Family Search for PF10221 (Mat89Bb)

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PF10221 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

INT13_HUMAN / Q9NVM9 Integrator complex subunit 13; Cell cycle regulator Mat89Bb homolog; Germ cell tumor 1; Protein asunder homolog; Sarcoma antigen NY-SAR-95 from Homo sapiens (Human) (see 5 papers)
Aligns to 4:692 / 706 (97.6%), covers 99.9% of PF10221, 994.1 bits

• function: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).
  subunit: Interacts with PAFAH1B1; this interaction may be required for proper recruitment of dynein complexes to the nuclear envelope at prophase.

INT13_MOUSE / Q8QZV7 Integrator complex subunit 13; Cell cycle regulator Mat89Bb homolog; Protein asunder homolog; Spermatogenesis-associated protein 30 from Mus musculus (Mouse) (see 2 papers)
Aligns to 4:692 / 732 (94.1%), covers 99.9% of PF10221, 989.0 bits

• function: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
  subunit: Interacts with PAFAH1B1; this interaction may be required for proper recruitment of dynein complexes to the nuclear envelope at prophase.

INT13_XENLA / Q6GLY5 Integrator complex subunit 13; Cell cycle regulator Mat89Bb homolog; Germ cell tumor 1; Protein asunder homolog; Sarcoma antigen NY-SAR-95 from Xenopus laevis (African clawed frog) (see paper)
Aligns to 4:701 / 715 (97.6%), covers 99.9% of PF10221, 981.1 bits

• function: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling (By similarity). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (By similarity). Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (By similarity). Plays a role in gastrulation and early embryogenesis (PubMed:15737938).

INT13_DROME / Q9VEX5 Protein asunder; Cell cycle regulator Mat89Bb; Integrator complex subunit 13; Maternal transcript 89Bb; Set apart in position or space protein from Drosophila melanogaster (Fruit fly) (see 5 papers)
Aligns to 2:667 / 689 (96.7%), covers 99.6% of PF10221, 695.4 bits

• function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing (PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5 (PubMed:23097424). Plays a role as a regulator of spermatogenesis (PubMed:19357193). Crucial regulator of the mitotic cell cycle and development (PubMed:15737938, PubMed:19357193). Required for the correct dynein-dynactin perinuclear localization important for nucleus- centrosome coupling that occur upon meiotic progression of primary spermatocytes (PubMed:19357193, PubMed:23904267). Plays a role in sperm motility and fertility (PubMed:19357193). May have a role in the PNG/PLU/GNU pathway (PubMed:15737938).
  subunit: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
  disruption phenotype: Results in almost complete steril males. Mature sperm formed in small amounts in testes are immotile or weakly motile; seminal vesicles are largely empty. Primary spermatocytes appeared normal (Cysts of 16 cells); however, spermatids show irregularities in nuclear size and number. Spermatocytes I exhibit failure of nucleus- centrosome coupling that normally occur upon meiotic phase entry; those that progress through meiotic divisions exhibit defects in spindle assembly and chromosome segregation. When injected into Xenopus embryos, causes developmental arrest with gastrulation defects and defective cell cycles resulting in polyploid nuclei. RNAi injection into HeLa cells or Drosophila syncytial embryos causes mitotic cell cycle, giving rise to multinucleated polyploidy cells.

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