Family Search for PF10348 (DUF2427)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10348 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

YBH6_SCHPO / O59714 Uncharacterized membrane protein C3B8.06 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPBC3B8.06 conserved fungal protein from Schizosaccharomyces pombe
Aligns to 15:118 / 511 (20.4%), covers 94.3% of PF10348, 95.1 bits

• The Natural Product Resveratrol Inhibits Yeast Cell Separation by Extensively Modulating the Transcriptional Landscape and Reprogramming the Intracellular Metabolome
  Wang, PloS one 2016
  • “...(from left to right): wild-type, SPAC24B11.12c, rho4, hht3,pof3, isp6, pmc1, SPBC21B10.13c, mfm2, SPBC19G7.04, ste7, spd1, SPBC3B8.06, SPBC1773.02c, SPBC800.11, SPAC6F6.13c, dak2, plr1, SPBC119.03, cdm1, chs2, SPBC25B2.08, SPBC27.05, gpx1, klp6, SPBC839.02, pho1, gal1, SPBPB2B2.18, SPCPB1C11.02, SPCC1183.11, SPAC9E9.04, bgs4, SPAPB24D3.07c, SPBC2A9.13, SPBC31F10.17c, cys11, SPCC757.12, SPAC24H6.13, SPCC965.06, SPBC28F2.11, ctr4, ace2,...”
• Cross-species Functionome analysis identifies proteins associated with DNA repair, translation and aerobic respiration as conserved modulators of UV-toxicity
  Rooney, Genomics 2011
  • “...slightly Rga9 RhoGAp, GTPase activator towards Rho/Rac/Cdc42-like small GTPases slightly Thi5 transcription factor Thi5 slightly Spbc3b8.06 conserved fungal protein slightly Coq2 para-hydroxybenzoate--polyprenyltransferase Coq2 slightly Pof3 F-box protein Pof3 slightly Oca2 serine/threonine protein kinase Oca2 slightly Lyn1 sequence orphan slightly Spac14c4.12c SWIRM domain protein slightly Kap1 chromatin...”

YCV1_YEAST / P25639 Uncharacterized membrane protein YCR061W from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YCR061W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern from Saccharomyces cerevisiae
Aligns to 85:189 / 631 (16.6%), covers 96.2% of PF10348, 94.3 bits

• Identification of Genes in Saccharomyces cerevisiae that Are Haploinsufficient for Overcoming Amino Acid Starvation
  Bae, G3 (Bethesda, Md.) 2017
  • “...YCR061W has no known function. The protein appears to be a multi-pass membrane protein (UniProt P25639; UniProt Consortium 2015 ). In a large-scale survey of GFP-tagged proteins, Ycr061w showed cytoplasmic localization ( Huh et al. 2003 ). The YCR061W gene was also found to be under...”
• Large-scale genomic rearrangements boost SCRaMbLE in Saccharomyces cerevisiae
  Cheng, Nature communications 2024
  • “...with segment 73 (Fig. 4c ). A rearrangement between synIII and chrIII, in which the YCR061W gene was from synIII and its neighboring gene YCR065W was from chrIII (Fig. 4c ), was also observed. However, no loxPsym sequence were detected at the breakpoint, which suggested that...”
• Meiotic prophase length modulates Tel1-dependent DNA double-strand break interference
  Ruiz, 2023
• Oxidative Stress Responses and Nutrient Starvation in MCHM Treated Saccharomyces cerevisiae
  Ayers, G3 (Bethesda, Md.) 2020
  • “...Ion Transporter/Metal Homeostasis: PHO84 Miscellaneous Function: MOG1 Miscellaneous Function: XYL2 BUD30 VVS1 (YBR241C) GUA1 TVS1 (YCR061W) PRM7 YHI9 SAM1 The other major insight of the combined screen and upregulation datasets is the presence of several amino acid biosynthetic genes. Many of these genes fall under the...”
  • “...a v acuolar protein v ital for s tress response, we named it Vvs1 . Ycr061w localizes to cytoplasmic puncta that do not appear to be vacuoles but instead vesicles ( Huh et al. , 2003 ; Tkach et al. , 2012 ). Ycr061w contains 10-11...”
• tRNA Genes Affect Chromosome Structure and Function via Local Effects
  Hamdani, Molecular and cellular biology 2019
  • “...in expression levels Q value Gene Upregulated YCR061w YDL124w YHR214c-B YNL160w YOR201c YOR202w YPL240c Likelihood ratio test Wald test Beta statistic...”
• Monitoring Protein Dynamics in Protein O-Mannosyltransferase Mutants In Vivo by Tandem Fluorescent Protein Timers
  Castells-Ballester, Molecules (Basel, Switzerland) 2018
  • “...those, the tFT-fusion proteins Pmt3, Tsc3, Kre6, Opy2, Vth2, Ted1, Fab1, Lam6, YNL058c, Coy1, Osm1, YCR061w, Sec12, Nis1, and Mnl2 showed the strongest changes ( Supplemental Table S1 ; net -score > 0.5; p -value < 0.1). According to TOPCONS [ 25 ], C-terminal tFT reporter...”
  • “...11 (Jem1, Emp24, Fab1, Tgl4, Vtc1, YNL058C, Ire1, Lam6, Van1, Vth2, YPR063C) and two (Sur1, YCR061W) tFT-fusion proteins with negative and positive -score values ( p -value < 0.1 and net -score > 0.2) could be detected, indicating that more proteins are stabilized than destabilized when...”
• Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins
  Lu, eLife 2018
  • “...Chong et al. (2015) to localize away from cytoplasm in rpd3 Acs1, Rad7, Mni1, Yjr008w, Ycr061w, Pab1, Pus4, Yor292c L iki3 Ribosomal subunits - - Rps9a, Rpl13b, Rps0b M Rapamycin Cytosolic ribosome [GO:0022626] 0.010879 4/5 Rpl23a, Rpl40a, Rpl40b, Rps10a Ribosomal subunits Q -factor Golgi vesicle transport...”
• Identification of Genes in Saccharomyces cerevisiae that Are Haploinsufficient for Overcoming Amino Acid Starvation
  Bae, G3 (Bethesda, Md.) 2017
  • “...Putative protein of unknown function; identified by fungal homology and RT-PCR M , C, v YCR061W YCR061W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern M + , C, v YBL065W YBL065W Dubious open reading frame; partially...”
  • “...function. YBR196C-A (M, C, v): The YBR196C-A gene encodes a putative protein of unknown function. YCR061W (M + , C, v): The protein encoded by YCR061W has no known function. The protein appears to be a multi-pass membrane protein (UniProt P25639; UniProt Consortium 2015 ). In...”
• Genome-wide landscape of position effects on heterogeneous gene expression in Saccharomyces cerevisiae
  Wu, Biotechnology for biofuels 2017
  • “...ARS310 YCR024C-A 3436 5.010.29 Low YCR027C 22 5.580.26 Low ARS315 YCR051W 10,077 8.140.12 Extreme high YCR061W 502 5.080.32 Low ARS319 YCR107W 1917 5.070.59 Low ARS603 YFL036W 5922 8.700.34 Extreme high YFL033C 254 6.870.06 Moderate ARS606 YFR006W 9795 5.270.36 Low YFR012W 87 5.570.32 Low ARS607 YFR021W 3081...”
• More

CNAG_03333 cytoplasmic protein from Cryptococcus neoformans var. grubii H99
Aligns to 268:369 / 877 (11.6%), covers 96.2% of PF10348, 80.9 bits

• Antifungal Mechanism of Action of Lauryl Betaine Against Skin-Associated Fungus Malassezia restricta
  Do, Mycobiology 2019
  • “...CNAG_02905 Hypothetical protein CNAG_03235 THO complex subunit 1 CNAG_03269 Aldehyde dehydrogenase CNAG_03325 ChAPs family protein CNAG_03333 Cytoplasmic protein CNAG_03348 Hypothetical protein CNAG_03370 Calcium-binding protein NCS-1 CNAG_03380 Hypothetical protein CNAG_03528 AP-2 complex subunit alpha CNAG_04174 PEX6 Peroxin-6 CNAG_04388 SOD2 Mitochondrial manganese superoxide dismutase CNAG_04450 Chromodomain-helicase-DNA-binding protein 1...”

MGG_08120 uncharacterized protein from Pyricularia oryzae 70-15
Aligns to 240:341 / 493 (20.7%), covers 79.0% of PF10348, 28.3 bits

• TOR-autophagy branch signaling via Imp1 dictates plant-microbe biotrophic interface longevity
  Sun, PLoS genetics 2018
  • “...into the M . oryzae genome downstream of nucleotide 5763887, Supercontig 2, in the allele MGG_08120. This allele is annotated as encoding an uncharacterized 433 amino acid, 59 kDa i ntegral m embrane p rotein with five transmembrane domains which we name Imp1 ( Fig 1A...”
  • “...-mediated transformation generated a rapamycin resistant strain, AT2, resulting from a T-DNA insertion event at MGG_08120 encoding an i ntegral m embrane p rotein (Imp1). LB and RB are the known left flank and right flank T-DNA sequences, respectively. (B) Targeted deletion of IMP1 in the...”

Or search for genetic data about PF10348 in the Fitness Browser