Family Search for PF10241 (KxDL)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10241 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

KXDL1_MOUSE / Q80XH1 KxDL motif-containing protein 1 from Mus musculus (Mouse) (see paper)
Aligns to 14:99 / 177 (48.6%), covers 100.0% of PF10241, 104.1 bits

• function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). May also be involved in the biogenesis of lysosome-related organelles such as melanosomes (PubMed:22554196).
  subunit: Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S1. Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain) (PubMed:22554196).
  disruption phenotype: Show defects in the lysosome-related organelles (LRO) biogenesis, mimicking mildly the human Hermansky-Pudlak syndrome (HPS).

E9Q4P0 KxDL motif-containing protein 1 (Fragment) from Mus musculus
Aligns to 14:99 / 193 (44.6%), covers 100.0% of PF10241, 104.1 bits

• Diazepam Accelerates GABA_AR Synaptic Exchange and Alters Intracellular Trafficking
  Lorenz-Guertin, Frontiers in cellular neuroscience 2019
  • “...1 Plasma Membrane Enzyme 7.0 5.9E-02 P11276 FN1 Fibronectin 1 Extracellular Space Enzyme 5.4 2.7E-02 E9Q4P0 KXD1 KxDL motif containing 1 Cytoplasm Other 5.4 3.1E-02 Q62277 SYP Synaptophysin Cytoplasm Transporter 5.0 5.0E-03 Q9QXY6 EHD3 EH domain containing 3 Cytoplasm Other 5.0 7.8E-02 P48774 GSTM3 Glutathione S...”
• Sex-Specific Differences in Oxytocin Receptor Expression and Function for Parental Behavior.
  Mitre, Gender and the genome 2017

KXDL1_HUMAN / Q9BQD3 KxDL motif-containing protein 1 from Homo sapiens (Human) (see paper)
NP_001165420 kxDL motif-containing protein 1 from Homo sapiens
Aligns to 14:99 / 176 (48.9%), covers 100.0% of PF10241, 103.8 bits

• function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May be involved in the biogenesis of lysosome- related organelles such as melanosomes (By similarity).
  subunit: Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Associates with the BLOC-1 complex. Interacts with BLOC1S1. Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain) (By similarity).
• BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain.
  Tunganuntarat, Scientific reports 2023
  • GeneRIF: BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain.
• The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles.
  Yang, Traffic (Copenhagen, Denmark) 2012
  • GeneRIF: KXD1 interacts with BLOS1.
• Lysosome assembly and disassembly changes endocytosis rate through the Leishmania cell cycle.
  Wang, MicrobiologyOpen 2020
  • “...subunit1 (BLOS1) P78537 NO HIT BLOS2 Q6QNY1 NO HIT SNAREassociated protein O95295 NO HIT KXD1 Q9BQD3 NO HIT BLOS8 Q96FH0 NO HIT BORCS5 Q969J3 NO HIT Lyspersin Q96GS4 NO HIT Diaskedin Q96B45 NO HIT ADPRIBOSYLATION FACTORLIKE PROTEIN 8B (Arl8B) Q9NVJ2 1.00E32 LmxM.30.2790 3.00E33 Tb927.9.13650 Yes ADPRIBOSYLATION...”

E9QNP0 KxDL motif-containing protein 1 from Mus musculus
Aligns to 14:99 / 232 (37.1%), covers 100.0% of PF10241, 103.6 bits

• Eggshell membrane modulates gut microbiota to prevent murine pre-cachexia through suppression of T helper cell differentiation.
  Jia, Journal of cachexia, sarcopenia and muscle 2022
  • “...0.07 P51667 Myosin regulatory light chain 2 MYL2 1.20 0.16 Q9JK37 Myozenin1 MYOZ1 4.02 0.17 E9QNP0 KxDL motifcontaining protein 1 KXD1 5.35 0.19 P43277 Histone H1.3 HIST1H1D 3.31 0.29 P05977 Myosin light chain 1/3 MLC1 32.51 0.31 A2AEX8 Four and a half LIM domains 1 FHL1...”
• Sex-Specific Differences in Oxytocin Receptor Expression and Function for Parental Behavior.
  Mitre, Gender and the genome 2017

LOC101904595 kxDL motif-containing protein 1-like from Bos taurus
Aligns to 14:99 / 176 (48.9%), covers 100.0% of PF10241, 100.6 bits

• Sliding window haplotype approaches overcome single SNP analysis limitations in identifying genes for meat tenderness in Nelore cattle
  Braz, BMC genetics 2019
  • “...NIPSNAP1 Protein coding ENSBTAG00000013147 NEFH Protein coding 18 14,849,540 14,991,573 ENSBTAG00000007096 GAS8 Protein coding ENSBTAG00000025283 LOC101904595 Pseudogene ENSBTAG00000029640 U1 SnRNA ENSBTAG00000033441 SHCBP1 Protein coding 24 47,570,379 47,596,815 24 48,585,933 48,632,298 24 55,868,854 55,975,740 25 17,590,025 17,598,054 ENSBTAG00000019596 GPRC5B Protein coding ENSBTAG00000044092 IQCK Protein coding 26 19,035,737...”

LO917_ORYSJ / Q6ASS9 KxDL motif-containing protein LO9-177 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
Aligns to 18:103 / 123 (69.9%), covers 100.0% of PF10241, 90.5 bits

• function: Contributes, together with ILI5/BUL1 and BC1, to the promotion of leaf inclination and grain size by modulating cell elongation.
  subunit: Homodimer (PubMed:27879391). Component of a nuclear cell elongation controlling complex made of ILI5/BUL1, LO9-177 and BC1 (PubMed:27879391, PubMed:28029278). Binds directly to ILI5/BUL1, ILI4/BU1, BUL2 and BUL3 (PubMed:27879391). Binds to BC1 in the nucleus (PubMed:27879391). Interacts with BCL1 (PubMed:34360554).

PADG_00901 uncharacterized protein from Paracoccidioides brasiliensis Pb18
Aligns to 75:146 / 146 (49.3%), covers 83.7% of PF10241, 84.0 bits

• Extracellular vesicle-mediated export of fungal RNA
  Peres, Scientific reports 2015
  • “...were initially amplified from isolated genomic DNA with primers for PADG_00645 (F:5-GGATCTGAAAGGCACCCGAA-3 and R:5-ACCCATACGCTCTACCCCTT-3) and PADG_00901 (R:5-CCGATGCCAGCACTACTACC-3; F:5-CCATGACATCGACACCGGAA-3). The reaction mixture (50l) contained 1U of Taq High-Fidelity Platinum polymerase (Invitrogen), 2mM MgSO 4 , 0.4mM of each primer and 0.2mM of dNTP in High-Fidelity PCR buffer....”

KXD1_YEAST / P53158 Biogenesis of lysosome-related organelles complex 1 subunit KXD1; BLOC-1 subunit KXD1; KxDL homolog from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YGL079W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; identified as a transcriptional activator in a high-throughput yeast one-hybrid assay from Saccharomyces cerevisiae
Aligns to 115:200 / 218 (39.4%), covers 100.0% of PF10241, 81.2 bits

