Family Search for PF10179 (NDNF)
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Running HMMer for PF10179
PF10179 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
NDNF_HUMAN / Q8TB73 Protein NDNF; Neuron-derived neurotrophic factor from Homo sapiens (Human) (see 3 papers)
Aligns to 192:335 / 568 (25.4%), covers 100.0% of PF10179, 144.1 bits
- function: Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).
subunit: Binds heparin and chondroitin sulfate.
NDNF_DANRE / F1QPX0 Protein NDNF from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 192:340 / 574 (26.0%), covers 100.0% of PF10179, 139.9 bits
- function: Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (By similarity).
disruption phenotype: Morpholino knockdown of the protein alters the migration of gonadotropin-releasing hormone (GnRH) expressing neurons.
NDNF_MOUSE / Q8C119 Protein NDNF; Epidermacan; Neuron-derived neurotrophic factor from Mus musculus (Mouse) (see 4 papers)
Aligns to 192:335 / 568 (25.4%), covers 99.2% of PF10179, 139.2 bits
- function: Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (PubMed:18757743). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).
subunit: Binds heparin and chondroitin sulfate.
disruption phenotype: Knockout mice lacking Ndnf are grossly normal and able to produce viable pups (PubMed:31883645). Absence of Ndnf in 13.5 dpc embryos results in abnormal development of the olfactory system and defective gonadotropin-releasing hormone (GnRH) expressing neurons migration to the hypothalamus (PubMed:31883645).
NDNF_DROME / Q9W192 Protein NDNF; Neuron-derived neurotrophic-like factor; Protein Nord from Drosophila melanogaster (Fruit fly) (see 2 papers)
Aligns to 208:333 / 587 (21.5%), covers 99.2% of PF10179, 113.6 bits
- function: Secretory protein that acts as a feedback regulator of dpp/BMP, wg and hh signaling pathways (PubMed:35609633, PubMed:35037619). In the developing wing, is a dosage-dependent modulator of dpp/BMP signaling involved in wing growth and crossvein patterning; low levels promote and high levels inhibit dpp/BMP signaling (PubMed:35609633, PubMed:35037619). In the early pupal wing, inhibits dpp/BMP signaling activity to prevent the formation of ectopic crossveins in the posterior compartment (PubMed:35609633, PubMed:35037619). Binds to dpp and gbb to modulate their release and activity decreasing dpp/BMP signaling in the responding cells (PubMed:35609633, PubMed:35037619). During wing development regulates dpp/BMP coreceptor dally availability on the cell surface (PubMed:35609633). Might have a role in testis development (PubMed:35609633).
subunit: Binds heparin (PubMed:35609633). Interacts with dally; the interaction promotes dally degradation (PubMed:35609633). Interacts with dpp and gbb (PubMed:35037619).
Or search for genetic data about PF10179 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory