Family Search for PF10224 (DUF2205)

PF10224.9 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

AFUA_2G03280, Afu2g03280 bZIP transcription factor, putative from Aspergillus fumigatus Af293
Aligns to 34:111 / 117 (66.7%), covers 98.7% of PF10224, 118.0 bits

• Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin
  Mattos, mSphere 2020
  • “...that undergoes activation in response to alkaline pH) ( 31 ), and a zipD mutant (AFUA_2G03280, encoding a TF important for calcium metabolism and osmotic response) ( 9 , 10 ), were previously found to have reduced CPE. TABLE3 Transcription factors with modulation of phosphorylation Gene...”
  • “...AFUA_3G02340 ncb2 b CBF/NF-Y family transcription factor, putative AFUA_2G14720 hapB CCAAT-binding transcription factor subunit HAPB AFUA_2G03280 zipD BZIP transcription factor, putative AFUA_2G01900 rtf1p RNA polymerase II transcription elongation factor Rtf1p, putative AFUA_1G12332 rph1 b Jumonji family transcription factor, putative AFUA_2G13380 areB GATA transcription factor (AreB), putative...”
• Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance
  de, PLoS genetics 2019
  • “...[Afu1g10550, Afu5g10620, Afu6g12522 ( skn7 ), Afu4g07090, Afu7g03910 ( nsdC ), and as previously described Afu2g03280 ( zipD ) Afu1g06900 ( crzA )] [ 26 32 ], while two mutants showed increased tolerance [Afu1g13190 and Afu3g08010 ( ace1 )] ( Fig 1A ). The calcium-dependent phosphatase...”
  • “...at 8.0 g/ml ( Fig 1C ). The null mutants corresponding to the genes Afu1g10550, Afu2g03280 ( zipD ), Afu5g10620, Afu6g12522 ( skn7 ), and Afu4g07090 were more sensitive than the wild-type strain to caspofungin at 1.0 g/ml and exhibited a reduction in the CPE at...”
• The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect
  Ries, mBio 2017
  • “...Previously, four TFs encoded by the genes htfA (Afu4g10110), zfpA (Afu8g05010), zfpB (Afu1g10230), and zipD (Afu2g03280) were found to be upregulated in the presence of calcium ( 27 , 28 ). Deletion of only zipD resulted in a reduced CPE and increased sensitivity to high levels...”

PTRG_04454 hypothetical protein from Pyrenophora tritici-repentis Pt-1C-BFP
Aligns to 88:162 / 175 (42.9%), covers 98.7% of PF10224, 114.0 bits

• Characterization of Alternaria infectoria extracellular vesicles
  Silva, Medical mycology 2014
  • “...response PTRT_04280 | PTRG_04280 | Pyrenophora tritici-repentis predicted protein (207 aa) 23715 Unknown PTRT_04454 | PTRG_04454 | Pyrenophora tritici-repentis conserved hypothetical protein (176 aa) 19309 Predicted coiled-coil protein PTRT_11337 | PTRG_11337 | Pyrenophora tritici-repentis hypothetical protein (527 aa) 61409 Unknown * For protein identification, we searched...”

C8V8D1 BZIP transcription factor, putative (AFU_orthologue AFUA_2G03280) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Aligns to 85:166 / 166 (49.4%), covers 94.7% of PF10224, 112.6 bits

• Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation.
  Ribeiro, mBio 2019
  • “...activator Spt7 SEAGTPPLGVSQGYR G5EB05 AN6221.2 ANIA_06221 Uncharacterized protein SSLASLNTTDSR G5EB07 nsdD AN3152.2 Uncharacterized protein KPSASILVPR C8V8D1 ANIA_04502 BZIP transcription factor SDSGEFPPIASK Q5BFB4 AN0766.2 ANIA_00766 C6 finger domain protein ASSTASPVVTLAQPVPK C8V7V5 ANIA_04585 CCR4-NOT transcription complex, subunit 3 RKTLTETPVGGPVGGVPLGLQPMK P36011 stuA AN5836 Cell pattern formation-associated protein StuA To...”

