Family Search for PF10239 (DUF2465)

PF10239 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

FA98A_HUMAN / Q8NCA5 Protein FAM98A from Homo sapiens (Human) (see paper)
Aligns to 28:327 / 518 (57.9%), covers 99.7% of PF10239, 432.5 bits

• function: Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).
  subunit: Interacts (via N- and C-terminus) with DDX1 (PubMed:28040436). Interacts (via N- and C-terminus) with C14orf166 (PubMed:28040436). Interacts with FAM98B (PubMed:28040436). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity).
• Blocking SLC7A11 attenuates the proliferation of esophageal squamous cell carcinoma cells.
  Li, Animal cells and systems 2024
  • “...48 Q8N365 Circadian-associated transcriptional repressor (CIART) 41442.45 9.49 1 1 0.0182 1 1 0.0182 49 Q8NCA5 Protein FAM98A (FAM98A) 55271.88 9.1 4 3 0.0637 1 1 0.027 50 Q8WWH4 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (ASZ1) 53457.62 5.6 1 1 0.0105 1...”
• Expanding the repertoire of human tandem repeat RNA-binding proteins.
  Ormazábal, PloS one 2023
  • “...Fig in S1 File ). 10.1371/journal.pone.0290890.g012 Fig 12 An example of a protein, FAM98A (UniProtKB: Q8NCA5), previously described as RNA-binding but not yet annotated as repetitive. The green representation highlights the regions predicted as tandem repeats by the methods mentioned above each structure. CE-Symm detects a...”
• Investigation on acquired palbociclib resistance by LC-MS based multi-omics analysis.
  Xue, Frontiers in molecular biosciences 2023
  • “...1.20E-10 Protein SCO1 homolog, mitochondrial SCO1 Q96I59 3.163047452 4.79E-09 9.90E-08 Probable asparagine--tRNA ligase, mitochondrial NARS2 Q8NCA5 3.136577654 6.53E-10 1.67E-08 Protein FAM98A FAM98A To understand the functions these DEPs played in the development of drug resistance, KEGG pathway enrichment analysis and GO enrichment analysis were performed. There...”
• Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach.
  Thirumal, Advances in protein chemistry and structural biology 2022
  • “...612570 P35556 FAM8A1 FAM8A1 ENSG00000137414 16372 51439 618409 Q9UBU6 FAM98A FAM98A ENSG00000119812 24520 25940 NA Q8NCA5 ERC1 ERC1 ENSG00000082805 17072 23085 607127 Q8IUD2 ALG11 ALG11 ENSG00000253710 32456 440138 613666 Q2TAA5 ALG5 ALG5 ENSG00000120697 20266 29880 604565 Q9Y673 AGTR2 AGTR2 ENSG00000180772 338 186 300034 P50052 ERGIC1 ERGIC1...”
• G-quadruplex-forming nucleic acids interact with splicing factor 3B subunit 2 and suppress innate immune gene expression
  Matsumoto, Genes to cells : devoted to molecular & cellular mechanisms 2021
  • “...12.47 3 6.35E+05 P18621 RPL17 60S ribosomal protein L17 5.98 1 7.60E+05 30.98 7 2.49E+06 Q8NCA5 FAM98A Protein FAM98A 2.31 1 6.11E+05 16.76 6 1.39E+06 P62266 RPS23 40S ribosomal protein S23 8.39 1 5.15E+05 29.37 4 1.14E+06 P62841 RPS15 40S ribosomal protein S15 33.79 2 3.95E+05...”
• Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.
  Cai, The Journal of biological chemistry 2021
  • “...Q8TDD1 DDX54 Yes Q6P158 DHX57 Yes Q08211 DHX9 Yes Q01844 EWSR1 Yes Q9NZB2 FAM120A Yes Q8NCA5 FAM98A Yes P22087 FBL Yes P51114 FXR1 Yes Q13283 G3BP1 Yes Q9UN86 G3BP2 Yes O14979 HNRNPDL Yes Q9BUJ2 HNRNPUL1 Yes Q1KMD3 HNRNPUL2 Yes Q14103 HNRNPD Yes O60506 SYNCRIP Yes O43390...”
• Mass Spectrometry and Computer Simulation Predict the Interactions of AGPS and HNRNPK in Glioma.
  Zhou, BioMed research international 2021
  • “...18 P07437 Tubulin beta chain TUBB 1858.30 54 O95470 Sphingosine-1-phosphate lyase 1 SGPL1 93.38 19 Q8NCA5 Protein FAM98A FAM98A 1783.77 55 P81605 Dermcidin DCD 85.59 20 P04350 Tubulin beta-4A chain TUBB4A 1767.33 56 O94925 Glutaminase kidney isoform, mitochondrial GLS 70.06 21 P47895 Aldehyde dehydrogenase family 1...”
• Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2.
  Llabrés, PloS one 2020
  • “...0.625 0.748 0.511 B8ZZN6 Q9Y3U8 Q92499 Q9NR30 0.558 0.941 0.854 Q53GL0 Q8TAD8 0.131 0.851 P09651 Q8NCA5 0.090 0.692 0.631 P14618 Q13310 0.634 0.814 0.565 P62937 P67870 0.679 0.916 0.262 B0QYN7 P19784 Q9Y4W2 Q9NW13 0.622 0.917 0.674 Q9HCD5 P11940 0.055 0.869 0.868 (d) Nucleocapsid protein N (P59595,...”
• More

FA98A_MOUSE / Q3TJZ6 Protein FAM98A from Mus musculus (Mouse) (see paper)
Aligns to 28:327 / 515 (58.3%), covers 99.7% of PF10239, 431.9 bits

• function: Positively stimulates PRMT1-induced protein arginine methylation (By similarity). Involved in skeletal homeostasis (PubMed:27777970). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970).
  subunit: Interacts (via N- and C-terminus) with DDX1 (By similarity). Interacts (via N- and C-terminus) with C14orf166 (By similarity). Interacts with FAM98B (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (PubMed:27777970).
• miR-29a/b₁ Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation
  Guo, Frontiers in endocrinology 2021
  • “...Rpl37 60S ribosomal protein L37 OS=Mus musculus GN=Rpl37 PE=3 SV=3 11 kDa < 0.0001 0.82 Q3TJZ6 Fam98a Protein FAM98A OS=Mus musculus GN=Fam98a PE=1 SV=1 55 kDa 0.00012 0.82 Q8K221 Arfip2 Arfaptin-2 OS=Mus musculus GN=Arfip2 PE=1 SV=2 38 kDa 0.00035 0.82 P62862 Fau 40S ribosomal protein S30...”

Q80VD1 Protein FAM98B from Mus musculus
Aligns to 34:330 / 429 (69.2%), covers 99.7% of PF10239, 430.6 bits

• Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells.
  Ortiz, Experimental biology and medicine (Maywood, N.J.) 2010
  • “...120A unknown <1.00E-14 FAM175B Q3TCJ1 family with sequence similarity 175, member B unknown <1.00E-14 FAM98B Q80VD1 family with sequence similarity 98, member B unknown <1.00E-14 FARSA Q8C0C7 phenylalanyl-tRNA synthetase, alpha subunit transcription/translation <1.00E-14 GGA3 Q8BMI3 golgi associated, gamma adaptin ear containing, ARF binding protein vesicle/trafficking <1.00E-14...”

Q5FWT1 Protein FAM98A from Rattus norvegicus
Aligns to 28:327 / 515 (58.3%), covers 99.7% of PF10239, 430.5 bits

• Proteomic investigation of acute and chronic hypoxia/reoxygenation responsive proteins and pathways in H9C2 cardiomyoblasts
  Öztuğ, Turkish journal of biology = Turk biyoloji dergisi 2024
  • “...alpha-1 (I) chain 4.23611E-10 P02466 Collagen alpha-2 (I) chain 2.48332E-08 Q4QRB4 Tubulin beta-3 chain 0.000495395 Q5FWT1 Protein FAM98A 1.40559E-06 Q5RK27 Solute carrier family 12 member 7 0.027116389 O88923 Adhesion G protein-coupled receptor L2 1.56564E-16 Q53UA7 Serine/threonine-protein kinase TAO3 0.021633618 Q6AY37 Melanoma-associated antigen B16 0.01109568 P09606 Glutamine...”
• Preliminary quantitative profile of differential protein expression between rat L6 myoblasts and myotubes by stable isotope labeling with amino acids in cell culture.
  Cui, Proteomics 2009
  • “...acidic leucine rich protein PAL31 IPI00192336.1 1.68NA 1 Q9EST6 170724 Protein FAM98A IPI00554081.1 1.73NA 1 Q5FWT1 313873 Protein KIAA0152 precursor IPI00371173.2 2.32 0.00 2 Q5FVQ4 304543 PTPRF interacting protein, binding protein 1 (liprin beta 1) IPI00567984.1 1.630.00 2 312855 Reticulon 3, isoform A1 IPI00421506.1 1.64 0.20...”

D4AE02 Family with sequence similarity 98, member B from Rattus norvegicus
Aligns to 34:330 / 434 (68.4%), covers 99.7% of PF10239, 430.3 bits

• Identification of protein targets for the antidepressant effects of Kai-Xin-San in Chinese medicine using isobaric tags for relative and absolute quantitation.
  Dong, Neural regeneration research 2020
  • “...D3ZK01, G3V8E8, Q6PDW6, D3ZK70, Q5U2Q7, D4AAZ9, D3ZBE6, Q5FVQ2, F1LPT0, Q5I034, Q5I0K3, G3V7C4, B2RZ66, P68255, G3V6X7, D4AE02, D3ZA45, F1M1L9 CMS: Chronic mild stress group; CON: control group; KXS: Kai-Xin-San group. Functional analysis of differentially expressed proteins in KXS-treated CMS rats Biological functional analysis demonstrated that the differentially...”

FAM98B / Q52LJ0 tRNA-splicing ligase complex FAM98B component (EC 6.5.1.8) from Homo sapiens (see 2 papers)
FA98B_HUMAN / Q52LJ0 Protein FAM98B from Homo sapiens (Human) (see 5 papers)
NP_775882 protein FAM98B from Homo sapiens
Aligns to 34:330 / 433 (68.6%), covers 99.7% of PF10239, 428.6 bits

• function: Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436).
  subunit: Homodimer (PubMed:28040436). Component of the tRNA-splicing ligase complex (PubMed:21311021, PubMed:24870230). Interacts with FAM98A (PubMed:28040436).
• Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell.
  Bartolec, Proceedings of the National Academy of Sciences of the United States of America 2023
  • “...models. The pentameric tRNA ligase complex comprising DDX1, FAM98B, RTRAF, RTCB, and ASHWIN (Uniprot: Q92499, Q52LJ0, Q9Y224, Q9Y3I0 and Q9BVC5; CORUM #6301) plays an essential role in tRNA splicing ( 64 ). While there are structures (including homologous structures) of some individual subunits and domains [PDB:...”
  • “...is in cyan, RTCB (Q9Y3I0) is in magenta, RTRAF (Q9Y224) is in orange and FAM98B (Q52LJ0) is in blue. ( A ) Rank 1 AF Multimer-v2 model of the tRNA ligase core complex. ( B ) All five AlphaFold Multimer-v2 models superimposed onto the Rank 1...”
• Blood Proteome Profiling Reveals Biomarkers and Pathway Alterations in Fragile X PM at Risk for Developing FXTAS.
  Zafarullah, International journal of molecular sciences 2023
  • “...NDUFA10 0.23 12.9 0.000778 0.017795 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 95 Q52LJ0 FAM98B 0.7 13.59 0.00078 0.017795 Protein FAM98B 96 O95819 MAP4K4 0.55 14.63 0.000791 0.01784 Mitogen-activated protein kinase kinase kinase kinase 4 97 Q8IV53 DENND1C 0.66 13.19 0.000835 0.018443 DENN domain-containing...”
• Molecular architecture of the human tRNA ligase complex
  Kroupova, eLife 2021
  • “...(gift from Scott Gradia, Addgene plasmid #55218) using ligation-independent cloning. DDX1 (UniProt Q92499), FAM98B (UniProt Q52LJ0), and ASW (UniProt Q9BVC5-1) were subcloned into the UC Berkeley MacroLab plasmids 438B (Addgene plasmid #55219), 438Rgfp (Addgene plasmid #55221), and 438C (Addgene plasmid #55220), respectively. The plasmids containing individual...”
  • “...5A vector (gift from Scott Gradia, Addgene plasmid #30121), while DNA sequence encoding FAM98B (UniProt Q52LJ0) N-terminally fused to StrepII tag, GFP, and TEV protease cleavage site (amplified from the UC Berkeley MacroLab 438-Rgfp vector, Addgene plasmid #55221) was cloned into site 2 of the same...”
• Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation
  Jia, Annals of translational medicine 2020
  • “...II transcriptional coactivator p15 SUB1 1.398 Q92888 Rho guanine nucleotide exchange factor 1 ARHGEF1 1.396 Q52LJ0 Isoform 2 of Protein FAM98B FAM98B 1.395 P49407 Arrestin beta 1 ARRB1 1.393 Q99733 Nucleosome assembly protein 1 like 4 NAP1L4 1.392 Q8WXF1 Paraspeckle component 1 PSPC1 1.390 Q9UL25 RAB21,...”
• Label-free LC-MS analysis of HER2+ breast cancer cell line response to HER2 inhibitor treatment
  Di, Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2015
  • “...) Fold change Highest condition ) a P13489 Ribonuclease inhibitor 4 310.49 0.000561 1.55 Neratinib Q52LJ0 Protein FAM98B 2 90.26 0.000932 1.62 Neratinib P49411 Elongation factor Tu, mitochondrial 3 201.31 0.001 1.52 Neratinib P35232 Prohibitin 2 118.62 0.002224 1.64 Neratinib Q8WUM4 Programmed cell death 6-interacting protein...”
• hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
  Pérez-González, PloS one 2014
  • “...9(7) 304 *RTCB_HUMAN tRNA-splicing ligase (HSPC 117) Q9Y3I0 55589 39(35) 1666 6(6) 248 *Protein FAM98B Q52LJ0 37489 13(13) 655 3(2) 203 Single-stranded DNA-binding protein 3 Q9BWW4 40533 2(2) 131 Transcription factor 4 P15884 71448 2(2) 120 Serrate RNA effector molecule homolog Q9BXP5 10092 2(2) 82 Heterogeneous...”
  • “...423 *RTCB_HUMAN tRNA-splicing ligase (HSPC 117) Q9Y3I0 55589 64(35) 3072 8 (7) 234 *Protein FAM98B Q52LJ0 37489 34(18) 1570 3(3) 167 Putative RNA binding protein Luc7-like 1 Q9NQ29 44023 2(2) 123 Transport and cytoskeleton related factors *Myosin light chain kinase 2, skeletal/cardiac muscle Q9H1R3 65104 21(2)...”
• FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
  Akter, The international journal of biochemistry & cell biology 2017 (PubMed)
  • GeneRIF: the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines
• hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
  Pérez-González, PloS one 2014
  • GeneRIF: hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.

CG5913 uncharacterized protein from Drosophila melanogaster
Aligns to 26:331 / 454 (67.4%), covers 99.3% of PF10239, 378.3 bits

• Rare variants in MYH15 modify amyotrophic lateral sclerosis risk
  Kim, Human molecular genetics 2019
  • “...OALS FAM98B FXR2 HIPK2 HK3 PDK3 KDM2A KIF27 CG5913 Fmr1 Hipk Hex-A Pdk Kdm2 cos Suppressor Suppressor Suppressor Suppressor Suppressor Suppressor Suppressor Yes...”
• Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk
  Slack, PLoS genetics 2010
  • “...body size. (A) Schematic representation of the Lnk locus along with the flanking genes CG17370, CG5913 and CG5948 . The three Lnk transcripts (RA, RB, and RC) are shown along with the positions of the P-element insertion d07478 and the deletion Del29 . Arrows show the...”
  • “...spanning from the 3 end of CG17370 to the beginning of the first exon of CG5913 was used for the genomic rescue construct. This was inserted by means of C31 mediated integration into a landing site on the second chromosome at 51D [28] . The wild-type...”
• The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
  Werz, PLoS genetics 2009
  • “...spanning from the 3 end of CG17370 to the beginning of the first exon of CG5913 was used as genomic rescue. The construct was inserted by means of C31 mediated integration into a landing site on the second chromosome at 51D [40] . Constitutive active forms...”

XP_006500159 protein FAM98B isoform X1 from Mus musculus
2 alignments in 34:303 / 402 (67.2%), covering up to 49.0% of PF10239, 372.2 bits

• LncRNA-Gm9866 promotes liver fibrosis by activating TGFβ/Smad signaling via targeting Fam98b.
  Liao, Journal of translational medicine 2023
  • GeneRIF: LncRNA-Gm9866 promotes liver fibrosis by activating TGFbeta/Smad signaling via targeting Fam98b.

E9PH82 Family with sequence similarity 98 member A from Homo sapiens
Aligns to 28:301 / 312 (87.8%), covers 90.1% of PF10239, 359.3 bits

• Serum estradiol levels in controlled ovarian stimulation directly affect the endometrium
  Ullah, Journal of molecular endocrinology 2017
  • “...actin-dependent regulator of chromatin subfamily D member 2 4.5084 8.3 52.238 2 SMARCD2 1.71E-02 1.37 E9PH82 Protein FAM98A 50.655 20.8 34.431 4 FAM98A 3.34E-02 1.39 Q9UDR5 Alpha-aminoadipic semialdehyde synthase, mitochondrial 5.4278 3.9 102.13 3 AASS 8.02E-03 1.4 E9PJ95 COMM domain-containing protein 9 12.306 11.4 20.687 1...”

F1RI46 Family with sequence similarity 98 member C from Sus scrofa
Aligns to 25:338 / 357 (88.0%), covers 98.7% of PF10239, 315.1 bits

• Protein profiling of testicular tissue from boars with different levels of hyperactive sperm motility.
  van, Acta veterinaria Scandinavica 2022
  • “...protein A0A287AWH5 DEP i CDC37L1 Hsp90 co-chaperone Cdc37-like 1 F1SK44 DEP i FAM98C Protein FAM98C F1RI46 Perseus i OSBPL2 Oxysterol-binding protein A0A286ZQP4 Perseus i MSMO1 Methylsterol monooxygenase 1 D0G7F0 Perseus i TUBG1 Tubulin gamma chain F2Z562 Perseus i SRSF1 Serine/arginine-rich splicing factor 1 Q3YLA6 Perseus i...”

Q6AXA1 Family with sequence similarity 98 member A L homeolog from Xenopus laevis
Aligns to 71:368 / 385 (77.4%), covers 99.3% of PF10239, 314.5 bits

• Xenopus meiotic microtubule-associated interactome
  Gache, PloS one 2010
  • “...Q6GQL3 XL unstudied 38.7 BAT2 Cytoplasme, spindle NA Weak signal on spindle microtubules 5 Mgc80361/ Q6AXA1 XL unstudied 42.8 Nucleus NA Spindle microtubules 6 Mgc81475/ Q6NRT3 XL Smu1 4 57.6 7 x WD LisH CTLH Cytoplasme, nucleus midbody NA Spindle microtubules, poles 7 TSGA14/ Q9BYV8 HS...”

Q17RN3 Protein FAM98C from Homo sapiens
Aligns to 26:334 / 349 (88.5%), covers 98.7% of PF10239, 301.3 bits

• New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
  Liu, Journal of neuroinflammation 2018
  • “...subunit TOM20 homolog 16.3 0.823 0.007395** Q15629 Translocating chain-associated membrane protein 1 43 0.809 0.023084* Q17RN3 Protein FAM98C 37.3 0.821 0.010317* Q4V339 COBW domain-containing protein 6 43.9 0.747 1.2E05*** Q567U6 Coiled-coil domain-containing protein 93 73.2 0.814 0.001351** Q5SSJ5 Heterochromatin protein 1-binding protein 3 61.2 0.828 0.000364***...”
• hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
  Pérez-González, PloS one 2014
  • “...167666 137(98) 6784 1(1) 72 *Protein FAM98A Q8NCA5 55734 20(13) 818 3(3) 183 Protein FAM98C Q17RN3 37903 5(5) 256 *Ubiquitin-40S ribosomal protein S27a P62979 18229 9(5) 447 3(3) 117 Coiled-coil domain-containing protein 8 Q9H0W5 59431 2(2) 82 *protein C14orf166 (CLE) Q9Y224 28143 591(46) 34290 14(13) 698...”

NP_001291467 protein FAM98A isoform 2 from Homo sapiens
Aligns to 1:132 / 323 (40.9%), covers 43.0% of PF10239, 229.2 bits

• Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling.
  Wang, Journal of gynecologic oncology 2022
  • GeneRIF: Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling.
• FAM98A promotes cancer progression in endometrial carcinoma.
  Li, Molecular and cellular biochemistry 2019 (PubMed)
  • GeneRIF: Mechanistically, it was demonstrated that miR-142-3p directly targeted FAM98A, and modulated its expression.
• FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
  Akter, The international journal of biochemistry & cell biology 2017 (PubMed)
  • GeneRIF: the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines
• FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion, and colony formation.
  Akter, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 (PubMed)
  • GeneRIF: FAM98A is expressed in numerous ovarian cancer cell lines and is important for the malignant characteristics of ovarian cancer cells.

Or search for genetic data about PF10239 in the Fitness Browser