Family Search for PF10166 (DUF2368)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

PF10166 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

PLRKT_RAT / D4ACN8 Plasminogen receptor (KT); Plg-R(KT) from Rattus norvegicus (Rat) (see paper)
Aligns to 1:134 / 147 (91.2%), covers 100.0% of PF10166, 197.0 bits

• function: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9 (By similarity).
  subunit: Interacts with PLAT (By similarity). Interacts with PLAUR.
• The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1
  Wang, Genes & diseases 2024
  • “...complex 12 314013 Trappc12 59 D4A8X8 CTTNBP2 N-terminal like (predicted), isoform CRA_a 310760 Cttnbp2nl 60 D4ACN8 Plasminogen receptor (KT) 293888 Plgrkt 61 D4A7S9 Tripartite motif protein 45 (predicted), isoform CRA_b 295323 Trim45 62 B2RYM5 Lys-63-specific deubiquitinase BRCC36 316794 Brcc3 63 D4A489 CLOCK-interacting pacemaker 314330 Cipc Figure6...”
• TMT-based quantitative proteomics analysis of the effects of Jiawei Danshen decoction myocardial ischemia-reperfusion injury.
  Zhu, Proteome science 2022
  • “...0.01 0.81 1.43 F1LS35 Hps5 Hermansky-Pudlak syndrome 5 protein homolog 6.15 1 0.04 0.80 1.22 D4ACN8 Plgrkt Plasminogen receptor (KT) 8.84 2 0.01 0.79 1.22 Q3B8R6 Azgp1 Alpha-2-glycoprotein 1, zinc 2.36 1 0.01 0.79 1.26 F1LYH3 Mto1 Mitochondrial tRNA translation optimization 1 1.36 1 0.02 0.77...”

NP_001029598 plasminogen receptor (KT) from Bos taurus
Aligns to 1:134 / 147 (91.2%), covers 100.0% of PF10166, 194.1 bits

• The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release.
  Bai, The Journal of biological chemistry 2011
  • GeneRIF: Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus.

PLRKT_HUMAN / Q9HBL7 Plasminogen receptor (KT); Plg-R(KT) from Homo sapiens (Human) (see 2 papers)
XP_005251567 plasminogen receptor (KT) isoform X1 from Homo sapiens
Aligns to 1:134 / 147 (91.2%), covers 100.0% of PF10166, 192.9 bits

• function: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.
  subunit: Interacts with PLAT and PLAUR.
• Protein N-myristoylation plays a critical role in the mitochondrial localization of human mitochondrial complex I accessory subunit NDUFB7.
  Harada, Scientific reports 2023
  • “...NOL3 208 Functions as an apoptosis repressor that blocks multiple modes of cell death 29 Q9HBL7 Plasminogen receptor (KT) PLGRKT 147 Receptor for plasminogen 30 The characteristics of seven proteins found to be N-myristoylated by the experiments shown in Fig. 2 are summarized. DMAC1, HCCS, NDUFB7,...”
• Network Pharmacology Integrated Molecular Docking Reveals the Mechanism of Anisodamine Hydrobromide Injection against Novel Coronavirus Pneumonia
  Su, Evidence-based complementary and alternative medicine : eCAM 2020
  • “...ITGAV P06756 KCNA3 P22001 MPO P05164 MTMR11 A4FU01 NOX4 Q9NPH5 ODC1 P11926 PLAUR Q03405 PLGRKT Q9HBL7 RSAD2 Q8WXG1 SERPINC1 P01008 STAT3 P40763 TIMP2 P16035 TXN P10599 TXNIP Q9H3M7 VIP P01282 Crucial targets. Table 2 Correlation score of molecular docking. Target Docking score Glide gscore Glide evdw...”
• Chronic Occupational Exposure to Ionizing Radiation Induces Alterations in the Structure and Metabolism of the Heart: A Proteomic Analysis of Human Formalin-Fixed Paraffin-Embedded (FFPE) Cardiac Tissue.
  Azimzadeh, International journal of molecular sciences 2020
  • “...WFS1 Wolframin 0.64 4.83 10 2 P30084 ECHS1 Enoyl-CoA hydratase, mitochondrial 0.63 5.17 10 3 Q9HBL7 PLGRKT Plasminogen receptor (KT) 0.63 2.44 10 2 P26440 IVD Isovaleryl-CoA dehydrogenase, mitochondrial 0.63 2.67 10 2 P60866 RPS20 Ribosomal protein S20 0.62 3.18 10 2 Q6DN03 HIST2H2BC Putative histone...”
• The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease.
  Suárez-Arroyo, American journal of cancer research 2016
• The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis.
  Samad, Journal of thrombosis and haemostasis : JTH 2022
  • GeneRIF: The plasminogen receptor Plg-RKT regulates adipose function and metabolic homeostasis.
• Plg-RKT Expression in Human Breast Cancer Tissues.
  Miles, Biomolecules 2022
  • GeneRIF: Plg-RKT Expression in Human Breast Cancer Tissues.
• Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
  Whyte, Blood 2021
  • GeneRIF: Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.
• Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.
  Vago, Frontiers in immunology 2019
  • GeneRIF: Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes.
• The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)), regulates catecholamine release.
  Bai, The Journal of biological chemistry 2011
  • GeneRIF: Plg-R(KT) was highly expressed in bovine adrenomedullary chromaffin cells, human pheochromocytoma tissue, PC12 pheochromocytoma cells, and murine hippocampus.
• Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.
  Lighvani, Blood 2011
  • GeneRIF: Plg-R(KT) plays a key role in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response.
• Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  Hendrickson, PloS one 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

