Family Search for PF10336 (DUF2420)

PF10336 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

RMR1_YEAST / P53060 Reduced meiotic recombination protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
YGL250W Putative protein of unknown function; deletion mutant results in reduced PIS1 expression and has growth defects on non-fermentable carbon sources and on minimal media; GFP-fusion protein localizes to both the cytoplasm and the nucleus from Saccharomyces cerevisiae
Aligns to 84:193 / 241 (45.6%), covers 99.1% of PF10336, 120.9 bits

• function: Required for normal levels of gene conversion events during meiosis.
• Genome-Scale Screening of Saccharomyces cerevisiae Deletion Mutants to Gain Molecular Insight into Tolerance to Mercury Ions
  Xian, Journal of fungi (Basel, Switzerland) 2024
  • “...YIR023W DAL81 YNR052C POP2 YDR457W TOM1 YGR056W RSC1 YML007W YAP1 Cell cycle (8) YBL031W SHE1 YGL250W RMR1 YHR030C SLT2 YPL161C BEM4 YAL024C LTE1 PHO85 PHO85 YGL019W CKB1 YNL271C BNI1 Protein synthesis, folding, modification, and destination (7) YBL022C PIM1 YEL036C ANP1 YKL134C OCT1 YPL090C RPS6A YBR044C TCM62...”
• FunPred 3.0: improved protein function prediction using protein interaction network
  Saha, PeerJ 2019
  • “...Carbohydrate metabolism YLR039c YIL039w Vesicular transport Two hybrid YMR307w YHR004c Two hybrid Carbohydrate metabolism YDL003w YGL250w Two hybrid Energy generation YNL271c YGR228w Meiosis Cell polarity Protein modification YML094w YBR108w Unable to predict YEL003w YDR334w Unable to predict All the proteins belonging to M mutually exclusive protein...”
• Exploring the mode of action of antimicrobial peptide MUC7 12-mer by fitness profiling of Saccharomyces cerevisiae genomewide mutant collection
  Lis, Antimicrobial agents and chemotherapy 2009
  • “...YOR035C YCR068W YBR291C YNR052C YNL147W YIL148W YHR021C YGL250W YCR045C YCR087C-A YCR050C YNL025C YDR414C YCR036W YMR154C YHL009C YBR290W YCL001W-A YDR069C...”
• Novel roles for selected genes in meiotic DNA processing
  Jordan, PLoS genetics 2007
  • “...gene conversion compared to the wild type ( Figure 2 B, Table 1 ) for ygl250w (6-fold), soh1 (>250-fold), and bre5 (>250-fold). Further analysis of these mutants is discussed below. Six mutants ( bre1 , vid21 , sgf73 , rmd11 , def1 , and lge1 )...”
  • “...analyses of these genes' roles in DNA processing are discussed below. Figure 2 Assessment of YGL250W , SOH1 , and BRE5 (A) Schematic representation of Chromosome II from the diploid W303 background which consists of two LYS2 heteroalleles ( lys25nde I and lys23nde I ). These...”
• Genomic analysis of PIS1 gene expression
  Gardocki, Eukaryotic cell 2005
  • “...YOR315W YPL162C YPL166W YPR151C NYV1 PAC1 RIF1 YDR445C YDR521W YGL250W YLL032C YLL054C YLL057C YPL144W TCM1 gene fused in frame to the lacZ reporter gene in...”
• Genome-wide analysis of the relationship between transcriptional regulation by Rpd3p and the histone H3 and H4 amino termini in budding yeast
  Sabet, Molecular and cellular biology 2004
  • “...However, for only seven genes (PGM1, FOX2, ECI1, YGL250W, YJL163C, YLR446W, and YNL033W) were the individual intact histone amino termini dispensable for...”
• Functional genomics reveals relationships between the retrovirus-like Ty1 element and its host Saccharomyces cerevisiae
  Griffith, Genetics 2003
  • “...KTI12, THP2 YBR077c, YDL115c, YDR496c, YFL032w, YGL250w, YGR064w, YKL053c-A, YLR052w, YLR322w, YML010c-B, YNL226w, YNL228w, YNL295w, YOL159c, YOR292c, YPL080c...”

SPCC1442.04c conserved fungal protein from Schizosaccharomyces pombe
Aligns to 232:330 / 409 (24.2%), covers 95.4% of PF10336, 64.2 bits

• Fission yeast Caprin protein is required for efficient heterochromatin establishment
  Zhang, 2024
• Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast
  Taglini, Nucleic acids research 2020
  • “...levels at several well-characterised HOODs revealed locus-specific effects of Mkt1 loss. At the meiotic gene SPCC1442.04c, H3K9me2 was completely abolished in the absence of Mkt1, the same as in dcr1 cells. In contrast, at two HOODs associated with Tf2 retroelements, Tf23 and Tf25, as well as...”
  • “...is generally required for maintenance of HOODs, the HOOD that we found to be Mkt1-dependent (SPCC1442.04c), was notable in a previous analysis for being Red1-independent ( 23 ). These findings are therefore suggestive of Mkt1 functioning in a parallel pathway to Red1 in the regulation of...”
• The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly
  Chang, Cell reports 2017
  • “...wild type. This was especially prominent in ectopic small RNA from the myb2 , and SPCC1442.04c genes as well as tf2 elements, which only occur in rrp6 mutant cells ( Yamanaka et al., 2013 ), suggesting they might be degraded by the exosome in wild type...”
• Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly
  Sugiyama, Molecular cell 2016
  • “...( HOOD-12 ), which is Mmi1-dependent, was abolished in erh1 rrp6 , whereas H3K9me2 at SPCC1442.04c ( HOOD-31 ) and the Tf2-5 retrotransposon ( HOOD-10 ), both of which are Mmi1-independent, was slightly increased ( Figures 7A and S7F ). Consistent with this, small RNAs derived...”
• Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing
  Chalamcharla, Proceedings of the National Academy of Sciences of the United States of America 2015
  • “...loci, including sexual differentiation genes such as myp2 and spcc1442.04c as well as Tf2 retrotransposons (Fig. 3A, Fig. S3, and Table S1). We then examined...”
  • “...this question, we performed 3 RACE of the spcc1442.04c transcript, which contains cryptic introns that promote RNAi-mediated generation of small RNAs and...”
• RNAi triggered by specialized machinery silences developmental genes and retrotransposons
  Yamanaka, Nature 2013
  • “...with degradation products ( Supplementary Fig. 2 ). Ago1-dependent production of siRNA from myp2 and SPCC1442.04c was confirmed by Northern blot ( Fig. 1c ), and is required for H3K9me at these loci ( Fig. 1d and Supplementary Fig. 3a ). In rrp6 + cells, loss...”
  • “...severe defects in silencing of Tf2 and sexual differentiation genes (e.g. mug5, mcp3, mek1 and SPCC1442.04c ), in contrast to mild or no defects in single mutants ( Fig. 3 and Supplementary Fig. 6c ). Transcript levels were higher when rrp6 was combined with RNAi mutants...”
• Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance
  Lee, Cell 2013
  • “...analyses of RNA-Seq data from wild-type and mutants revealed unannotated cryptic introns in Tf2 and SPCC1442.04c loci showing siRNA clusters ( Figures 6C and S5A ). Unlike known introns, splicing of cryptic introns in Tf2 and SPCC1442.04c is detected in a small fraction of total reads....”
  • “...splicing was not detected in nrl1 , even amongst a greater number of Tf2 and SPCC1442.04c sequencing reads as compared to wild type ( Figure 6C ). We asked whether the introns in RNAi-targeted loci are involved in generation of small RNAs and H3K9me. Deletion of...”
• Reduction of ribosome level triggers flocculation of fission yeast cells
  Li, Eukaryotic cell 2013
  • “...of these upregulated genes, mug57, mug97, mei4, and SPCC1442.04c, were common to both sexually and nonsexually flocculating cells. In addition, seven genes...”
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