Family Search for PF10239 (DUF2465)

PF10239.9 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

FA98B_HUMAN / Q52LJ0 Protein FAM98B from Homo sapiens (Human) (see 4 papers)
FAM98B / Q52LJ0 tRNA-splicing ligase complex FAM98B component (EC 6.5.1.8) from Homo sapiens (see 2 papers)
NP_775882 protein FAM98B from Homo sapiens
Aligns to 17:331 / 433 (72.7%), covers 100.0% of PF10239, 449.9 bits

• function: Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436).
  subunit: Homodimer (PubMed:28040436). Component of the tRNA-splicing ligase complex (PubMed:21311021, PubMed:24870230). Interacts with FAM98A (PubMed:28040436).
• Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation
  Jia, Annals of translational medicine 2020
  • “...Rho guanine nucleotide exchange factor 1 ARHGEF1 1.396 Q52LJ0 Isoform 2 of Protein FAM98B FAM98B 1.395 P49407 Arrestin beta 1 ARRB1 1.393 Q99733 Nucleosome...”
• Label-free LC-MS analysis of HER2+ breast cancer cell line response to HER2 inhibitor treatment
  Di, Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2015
  • “...) Fold change Highest condition ) a P13489 Ribonuclease inhibitor 4 310.49 0.000561 1.55 Neratinib Q52LJ0 Protein FAM98B 2 90.26 0.000932 1.62 Neratinib P49411 Elongation factor Tu, mitochondrial 3 201.31 0.001 1.52 Neratinib P35232 Prohibitin 2 118.62 0.002224 1.64 Neratinib Q8WUM4 Programmed cell death 6-interacting protein...”
• hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
  Pérez-González, PloS one 2014
  • “...9(7) 304 *RTCB_HUMAN tRNA-splicing ligase (HSPC 117) Q9Y3I0 55589 39(35) 1666 6(6) 248 *Protein FAM98B Q52LJ0 37489 13(13) 655 3(2) 203 Single-stranded DNA-binding protein 3 Q9BWW4 40533 2(2) 131 Transcription factor 4 P15884 71448 2(2) 120 Serrate RNA effector molecule homolog Q9BXP5 10092 2(2) 82 Heterogeneous...”
  • “...423 *RTCB_HUMAN tRNA-splicing ligase (HSPC 117) Q9Y3I0 55589 64(35) 3072 8 (7) 234 *Protein FAM98B Q52LJ0 37489 34(18) 1570 3(3) 167 Putative RNA binding protein Luc7-like 1 Q9NQ29 44023 2(2) 123 Transport and cytoskeleton related factors *Myosin light chain kinase 2, skeletal/cardiac muscle Q9H1R3 65104 21(2)...”
• FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
  Akter, The international journal of biochemistry & cell biology 2017 (PubMed)
  • GeneRIF: the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines
• hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
  Pérez-González, PloS one 2014
  • GeneRIF: hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.

FA98A_HUMAN / Q8NCA5 Protein FAM98A from Homo sapiens (Human) (see paper)
Aligns to 11:328 / 518 (61.4%), covers 100.0% of PF10239, 449.1 bits

• function: Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436).
  subunit: Interacts (via N- and C-terminus) with DDX1 (PubMed:28040436). Interacts (via N- and C-terminus) with C14orf166 (PubMed:28040436). Interacts with FAM98B (PubMed:28040436). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity).
• Comparative proteomic analysis of osteogenic differentiated human adipose tissue and bone marrow-derived stromal cells.
  Dadras, Journal of cellular and molecular medicine 2020
  • “...SET 8 P48357 Leptin receptor P11586 C1tetrahydrofolate synthase, cytoplasmic 9 Q6WCQ1 Myosin phosphatase Rhointeracting protein Q8NCA5 Protein FAM98A 10 P31513 Dimethylaniline monooxygenase [Noxideforming] 3 Q9BS40 Latexin John Wiley & Sons, Ltd Comparing the abundance of 2095 proteins quantified in 80% of both cell types revealed 281...”
• hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
  Pérez-González, PloS one 2014
  • “...proteins *Nuclear pore complex protein Nup153 P49790 15511 4(4) 208 1(1) 52 Others Protein FAM98A Q8NCA5 55734 14(12) 707 Nibrin O60934 85458 3(3) 119 *protein C14orf166 (CLE) Q9Y224 28143 78(21) 3899 10(10) 513 Cytosolic hCLE-associated Proteins Protein name Accession Number UniProtKB/Swiss-Prot MW (Da) Identified Pep (non-redundant)...”
  • “...58 Others *Golgin subfamily A member 3 Q08378 167666 137(98) 6784 1(1) 72 *Protein FAM98A Q8NCA5 55734 20(13) 818 3(3) 183 Protein FAM98C Q17RN3 37903 5(5) 256 *Ubiquitin-40S ribosomal protein S27a P62979 18229 9(5) 447 3(3) 117 Coiled-coil domain-containing protein 8 Q9H0W5 59431 2(2) 82 *protein...”
• Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles.
  Naganuma, The EMBO journal 2012
• Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery
  Freibaum, Journal of proteome research 2010
  • “...mago WIBG 23 Q9BRP8 3 2 17 0 0 0 * Protein FAM98A FAM98A 55 Q8NCA5 3 2 6 0 0 0 * Protein LSM12 homolog LSM12 22 Q3MHD2 3 2 14 0 0 0 * Protein PAT1 homolog 1 PATL1 87 Q86TB9 3 2 3...”
• Identification of the RGG box motif in Shadoo: RNA-binding and signaling roles?
  Corley, Bioinformatics and biology insights 2008
  • “...(153166) NA 42 FA98A_HUMAN, Protein FAM98A 519 RGG HEQGGG RGGRGG YDHGG RGG (352374) NA 43 (Q8NCA5) FA98A_HUMAN (Q8NCA5) 519 RGG G RGGRGGRGGRGG (458473) NA 44 LS14A_HUMAN, LSM14 protein homolog A (Q8ND56) 463 RGG YRG RGG LGF RGG RGRGGG RGG (406429) Putative alpha synuclein binding protein. a...”
  • “...3 4 BRWD3_HUMAN Q6RI45 34 42 4 4 CA077_HUMAN Q9Y3Y2 4 2 0 1 FA98A_HUMAN Q8NCA5 5 9 1 LS14A_HUMAN Q8ND56 4 7 1 11 a Searches were conducted using the ScanProsite program available on the ExPASy Proteomics Server of the Swiss Institute of Bioinformatics website...”

