Family Search for PF10154 (DUF2362)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10154 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CL004_HUMAN / Q9NQ89 Protein C12orf4 from Homo sapiens (Human) (see 3 papers)
NP_001291740 protein C12orf4 isoform a from Homo sapiens
Aligns to 41:546 / 552 (91.7%), covers 99.6% of PF10154, 735.5 bits

• function: Plays a role in mast cell degranulation.
• A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion.
  Rashvand, The journal of gene medicine 2022 (PubMed)
  • GeneRIF: A novel variant of C12orf4 linked to autosomal recessive intellectual disability type 66 with phenotype expansion.
• Identification of C12orf4 as a gene for autosomal recessive intellectual disability.
  Philips, Clinical genetics 2017 (PubMed)
  • GeneRIF: Results indicate a founder missense variant (p.Leu328Pro) in seven affected individuals from two Finnish consanguineous families and a deletion (p.Gln267fs) in one affected individual from a consanguineous Dutch family in the C12orf4 gene on chromosome 12.
• In-cell intrabody selection from a diverse human library identifies C12orf4 protein as a new player in rodent mast cell degranulation.
  Mazuc, PloS one 2014
  • GeneRIF: Mass spectrometry analysis identified protein RGD1311164 (C12orf4), with no previously described function. Our data demonstrate that RGD1311164 is a cytoplasmic protein implicated in the early signaling events following FcepsilonRI-induced cell activation

CL004_RAT / D4A770 Protein C12orf4 homolog from Rattus norvegicus (Rat) (see paper)
Aligns to 41:546 / 552 (91.7%), covers 99.6% of PF10154, 728.7 bits

• function: Plays a role in mast cell degranulation.

CG9986 uncharacterized protein from Drosophila melanogaster
Aligns to 39:528 / 535 (91.6%), covers 99.2% of PF10154, 556.2 bits

• Transcriptional coupling of distant regulatory genes in living embryos
  Levo, Nature 2022
  • “...CG8239 CG8312 CG8312 CG8388 CG8388 CG8654 CG8654 CG8788 CG8788 CG8960 CG8960 CG9005 CG9005 CG9215 CG9215 CG9986 CG9986 CG7533 chrb CG5813 chif CG11798 chn CG2125 ci CG8443 ciu CG17894 cnc CG17943 comm CG7554 comm2 CG1621 Coop CG2530 corto CG8502 Cpr49Ac CG7663 Cpr78Cb CG7450 CrebA CG5814 CycB3 CG3938...”
• High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death
  Tsuji, Physiological genomics 2020 (secret)

Or search for genetic data about PF10154 in the Fitness Browser