Family Search for PF10290 (DUF2403)

PF10290.9 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

TOS1 protein similar to alpha agglutinin anchor subunit from Candida albicans (see 3 papers)
Aligns to 36:98 / 468 (13.5%), covers 98.4% of PF10290, 94.9 bits

• CharProtDB CGD description: Protein described as similar to alpha agglutinin anchor subunit; exogenously expressed protein is a substrate for Kex2p processing in vitro; fluconazole-induced; transcription is induced in response to alpha pheromone in SpiderM medium

TOS1_YEAST / P38288 Protein TOS1; Target of SBF 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YBR162C Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C (RefSeq) from Saccharomyces cerevisiae
Aligns to 38:100 / 455 (13.8%), covers 100.0% of PF10290, 94.8 bits

• Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins
  Konduri, Cells 2020
  • “...protein, effector of proteotoxic stress response + TOD6 YBL054W 6319417 Twin of dot6p + TOS1 YBR162C 6319638 Covalently bound cell wall protein of unknown function UTR1 YJR049C 6322509 ATPNADH kinase NADK + + YBL081W YBL081W 6319390 Uncharacterized protein YCL020W YCL020W 10383771 Retrotransposon TYA Gag gene co-transcribed...”
• The Chromatin and Transcriptional Landscape of Native Saccharomyces cerevisiae Telomeres and Subtelomeric Domains
  Ellahi, Genetics 2015
  • “...RME1 YGR044C MFA1 YDR461W SUN4a YNL066W STE2 YFL026W ZRT1a YGL255W YBR162C TOS1a MFA2b YNL145W Wild type sir2D sir3D sir4D 0 0 0.8 1.3 3.2 3.7 4.6 6.7 6.8 8.1...”
• Mapping yeast N-glycosites with isotopically recoded glycans
  Breidenbach, Molecular & cellular proteomics : MCP 2012
  • “...356, 390 a YBR093C P00635 PHO5 Asn-315, 356 a , 390 a YBR139W P38109 Asn-339 YBR162C P38288 TOS1 Asn-236 YBR171W P33754 SEC66 Asn-12 YBR229C P38138 ROT2 Asn-173, 907 YBR286W P37302 APE3 Asn-85, 96, 115, 150, 162, 371, 427 YCL043C P17967 PDI1 Asn-117, 155, 425 YCL045C P25574...”
• The checkpoint transcriptional response: make sure to turn it off once you are satisfied
  Smolka, Cell cycle (Georgetown, Tex.) 2012
  • “...2008 not observed vegetative growth: decreased rate 3 YBR162C TOS1 Unknown - not observed 4 YCR065W HCM1 Transcription factor not observed 5 YDL003W MCD1...”
• Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance
  Shah, Physiological genomics 2011
  • “...YDL204W YER043C YBR214W YMR079W YJR134C YGL213C YLR178C YBR162C YPL203W YFR010W YEL021W YGR094W YOR230W YKL196C YKL126W YLR301W YBR056W YNL134C CRM1 NUP2 ASC1...”
• A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection
  Greenall, Genome biology 2008
  • “...Hypothetical protein YMC2 YBR104W Putative mitochondrial inner membrane transporter ETR1 YBR026C 2-enoyl thioester reductase TOS1 YBR162C Covalently-bound cell wall protein of unknown function Twenty-two genes whose expression is altered in cdc13-1 strains and that are also suppressors of cdc13-1 temperature sensitivity [ 35 ]. Figure 6...”
• A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin
  Pagé, Genetics 2003 (secret)
• A computational genomics approach to the identification of gene networks
  Wagner, Nucleic acids research 1997
  • “...ORF 1 YAL063C Cluster statistics Sites/bpa Positionb 2 GDH3 -1677 YBR162c -3e 7/551 2 YSY6 4 HOd 4 UME6 PDE1 7 SNG1 -242 4/113 -110 YGR198W -103 YGR033C -187...”
• More
• Mapping yeast N-glycosites with isotopically recoded glycans
  Breidenbach, Molecular & cellular proteomics : MCP 2012
  • “...390 a YBR093C P00635 PHO5 Asn-315, 356 a , 390 a YBR139W P38109 Asn-339 YBR162C P38288 TOS1 Asn-236 YBR171W P33754 SEC66 Asn-12 YBR229C P38138 ROT2 Asn-173, 907 YBR286W P37302 APE3 Asn-85, 96, 115, 150, 162, 371, 427 YCL043C P17967 PDI1 Asn-117, 155, 425 YCL045C P25574 EMC1...”

