Family Search for PF10233 (Cg6151-P)

PF10233 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

PADG_11110 golgi apparatus membrane protein TVP18 from Paracoccidioides brasiliensis Pb18
Aligns to 19:129 / 147 (75.5%), covers 100.0% of PF10233, 142.5 bits

• Chemoproteomic identification of molecular targets of antifungal prototypes, thiosemicarbazide and a camphene derivative of thiosemicarbazide, in Paracoccidioides brasiliensis
  Borba, PloS one 2018
  • “...x x PADG_04092 Peptidyl-prolyl cis-trans isomerase B x PADG_05203 Peptidyl-prolyl cis-trans isomerase ssp 1 x PADG_11110 Golgi apparatus membrane protein TVP18 x Protein/peptide degradation PADG_03221 Thimet oligopeptidase x x PADG_06290 Proteasome component PRE5 x PADG_03982 Proteasome component C1 x PADG_03967 Proteasome component C5 x PADG_03680 Proteasome...”

TVP18_YEAST / Q04767 Golgi apparatus membrane protein TVP18; TLG2 compartment vesicle protein of 18 kDa from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YMR071C Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments (RefSeq) from Saccharomyces cerevisiae
A6ZMD0 Golgi apparatus membrane protein TVP18 from Saccharomyces cerevisiae (strain YJM789)
NP_013787 Tvp18p from Saccharomyces cerevisiae S288C
Aligns to 30:141 / 167 (67.1%), covers 100.0% of PF10233, 132.5 bits

• function: Golgi membrane protein involved in vesicular trafficking.
  subunit: Interacts with TVP15 and YIP4.
• Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
  Hua, Cell systems 2018
  • “...YGR247W, YFL004W, YBR023C, YIL044C, YMR052W, YDL204W, YBR067C, YDR153C, YIL043C, YNL095C, YDR476C, YOR307C, YOR321W, YCR011C, YMR237W, YMR071C, YER004W, YPR028W, YGL255W, YPL170W, YKL063C, YJL044C, YLR023C, YMR215W, YMR251W-A, YGR261C, YPR091C, YDR056C, YLL028W, YLR330W, YBL010C, YNR019W, YGL124C, YDR294C, YNL046W, YDR519W, YKR088C, YLR042C, YKL094W, YCR048W, YCR043C, YDR084C, YKR067W, YJL196C, YLL061W, YML101C,...”
• Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae
  Sullivan, Eukaryotic cell 2009
  • “...YDR436w YDL090c YER155c YLR361c YMR323w YDL244w YCL017c YDR051c YMR071c YPL158c YFL040w YKL027w YNR075w YGL083w YHR080c ELF1 YKU80 ADA2 RDN25 RRF1 HOF1 RAS2...”
• A novel pathway that coordinates mitotic exit with spindle position
  Nelson, Molecular biology of the cell 2007
  • “...yhr033w, yhr198c, yip3, yjl218w, yjr056c, ykl056c, ykl063c, ymr071c, ymr181c, ymr196w, ymr226c, ynl101w, ynl116w, ynl187w, ynl335w, yor033w, and ypl070w. A mild...”
• After the duplication: gene loss and adaptation in Saccharomyces genomes
  Cliften, Genetics 2006
  • “...YKL001C MET14 YKL154W SRP102 YLR066W SPC3 YML036W YML036W YMR071C YMR071C YMR074C YMR074C YOL108C INO4 YOR327C SNC2 YOR351C MEK1 S. castellii's position as the...”
• A genetic dissection of Aip1p's interactions leads to a model for Aip1p-cofilin cooperative activities
  Clark, Molecular biology of the cell 2006
  • “...BSP1 YNL138w YNL079c YNL093w YNL106c YGR268c YGR241c YMR071c YER123w YLR429w YHR016c YMR091c YMR092c YHR181w YOL113w YKL129c YMR095c YMR109w YFR024c-A YLR337c...”
• Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method
  Xie, Proceedings of the National Academy of Sciences of the United States of America 2005
  • “...13 14 Control YOR200W YOR199W YLR288C YNL005C YNR041C YMR071C YOR187W YPR124W YJR104C YMR066W YDL198C YDL181W YMR038C YGR076C YNL135C Gene name MEC3 MRP7 COQ2...”
• Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments
  Inadome, Molecular and cellular biology 2005
  • “...protein of 26 kDa), the products of YKR088c, YDR084w, YMR071c, and YDR100w found in the Tlg2 compartment as Tvp38, Tvp23, Tvp18, and Tvp15 (Tlg2 compartment...”
  • “...H. sapiens Svp26 (Yhr181w) Tvp38 (Ykr088c) Tvp23 (Ydr084w) Tvp18 (Ymr071c) Tvp15 (Ydr100w) Gvp36 (Yil041w) 288 26,283 4 337 38,306 5 199 23,151 3 167 18,692 3...”
• PalmPred: an SVM based palmitoylation prediction method using sequence profile information.
  Kumari, PloS one 2014
  • “...in the text. Protein Uniprot ID Uniprot annotation Experimentally identified sites IFS-Palm WAP-Palm PalmPred TVP18 A6ZMD0 78 HIP1 P06775 603 339, 463 339 RHO2 P06781 188* 188 188 188 NUC1 P08466 TUB1 P09733 14 GPA2 P10823 4 4 4 GAP1 P19145 286 YCK1 P23291 537 #...”
• CSS-Palm 2.0: an updated software for palmitoylation sites prediction
  Ren, Protein engineering, design & selection : PEDS 2008
  • “...P48525 P08466 P32867 P39926 Q12241 Q08144 P50108 P46985 A6ZMD0 Q06170 Amino acid permeases (AAPs) Agp1 P25376 Bap2 P38084 Gap1 P19145 Gnp1 P48813 Hip1 P06775...”
• Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae.
  Inadome, Experimental cell research 2007 (PubMed)
  • GeneRIF: Tvp proteins collectively assist in the effective maintenance/function of the late Golgi/endosomal compartments.