FA98A_MOUSE / Q3TJZ6 Protein FAM98A from Mus musculus (Mouse) (see paper)
Aligns to 11:328 / 515 (61.7%), covers 100.0% of PF10239, 448.4 bits

• function: Positively stimulates PRMT1-induced protein arginine methylation (By similarity). Involved in skeletal homeostasis (PubMed:27777970). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970).
  subunit: Interacts (via N- and C-terminus) with DDX1 (By similarity). Interacts (via N- and C-terminus) with C14orf166 (By similarity). Interacts with FAM98B (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (PubMed:27777970).

Q5FWT1 Protein FAM98A from Rattus norvegicus
Aligns to 11:328 / 515 (61.7%), covers 100.0% of PF10239, 447.0 bits

• Preliminary quantitative profile of differential protein expression between rat L6 myoblasts and myotubes by stable isotope labeling with amino acids in cell culture.
  Cui, Proteomics 2009
  • “...acidic leucine rich protein PAL31 IPI00192336.1 1.68NA 1 Q9EST6 170724 Protein FAM98A IPI00554081.1 1.73NA 1 Q5FWT1 313873 Protein KIAA0152 precursor IPI00371173.2 2.32 0.00 2 Q5FVQ4 304543 PTPRF interacting protein, binding protein 1 (liprin beta 1) IPI00567984.1 1.630.00 2 312855 Reticulon 3, isoform A1 IPI00421506.1 1.64 0.20...”

Q80VD1 Protein FAM98B from Mus musculus
Aligns to 17:331 / 429 (73.4%), covers 100.0% of PF10239, 446.7 bits

• Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells.
  Ortiz, Experimental biology and medicine (Maywood, N.J.) 2010
  • “...120A unknown <1.00E-14 FAM175B Q3TCJ1 family with sequence similarity 175, member B unknown <1.00E-14 FAM98B Q80VD1 family with sequence similarity 98, member B unknown <1.00E-14 FARSA Q8C0C7 phenylalanyl-tRNA synthetase, alpha subunit transcription/translation <1.00E-14 GGA3 Q8BMI3 golgi associated, gamma adaptin ear containing, ARF binding protein vesicle/trafficking <1.00E-14...”

CG5913 uncharacterized protein from Drosophila melanogaster
Aligns to 9:333 / 454 (71.6%), covers 99.7% of PF10239, 380.1 bits

• Rare variants in MYH15 modify amyotrophic lateral sclerosis risk
  Kim, Human molecular genetics 2019
  • “...OALS FAM98B FXR2 HIPK2 HK3 PDK3 KDM2A KIF27 CG5913 Fmr1 Hipk Hex-A Pdk Kdm2 cos Suppressor Suppressor Suppressor Suppressor Suppressor Suppressor Suppressor Yes...”
• Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk
  Slack, PLoS genetics 2010
  • “...body size. (A) Schematic representation of the Lnk locus along with the flanking genes CG17370, CG5913 and CG5948 . The three Lnk transcripts (RA, RB, and RC) are shown along with the positions of the P-element insertion d07478 and the deletion Del29 . Arrows show the...”
  • “...spanning from the 3 end of CG17370 to the beginning of the first exon of CG5913 was used for the genomic rescue construct. This was inserted by means of C31 mediated integration into a landing site on the second chromosome at 51D [28] . The wild-type...”
• The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
  Werz, PLoS genetics 2009
  • “...spanning from the 3 end of CG17370 to the beginning of the first exon of CG5913 was used as genomic rescue. The construct was inserted by means of C31 mediated integration into a landing site on the second chromosome at 51D [40] . Constitutive active forms...”

E9PH82 Protein FAM98A from Homo sapiens
Aligns to 11:301 / 312 (93.3%), covers 90.7% of PF10239, 374.5 bits

• Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium
  Ullah, Journal of molecular endocrinology 2017
  • “...actin-dependent regulator of chromatin subfamily D member 2 4.5084 8.3 52.238 2 SMARCD2 1.71E-02 1.37 E9PH82 Protein FAM98A 50.655 20.8 34.431 4 FAM98A 3.34E-02 1.39 Q9UDR5 Alpha-aminoadipic semialdehyde synthase, mitochondrial 5.4278 3.9 102.13 3 AASS 8.02E-03 1.4 E9PJ95 COMM domain-containing protein 9 12.306 11.4 20.687 1...”

Q6AXA1 MGC80361 protein from Xenopus laevis
Aligns to 54:369 / 385 (82.1%), covers 99.7% of PF10239, 359.3 bits

• Xenopus meiotic microtubule-associated interactome
  Gache, PloS one 2010
  • “...Q6GQL3 XL unstudied 38.7 BAT2 Cytoplasme, spindle NA Weak signal on spindle microtubules 5 Mgc80361/ Q6AXA1 XL unstudied 42.8 Nucleus NA Spindle microtubules 6 Mgc81475/ Q6NRT3 XL Smu1 4 57.6 7 x WD LisH CTLH Cytoplasme, nucleus midbody NA Spindle microtubules, poles 7 TSGA14/ Q9BYV8 HS...”

Q17RN3 Protein FAM98C from Homo sapiens
Aligns to 15:336 / 349 (92.3%), covers 94.1% of PF10239, 299.5 bits

• New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
  Liu, Journal of neuroinflammation 2018
  • “...subunit TOM20 homolog 16.3 0.823 0.007395** Q15629 Translocating chain-associated membrane protein 1 43 0.809 0.023084* Q17RN3 Protein FAM98C 37.3 0.821 0.010317* Q4V339 COBW domain-containing protein 6 43.9 0.747 1.2E05*** Q567U6 Coiled-coil domain-containing protein 93 73.2 0.814 0.001351** Q5SSJ5 Heterochromatin protein 1-binding protein 3 61.2 0.828 0.000364***...”
• hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
  Pérez-González, PloS one 2014
  • “...167666 137(98) 6784 1(1) 72 *Protein FAM98A Q8NCA5 55734 20(13) 818 3(3) 183 Protein FAM98C Q17RN3 37903 5(5) 256 *Ubiquitin-40S ribosomal protein S27a P62979 18229 9(5) 447 3(3) 117 Coiled-coil domain-containing protein 8 Q9H0W5 59431 2(2) 82 *protein C14orf166 (CLE) Q9Y224 28143 591(46) 34290 14(13) 698...”

D4AE02 Uncharacterized protein from Rattus norvegicus
Aligns to 17:305 / 433 (66.7%), covers 90.1% of PF10239, 277.1 bits

• Identification of protein targets for the antidepressant effects of Kai-Xin-San in Chinese medicine using isobaric tags for relative and absolute quantitation.
  Dong, Neural regeneration research 2020
  • “...D3ZK01, G3V8E8, Q6PDW6, D3ZK70, Q5U2Q7, D4AAZ9, D3ZBE6, Q5FVQ2, F1LPT0, Q5I034, Q5I0K3, G3V7C4, B2RZ66, P68255, G3V6X7, D4AE02, D3ZA45, F1M1L9 CMS: Chronic mild stress group; CON: control group; KXS: Kai-Xin-San group. Functional analysis of differentially expressed proteins in KXS-treated CMS rats Biological functional analysis demonstrated that the differentially...”

NP_001291467 protein FAM98A isoform 2 from Homo sapiens
Aligns to 1:133 / 323 (41.2%), covers 40.6% of PF10239, 227.2 bits

• FAM98A promotes cancer progression in endometrial carcinoma.
  Li, Molecular and cellular biochemistry 2019 (PubMed)
  • GeneRIF: Mechanistically, it was demonstrated that miR-142-3p directly targeted FAM98A, and modulated its expression.
• FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
  Akter, The international journal of biochemistry & cell biology 2017 (PubMed)
  • GeneRIF: the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines
• FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.
  Akter, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 (PubMed)
  • GeneRIF: FAM98A is expressed in numerous ovarian cancer cell lines and is important for the malignant characteristics of ovarian cancer cells.

Or search for genetic data about PF10239 in the Fitness Browser