Family Search for PF10241 (KxDL)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10241 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

KXDL1_MOUSE / Q80XH1 KxDL motif-containing protein 1 from Mus musculus (Mouse) (see paper)
Aligns to 14:99 / 177 (48.6%), covers 100.0% of PF10241, 104.1 bits

• function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). May also be involved in the biogenesis of lysosome-related organelles such as melanosomes (PubMed:22554196).
  subunit: Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S1. Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain) (PubMed:22554196).
  disruption phenotype: Show defects in the lysosome-related organelles (LRO) biogenesis, mimicking mildly the human Hermansky-Pudlak syndrome (HPS).

KXDL1_HUMAN / Q9BQD3 KxDL motif-containing protein 1 from Homo sapiens (Human) (see paper)
Aligns to 14:99 / 176 (48.9%), covers 100.0% of PF10241, 103.8 bits

• function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May be involved in the biogenesis of lysosome- related organelles such as melanosomes (By similarity).
  subunit: Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Associates with the BLOC-1 complex. Interacts with BLOC1S1. Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain) (By similarity).

LO917_ORYSJ / Q6ASS9 KxDL motif-containing protein LO9-177 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
Aligns to 18:103 / 123 (69.9%), covers 100.0% of PF10241, 90.5 bits

• function: Contributes, together with ILI5/BUL1 and BC1, to the promotion of leaf inclination and grain size by modulating cell elongation.
  subunit: Homodimer (PubMed:27879391). Component of a nuclear cell elongation controlling complex made of ILI5/BUL1, LO9-177 and BC1 (PubMed:27879391, PubMed:28029278). Binds directly to ILI5/BUL1, ILI4/BU1, BUL2 and BUL3 (PubMed:27879391). Binds to BC1 in the nucleus (PubMed:27879391). Interacts with BCL1 (PubMed:34360554).

KXD1_YEAST / P53158 Biogenesis of lysosome-related organelles complex 1 subunit KXD1; BLOC-1 subunit KXD1; KxDL homolog from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 115:200 / 218 (39.4%), covers 100.0% of PF10241, 81.2 bits

• function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
  subunit: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.

Or search for genetic data about PF10241 in the Fitness Browser