongs to class L1. Another cluster of genes, from ECs3512 to ECs3508, seems to comprise an operon that lies at the end of prophage-like element Sp17. In addition, class...”
- Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes
Ogura, Genome biology 2007 - “...0 0 ECs0542 S-loop42 Absent RTX-like protein - - - - [8] 0 0 0 ECs0814 Sp3 Absent SfpA (systemic factor protein A)-like protein - - - - [8] [8] [6] [6] ECs1205 Sp5 Absent Shiga toxin 2 subunit A - - - - 4 1...”
- Global transcriptional response of Escherichia coli O157:H7 to growth transitions in glucose minimal medium
Bergholz, BMC microbiology 2007 - “...aroG -3.09 1 ECs2445 osmE 2.33 2 ECs0800 ybhC -2.13 1 ECs2510 yeaV 2.06 3 ECs0814 O157 -2.15 1 ECs2692 yodD 2.96 2 ECs0869 ybhQ 3.14 2 ECs2714 espJ -2.01 1 ECs0890 dps 2.64 2 ECs2737 pchC 3.43 2 ECs0943 artJ -2.81 1 ECs2814 yeeD -2.09...”
- Regulators encoded in the Escherichia coli type III secretion system 2 gene cluster influence expression of genes within the locus for enterocyte effacement in enterohemorrhagic E. coli O157:H7
Zhang, Infection and immunity 2004 - “...0.008 3.95 3.51 3.13 0.033 0.027 0.042 2.87 0.023 ECs0814 ECs4561 ECs4578 On plasmid pO157 tir grlR tagA ECs1192 LZ3 P value ECs4556 ECs4560 ECs2711 espA cesT...”
- “...0.00004 0.045 ECs4590 ECs4554 ECs4555 ECs4553 ECs4577 ECs2819 ECs4561 ECs0814 espG espB espD cesd2 grlA hisL tir 4.78 3.61 3.33 2.96 2.95 2.87 2.80 2.70 0.003...”
Z0955 unknown protein encoded by prophage CP-933K from Escherichia coli O157:H7 EDL933
Aligns to 9:319 / 319 (97.5%), covers 97.5% of PF09982, 135.9 bits
- Hybrid Vigor: Importance of Hybrid λ Phages in Early Insights in Molecular Biology
Feiss, Microbiology and molecular biology reviews : MMBR 2022 (secret) - A Highly Conserved Bacterial D-Serine Uptake System Links Host Metabolism and Virulence
Connolly, PLoS pathogens 2016 - “...down-regulated including 38 LEE associated genes, 5 genes encoding NLE proteins and an LpxR homologue (Z0955) suggested to play a role in pathogenesis by modulating lipid-A and, hence, cytokine responses [ 34 ]. The RNA-seq data were validated by qRT-PCR analysis for five genes ( espD...”
- Microarray analysis of the Ler regulon in enteropathogenic and enterohaemorrhagic Escherichia coli strains
Bingle, PloS one 2014 - “...zinc metalloprotease pO157 L7032 2 etpC component of type II secretion system for StcE pO157 Z0955 5 - systemic factor protein A homologue PP (OI#36) Z4458 36 yhaI putative cytochrome Z5100 7 espF LEE-encoded effector EspF LEE (OI#148) Z5102 24 orf29 component of T3SS, SsaH family...”
- Characterizing the Escherichia coli O157:H7 proteome including protein associations with higher order assemblies
Pieper, PloS one 2011 - “...atypical lipid anchor motifs are Z1474 (motif ITGC 17 A), YijI (motif CASC 49 S), Z0955 (motif FTTC 18 S), Z3360 (motif MKAC 44 S) and Z0984 (motif LCGC 27 G). Further support of membrane attachment was obtained for twelve of the 55 proteins via LC-MS/MS...”
- “...or OM) unkn 1775 0 LTGC 18 S 3 unknown protein encoded by prophage CP-933K Z0955 - 34904 L (hydr LS) unkn 1564 0 FTTC 18 S 2 predicted exopolysaccharide export protein GfcE Z1400 gfcE 41739 L (IM or OM) OM 1386 43 LTAC 21 T...”
- Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7
Tree, Infection and immunity 2009 - “...in three of four experimentsa Common name L7027 L7031 Z0955 Z1823 Z1824 Z2478b Z2479b Z3071 Z3572 Z5100 Z5102 Z5103 Z5104 Z5105 Z5106 Z5107 Z5108 Z5109 Z5110...”
- “...Z5135 Z5137 Z5139 Z5142 Z5953b Z6024 Z4668 Z3013b L7027 L7031 Z0955 Z1823 Z1824 pspD pspC Z3071 argT espF Z5102 escF Z5104 espB espD espA sepL escD eae Z5111...”
- Global effect of RpoS on gene expression in pathogenic Escherichia coli O157:H7 strain EDL933
Dong, BMC genomics 2009 - “...12.6 0.2 -2 O-Island 11 Unknown Z0397 5.1 0.3 6.2 0.1 -2 O-Island 14 Unknown Z0955 9.7 0.3 11.5 0.0 -4 O-Island 36 Unknown (prophage CP-933K) Z1146 11.7 0.3 12.7 0.3 -2 O-Island 43 Putative urease accessory protein E Z1144 11.3 0.2 12.4 0.2 -2 O-Island...”
t1208 putative outer membrane protein from Salmonella enterica subsp. enterica serovar Typhi Ty2
Aligns to 9:319 / 319 (97.5%), covers 95.0% of PF09982, 130.8 bits
lpxR / Q8ZPT3 lipid A 3'-O-acyloxyacylase from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
STM1328 putative outer membrane protein from Salmonella typhimurium LT2
SL1344_1263, SL1344_RS06600 lipid A deacylase LpxR family protein from Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344
Aligns to 9:319 / 319 (97.5%), covers 93.5% of PF09982, 130.1 bits
- Hybrid Vigor: Importance of Hybrid λ Phages in Early Insights in Molecular Biology
Feiss, Microbiology and molecular biology reviews : MMBR 2022 (secret) - Rcs signalling-activated transcription of rcsA induces strong anti-sense transcription of upstream fliPQR flagellar genes from a weak intergenic promoter: regulatory roles for the anti-sense transcript in virulence and motility
Wang, Molecular microbiology 2009 - “...yjbJ ( dinF ) 3.25.3 0.71.6 sfbA ( sfbA ) 2.3 0.5 STM4242 3.6 0.6 STM1328 6.6 0.4 STM4510 5.6 1.5 STM2287 4.9 0.4 STM4519 5.4 2.4 tdcE ( tdcD ) 3.2 0.7 yahoo 5.6 1.7 Others positively regulated yaiA ( aroL ) 2.8 1.0 aceA~B...”
- The RNA chaperone Hfq is essential for the virulence of Salmonella typhimurium
Sittka, Molecular microbiology 2007 - “...macrophage survival; virulence membrane protein PagC precursor 2D STM1254 (OM) Putative outer membrane lipoprotein 2D STM1328 (OM) Putative OMP 2D AroD CP 3-Dehydroquinate dehydratase 2D LppB OM Putative methyl-accepting chemotaxis protein; major outer membrane lipoprotein 2D LppA OM Murein lipoprotein, links outer and inner membranes; major...”
- “...( Table 2 ), five have no known homologues in E. coli (SipA, SipC, STM1254, STM1328 and STM2494). Of the remaining 66, seven overlap with previously published Hfq-associated E. coli mRNAs, i.e. CspD, Dps, LppA, LppB, OmpX, RplL and YfiA ( Zhang et al ., 2003...”
- An outer membrane enzyme encoded by Salmonella typhimurium lpxR that removes the 3'-acyloxyacyl moiety of lipid A
Reynolds, The Journal of biological chemistry 2006 - “...expression vector, lac promoter, ampr pET23a expressing lpxR (STM1328) pWSK29 expressing lpxR (STM1328) Novagen 33 This work This work S. typhimurium strain LT2...”
- “...of lpxR Expression Vectors--S. typhimurium lpxR, formerly STM1328, was cloned into pET23a (Novagen) behind the T7 promoter. The predicted coding region...”
- Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin
Yim, Journal of bacteriology 2006 - “...STM1956/fliA (F) STM1914/flhBA STM1183/flgK STM2199/cirA STM1328 STM1248 STM1444/slyA STM1154 to -1155/yceE, htrB pSLT041-39/spvRAB STM4118/yijP STM4454/treB...”
- “...14028 14028 a crp::Tn10 fis::tet hns::Tn10 ihfB::cat fnr::Tn10 rpoS::amp fliA flhB cirA STM1328 22 2 2 222 222 22 22 22 *b * 22 22 22 2 22 22 2 2 2 22 22 2...”
- Salmonella enterica highly expressed genes are disease specific
Rollenhagen, Infection and immunity 2006 - “...STM0974 STM2283 STM2344 STM0744 STM3881 STM0608 STM2876 STM1328 STM2328 STM2875 rtsA focA glpT rtsAB focA-pflB glpTQ STM2344-2340 ybgC-tolQRAB-pal-ybgF rbsDACBK...”
- “...mice Gene STM0608 STM2283 STM3881 STM0974 STM4315 STM1328 STM2330 STM2344 STM2876 STM4423 ahpC glpT rbsD focA lrhA hilA Expression level in...”
- Identification of new flagellar genes of Salmonella enterica serovar Typhimurium
Frye, Journal of bacteriology 2006 - “...0.53 76. STM1328 .................................................................................... 0.57 77....”
- Down-regulation of key virulence factors makes the Salmonella enterica serovar Typhimurium rfaH mutant a promising live-attenuated vaccine candidate
Nagy, Infection and immunity 2006 - “...directed toward the realignment of the envelope. STM1131, STM1328, nmpC, and ompF, which encode proteins found in the outer membrane, were down-regulated,...”