TVP18_SCHPO / O74375 Golgi apparatus membrane protein tvp18 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 30:141 / 164 (68.3%), covers 100.0% of PF10233, 120.7 bits

• function: Golgi membrane protein involved in vesicular trafficking.

TC 1.A.55.1.1 / Q9UGQ2 Mammalian Ca2+ channel, Flower, homologue, isoform a from Homo sapiens (see 5 papers)
Aligns to 34:143 / 172 (64.0%), covers 99.1% of PF10233, 107.3 bits

• substrates: Ca2+
• Pathogenic nsSNPs that increase the risks of cancers among the Orang Asli and Malays.
  Khoruddin, Scientific reports 2021
  • “...FASTA format was used as the input. UniProtKB accession numbers for the sequences are: CACFD1, Q9UGQ2; RREB1, Q92766; LRRC34, Q8IZ02; ETFA, P13804; CPVL, Q9H3G5; INCENP, Q9NQS7; FARP2, O94887; and TYR, P14679. Consurf created an output consists of the protein sequence and multiple sequence alignment colored by...”
  • “...the protein stability of the damaging nsSNPs. UniProtKB accession numbers for the sequences are: CACFD1, Q9UGQ2; RREB1, Q92766; LRRC34, Q8IZ02; ETFA, P13804; CPVL, Q9H3G5; INCENP, Q9NQS7; FARP2, O94887; and TYR, P14679. The output included the indicator of the prediction (increase/decrease) of protein stability based on the...”

NP_001100031 calcium channel flower homolog from Rattus norvegicus
Aligns to 33:142 / 171 (64.3%), covers 99.1% of PF10233, 106.6 bits

• A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.
  Yao, PLoS biology 2017
  • GeneRIF: The role of Fwe protein isoform 2 in endocytosis in hippocampal neurons

NP_001229298 calcium channel flower homolog isoform c from Homo sapiens
Aligns to 34:143 / 233 (47.2%), covers 99.1% of PF10233, 106.2 bits

• Biomarkers for C9orf7-ALS in Symptomatic and Pre-symptomatic Patients: State-of-the-art in the New Era of Clinical Trials.
  Querin, Journal of neuromuscular diseases 2022
  • GeneRIF: Biomarkers for C9orf7-ALS in Symptomatic and Pre-symptomatic Patients: State-of-the-art in the New Era of Clinical Trials.

TC 1.A.55.1.3 / Q93533 Roundworm Flower homologue (166aas) from Caenorhabditis elegans (see paper)
Aligns to 33:142 / 166 (66.3%), covers 99.1% of PF10233, 98.4 bits

• substrates: Ca2+

FLOWR_DROME / Q95T12 Calcium channel flower; 3L5 from Drosophila melanogaster (Fruit fly) (see 2 papers)
TC 1.A.55.1.2 / Q95T12 Insect Ca2+ channel, Flower (194 aas; 4 putative TMSs) from Drosophila melanogaster (see 4 papers)
NP_648804 flower, isoform A from Drosophila melanogaster
Aligns to 35:147 / 194 (58.2%), covers 100.0% of PF10233, 96.2 bits