SPBP23A10.11c conserved fungal protein (RefSeq) from Schizosaccharomyces pombe
Aligns to 38:100 / 507 (12.4%), covers 98.4% of PF10290, 93.7 bits

• mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe
  Mukherjee, Open biology 2018
  • “...meiotic RNA turnover rep2 MBF Transcription Factor mug110 unknown SPACUNK4.17 NAD binding dehydrogenase family protein SPBP23A10.11c cell wall biosynthesis RIP-CHIP only SPBC32F12.07c ubiquitin E3 ligase yox1 MBF regulatory subunit efc25 Ras1 guanyl-nucleotide exchange factor SPCC1223.14 chorismate synthesis SPCC757.12 alpha amylase homologue snoU14 unknown but2 protein neddylation...”
  • “...to moderate, but this gene could play a yet undiscovered role in early meiosis. Finally, SPBP23A10.11c (electronic supplementary material, figure S4) is poorly characterized. It is an orthologue of S. cerevisiae TOS1 , which encodes a cell wall protein under the control of the SBF/MBF transcription...”
• Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains
  Chen, Yeast (Chichester, England) 2016
  • “...deletion strains were generated previously: SPAC23C4.04c, SPAC27E2.12, SPAPB1A10.16, SPCC1393.14, SPAC2F7.16c, SPBC16G5.19, SPBC17G9.06c, SPBC685.08, SPBC6B1.12c, SPBC800.14c, SPBP23A10.11c, SPBPB8B6.06c, SPAC15E1.03, SPBC215.15, SPAC23D3.14c, SPAC9.09, SPAPB15E9.01c, SPBC21D10.06c, SPBPB8B6.03 as kanMX4 deletions and graciously provided to us ( Spirek et al. , 2010 ). We attempted to confirm each of these...”
• Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5
  Nuñez, eLife 2016
  • “...proteins with potential functions in cell separation. Transcripts for a predicted -1,3 glucanase (encoded by SPBP23A10.11C) and predicted -glucosidase Psu2 are more abundant in sts5 cells (See Figure 3source data 1 ), consistent with a role for -1,3 glucan degradation in the primary septum during the...”
• S. pombe genome deletion project: an update
  Spirek, Cell cycle (Georgetown, Tex.) 2010
  • “...SPBC685.08 * viable SPBC16C6.09 viable SPBC6B1.12c * viable SPBC428.19c essential SPBC800.14c * viable SPCC18.04 essential SPBP23A10.11c * viable SPCC645.05c essential SPBPB8B6.03 * viable SPAC589.12 viable SPBPB8B6.06c * viable SPBC1778.01c viable SPCC290.04 * viable SPBC32F12.01c viable * genes which were missing from the S. pombe genome deletion...”

SS1G_12263 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
Aligns to 35:96 / 492 (12.6%), covers 100.0% of PF10290, 91.7 bits

• An Interspecies Comparative Analysis of the Predicted Secretomes of the Necrotrophic Plant Pathogens Sclerotinia sclerotiorum and Botrytis cinerea
  Heard, PloS one 2015
  • “...1 precursor SS1G_12059 HP similar to endoglucanase B C016 SS1G_12262 allergen Asp f 4 precursor SS1G_12263 carboxypeptidase C017 SS1G_12499 Serine carboxypeptidase SS1G_12500 carboxypeptidase KEX1 precursor C018 SS1G_07183 PP SS1G_07184 glycoside hydrolase family 32 protein C019 SS1G_05449 carboxypeptidase cpdS precursor SS1G_05454 chitotriosidase-1 precursor C020 SS1G_05493 HP similar...”