PLRKT_MOUSE / Q9D3P8 Plasminogen receptor (KT); Plg-R(KT) from Mus musculus (Mouse) (see 3 papers)
Aligns to 1:134 / 147 (91.2%), covers 100.0% of PF10166, 192.8 bits

• function: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.
  subunit: Interacts with PLAT. Interacts with PLAUR (By similarity).
• Proteomic analysis reveals semaglutide impacts lipogenic protein expression in epididymal adipose tissue of obese mice.
  Zhu, Frontiers in endocrinology 2023
  • “...1.447067984 Q9CY64 Biliverdin reductase A Blvra 0.760695509 1.40052152 Q9D379 Epoxide hydrolase 1 Ephx1 0.700642139 1.425222882 Q9D3P8 Plasminogen receptor (KT) Plgrkt 0.660636171 1.344838373 Q9D7G0 Ribose-phosphate pyrophosphokinase 1 Prps1 0.708687594 1.652020885 Q9EPL9 Peroxisomal acyl-coenzyme A oxidase 3 Acox3 0.774813018 1.314661776 Q9ES57 Cell surface glycoprotein CD200 receptor 1 Cd200r1...”
• Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin
  Müller, Biomedicines 2022
  • “...821 1.3 Q9R0P6 Signal peptidase complex catalytic subunit SEC11A 819 1.3 P54116 Stomatin 680 1.1 Q9D3P8 Plasminogen receptor (KT) 601 1.0 Q9R0Q3 Transmembrane emp24 domain-containing protein 2 600 1.0 P46638 Ras-related protein Rab-11B 573 0.9...”
• Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle.
  Murphy, Data in brief 2018
  • “...2.27E-07 11.5 P01843 1 SV Ig lambda-1 chain C region 1 1 1.8 7.63E-05 11.1 Q9D3P8 Plgrkt Plasminogen receptor (KT) 1 1 56.6 5.39E-04 8.7 P13542 Myh8 Myosin-8 1 1 53.5 3.30E-03 8.5 Q8BTM8 Flna Filamin-A 1 1 1.6 6.18E-03 8.4 Q99P91 Gpnmb Transmembrane glycoprotein NMB...”

CG13404 uncharacterized protein from Drosophila melanogaster
Aligns to 4:137 / 154 (87.0%), covers 86.6% of PF10166, 148.2 bits

• Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection
  Guzman, Genetics 2021
  • “...but have no previous association with C. burnetii pathogenesis. Furthermore, since the mammalian ortholog of CG13404 ( PLGRKT ) is an important regulator of macrophage function, CG13404 could play a role in host susceptibility to C. burnetii through hemocyte regulation. These insights provide a foundation for...”
  • “...X_13210675_SNP Intronic 7.0 10 -6 Average 2.4 Putative enhancer site Calcium regulation; IP3 signaling NET1 CG13404 X_14160126_SNP Exonic; synonymous 6.1 10 -6 Female 4.3 Active enhancer, TFBS hot spot Plasminogen receptor (KT) PLGKRT * Human orthologs from DIOPT. Ortholog with highest weighted score reported. Validation of...”
• Natural Genetic Variation inDrosophila melanogasterReveals Genes Associated withCoxiella burnetiiInfection
  Guzman, 2020

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