• function: A calcium channel that regulates synaptic endocytosis and hence couples exo- with endocytosis. Isoform A and isoform B are mainly required in the nervous system and necessary in photoreceptor cells.
  subunit: Homomultimer; Isoform B.
  disruption phenotype: Impaired intracellular resting calcium levels and impaired endocytosis in presynaptic terminals, exocytosis is normal. Mutant boutons at the neuromuscular junctions exhibit a significant depletion in the number of synaptic vesicles. There are numerous extra boutons which are often small, clustered, and flowery in nature. Mutant nerve terminals display omega structures and collared pits.
• substrates: Ca2+
• Proteomic changes in response to crystal formation in Drosophila Malpighian tubules
  Chung, Fly 2016
  • “...0.045 0.036 1.425 1.408 1.057 0.563 M9PJN5 Q8IPZ3 Q95T12 9(8) 1(1) 1(1) HDAC6 CG17221 flower FBgn0026428 FBgn0031500 FBgn0261722 Zinc ion binding Vacuolar...”
• Identification of Drosophila centromere associated proteins by quantitative affinity purification-mass spectrometry
  Barth, Data in brief 2015
  • “...6.77.2E02 1.80E03 7.11.0E01 9.20E04 MED30 FBpp0072457 FBgn0035149 Q9W0P3 6.67.5E02 1.40E04 6.66.6E02 1.80E04 Fwe FBpp0075297 FBgn0261722 Q95T12 6.69.6E02 1.60E04 6.48.1E02 1.30E04 Rrp4 FBpp0072020 FBgn0034879 Q9W1M9 6.41.1E01 1.70E03 6.36.4E02 1.30E03 CG1789 FBpp0071194 FBgn0030063 Q9W3C0 6.32.1E02 1.10E03 6.82.7E02 7.30E04 qkr58E-2 FBpp0071739 FBgn0022985 Q9W254 6.39.7E02 1.80E04 6.16.8E02 2.10E04 prod FBpp0085785...”
• Cell Fitness: More Than Push-Ups.
  Ferrari, International journal of molecular sciences 2021
  • GeneRIF: Cell Fitness: More Than Push-Ups.
• A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila.
  Li, eLife 2020
  • GeneRIF: A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila.
• A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.
  Yao, PLoS biology 2017
  • GeneRIF: Fwe promotes clathrin-mediated endocytosis independently of Ca2+channeling.
• Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.
  Rhiner, Developmental cell 2010 (PubMed)
  • GeneRIF: Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as "winners" or "losers.".
• A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.
  Yao, Cell 2009
  • GeneRIF: Study reports the identification of a protein that has not been previously characterized in any species and whose loss affects endocytosis. It contains three or four transmembrane domains and is associated with synaptic vesicles.

Bm1_34880 LD28933p, putative from Brugia malayi
Aligns to 33:142 / 175 (62.9%), covers 100.0% of PF10233, 93.1 bits

• A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes
  Galvin, PLoS neglected tropical diseases 2014
  • “...binding family member 2 F30A10.1 * Bm1_28345 GAYLSKPITEKISECGG 1.596 Protein phosphatase 2C containing protein T23F11.1 Bm1_34880 GAATSGLQSQMQQEHDP 1.384 LD28933p F20D1.1 Bm1_31655 GQQQSAFVVEIASSRFG 1.301 hypothetical protein Y67A10A.7 Bm1_07365 GKAGSKVKNYSKIKKNN 1.146 TLD family protein K08E7.1 * Bm1_41730 GSCLGKKSSTTILEAVH 0.948 protein-tyrosine kinase F49B2.5 * Bm1_38795 GLTISGLFGRLFGKKQV 0.755 ADP-ribosylation factor...”

XP_011671877 calcium channel flower homolog isoform X1 from Strongylocentrotus purpuratus
Aligns to 38:147 / 181 (60.8%), covers 98.2% of PF10233, 90.4 bits

• De novo assembly of a transcriptome from the eggs and early embryos of Astropecten aranciacus
  Musacchia, PloS one 2017
  • “...Strongylocentrotus purpuratus XP_786430 0.0 comp189572 Calcium channel flower homolog isoform X1 171 72%/52% Strongylocentrotus purpuratus XP_011671877 8e-40 * Acquisition of the composite sequence containing all the expected domains required higher coverage filtering. a-f Isoforms exist. The longest one was considered for BLAST analyses. a) An additional...”

TC 1.A.55.3.1 / Q5DFV8 Flatworm Flower homologue (195aas) from Schistosoma japonicum (see paper)
Aligns to 15:124 / 195 (56.4%), covers 91.2% of PF10233, 66.1 bits

• substrates: Ca2+

Or search for genetic data about PF10233 in the Fitness Browser