PGA52_CANAL / Q59L72 GPI-anchored protein 52 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
Aligns to 23:90 / 384 (17.7%), covers 96.8% of PF10290, 85.0 bits

• Proteomic analysis of a Candida albicans pga1 Null Strain
  Awad, EuPA open proteomics 2018
  • “...PGA32 Q5ADQ7 Probable GPI-anchored adhesin-like protein Pga32 11 6 2 TTLGQVTTPSR 0 LSSSKSIYSNSTTSR 1 PGA52 Q59L72 GPI-anchored protein 52 4 6.3 1 QAGADVATTLATVTGQSATTTSKK 1 PGA55 Q59SG9 Probable GPI-anchored adhesin-like protein Pga55 23 0.8 1 ATGENGEEITK 0 PIR1 Q59SF7 Cell wall mannoprotein Pir1 2 6.6 1 ACSSANNLEMTLHDSVLKDTHER...”

YJL171C GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein (RefSeq) from Saccharomyces cerevisiae
Aligns to 26:93 / 396 (17.2%), covers 98.4% of PF10290, 83.3 bits

• Aligning functional network constraint to evolutionary outcomes
  Wollenberg, BMC evolutionary biology 2020
  • “...[ 49 ] I KRE5 YOR336W Lang et al., 2013 [ 49 ] I TOH1 YJL171C Lang et al., 2013 [ 49 ] P SUL4 YBR294W Gresham et al. 2008 [ 51 ] I GAL3 YDR009W Hittinger et al., 2004 [ 52 ] Stern, 2013 [...”
• Quantitative Profiling of N-linked Glycosylation Machinery in Yeast Saccharomyces cerevisiae
  Poljak, Molecular & cellular proteomics : MCP 2018
  • “...Alpha-1,2-mannosyltransferase MNN5 Cell wall protein YJL171C Glucan 1,3-beta-glucosidase 2 Glucan 1,3-beta-glucosidase 2 Aspartic proteinase MKC7 Protein...”
• Isolation of native plasma membrane H+-ATPase (Pma1p) in both the active and basal activation states
  Pedersen, FEBS open bio 2018
  • “...Gas5p (cell wall protein) 51.8 kDa 13 YBR078W Ecm33p (cell wall protein) 48.2 kDa 5.8 YJL171C Toh1p (cell wall protein) 42.9 kDa 18 YGR282C Bgl2p (cell wall protein) 34.1 kDa 2.6 YNL055C Por1p (mitochondrial porin) 30.3 kDa 37 John Wiley & Sons, Ltd Transport coupling efficiencies...”
• Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
  Hua, Cell systems 2018
  • “...YCR043C, YDR084C, YKR067W, YJL196C, YLL061W, YML101C, YDL232W, YOL030W, YMR054W, YDR410C, YBR273C, YLR120C, YHR110W, YOR044W, YDL137W, YJL171C, YOR285W, YMR029C, YLR064W, YPL137C, YOR092W, YBR159W, YGL083W, YNL156C, YDL128W, YBR296C, YOR175C, YJL198W, YOL101C, YHL019C, YJL117W, YGR263C, YML059C, YOR214C, YNR013C, YOR087W, YJL192C, YGR177C, YBL102W, YPL195W, YLL052C, YLR390W-A, YDR264C, YOR299W, YMR152W, YLL055W,...”
• Differential Proteome Analysis of a Flor Yeast Strain under Biofilm Formation
  Moreno-García, International journal of molecular sciences 2017
  • “...wall proteins were also anchored membrane components, and six of them (Ccw14p, Crh1p, Ecm33p, Gas1p, YJL171C and YNL190W) were more abundant under BFC; and so were others involved in the synthesis of -glucans under NBFC (Skn1p, Gsc2p and kre6p). Furthermore, ten of the twenty-three cell wall...”
  • “..., Tef1p Respiratory chain Cor1p, Cyb2p Qcr6p Anchored component of membrane Crh1p, Dcw1p, Ecm33p, Plb1p, YJL171C, YNL190W Ccw14p , Cwp1p, Gas1p , Pst1p Gas3p, Gas5p Fungal-type cell wall Bgl2p, Crh1p, Ecm33p, Pho5p, Scw10p, Tos1p, YJL171C, YNL190W Ccw14p , Cwp1p, Exg1p, Gas1p , Pst1p, Scw4p , Ssa1p,...”
• Ecological interactions among Saccharomyces cerevisiae strains: insight into the dominance phenomenon
  Pérez-Torrado, Scientific reports 2017
  • “...cell wall damage 18 . A series of genes, namely CMK2, HSP150, PHO84, PRM10, PST1, YJL171C, YPS3, which were upregulated in conditions of transient cell damage 18 , were also upregulated in the non-dominant strain ( Table 1 ). Taken all together, these observations suggest that...”
  • “...B6 biosynthesis 3.6 3.0 YJL107C Putative protein of an unknown function 2.8 3.2 4.5 yes YJL171C GPI-anchored cell-wall protein of an unknown function 1.5 2.0 yes YJR061W Putative protein of an unknown function 2.3 1.9 2.3 YPS3 Aspartic protease from the cell wall 2.3 3.9 2.6...”
• Membrane Proteomics Analysis of the Candida glabrata Response to 5-Flucytosine: Unveiling the Role and Regulation of the Drug Efflux Transporters CgFlr1 and CgFlr2
  Pais, Frontiers in microbiology 2016
  • “...CAGL0E03201g CHO2 Ortholog(s) have phosphatidylethanolamine N-methyltransferase activity, role in phosphatidylcholine biosynthetic process 1.56 1.56 CAGL0M08206g YJL171c S. cerevisiae ortholog encodes a GPI-anchored cell wall protein of unknown function; induced in response to cell wall damage 0.59 0.5 CgHFD1 (CAGL0K03509g) HFD1 Putative mitochondrial fatty aldehyde dehydrogenase 0.29...”
• Antibodies elicited by yeast glycoproteins recognize HIV-1 virions and potently neutralize virions with high mannose N-glycans
  Zhang, Vaccine 2015
  • “...2.1. Cloning and protein expression and purification Genes encoding the yeast glycoproteins Pst1, Gp38, Ecm33, YJL171c and Gas1 were cloned into a modified pYES2/CT yeast expression vector with their endogenous signal sequence and a C-terminal 8His tag and Strep-II tag [ 24 ]. Each of the...”
  • “...proved to be inducible with galactose and was secreted into the culture media. Gp38, Ecm33, YJL171c and Gas1were purified using Ni-NTA tag affinity chromatography, while Pst1 was purified using SP-Sepharose C50 ion exchange media due to its high isoelectric point (pH 9.25). 2.2. Immunization of rabbits...”
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YJR1_YEAST / P46992 Cell wall protein YJL171C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
Aligns to 26:93 / 396 (17.2%), covers 98.4% of PF10290, 83.3 bits

