Family Search for PF10300 (Iml2-TPR_39)
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PF10300 hits 19 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
TT39B_MOUSE / Q8BYY4 Tetratricopeptide repeat protein 39B; TPR repeat protein 39B from Mus musculus (Mouse) (see paper)
Aligns to 75:533 / 617 (74.4%), covers 99.8% of PF10300, 614.5 bits
- function: Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3).
disruption phenotype: Chow-fed deficient mice display increased HDL- cholesterol level, accompanied by increased ABCA1 and MYLIP expression, increased oxysterols receptors LXR (NR1H3 and NR1H2) protein level without change in NR1H2/3 mRNA levels. Many NR1H2/3 targets are up- regulated, including ABCG5/8, SCD1, ELOVL5, INSIG2 and LPCAT3. Deficiency of TTC39B reduced processing of SREBP1 a pivotal regulator of lipogenesis. When fed with a high-fat/high-cholesterol/bile-salt diet during 20 weeks, used as a model of steatohepatitis resembling human non-alcoholic steatohepatitis, mice show increased HDL cholesterol and APOA1 levels, reduced VLDL (very low density lipoprotein), and reduced mortality compared with wild-type. The livers of deficient mice shown diminished hepatic triglyceride and cholesteryl ester accumulation, fewer inflammatory foci consisting of neutrophils and lymphocytes, less hepatocellular ballooning degeneration and less hepatocyte proliferation compared to control. Knockout mice lacking both TTC39B and LDLR, fed a Western diet for 20 weeks, exhibit a reduction in LDL-cholesterol, but plasma triglyceride levels are not different. Atherosclerotic lesion area of the aorta are reduced compared to LDLR single knockout mice.
YKR18_YEAST / P36114 IML2-like protein YKR018C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
Aligns to 36:629 / 725 (81.9%), covers 99.8% of PF10300, 469.1 bits
IML2_YEAST / P47031 Inclusion body clearance protein IML2; Increased minichromosome loss protein 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 38:634 / 731 (81.7%), covers 99.8% of PF10300, 453.0 bits
- function: Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.
subunit: Interacts with lipid droplet proteins PET10 and PDR16.
Or search for genetic data about PF10300 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory