Family Search for PF10295 (DUF2406)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10295 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

YM8V_YEAST / Q03559 Uncharacterized protein YMR295C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YMR295C Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene from Saccharomyces cerevisiae
Aligns to 49:118 / 197 (35.5%), covers 100.0% of PF10295, 100.3 bits

• When Phosphatases Go Mad: The Molecular Basis for Toxicity of Yeast Ppz1
  Casamayor, International journal of molecular sciences 2022
  • “...eIF4G Ydr239c S257, S260, Y261 D Protein of unknown function that might bind to ribosomes Ymr295c S11, T13, S14 D Protein of unknown function that might bind to ribosomes ijms-23-04304-t002_Table 2 Table 2 Transcription factors (TF) controlling the set of genes upregulated by low glucose according...”
• Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell
  Ruta, Nutrients 2020
  • “..., 113 ]. The analysis identified seven previously unannotated proteins, Atg14, Rim20, Ret2, Spt21, Ylr257W, Ymr295c, and Ygr017w, as potential components of TOR-mediated rapamycin and caffeine signaling in S. cerevisiae . Study of Ylr257w would be particularly informative since it was the only protein whose removal...”
• The dynamic three-dimensional organization of the diploid yeast genome
  Kim, eLife 2017
  • “...S. cerevisiae copy of the region, ranging from a 20 kb region from NGL2 through YMR295C ( Figure 4figure supplement 1A ) to a single 1 kb intergenic region containing the promoters for HAS1 and TDA1 ( HAS1pr-TDA1pr ; Figure 4D ). Every deletion that included...”
• New Regulators of Clathrin-Mediated Endocytosis Identified in Saccharomyces cerevisiae by Systematic Quantitative Fluorescence Microscopy
  Farrell, Genetics 2015
  • “...YGR026Wb YBL029C-A YBR016Wa YDR090Cb YDR034W-Ba YDR033Wb YMR295C YDR344C YDR210Wa YLR413Wb YBR052C YLR407W YOL019Wb YOR161Cb YPL032C YGL108Cc YDR032C YLR353Wb...”
  • “...YGR065C YOR094W YER118C YLR429W YDR033W YDR388W YPR124W YMR295C YML016C YOR165W YMR266W YPR171W YML116W YNL087W YDR233C YDR093W YJR058C YDR344C YBR086C YDR210W...”
• Pichia pastoris regulates its gene-specific response to different carbon sources at the transcriptional, rather than the translational, level
  Prielhofer, BMC genomics 2015
  • “...cells); genes linked to ribosome association, interaction or biogenesis ( TMA108, DOT6, GDE1, TMA64, PAS_FragB_0030, YMR295C, MTC1, YOR019W, MTG1 ); negative regulation of RNA polymerase III transcription and TOR signaling ( KNS1 ); RRPE (ribosomal RNA processing element)-binding and glucose-induced transition from quiescence to growth (...”
• Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells
  Johnson, PloS one 2014
  • “...ROX1 YMR122W-A DPP1 OSH2 UBA1 ASP3-4 IMD4 RPS9A YMR265C DUF1 PAU17 UBC12 BTN2 IZH3 RSB1 YMR295C ECL1 PCL6 VBA3 BUD23 KTI11 SCS7 YNL155W ECM1 PDC6 VBA5 CAR1 LIP5 SCW10 YNL234W ECM4 PEP5 VPS13 CDC3 LSB1 SFK1 YNR014W EMC2 PGK1 VPS15 CHS1 MAL12 SFM1 YOL014W EMI5 PHO84...”
• Towards systematic discovery of signaling networks in budding yeast filamentous growth stress response using interventional phosphorylation data
  Zhang, PLoS computational biology 2013
  • “...4 FAP7, ITR1, LSB3, LEU1, FLC3, SPT6, YGR125W, CRP1, KEL1, LCB3, YBT1, BDF1, YMR031C, DDR48, YMR295C, GPD2, ZEO1, CAF20, SNF2 - 5 PIN4, CYC8, BUD3, LYS20, CDC34, MAK21, BFR2, SUM1, GLY1, NUP145, PRP43, SPT6, ENP2, YOR1, SSZ1, NUP2, YLR345W, SUB1, ESC1, BDP1, DCP2, RPC31, SLA2, NOP8,...”
• Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae
  Stewart-Ornstein, Molecular cell 2012
  • “...four histone proteins present in the dataset (Htz1, Hta2, Htb2) in addition to Tcb3 and YMR295C, two cell cycle regulated proteins ( Spellman et al., 1998 ). If the putative amino acid, mitochondrial, and stress responsive clusters are co-regulated as the noise analysis predicts, then the...”
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YGR273C Putative protein of unknown function; deletion mutant has no readily detectable phenotype from Saccharomyces cerevisiae
Aligns to 33:112 / 174 (46.0%), covers 98.4% of PF10295, 89.2 bits

• Isc10, an Inhibitor That Links the Anaphase-Promoting Complex to a Meiosis-Specific Mitogen-Activated Protein Kinase
  Rimal, Molecular and cellular biology 2020 (secret)
• Functional studies of the yeast med5, med15 and med16 mediator tail subunits
  Larsson, PloS one 2013
  • “...assembly, localizes to the cell wall YBR040W FIG1 Integral membrane protein required for efficient mating YGR273C IBI1 Putative protein of unknown function, expression downregulated by treatment with 8-methoxypsoralenplus UVA irradiation YFL012W NA Putative protein of unknown function, transcribed during sporulation YDR042C NA Putative protein of unknown...”
• Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications
  Patil, RNA biology 2012
  • “...PAU13 SSA4 YGL138C YOL155W-A ECM12 HXT12 PAU24 TSL1 YGR273C YOR214C FIT1 HXT5 PIR3 UBI4 YHR086W-A YOR268C FIT2 INO1 PTR2 XBP1 YJR005C-A YOR289W response...”
• Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast
  Dardalhon, FEMS yeast research 2007
  • “...and mitochondrial biogenesis. Twenty-nine genes were down-regulated. The strongest repression was 3.8-fold for the ORF YGR273c of unknown function. The analysis of the kinetics of gene induction following genotoxic damage was informative about the timing of events during the posttreatment period. Indeed, 41 genes were induced...”
• Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3'-extension of 5S rRNA in Saccharomyces cerevisiae
  Nariai, Nucleic acids research 2005
  • “...insert DNA corresponds to chromosome VII from 1037596 to 1048620, including YGR271c-A , YGR272c , YGR273c , TAF1 , RTT102 , REX1 , YGR277c and CWC22 . Subcloning revealed that the complementing activity was contained in REX1/RNH70/YGR276c (data not shown). In order to confirm that the...”
• Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression
  Pierce, Molecular and cellular biology 2003
  • “...YER106W YJL038C YJR025C YGL230C YHR147C YFR023W YDL114W YGR273C YOL047C YJL043W YJR078W YBR180W YGL015C YKL178C YBR040W YPR054W YOL024W YIR027C YMR096W YOL091W...”
  • “...YNL319W BNA5 MAM1 YJL038C BNA1 YGL230C MRPL6 PES4 YDL114W YGR273C YOL047C YJL043W BNA2 DTR1 YGL015C STE3 FIG1 SMK1 YOL024W DAL1 SNZ1 SPO21 YGR259C TNA1 SP075...”
• Disruption of six novel genes from chromosome VII of Saccharomyces cerevisiae reveals one essential gene and one gene which affects the growth rate
  Fiori, Yeast (Chichester, England) 2000 (PubMed)
  • “...mutants was analysed. Disruptions of ORFs YGR256w, YGR272c, YGR273c, YGR275w and YGR276c were carried out using the disruption marker kanMX4 anked by short...”
  • “...be associated to the inactivation of ORFs YGR256w, YGR273c, YGR275w and YGR276c. Two of these genes have recently been further characterized: ORF YGR255w,...”

YHY4_SCHPO / O60153 Uncharacterized protein C19C7.04c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPBC19C7.04c conserved fungal protein from Schizosaccharomyces pombe
Aligns to 12:72 / 124 (49.2%), covers 98.4% of PF10295, 62.4 bits

• subunit: Interacts with dil1.
• An essential role for the Ino80 chromatin remodeling complex in regulation of gene expression during cellular quiescence
  Zahedi, Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2023
  • “...1,6382E-05 SPNCRNA.1530 II 2580400 2581182 SPNCRNA.1530 9,90488058 0,0021415 SPBC25B2.08 II 2611366 2612917 SPBC25B2.08 2,18518869 0,00197078 SPBC19C7.04c II 2825251 2826700 SPBC19C7.04c 2,71034397 0,00015799 SPNCRNA.1564 II 2934727 2935979 SPBC1703.11-antisense-1 2,52684517 0,00180399 SPNCRNA.1573 II 3020526 3022271 SPBC15D4.05-antisense-1 6,22415483 4,9082E-12 SPNCRNA.413 II 3150075 3150475 SPNCRNA.413 2,82207927 0,00847413 SPBC13A2.04c II 3405575...”
• Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription
  Heo, Cell reports 2021
  • “...where annotated genes are organized in convergent orientation ( FigureS2 D), such as cyr1 - spbc19c7.04c ( Figures 5 A and 5B). Because RNA-seq cannot reliably map the TSS of novel transcripts seen in ssu72 , novel antisense transcripts could result either from the new transcription...”
  • “...browser tracks for representative loci ( cyr1 and pom152 ) and their neighboring genes ( spbc19c7.04c and spncrna.1527 ). The tracks of WT, ssu72 , hos2 , and hos2 ssu72 are blue, red, green, and crimson, respectively. For each gene, seven tracks are presented, as follows:...”
• Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22
  Benjamin, PLoS genetics 2021
  • “...pho1 mRNA promoter, thereby enhancing lncRNA interference with mRNA expression. The Pombase annotation of the SPBC19C7.04c gene, which was downregulated ~8-fold in DPS mutants, suggests that it, too, might be subject to upstream transcription interference. SPBC19C7.04c encodes a 124-amino acid conserved fungal protein. The SPBC19C7.04c mRNA...”
  • “...The 5-flanking gene, SPNCRNA.1553, specifies a 2044-nucleotide lncRNA that overlaps the putative 5-UTR of the SPBC19C7.04c mRNA. 10.1371/journal.pgen.1009452.g003 Fig 3 Coding genes down-regulated in DPS mutants. (A) Venn diagram depicting numbers of overlapping and non-overlapping down-regulated protein-coding genes. (B) List of 40 protein-coding genes that were...”
• A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast
  Kim, Aging 2014
  • “...1 SPBC1289.14 oxidation-reduction 3 SPBC1198.01, but1, SPAC5H10.04 others 18 SPAC869.06c, SPAPB18E9.04c, SPBPB21E7.02c, SPBPB21E7.04c, SPAC1F7.06, SPAPB18E9.03c, SPBC19C7.04c, SPAC4F10.17, SPAC1093.01, SPAC11D3.02c, SPAC15F9.01c, SPAC9E9.01, SPAC30D11.02c, SPBC530.07c, SPCPB16A4.06c, mug138, SPCC417.12, SPAC1142.01 Table 2 Functional categories of 97 genes higher expressed in phx1 Function Number of genes Gene ID or Name...”
• Genomic binding profiling of the fission yeast stress-activated MAPK Sty1 and the bZIP transcriptional activator Atf1 in response to H2O2
  Eshaghi, PloS one 2010
  • “...Dependency b Product 1 25 SPBC106.02c|srx1 Atf1 sulfiredoxin 2 39 SPBC660.07|ntp1 Atf1 alpha,alpha-trehalase 3 47 SPBC19C7.04c Atf1 unknown 4 50 SPAC22H12.01c Atf1 unknown 5 53 SPBC30D10.14 Atf1 dienelactone hydrolase family 6 60 SPCC70.08c Atf1 methyltransferase (predicted) 7 77 SPBC16A3.02c Atf1 mitochondrial peptidase (predicted) 8 57 SPAC23G3.03|sib2...”
• Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation
  Nugent, BMC genomics 2010
  • “...SPBC1773.06c 2.76 0.000469242 SPAPB8E5.10 3.98 1.31E-12 SPBPB2B2.02 2.06 0.000305555 SPBC1685.05 2.86 1.62E-11 SPBC16E9.16c 4.00 6.07E-13 SPBC19C7.04c 2.09 0.001283597 SPAC4F10.17 2.88 6.57E-09 SPAC29A4.12c 4.06 1.45E-09 SPAC5H10.04 2.10 1.33E-06 SPCC16A11.15c 2.94 5.09E-11 SPAC869.08 4.08 1.01E-15 SPBC947.05c 2.11 5.62E-08 SPCC1739.08c 2.96 0.021512753 SPBC3H7.08c 4.09 9.33E-14 SPAC3H8.09c 2.11 1.77E-10 SPAC23C11.06c...”
• Global transcriptional response after exposure of fission yeast cells to ultraviolet light
  Skjølberg, BMC cell biology 2009
  • “...may have a role in mating efficiency Protein of unknown function SPAPB18E9.03c SPNCRNA.101 SPAC18G6.09c SPAPB1A10.06 SPBC19C7.04c SPAC17A5.8 SPAC23H3.15c SPCC2H8.01 SPAC8C9.10c Gene annotations are from GeneDB http://www.genedb.org/genedb/pombe/index.jsp . Profile analyses To further analyse the kinetics of gene expression in the time-course experiment we applied the software package...”
• Functional comparison of the Tup11 and Tup12 transcriptional corepressors in fission yeast
  Fagerström-Billai, Molecular and cellular biology 2005
  • “...SPAC27D7.10c SPAC27D7.11c SPBC1105.01 SPBC15D4.02 SPBC19C7.04c SPBC646.06c SPMIT.05 SPAC13F5.03c SPAC23D3.12 SPAC2E1P3.05c SPBC713.12 SPBC106.02c SPBP4G3.02...”
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MUG9_SCHPO / O94243 Meiotically up-regulated gene 9 protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 16:75 / 208 (28.8%), covers 93.8% of PF10295, 50.3 bits

• function: Has a role in meiosis.

Or search for genetic data about PF10295 in the Fitness Browser