• Quantitative Profiling of N-linked Glycosylation Machinery in Yeast Saccharomyces cerevisiae
  Poljak, Molecular & cellular proteomics : MCP 2018
  • “...P40533 P40557 P40557 P41543 P43561 P43561 P43611 P46982 P46992 P52911 P52911 P53379 P54003 Q03103 Q03281 Q03674 Q03674 Q03691 Q06689 GPI16 FET3 FET3 STT3 PLB1...”
• SWATH-MS Glycoproteomics Reveals Consequences of Defects in the Glycosylation Machinery
  Zacchi, Molecular & cellular proteomics : MCP 2016
  • “...similarity to TOH1 Also known as: JL171C, P46992. GPI-anchored cell wall protein; unknown function; sequence similarity to TOS1. GPI-anchored aspartic protease;...”
• Mapping yeast N-glycosites with isotopically recoded glycans
  Breidenbach, Molecular & cellular proteomics : MCP 2012
  • “...YHR202W P38887 Asn-305 YIL015W P12630 BAR1 Asn-268, 366, 398 YJL002C P41543 OST1 Asn-99, 400 YJL171C P46992 Asn-51, 99, 122, 174, 219, 249, 267, 300 YJL172W P27614 CPS1 Asn-176, 228 YJL192C P39543 SOP4 Asn-35 YKL039W P32857 PTM1 Asn-132 YKL046C P36091 DCW1 Asn-203, 240 YLR066W Q12133 SPC3 Asn-173...”
• An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies
  Luallen, Journal of virology 2008
  • “...numbers P38616 for Gp38 (15), P38248 for Ecm33 (55), P46992 for YJL171c (17), and P22146 for Gas1 (42). (B) The glycoproteins from TM cells were...”
  • “...17, 2017 by University of California, Berkeley P38616 P38248 P46992 P22146 Protein name proteins from SIV and some clade C isolates (data not shown). When the...”

PGA52 GPI-anchored cell surface protein from Candida albicans (see paper)
Aligns to 23:90 / 384 (17.7%), covers 96.8% of PF10290, 78.2 bits

• CharProtDB CGD description: GPI-anchored cell surface protein of unknown function; fluconazole-induced; possibly an essential gene, disruptants not obtained by UAU1 method

ARB_06390 hypothetical protein from Trichophyton benhamiae CBS 112371
Aligns to 37:97 / 440 (13.9%), covers 96.8% of PF10290, 71.6 bits

• RNA Sequencing-Based Genome Reannotation of the Dermatophyte Arthroderma benhamiae and Characterization of Its Secretome and Whole Gene Expression Profile during Infection
  Tran, mSystems 2016 (no snippet)

PPTG_16550 hypothetical protein from Phytophthora parasitica INRA-310
Aligns to 114:174 / 415 (14.7%), covers 88.9% of PF10290, 42.4 bits

• Transcriptomic and Ultrastructural Signatures of K+-Induced Aggregation in Phytophthora parasitica Zoospores
  Bassani, Microorganisms 2020
  • “..., 50 ]), a CRN effector (PPTG_07145; [ 51 ]), a TOS1-like glycosyl hydrolase effector (PPTG_16550; [ 52 ]), a cell-wall-degrading enzyme (PPTG_19098; [ 53 ]), a thioredoxin and a glutathione transferase (PPTG_08056 and PPTG_16940). Transcription of pathogenicity-related genes in zoospores, at such a high level,...”
• Bioinformatic characterisation of genes encoding cell wall degrading enzymes in the Phytophthora parasitica genome
  Blackman, BMC genomics 2014
  • “...predicted to act on hemicellulose or -1,3-glucans (described earlier). Of the two remaining GH16 proteins, PPTG_16550 has homology to TOS1-like proteins [e. g. NCBI: EMR65012 from Eutypa lata and NCBI: EJT42179 from Saccharomyces kudriavzevii ]. TOS1 proteins have some similarity to known -1,3-glucanases and mutation of...”
  • “...other GH16 protein [PPTG_03558] has a dbCAN value of 1.7e-05 and has some homology to PPTG_16550 and to non-CAZyme carboxypeptidases. There are 20 proteins in the GH17 family in P. parasitica , three of which [PPTG_18983, 09700 P10297 and 09701 P1569 ] also contain a CBM13...”

D0N3P2 Secretory protein OPEL from Phytophthora infestans (strain T30-4)
Aligns to 187:245 / 488 (12.1%), covers 84.1% of PF10290, 40.6 bits

• The Phytophthora infestans Haustorium Is a Site for Secretion of Diverse Classes of Infection-Associated Proteins
  Wang, mBio 2018
  • “...cysteine-rich protein SCR108 MAMP-like proteins D0P3R6 Elicitin-like protein INF4 D0NUD3 Elicitin-like protein D0NKU2 Elicitin-like protein D0N3P2 Secretory protein Opel D0P1U2 NPP1-like protein D0N0V1 NPP1-like protein Carbohydrate-active enzymes (CAZymes) D0MS99 Pectinesterase PE1 D0MQ88 Glucan 1,3-beta-glucosidase D0NCV1 Glucan 1,3-beta-glucosidase D0NSK6 Glycoside hydrolase D0N0L9 Glycosyl transferase D0NNQ8 1,3-Beta-glucanosyltransferase In...”

Or search for genetic data about PF10290 in the Fitness Browser