Family Search for PF10350 (DUF2428)
PF10350 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
G1SEM4 THADA armadillo repeat containing from Oryctolagus cuniculus
Aligns to 1149:1450 / 2153 (14.0%), covers 99.6% of PF10350, 334.5 bits
THADA_HUMAN / Q6YHU6 Thyroid adenoma-associated protein; Gene inducing thyroid adenomas protein from Homo sapiens (Human) (see paper)
NP_071348 thyroid adenoma-associated protein isoform a from Homo sapiens
Aligns to 947:1248 / 1953 (15.5%), covers 99.6% of PF10350, 334.1 bits
- Clinicopathologic Characteristics of Thyroid Nodules Positive for the THADA-IGF2BP3 Fusion on Preoperative Molecular Analysis.
Morariu, Thyroid : official journal of the American Thyroid Association 2021 (PubMed)- GeneRIF: Clinicopathologic Characteristics of Thyroid Nodules Positive for the THADA-IGF2BP3 Fusion on Preoperative Molecular Analysis.
- Replication study of THADA rs13429458 variant with PCOS susceptibility and its related traits in Indian women.
Dadachanji, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 (PubMed)- GeneRIF: Replication study of THADA rs13429458 variant with PCOS susceptibility and its related traits in Indian women.
- Pooled genetic analysis identifies variants that confer enhanced susceptibility to PCOS in Indian ethnicity.
Vishnubotla, Gene 2020 (PubMed)- GeneRIF: Of the 15 variants, 3 variants (rs13405728 in LHCGR; rs13429458 in THADA and rs2209972 IDE genes) were found to be associated with PCOS. The association was successfully replicated in an independent cohort. Insilico analysis categorized two variants (rs13429458-THADA and rs2209972-IDE genes) as deleterious.
- Association study between variants in LHCGR DENND1A and THADA with preeclampsia risk in Han Chinese populations.
Zhang, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2019 (PubMed)- GeneRIF: Genetic variants of PCOS (rs13405728 in LHCGR gene; rs13429458 in THADA gene and rs2479106 in DENND1A gene) may not be involved in the development of preeclampsia in Han Chinese women.
- THADA_rs13429458 Minor Allele Increases the Risk of Polycystic Ovary Syndrome in Asian, but Not in Caucasian Women: A Systematic Review and Meta-Analysis.
Park, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2019 (PubMed)- GeneRIF: THADA_rs13429458 Minor Allele is associated with Polycystic Ovary Syndrome in Asian, but Not in Caucasian Women.
- THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.
Panebianco, Proceedings of the National Academy of Sciences of the United States of America 2017 - GeneRIF: THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.
- THADA Regulates the Organismal Balance between Energy Storage and Heat Production.
Moraru, Developmental cell 2017 - GeneRIF: this identifies THADA as a regulator of the balance between energy consumption and energy storage, which was selected during human evolution.
- THADA gene polymorphism and prostate cancer risk: a meta-analysis.
Zhao, Oncology research and treatment 2014 (PubMed)- GeneRIF: Our results showed that rs1465618 in THADA may be a shared susceptibility variant for PCa in multiple populations.
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- Intellectual disability-associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs
Li, EMBO reports 2020 - “...crucial substrate and may serve as the main functional executor of Trm7. Human THADA (UniProt: Q6YHU6) and WDR6 (UniProt: Q9NNW5) are proposed to be the homologs of Trm732 and Trm734, respectively (Guy & Phizicky, 2015 ). THADA contains 1,953 AA residues, but only its 9881,470 peptide...”
- Increased C-X-C Motif Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis.
Andrés-Benito, International journal of molecular sciences 2020 - “...kinase C delta type i Q05655 1 41.25 0.46 0.03 THADA THADA armadillo repeat containing Q6YHU6 1 46.64 0.48 0.01 NHLC2 NHL repeat-containing protein 2 Q8NBF2 1 73.60 0.49 0.03 PLSI plastin 1 Q14651 1 25.89 0.54 0.03 RFA2 replication protein A2 P15927 1 93.57 0.54...”
- MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.
Pymm, Nature structural & molecular biology 2017 - “...epitopes from the self-repertoire of HLA-B*57:01. We selected the peptides TSTTSVASSW (UniProt Q14679), TSTFEDVKILAF (UniProt Q6YHU6) and SSTRGISQLW (UniProt Q96HA1), each of which formed part of a nested set (set 233, set 926 and set 736, respectively; Supplementary Table 2 ). Crystals of the refolded HLA-B*57:01peptide...”
