Family Search for PF10260 (SAYSvFN)

PF10260 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

SAYS1_DROME / Q9VBW0 SAYSvFN domain-containing protein 1 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 100:169 / 177 (39.5%), covers 98.6% of PF10260, 104.9 bits

• function: Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates (PubMed:36848233). Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain to lysosomes for degradation (By similarity).

SAYS1_HUMAN / Q9NPB0 SAYSvFN domain-containing protein 1 from Homo sapiens (Human) (see 2 papers)
Aligns to 105:175 / 183 (38.8%), covers 100.0% of PF10260, 100.9 bits

• function: Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates (PubMed:36848233). Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain via the TRAPP complex to lysosomes for degradation (PubMed:36848233).
  subunit: Associates (via N-terminus) with ribosomes.
• Quantitative plasma proteomics of survivor and non-survivor COVID-19 patients admitted to hospital unravels potential prognostic biomarkers and therapeutic targets
  Flora, 2021

SAYS1_MOUSE / Q8K190 SAYSvFN domain-containing protein 1 from Mus musculus (Mouse) (see paper)
NP_080485 SAYSvFN domain-containing protein 1 from Mus musculus
Aligns to 100:170 / 188 (37.8%), covers 100.0% of PF10260, 99.6 bits

• function: Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates (By similarity). Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain via the TRAPP complex to lysosomes for degradation (By similarity).
  subunit: Associates (via N-terminus) with ribosomes.
  disruption phenotype: No visible phenotype; mice are fertile, with no differences in sperm morphology or motility, although the cauda epididymis contains slightly less sperm.
• The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.
  Chang, Biochemical and biophysical research communications 2023 (PubMed)
  • GeneRIF: The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.

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