Family Search for PF10303 (DUF2408)

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PF10303 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CUB1_YEAST / Q08977 Cu(2+) suppressing and bleomycin sensitive protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YPL260W Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene from Saccharomyces cerevisiae
3 alignments in 209:525 / 551 (57.5%), covering up to 100.0% of PF10303, 211.6 bits

• function: Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.
  subunit: Monomer.
  disruption phenotype: Leads to sensitivity to bleomycin (Ref.7). Bleomycin sensnsitivity is even increased when CUB1 deletion is combined with proteasome mutants including PRE9 or UMP1 disruptions (Ref.7). Suppresses the copper tolerance induced by the proteasome subunit PRE9 disuption (Ref.7). Leads to synthetic sickness with deletion of RAD6 on media containing bleomycin, but not hydroxyurea (HU) (Ref.7).
• Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis
  Martínez-Matías, Scientific reports 2021
  • “...ALD4, TDH1, SSA4, CTT1, TSL1, HSP78, GPH1, GLK1, PRB1, YML131W, PGM2, YMR196W, TPS2, HSP150, VPS13, YPL260W ) and 6 upregulated genes (i.e. RPS20, IPI3, SND3, RPL3, PHB2, YBL036C ) contained at least one STRE, indicating that other signaling systems are also involved in regulating the mtl1...”
• Condition-Specific Modeling of Biophysical Parameters Advances Inference of Regulatory Networks
  Tchourine, Cell reports 2018
  • “...TIR2 0.27 EHT 1 0.59 GCY1 0.11 KIN3 0.75 NCP1 0.13 ADE3 0.10 GNP1 0.21 YPL260W 0.25 PHO90 0.19 FHN1 0.35 FIG1 0.26 YIP3 0.55 FMP48 0.11 HST3 0.67 YGL108C 0.13 SLP1 0.10 DAL80 0.18 ILV1 0.22 MCH5 0.16 (A) New targets (i.e., interactions not in...”
• The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock
  Garre, PLoS genetics 2018
  • “...* YBR225W Uncharacterized 0,32 0,17 0,16 0,00 2,98 * 2,11 * 2,29 * 1,42 * YPL260W Uncharacterized 2,52 * 1,46 * 1,89 * 0,83 * 3,08 * 2,45 * 1,80 * 1,18 * SRC1 Linked to TREX 3,25 * 1,77 * 2,97 * 1,49 * 2,66...”
• Global alterations of the transcriptional landscape during yeast growth and development in the absence of Ume6-dependent chromatin modification
  Lardenois, Molecular genetics and genomics : MGG 2015
  • “...the kinetochore-associated Ndc80 complex). This CC also highlights possible functions for two poorly characterized proteins (Ypl260w, Ylr456w) in meiotic cell division because they interact with Ndc80. Network interactions identify hub proteins among Ume6 target genes that are relevant for the ume6 / ume6 mutants growth and...”
• Genomic analysis of Saccharomyces cerevisiae isolates that grow optimally with glucose as the sole carbon source
  Aragon, Electrophoresis 2012
  • “...the regulation of growth as well as nutrient sensing in yeast [ 11 ]. Furthermore, YPL260w, which is a putative substrate of cAMP-dependent protein kinase (PKA) [ 12 ] was also identified, where PKA is known to regulate cellular growth in response to available nutrients [...”
  • “...in protein degradation UBP3 Pro407Ser Ubiquitin-specific protease VPS41 Asn928Ser Vacuolar membrane protein YPR114w Ser110Gly Unknown YPL260w Met241Lys Putative substrate of cAMP-dependent protein kinae (PKA) YJR061w Phe555Leu Unknown TBS1 Asn1013Asp Unknown 1 Saccharomyces Genome Database Table 3 Significant gene expression changes in gene ontology categories determined using...”
• Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli
  Okagaki, Eukaryotic cell 2011
  • “...(CNAG_04455) Expressed sequence AA960436 (CNAG_01624) ypl260W (CNAG_05236) yor378W07-A (CNAG_03713) tpo105 (CNAG_04546) rim10102 (CNAG_05431) fms102...”
• Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae
  Westmoreland, PloS one 2009
  • “...RTG1, SER1, SPT20, TAF14, TCM62, TFP3, THP1, TRK1, VMA6, YCL007C, YDR049W, YGR160W, YNL140C, YOL046C, YOR152C, YPL260W, YPL261C AAK1, CSNK2B, CSNK2B, CYLC1, POU2F1, CRKRS, ATP6V1D, BTF3L4, ERGIC2, none, PPOX, HIST1H4A, TRIAP1, none, N6AMT1, GCN20, PIAS4, PASK, PUS1, PUS7, FAM135A, HLTF, POLR1E, RPL12, RPL13, RPL18A, RPLP1, none, PSAT1,...”
• An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase
  Budovskaya, Proceedings of the National Academy of Sciences of the United States of America 2005
  • “...PSP1, YBL029w, YBR028c, YHR032w, YJL046w, YLL029w, YLR177w, YLR419w, YPL260w The genes encoding the 5 proteins previously shown to be substrates of PKA are...”
• Insight into the Antioxidant Effect of Fermented and Non-Fermented Spirulina Water and Ethanol Extracts at the Proteome Level Using a Yeast Cell Model
  Masten, Antioxidants (Basel, Switzerland) 2021
  • “...chain (Tub1) Phagosome function RVB1 Q03940 RuvB-like protein 1 (Rvb1) DNA damage, DNA repair CUB1 Q08977 Cu (2+) suppressing and bleomycin sensitive protein 1 (Cub1) DNA repair and/or proteasome function NAS2 P40555 Probable 26S proteasome regulatory subunit p27 (Nas2) Proteasome regulatory complex assembly NAS6 P50086 Probable...”

CNAG_05236 hypothetical protein from Cryptococcus neoformans var. grubii H99
2 alignments in 190:462 / 462 (47.6%), covering up to 99.2% of PF10303, 179.8 bits

• Identification of Disease-Associated Cryptococcal Proteins Reactive With Serum IgG From Cryptococcal Meningitis Patients
  Gressler, Frontiers in immunology 2021
  • “...ATP binding 0005524 ( 45 , 65 ) Extracellular vesicle ( 76 ) Hypothetical protein CNAG_05236 52,24 AFR94491 x x x Fumarate hydratase 4.2.1.2 No data available Hypothetical protein CNAG_06113 36,61 AFR98337 x x x No data available RNA binding 0003723 Extracellular vesicle ( 76 )...”
• Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli
  Okagaki, Eukaryotic cell 2011
  • “...Expressed sequence AA960436 (CNAG_01624) ypl260W (CNAG_05236) yor378W07-A (CNAG_03713) tpo105 (CNAG_04546) rim10102 (CNAG_05431) fms102 (CNAG_05027) cnh3700...”

CUB1_SCHPO / Q9P6K3 CUB1 family protein C30C2.08 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
2 alignments in 172:453 / 457 (50.1%), covering up to 99.2% of PF10303, 179.3 bits

• function: Involved in bleomycin tolerance with links to DNA repair and/or proteasome function.

C0NGE0 Aconitate hydratase from Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
2 alignments in 10:346 / 1174 (25.6%), covering up to 96.9% of PF10303, 116.3 bits

• Antibody Binding Alters the Characteristics and Contents of Extracellular Vesicles Released by Histoplasma capsulatum.
  Matos, mSphere 2016

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