• function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
  subunit: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
• Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress
  Lin, Oxidative medicine and cellular longevity 2019
  • “...DNA-binding domains YFR015C GSY1 Glycogen synthase YFR040W SAP155 Sit4-associated protein YGL006W PMC1 Plasma membrane calcium YGL079W KXD1 KxDL homolog YGL200C EMP24 Endomembrane protein YGR254W ENO1 Enolase YHL002W HSE1 Has symptoms of class E mutants; resembles Hbp, STAM, and EAST YIL002C INP51 Inositol polyphosphate 5-phosphatase YJL013C MAD3...”
• Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1
  Hayes, Traffic (Copenhagen, Denmark) 2011
  • “...residues that includes a KxDL (Lys-x-Asp-Leu) motif near the carboxy-terminus ( Fig. 4B ). Since YGL079W is the yeast KxDL homologue, we propose the name KXD1. The multiple interactions between all of Bls1p, Snn1p, Cnl1p, Vab2p, Bli1p and Kxd1p indicate that the latter three might also...”
• Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae
  Norambuena, BMC chemical biology 2008
  • “...deletion strain YLR426W YNL080C YDR525W-A/SNA2 YDR105C/TMS1 Not previously associated to sorting pathway YCL075W YCR095C YDR357C YGL079W YIL039W YIL041W/Gvp36p YIL130W/ASG1 YJL077C/ICS3 YKR088C/TVP38 YLL049W YLR361C/DCR2 YMR158C-B YMR315W YNL063W/MTQ1 YOL111C The name in parenthesis correspond to the known gene on the complementary DNA strain of dubious genes Other unknown...”
  • “...localized to Golgi vesicles [ 26 ]. The mutants for the unknown ORFs YDR357C and YGL079W were hypersensitive to Sortin2 and their gene products were identified as interacting partners in a two-hybrid assay [ 22 ]. The GFP fusion of Ygl079wp co-localizes with an endosome marker...”
• Transcriptional activators in yeast
  Titz, Nucleic acids research 2006
  • “...YDR520C Unknown# C,N YER045c YER045C Transcription N YER051W YER051W Unknown# ? YGL036W YGL036W Unknown# C YGL079W YGL079W Unknown# C YGL223C YGL223C Vesicular transport# G YGR120C YGR120C Vesicular transport G YGR130C YGR130C Unknown# C YHL012W YHL012W Unknown# ? YHR160C YHR160C Transport P YIL019W YIL019W Unknown# C,N YIL079C...”
• Clustering proteins from interaction networks for the prediction of cellular functions
  Brun, BMC bioinformatics 2004
  • “...NKP2 Mitosis (60%, 1) ; Chromatin/chromosome structure (60%, 1) ; SOG2 Mitosis (60%, 1) ; YGL079W Mitosis (71%,1) ; APP2 Cell structure (50%, 1) ; YBR108W Cell structure (50%, 2) ; YGR058W Cell structure (50%, 1) ; YLR456W RNA processing/modification (57%, 1) ; YNL092W RNA processing/modification...”
• Transcriptional response of yeast to aflatoxin B1: recombinational repair involving RAD51 and RAD1
  Keller-Seitz, Molecular biology of the cell 2004
  • “...yfl060c ydl105w ygl102c ylr181c yil040w yer104w yjl104w ybr013c ygl131c ygr126w yjl109c yjr038c ygl079w yil019w 0 0 0 0 0 0 0 0 SNO3 QRI2 0 0 0 0 0 0 0 0 0 0 0...”

AT3G29130 hypothetical protein from Arabidopsis thaliana
Aligns to 15:100 / 119 (72.3%), covers 98.8% of PF10241, 80.8 bits

• Spatial dissection of the Arabidopsis thaliana transcriptional response to downy mildew using Fluorescence Activated Cell Sorting
  Coker, Frontiers in plant science 2015
  • “...GENES) LOCALIZED INDUCTION (52 GENES) ID Name ID Name ID Name ID Name AT1G01680 PUB54 AT3G29130 AT1G02850 BGLU11 AT3G21710 AT1G02520 PGP11 AT3G47480 AT1G05260 RCI3, RCI3A AT3G46616 AT1G02850 BGLU11 AT3G61280 AT1G26420 AT3G52710 AT1G14880 PCR1 AT4G01350 AT1G30720 AT3G61390 AT1G19610 LCR78, PDF1.4 AT4G12480 pEARLI 1 AT1G30730 AT4G01720 WRKY47 AT1G33960...”
• Genome-wide comparative analysis of 20 miniature inverted-repeat transposable element families in Brassica rapa and B. oleracea
  Sampath, PloS one 2014
  • “...175 AT2G02970 Bra024796 - - Bol007213 - - gda1/cd39 Nucleoside phosphatase family protein 4672 252 AT3G29130 Bra025377 - - Bol043009 - - Molecular function unknown 4851 174 AT4G27060 Bra026382 - - - - - Convoluta, spiral 2, spr2, tor1, tortifolia 1 4872 161 AT2G15290 - -...”

Or search for genetic data about PF10241 in the Fitness Browser