Family Search for PF10332 (DUF2418)

PF10332 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

MU154_SCHPO / P87236 Meiotically up-regulated gene 154 protein from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
SPCC4G3.11 conserved fungal protein from Schizosaccharomyces pombe
Aligns to 146:239 / 316 (29.7%), covers 97.9% of PF10332, 101.4 bits

• function: Has a role in meiosis.
• Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance
  Deshpande, DNA repair 2009
  • “...0.8 CEP Aprataxin 21 SPCC594.02c 0.8 CFP 22 SPBC21.02 0.8 CEF Contains TLD domain 23 SPCC4G3.11 10 CFP * Status from GeneDB. CEP:Conserved Eukaryotic Protein; CFP: Conserved Fungal Protein; SO: Sequence Orphan...”

NUR1_YEAST / Q12066 Nuclear rim protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
YDL089W Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate from Saccharomyces cerevisiae
NP_010194 Nur1p from Saccharomyces cerevisiae S288C
Aligns to 228:318 / 484 (18.8%), covers 89.6% of PF10332, 74.9 bits

• function: Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
  subunit: Interacts with CSM1.
• The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis
  Koch, Nucleus (Austin, Tex.) 2020
  • “...MAT a VPS15 YBR170C MAT a NPL4 YDL019C MAT a OSH2 YDL088C MAT a ASM4 YDL089W MAT a NUR1 YDL116W MAT a NUP84 YDR073W MAT a SNF11 YDR120C MAT a TRM1 YDR159W MAT a SAC3 YDR192C MAT a NUP42 YDR395W MAT a SXM1 YDR410C MAT a...”
• High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division
  Dickerson, BMC cell biology 2016
  • “...PolII enrichments at the integration sites of the 70.6kb strain. TetO array was integrated between YDL089w and YDL088c, and lacO array was integrated between YDL055c and YDL054c. (C) PolII enrichments at the integration sites of the 25.3kb strain. This strain is flanked by the ura3-1 point...”
• Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae
  Leung, G3 (Bethesda, Md.) 2014
  • “..., SER2 , SLX9 , SLY41 , SPF1 , SUR4 , SWI4 , URE2 , YDL089W RTT107 HU Positive AEP2 , AIM26 , ARO1 , ARP7 , BTS1 , BUB3 , BUD21 , BUD6 , BUL1 , CDC48 , CYC8 , CYK3 , CYT1 , DBP1...”
• cis- and trans-acting localization determinants of pH response regulator Rim13 in Saccharomyces cerevisiae
  Subramanian, Eukaryotic cell 2012
  • “...common ancestor of the ascomycetes, RIM13 is flanked by YDL089W and YDL090C. In S. cerevisiae, RIM13 is flanked by YMR153W and YMR155W, which are not homologous...”
• Predicting multiplex subcellular localization of proteins using protein-protein interaction network: a comparative study
  Jiang, BMC bioinformatics 2012
  • “...cellular bud neck (IDA) cellular bud neck septin collar (IDA) incipient cellular bud site (IDA) YDL089W ambiguous; nuclear periphery Membrane nuclear periphery (IDA) Unknown YDR069C ambiguous; endosome Cytoplasm. Late endosome membrane; endosome (IDA) membrane fraction (IDA) proteasome complex (IPI) mitochondrion (IDA) YDR507C ambiguous;bud bud neck;cytoplasm Cytoplasm....”
• A regression model approach to enable cell morphology correction in high-throughput flow cytometry
  Knijnenburg, Molecular systems biology 2011
  • “...Eaf6 Nat3 Yaf9 Chd1 Mlp2 Set3 Nat5 Arp6 Nto1 Snf6 Pip2 Htz1 Vps71 Eaf7 Nup42 Ydl089w Dyn2 Nap1 Sgf11 Asf1 Nup120 Snt1 Swc3 Ies1 Gtt3 Pex3 Gfd1 Nat4 Snf11 Cdc73 Nup133 Spt20 Vps75 Ngg1 Hst1 Pml39 Hat1 Nhp10 Snf2 Eaf3 Nup84 Swc5 Nup2 Ioc2 Rad54 Hat2...”
• The nuclear envelope in genome organization, expression and stability
  Mekhail, Nature reviews. Molecular cell biology 2010
  • “...; also known as Src1) and nuclear rim 1 ( Nur1 ; also known as YDL089W), forming a complex called CLIP (chromosome linkage INM proteins) ( FIG. 2 ). Heh1, the orthologue of human MAN1, is a member of a family of INM proteins containing a...”
  • “...helix 1 (Heh1; also known as Src1) and nuclear rim 1 (Nur1; also known as YDL089W)), linking rDNA repeats to the nuclear envelope 4 , 68 (2). CLIP is required for the maintenance of rDNA repeat stability but not for silencing at IGS1 (REF. 4 )....”
• Role for perinuclear chromosome tethering in maintenance of genome stability
  Mekhail, Nature 2008
  • “...Nucleolus rDNA ribosomal RNA genes copy number unequal recombination silencing heterochromatin chromosome Heh1 Man1 Nur1 Ydl089w CLIP LEM domain HEH fold Emerin Sir2 SIRT1 RENT Net1 Cdc14 nuclear envelope perinuclear nuclear periphery Eukaryotic rDNA is tandemly repeated anywhere from 100 to over 10,000 times 8 ....”
  • “...INM proteins Heh1 (helix extension helix 1, also called Src1) and Nur1 (nuclear rim 1, Ydl089w) ( Fig. 1c, d ; Supplementary Table 1 , part A) 16 . Heh1, the orthologue of human Man1, is a member of a family of INM proteins containing a...”
• More
• Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast.
  Godfrey, PLoS genetics 2015
  • GeneRIF: Nur1 dephosphorylation thus describes a positive feedback loop in Cdc14 phosphatase activation during mitotic exit, required for faithful chromosome segregation and completion of the cell division

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