NP_115936 short coiled-coil protein isoform 4 from Homo sapiens
Aligns to 42:117 / 122 (62.3%), covers 96.0% of PF10224, 96.1 bits

• Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.
  Stringer, Translational psychiatry 2016
  • GeneRIF: SCOC SNPs were associated with lifetime cannabis use, but the association did not reach genome-wide significance. [Meta-Analysis]
• Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation.
  Behrens, PloS one 2013
  • GeneRIF: SCOC forms a stable homogeneous complex with the coiled coil domain of FEZ1. SCOC dimerization and the SCOC surface residue R117 are important for this interaction.
• Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).
  Alborghetti, PloS one 2013
  • GeneRIF: Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1), SCOCO (short coiled-coil protein) and kinesins (kinesin heavy chain) are involved in biological transport process.
• Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
  McKnight, The EMBO journal 2012
  • GeneRIF: The identification of SCOC and WAC as novel regulatory proteins with diverse functions in autophagy contributes towards a fuller understanding of autophagosome formation.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

SCOC_HUMAN / Q9UIL1 Short coiled-coil protein from Homo sapiens (Human) (see 3 papers)
Aligns to 79:154 / 159 (47.8%), covers 96.0% of PF10224, 95.1 bits

• function: Positive regulator of amino acid starvation-induced autophagy.
  subunit: Homodimer (PubMed:24098481). Interacts with ARL1, ARL2 and ARL3 (PubMed:11303027). Directly interacts with FEZ1 and UVRAG (PubMed:22354037, PubMed:24098481). The interaction with UVRAG is reduced by amino acid starvation, but the complex is stabilized in the presence of FEZ1. Interacts with NRBF2 (PubMed:22354037).
• Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation
  Behrens, PloS one 2013
  • “...essential for this interaction. Materials and Methods Purification and crystallization of SCOC SCOC(78-159) (SwissProt entry Q9UIL1 isoform1) was cloned in pET28a (Novagen) using NcoI and XhoI cleavage sites. A synthetic gene (Mr Gene) optimized for E. coli expression was used as a template for PCR. The...”
• Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike.
  Wejda, The Journal of biological chemistry 2012

SLO1_YEAST / Q3E784 SCOCO-like protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YER180C-A Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO (RefSeq) from Saccharomyces cerevisiae
Aligns to 14:85 / 85 (84.7%), covers 77.3% of PF10224, 33.3 bits

• subunit: Interacts with ARL3.
• SCRaMbLE generates evolved yeasts with increased alkali tolerance
  Ma, Microbial cell factories 2019
  • “...yML098 revealed five deletions (YEL060C, an intergenic sequence between YER032W and YEL033C, YER161C-YER164W, YER175C-YER176W, and YER180C-A). Figure S8. Sequencing depth of synthetic chromosome V in yML099. Deep sequencing coverage of yML099 revealed three deletions (YER091C-YER092W, YER134C-YER135C, YER161C-YER164W) and one duplication (YER132C-YER133W). Figure S9. Sequencing depth of...”
• Precise control of SCRaMbLE in synthetic haploid and diploid yeast
  Jia, Nature communications 2018
  • “...in yJBH012 and the YEL016C-YEL013W deletion was observed in yJBH026. Two deletions ( YEL016C-YEL013W and YER180C-A ) were observed in yJBH027. Long-read sequencing analysis of synV in yJBH001 showed the same two deletions without any inversions or translocations (Supplementary Fig. 9 ). Interestingly, a common deletion...”
• Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii
  Brachat, Genome biology 2003
  • “...x AER271W 81 YCR075W-A/YNR034W-A 75/99 44.00/46.15 x ACL158W 95 YDL160C-A 80 55.70 x AGR097W-A 66 YER180C-A 85 83.70 x AFR298C 73 YIL156W-B 73 71.23 x x x AFL216C 49 YJL127C-B 52 61.22 x x AAL130W 93 YJR005C-A/YGR169C-A 92/93 74.44/50.82 x x ABR148C-A 117 YJR112W-A 109 56.44...”

Or search for genetic data about PF10224 in the Fitness Browser