A8C756 Thyroid adenoma-associated protein homolog from Mus musculus
NP_898842 thyroid adenoma-associated protein homolog from Mus musculus
Aligns to 938:1239 / 1938 (15.6%), covers 99.6% of PF10350, 322.9 bits
NP_001326116 thyroid adenoma-associated-like protein from Arabidopsis thaliana
Aligns to 990:1311 / 2130 (15.1%), covers 99.3% of PF10350, 296.0 bits
AT3G55160 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 959:1280 / 2149 (15.0%), covers 99.3% of PF10350, 296.0 bits
- The Arabidopsis THADA homologue modulates TOR activity and cold acclimation
Dong, Plant biology (Stuttgart, Germany) 2019 (PubMed)- “...and homology modeling to identify the AtTHADA (AT3G55160) in Arabidopsis thaliana as the highly probable orthologue protein. Reverse genetics approaches were...”
- “...modulates TOR activity (Figure S1B). Homology modelling of AT3G55160 and human THADA revealed a similar tertiary structure of the two proteins. A search for...”
THADA_DROME / Q9VWB9 Thyroid adenoma-associated protein homolog from Drosophila melanogaster (Fruit fly) (see paper)
NP_608361 THADA, isoform B from Drosophila melanogaster
Aligns to 838:1113 / 1746 (15.8%), covers 97.5% of PF10350, 276.5 bits
- function: Plays a key role in energy homeostasis by regulating the balance between energy storage and heat production. Functions by negatively regulating Ca(2+) signaling pathways that are involved in heat production and maintaining correct lipid storage in the fat body. Regulates Ca(2+) signaling pathways by reducing the activity of the calcium-transporting ATPase SERCA possibly by promoting uncoupling of SERCA ATP hydrolysis from calcium pumping. May also function in the nervous system to control feeding behavior.
subunit: Interacts with SERCA.
disruption phenotype: No visible phenotype. However, flies are hypersensitive to the cold, hyperphagic and display elevated triglyceride stores resulting in an increased resistance to starvation. Heat production is impaired and flies are slow to recover after cold treatment. The size of the lipid droplets in larval fat bodies are significantly increased and flies display increased feeding. Total body glycogen is also significantly increased in adult females but not in males. Mutants also display an increase in calcium-dependent SERCA activity. No effect on levels of circulating sugars, glucose and trehalose. - THADA Regulates the Organismal Balance between Energy Storage and Heat Production.
Moraru, Developmental cell 2017 - GeneRIF: this identifies THADA as a regulator of the balance between energy consumption and energy storage, which was selected during human evolution.
AFUA_2G14180 HEAT repeat protein from Aspergillus fumigatus Af293
Aligns to 703:940 / 1643 (14.5%), covers 99.6% of PF10350, 237.0 bits
- Receptor-mediated signaling in Aspergillus fumigatus
Grice, Frontiers in microbiology 2013 - “...ion transporter AFUA_2G12050 XP_755537.1 Midasin AFUA_2G12150 XP_755547.1 Integral membrane protein AFUA_2G12640 XP_755596.1 HEAT repeat protein AFUA_2G14180 XP_755751.2 Conserved hypothetical protein AFUA_2G15100 XP_755844.2 Integral membrane protein AFUA_2G15440 XP_755879.2 DUF92 domain protein AFUA_2G15640 XP_755899.1 Rhomboid family membrane protein AFUA_2G16490 XP_755986.1 Integral membrane protein AFUA_2G16985 XP_001481687.1 Sulfatase domain protein...”
YQK7_SCHPO / O60081 Uncharacterized protein C1494.07 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
SPCC1494.07 conserved eukaryotic protein (RefSeq) from Schizosaccharomyces pombe
Aligns to 624:868 / 1502 (16.3%), covers 99.3% of PF10350, 220.1 bits
TR732_YEAST / Q03496 tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YMR259C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene (RefSeq) from Saccharomyces cerevisiae
NP_013986 tRNA methylation protein TRM732 from Saccharomyces cerevisiae S288C
Aligns to 614:839 / 1420 (15.9%), covers 99.6% of PF10350, 163.3 bits
- function: Required together with TRM7 for the methylation of the 2'-O- ribose of cytidine at position 32 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)).
subunit: Interacts with TRM7; for 2'-O-methylation of cytidine 32 in substrate tRNAs. - Next-Generation Sequencing-Based RiboMethSeq Protocol for Analysis of tRNA 2'-O-Methylation.
Marchand, Biomolecules 2017 - “...unique MTase Trm7 (encoded by YBR061C) [ 35 ], which also tightly interacts with ORF YMR259c (now named Trm732) for 2- O -methylation of C32 and with Rtt10 (named Trm734) for 2- O -methylation of N34 in substrate tRNAs [ 36 ]. Moreover, the presence of...”
- Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop
Guy, RNA (New York, N.Y.) 2012 - “...and in vitro evidence that Trm7 interacts with ORF YMR259c (now named Trm732) for 29-O-methylation of C32, and with Rtt10 (named Trm734) for 29-O-methylation of...”
- “...Keywords: RTT10 ; TRM7; tRNAPhe; wyebustosine; YMR259c INTRODUCTION Post-transcriptional modifications of tRNA are numerous, widely conserved in nature,...”
- Proteome-wide overexpression of host proteins for identification of factors affecting tombusvirus RNA replication: an inhibitory role of protein kinase C
Shah, Journal of virology 2012 - “...YCK1 YCT1 YDJ1 YGL262W YGR026Wb YGR130C YLR126C YMR1 YMR259C YOS1 YPT1 YPT52 YSY6 a Gene names are based on the Saccharomyces genome database. Downregulators...”
- Extending bicluster analysis to annotate unclassified ORFs and predict novel functional modules using expression data
Bryan, BMC genomics 2008 - “...MIPS ribosomal biogenesis. YDL167C (NRP1) Transcription: rRNA (11.04.01) Role in ribosome biogenesis and assembly (RCA). YMR259C Transcription: rRNA (11.04.01)/ Transport Routes (20.09) Putative protein, unknown function; GFP-fusion protein localizes to the cytoplasm. YNL022C Transcription: rRNA (11.04.01) Putative protein of unknown function. GFP-fusion protein localizes to a...”
- Detecting patterns of protein distribution and gene expression in silico
Geraghty, Proceedings of the National Academy of Sciences of the United States of America 1999 - “...YNL009W YGR154C YBR204C YLR109W YEL029C YIL094C YDR449C YGL067W YMR259C YBL071C YBR012C YJR019C YLR284C YOR180C YPR128C YOL044W PTS1 ORE SKL SKL SKF SKL AKL SKL...”
- Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
Guy, RNA (New York, N.Y.) 2012 - GeneRIF: Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop.
CG3368 uncharacterized protein from Drosophila melanogaster
Aligns to 636:899 / 1120 (23.6%), covers 99.3% of PF10350, 140.9 bits
- Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila
Havula, PLoS genetics 2013 - “...coding region of mlx as well as 17 C-terminal amino acids of the neighbouring gene CG3368 ( Figure 1A ). As controls, we recovered lines from which the P-element had been excised precisely, leaving mlx intact. If not differently stated, the precise excision line is used...”
- “...out the possibility that sugar intolerance was due to disturbed function of the neighbouring gene CG3368, we used RNAi for ubiquitous knockdown. CG3368 was efficiently silenced, but no sugar intolerance was observed ( Figure S1DS1F ). Thus, mlx gene function is essential for tolerance to dietary...”
- Drosophila sosie functions with β(H)-Spectrin and actin organizers in cell migration, epithelial morphogenesis and cortical stability
Urwyler, Biology open 2012 - “...primers used for the RT-PCR shown in D are also indicated (ad). The neighbor gene CG3368 is encoded on the opposite strand. ( B ) Compound egg chamber in a sie 1 /Df(3R)Exel6200 ovary. Two focal planes of the same egg chamber are shown and the...”
- A misexpression screen to identify regulators of Drosophila larval hemocyte development
Stofanko, Genetics 2008 - “...CG32556 CG32813 CG32813 CG33182 CG3363 CG3368 CG3624 Gene P{EPgy2}EY09041 P{EPgy2}EY09604 P{EP}EP1515 P{EPgy2}EY08487 P{EP}EP1613 P{EPgy2}EY10303...”
Or search for genetic data about PF10350 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory