Family Search for PF10179 (DUF2369)

PF10179.9 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

NDNF_HUMAN / Q8TB73 Protein NDNF; Neuron-derived neurotrophic factor from Homo sapiens (Human) (see 2 papers)
NP_078850 protein NDNF precursor from Homo sapiens
Aligns to 291:383 / 568 (16.4%), covers 98.9% of PF10179, 125.1 bits

• function: Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).
  subunit: Binds heparin and chondroitin sulfate.
• Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.
  Messina, American journal of human genetics 2020
• Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.
  Schira, Molecular & cellular proteomics : MCP 2015
• Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.
  Messina, American journal of human genetics 2020
  • GeneRIF: Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.
• Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer.
  Zhang, JCI insight 2019
  • GeneRIF: Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer.
• Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.
  Ohashi, The Journal of biological chemistry 2014
  • GeneRIF: NDNF acts as an endogenous modulator that promotes endothelial cell function and ischemia-induced revascularization through eNOS-dependent mechanisms
• A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
  Kalsi, Human molecular genetics 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
• Mosaicism for terminal deletion of 4q.
  Utine, Genetic counseling (Geneva, Switzerland) 2006 (PubMed)
  • GeneRIF: direct duplication of chromosome 4q27q31.3 de novo results in partial trisomy of its long arm.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

NDNF_MOUSE / Q8C119 Protein NDNF; Epidermacan; Neuron-derived neurotrophic factor from Mus musculus (Mouse) (see 3 papers)
NP_765987 protein NDNF precursor from Mus musculus
Aligns to 291:383 / 568 (16.4%), covers 98.9% of PF10179, 122.9 bits

• function: Promotes neuron migration, growth and survival as well as neurite outgrowth (By similarity). Promotes matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).
  subunit: Binds heparin and chondroitin sulfate.
• Neuron-derived neurotrophic factor ameliorates adverse cardiac remodeling after experimental myocardial infarction.
  Joki, Circulation. Heart failure 2015 (PubMed)
  • GeneRIF: Intramuscular administration of NDNF ameliorates post-MI remodeling and function in mice by its abilities to reduce myocyte apoptosis and promote neovascularization.
• Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.
  Ohashi, The Journal of biological chemistry 2014
  • GeneRIF: NDNF acts as an endogenous modulator that promotes endothelial cell function and ischemia-induced revascularization through eNOS-dependent mechanisms

NP_500282 NDNF (Neuron Derived Neurotrophic Factor) homolog from Caenorhabditis elegans
Aligns to 226:343 / 536 (22.0%), covers 100.0% of PF10179, 105.9 bits

• Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development
  Kuang, BMC neuroscience 2010
  • “...analysis Human (NP_078850), mouse (NP_765987), bovine (XP_597721), chicken (XP_420627), frog (NP_001085901), fly (NP_611900) and nematode (NP_500282) protein sequences were used in this study. In addition, the rat NDNF protein sequence was acquired by homology comparison. A sequence alignment software program, Clustalw 2.0, was used to align...”

LOC101887233 uncharacterized protein LOC101887233 from Musca domestica
Aligns to 388:484 / 694 (14.0%), covers 100.0% of PF10179, 68.4 bits

• Symbiotic microbes affect the expression of male reproductive genes in Glossina m. morsitans
  Scolari, BMC microbiology 2018
  • “...hypothetical protein FF38_02107 [ Lucilia cuprina ] KNC28398.1 0.0 6.40 GMOY002247 nord PREDICTED: uncharacterized protein LOC101887233 [ Musca domestica ] XP_005185286.1 0.0 14.60 GMOY002466 peroxidase [ Lucilia cuprina ] KNC34773.1 0.0 25.87 GMOY002491 protein takeout [ Lucilia cuprina ] KNC23528.1 2.00E-67 44.31 GMOY002881 hypothetical protein FF38_01910...”

NP_611900 nord from Drosophila melanogaster
Aligns to 289:385 / 587 (16.5%), covers 100.0% of PF10179, 66.9 bits

• Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development
  Kuang, BMC neuroscience 2010
  • “...Methods Protein sequence analysis Human (NP_078850), mouse (NP_765987), bovine (XP_597721), chicken (XP_420627), frog (NP_001085901), fly (NP_611900) and nematode (NP_500282) protein sequences were used in this study. In addition, the rat NDNF protein sequence was acquired by homology comparison. A sequence alignment software program, Clustalw 2.0, was...”

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