- Dual perspective proteomics infectome profiling discoversSalmonellatype III secretion system effector functions in macrophages
Geddes-McAlister, 2021 - Intracellular niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica
Powers, PLoS pathogens 2021 - “...Taken together, our findings suggest the filaments could be SiiE. Like the sii operon, lpxR (SL1344_1263) is also co-regulated with SPI1 [ 74 ] and encodes an outer membrane 3- O -deacylase of lipid A [ 75 , 76 ]. Transcriptional reporters did not verify cytosolic...”
- Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC
Cooper, Nature communications 2021 - “...0.83 2E05 2E04 SL1344_RS14890 hilA T3SS1 0.59 6E04 0.003 SL1344_RS15005 invF T3SS1 0.53 0.006 0.020 SL1344_RS06600 lpxR T3SS1 1.22 4E08 6E07 SL1344_RS06605 hypoth. Lipid A deacylase 1.45 0.008 0.024 SL1344_RS06610 hypoth. Unknown 1.33 9E09 1E07 SL1344_RS22130 hypoth. Endonuclease 1.39 4E07 5E06 SL1344_RS22135 hypoth. Unknown 0.82 0.018...”
- In silico clustering of Salmonella global gene expression data reveals novel genes co-regulated with the SPI-1 virulence genes through HilD
Martínez-Flores, Scientific reports 2016 - “...genes that are co-expressed with SPI-1: gtgE , phoH , sinR , SL1344_1028 (SL1028 ), SL1344_1263 (SL1263 or lpxR ), SL1344_1896 (SL1896 ), SL1344_3812 (SL3812 ), SL1344_4247 (SL4247 ) and SL1344_4433 (SL4433 ). Expression analyses and protein-DNA interaction assays show that HilD regulates six of these...”
3fidA / Q8ZPT3 Lpxr from salmonella typhimurium (see paper)
Aligns to 4:296 / 296 (99.0%), covers 87.0% of PF09982, 129.1 bits
YE3039 hypothetical protein from Yersinia enterocolitica subsp. enterocolitica 8081
Aligns to 6:319 / 319 (98.4%), covers 76.4% of PF09982, 127.4 bits
- The RNA chaperone Hfq impacts growth, metabolism and production of virulence factors in Yersinia enterocolitica
Kakoschke, PloS one 2014 - “...YE0364 frdA / b4154 fumarate reductase flavoprotein subunit anaerobic respiration 3301, 4302, 5301 + 35 YE3039 lpxR / sfpA lipopolysaccharide deacylase, systemic factor protein A 5801 + 74 YE2622 fyuA outer membrane pesticin and yersiniabactin receptor siderophore transport; iron ion transport 6803 + 74 YE1771 fcuA...”
- Deciphering the acylation pattern of Yersinia enterocolitica lipid A
Reinés, PLoS pathogens 2012 - “...number AM286415; [20] ) revealed that this pathogen may encode an LpxR orthologue (locus tag YE3039). The predicted YeO8 LpxR (YeLpxR) has 73% and 20% amino acid identities to S. enterica and H. pylori LpxR proteins, respectively. Furthermore, YeLpxR has 100% amino acid identity to Y....”
- “...construction In silico analysis led to the identification of Y. enterocolitica 8081 homologue of lpxR (YE3039), yopP (YEP0083) and yopE (YEP0053) [accession number AM286415; [20] ]. To obtain the lpxR , yopP , and yopE mutants two sets of primers ( Table S1 ) were used...”
- Characterization of a novel porin involved in systemic Yersinia enterocolitica infection
Mildiner-Earley, Infection and immunity 2006 - “...on analysis of the sequence around sif15 (YE3039), it does not appear to be part of an operon (http://www.sanger.ac.uk /Projects/Y_enterocolitica/)....”
YE105_C2442 lipid A-modifier LpxR family protein from Yersinia enterocolitica subsp. palearctica 105.5R(r)
Aligns to 6:319 / 319 (98.4%), covers 86.6% of PF09982, 124.5 bits
- Deciphering the acylation pattern of Yersinia enterocolitica lipid A
Reinés, PLoS pathogens 2012 - “...Y11 serotype O:3 (locus tag Y11_05741; accession number FR729477) and Y105 serotype O:9 (locus tag YE105_C2442; accession number CP002246) LpxR homologs. Analysis of the available Y. pestis and Y. pseudotuberculosis genomes revealed that they do not encode any gene similar to lpxR . 10.1371/journal.ppat.1002978.g001 Figure 1...”
Y11_05741 lipid A-modifier LpxR family protein from Yersinia enterocolitica subsp. palearctica Y11
Aligns to 6:319 / 319 (98.4%), covers 86.3% of PF09982, 124.2 bits
- Deciphering the acylation pattern of Yersinia enterocolitica lipid A
Reinés, PLoS pathogens 2012 - “...Furthermore, YeLpxR has 100% amino acid identity to Y. enterocolitca Y11 serotype O:3 (locus tag Y11_05741; accession number FR729477) and Y105 serotype O:9 (locus tag YE105_C2442; accession number CP002246) LpxR homologs. Analysis of the available Y. pestis and Y. pseudotuberculosis genomes revealed that they do not...”
Or search for genetic data about PF09982 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory