Family Search for PF10240 (DUF2464)

PF10240 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MB12B_HUMAN / Q9H7P6 Multivesicular body subunit 12B; ESCRT-I complex subunit MVB12B; Protein FAM125B from Homo sapiens (Human) (see paper)
NP_258257 multivesicular body subunit 12B isoform 1 from Homo sapiens
Aligns to 48:299 / 319 (79.0%), covers 100.0% of PF10240, 293.4 bits

• function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
  subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex.
• Proteins from toad's parotoid macroglands: do they play a role in gland functioning and chemical defence?
  Kowalski, Frontiers in zoology 2023
  • “...94,630 2 2 A-kinase anchor protein 4 Signal transduction, establishment of protein localisation 6, 7 Q9H7P6 30 35,919 1 3 Multivesicular body subunit 12B Membrane fission, protein transport 8 Q8CG76 30 40,954 1 2 Aflatoxin B1 aldehyde reductase member 2 Lipid metabolism 7 A2VCK2 30 37,963...”
• Management of Tamm-Horsfall Protein for Reliable Urinary Analytics.
  Xu, Proteomics. Clinical applications 2019
  • “...protein 37C Q86XT2 VPS37D Vacuolar protein sortingassociated protein 37D Q96EY5 MVB12A Multivesicular body subunit 12A Q9H7P6 MVB12B Multivesicular body subunit 12B ESCRTII Q9BRG1 VPS25 Vacuolar proteinsortingassociated protein 25 2 3 Q86VN1 VPS36 Vacuolar proteinsortingassociated protein 36 ESCRTIII O43633 CHMP2A Charged multivesicular body protein 2a 6 11...”
• Biochemical and biological characterization of exosomes containing prominin-1/CD133
  Rappa, Molecular cancer 2013
  • “...coverage ESCRT-I VPS-28 Q9UK41 9 57 VPS-37B Q9H9H4 9 55 FAM125A Q96EYS 6 37 FAM125B Q9H7P6 5 38 TSG101 Q99816 13 37 ESCRT-III CHMP2A O43633 3 16 CHMP4B Q9H444 6 35 CHMP5 Q9NZZ3 4 31 ESCRT-associated proteins Brox Q5VW32 10 40 PDCD6IP Q8WUM4 63 75 VPS-4A...”
• Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT).
  Wang, Proteomics 2012
  • “...9 Vacuolar protein sorting-associated protein 37D(VPS37D) Q86XT2 55 190 9 Multivesicular body subunit 12B (MVB12B) Q9H7P6 73 172 9 Vacuolar protein sorting-associated protein 37C(VPS37C) A5D8V6 32 100 9 Vacuolar protein sorting-associated protein 37A(VPS37A) Q8NEZ2 23 8 5 Vacuolar protein-sorting-associated protein 25 (VSP25) (EAP20) Q9BRG1 ESCRT-II complex...”
• A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort.
  Nag, Human molecular genetics 2014
  • GeneRIF: Study suggests a novel association between SNPs in FAM125B andintra-ocular pressure in the TwinsUK cohort.
• Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit.
  Boura, Proceedings of the National Academy of Sciences of the United States of America 2012
  • GeneRIF: The 1.3-A atomic resolution crystal structure of the MVB12B MABP domain reveals a beta-prism fold, a hydrophobic membrane-anchoring loop, and an electropositive phosphoinositide-binding patch.
• Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
  Letra, American journal of medical genetics. Part A 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
• Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications.
  Tsunematsu, Biochemical and biophysical research communications 2010 (PubMed)
  • GeneRIF: These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A and the functions of ESCRT-I.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

MB12A_HUMAN / Q96EY5 Multivesicular body subunit 12A; CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; Protein FAM125A from Homo sapiens (Human) (see 3 papers)
Aligns to 10:261 / 273 (92.3%), covers 99.6% of PF10240, 231.8 bits

• function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.
  subunit: Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with CD2AP and CIN85/SH3KBP1. Interacts with CD2AP (via one of the SH3 domains). Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37D; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with CEP55.
• Shikonin promotes hypertrophic scar repair by autophagy of hypertrophic scar-derived fibroblasts.
  Zhang, Acta cirurgica brasileira 2023
  • “...transport through interaction with t-SNAREs homolog 1A Q9HA65 TBC1D17 79735 TBC1 domain family member 17 Q96EY5 MVB12A 93343 Multivesicular body subunit 12A Q96F24 NRBF2 29982 Nuclear receptor-binding factor 2 Source: Elaborated by the authors. Shikonin increases autophagy in hypertrophic scar-derived fibroblasts via the AMPK/mTOR signal pathway...”
• Urinary proteome profiling for children with autism using data-independent acquisition proteomics.
  Meng, Translational pediatrics 2021
  • “...XIII B chain 0.3423 0.0011 P61225 Ras-related protein Rap-2b 0.341 0.0091 P80303 Nucleobindin-2 0.3409 0.006 Q96EY5 Multivesicular body subunit 12A 0.3362 0.0023 Q9H1C7 Cysteine-rich and transmembrane domain-containing protein 1 0.3296 0.0058 Q96CS7 Pleckstrin homology domain-containing family B member 2 0.3266 0.0036 Q13621 Solute carrier family 12...”
• Management of Tamm-Horsfall Protein for Reliable Urinary Analytics.
  Xu, Proteomics. Clinical applications 2019
  • “...37B A5D8V6 VPS37C Vacuolar protein sortingassociated protein 37C Q86XT2 VPS37D Vacuolar protein sortingassociated protein 37D Q96EY5 MVB12A Multivesicular body subunit 12A Q9H7P6 MVB12B Multivesicular body subunit 12B ESCRTII Q9BRG1 VPS25 Vacuolar proteinsortingassociated protein 25 2 3 Q86VN1 VPS36 Vacuolar proteinsortingassociated protein 36 ESCRTIII O43633 CHMP2A Charged...”
• Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT).
  Wang, Proteomics 2012
  • “...Signal transducing adapter molecule 1 (STAM1) Q92783 16 5 5 Multivesicular body subunit 12A (MVB12A) Q96EY5 ESCRT-I complex 60 765 9 Vacuolar protein sorting-associated protein 28 (VPS28) Q9UK41 82 698 9 Tumor susceptibility gene 101 protein (TSG101) Q99816 57 550 9 Vacuolar protein sorting-associated protein 37B(VPS37B)...”

Q78HU3 Multivesicular body subunit 12A from Mus musculus
Aligns to 8:259 / 271 (93.0%), covers 99.6% of PF10240, 227.7 bits

• Using CRISPR-Cas9/phosphoproteomics to identify substrates of calcium/calmodulin-dependent kinase 2δ.
  Park, The Journal of biological chemistry 2023
  • “...Microtubule-associated tumor suppressor 1 homolog S1143 AIS R QL S T E QAAL 0.45 0.0001 Q78HU3 Mvb12a Multivesicular body subunit 12A S168 QDM R GL S L D PPKE 0.74 0.0000 Q9CX66 Nopchap1 NOP protein chaperone 1 S125 EMS R SD S K E EDSP 0.46...”

Q6P777 Multivesicular body subunit 12A from Rattus norvegicus
Aligns to 8:259 / 271 (93.0%), covers 99.6% of PF10240, 226.8 bits

• Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat
  Tang, Stem cell research & therapy 2021
  • “...Q9EP88 Slc25a14 1.34 Up 0.043 A0A0G2JZC6 Arhgef11 1.33 Up 0.003 D4AD58 Etfrf1 1.31 Up 0.033 Q6P777 Mvb12a 1.31 Up 0.021 D3ZPW6 Lage3 1.30 Up 0.011 Q64724 LOC103689942 1.30 Up 0.026 D3ZMW3 Msto1 1.30 Up 0.014 B5DEJ9 Sbf2 1.30 Up 0.006 A0A0G2JSK1 Serpina3c 1.29 Up 0.003 Q4QQU5...”

XP_006498436 multivesicular body subunit 12B isoform X11 from Mus musculus
Aligns to 46:225 / 241 (74.7%), covers 69.6% of PF10240, 218.8 bits

• Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.
  Nandakumar, Nature microbiology 2019
  • GeneRIF: Multivesicular body protein MVB12b is a target for TANK-binding kinase 1 phosphorylation, which is essential for the sorting of DNA into extracellular vesicles and stimulation of bystander cells.

NP_001291476 multivesicular body subunit 12A isoform 2 from Homo sapiens
Aligns to 1:169 / 181 (93.4%), covers 67.6% of PF10240, 151.0 bits

• A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
  Flower, Nature structural & molecular biology 2020
  • GeneRIF: A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
• Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications.
  Tsunematsu, Biochemical and biophysical research communications 2010 (PubMed)
  • GeneRIF: These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A and the functions of ESCRT-I.
• CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP.
  Konishi, The Journal of biological chemistry 2006 (PubMed)
  • GeneRIF: CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP

A8K2M7 cDNA FLJ77039, highly similar to Homo sapiens c-myc promoter binding protein (MYCPBP), mRNA (Fragment) from Homo sapiens
Aligns to 43:234 / 927 (20.7%), covers 51.0% of PF10240, 22.4 bits

• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...(Fragment) OS=Homo sapiens GN=RPL5 PE=2 SV=1 - [Q8WYP1_HUMAN] 11.29 4 1 1 62 7.4 10.33 A8K2M7 cDNA FLJ77039, highly similar to Homo sapiens c-myc promoter binding protein (MYCPBP), mRNA (Fragment) OS=Homo sapiens PE=2 SV=1 - [A8K2M7_HUMAN] 1.08 1 1 1 927 104.8 8.29 B4DUL7 cDNA FLJ58283,...”

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