Family Search for PF10572 (UPF0556)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF10572 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
NP_001002480 myeloid-derived growth factor precursor from Danio rerio
Q6DGL1 Myeloid-derived growth factor from Danio rerio
Aligns to 34:162 / 164 (78.7%), covers 99.2% of PF10572, 178.2 bits
- Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage.
Houseright, The Journal of cell biology 2021 - GeneRIF: Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage.
- The identification and characterization of a novel protein, c19orf10, in the synovium
Weiler, Arthritis research & therapy 2007 - “...NP_01001164 ; Canis familiaris , ENSCAFT30192 ; Gallus gallus , NP_001006342 ; Danio rerio , NP_001002480 ; Tetraodon nigroviridis , CAG08012 ; and Leucoraja erinacea , CV067465 (translated in reading frame +3); Squalus acanthias , CX789984 (translated in reading frame +2). c19orf10, chromosome 19 open reading...”
- Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage
Houseright, The Journal of cell biology 2021 - “...human MYDGF (UniProtKB accession no. Q969H8 ; residues V32-L173), mature zebrafish MYDGF (UniProtKB accession no. Q6DGL1 ; E27-L164; The UniProt Consortium, 2017 ), and the 22 seed sequences of MYDGF homologues provided in Pfam (Pfam accession no. PF10572). The 80 residues of human MYDGF that were...”
- “...Expression and purification of zebrafish MYDGF The insert encoding mature zebrafish MYDGF (UniProtKB accession no. Q6DGL1 ; E27-L164) was amplified by PCR from cloned Danio rerio using primers (5-CTGTGTGGTACCGAAAGGACCAAAACACTGGACTTCG; 3-TAGAGGGCTAGCTCAGAGTTCATCATGCCGTATTCGAC), which introduced restriction sites for cloning (5 Kpn1 and 3 Nhe1) into pET.ELMER ( Maurer et...”
- Myeloid-derived growth factor is a resident endoplasmic reticulum protein
Bortnov, The Journal of biological chemistry 2018 (secret)
NP_001006342 myeloid-derived growth factor precursor from Gallus gallus
Aligns to 37:165 / 167 (77.2%), covers 99.2% of PF10572, 169.1 bits
- The identification and characterization of a novel protein, c19orf10, in the synovium
Weiler, Arthritis research & therapy 2007 - “...SSC.4092 ; Bos taurus , NP_01001164 ; Canis familiaris , ENSCAFT30192 ; Gallus gallus , NP_001006342 ; Danio rerio , NP_001002480 ; Tetraodon nigroviridis , CAG08012 ; and Leucoraja erinacea , CV067465 (translated in reading frame +3); Squalus acanthias , CX789984 (translated in reading frame +2)....”
MYDGF_MOUSE / Q9CPT4 Myeloid-derived growth factor; MYDGF from Mus musculus (Mouse) (see 2 papers)
NP_543027 myeloid-derived growth factor precursor from Mus musculus
Aligns to 33:164 / 166 (79.5%), covers 99.2% of PF10572, 168.6 bits
- function: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway.
disruption phenotype: Mice show normal postnatal body mass gain, develop normally and are fertile. Show larger infarct collagen-rich scars and more severe heart contractile dysfunction compared to wild- type mice after ischemia and reperfusion (IR) injury. - Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy
Hendrickx, Biomedicines 2022 - “...protein S27a 0.748 0.0245 F6ZDS4 Tpr Nucleoprotein TPR 0.979 0.0253 Q9WUM3 Coro1b Coronin-1B 0.43 0.0253 Q9CPT4 Mydgf Myeloid-derived growth factor 1.1 0.0255 Q8BGY7 Fam210a Protein FAM210A 0.831 0.0261 Q9CR00 Psmd9 26S proteasome non-ATPase regulatory subunit 9 0.754 0.0261 Q9D7H3 RtcA RNA 3-terminal phosphate cyclase 0.973 0.0261...”
- Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency.
Adam, Kidney360 2020 - “...14 44 ATP synthase F1 subunit Extracellular Cytokines P08721 OSTP 7 86 Secreted phosphoprotein 1 Q9CPT4 MYDGF 3 14 Myeloid-derived growth factor P06684 CO5 4 12 Complement C5 Growth factors P07522 EGF 44 590 EGF P01015 ANGT 15 189 Angiotensinogen P23785 GRN 7 98 Granulin precursor...”
- Myeloid-derived growth factor is a resident endoplasmic reticulum protein
Bortnov, The Journal of biological chemistry 2018 (secret) - Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne muscular dystrophy
Murphy, Clinical proteomics 2018 - “...18 3 10.1094 0.02249 1.65 Q9JKR6 Hyou1 Hypoxia up-regulated protein 1 7 26.4824 0.00022 1.64 Q9CPT4 Mydgf Myeloid-derived growth factor 2 6.4866 0.01417 1.62 P52840 Sult1a1 Sulfotransferase 1A1 3 11.3351 0.00914 1.62 P20029 Hspa5 78kDa glucose-regulated protein 9 32.5662 0.00432 1.61 Q9QZ85 Iigp1 Interferon-inducible GTPase 1...”
- Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease.
Thygesen, Frontiers in cellular neuroscience 2018 - “...Q64455 0.85 Arhgap23 Q69ZH9 0.83 Tspan2 Q922J6 0.77 Hdgf P51859 1.15 Hapln4 Q80WM4 0.86 D17Wsu104e Q9CPT4 1.11 F8a1 Q00558 0.85 Gsr P47791 0.82 Timm10b Q9WV96 0.80 Cep97 Q9CZ62 0.83 Osbpl6 Q8BXR9 0.81 Rsu1 Q01730 1.14 Mrpl4 Q9DCU6 0.87 Xrn1 P97789 0.78 The regulated proteins were analyzed...”
- Towards further defining the proteome of mouse saliva
Blanchard, Proteome science 2015 - “...protein 3A (Salivary protein MSG1) (Submaxillary gland androgen-regulated protein 1) Q6ZPJ0 Testis-expressed sequence 2 protein Q9CPT4 UPF0556 protein C19orf10 homolog (Interleukin-25) (IL-25) (Stromal cell-derived growth factor SF20) Q5SXG7 Vitelline membrane outer layer protein 1 homolog Fifty-seven of the 345 proteins identified in mouse saliva, were found...”
- Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg.
Jonchère, BMC genomics 2010 - “...adhesion, synaptic transmission, may modulate calcium-mediated postsynaptic signals. Contains cadherin domain UPF0556 protein C19orf10 homolog (Q9CPT4) Uncharacterised protein family UPF0556 Beta-amyloid protein 751 isoform (Q9DGJ7) Protein containing Amyloid A4 extracellular, Beta-amyloid peptide, Kunitz/Bovine pancreatic trypsin inhibitor domains Anthrax toxin receptor 1 (Q9H6X2) Protein with Anthrax receptor...”
- The Urine Proteome as a Biomarker of Radiation Injury: Submitted to Proteomics- Clinical Applications Special Issue: "Renal and Urinary Proteomics (Thongboonkerd)".
Sharma, Proteomics. Clinical applications 2008 - More
- Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.
Xu, Arteriosclerosis, thrombosis, and vascular biology 2023 (PubMed)- GeneRIF: Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.
- Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease.
Zhan, Kidney international 2022 (PubMed)- GeneRIF: Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease.
- Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
Wang, Theranostics 2021 - GeneRIF: Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
- Myeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in mice.
Meng, Science advances 2021 - GeneRIF: Myeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in mice.
- Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes.
Wang, Endocrinology 2020 (PubMed)- GeneRIF: maintains glucose homeostasis by inducing glucagon-like peptide-1 production and secretion
- MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease.
He, Diabetologia 2020 (PubMed)- GeneRIF: MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease.
- Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration.
Wang, Theranostics 2020 - GeneRIF: Mydgf promotes Cardiomyocyte proliferation and Neonatal Heart regeneration.
- IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology.
Claudio, Journal of immunology (Baltimore, Md. : 1950) 2019 - GeneRIF: The IL-25 made notable contributions to chronic HDM-induced allergic asthma pathology by facilitating clustering and cross-stimulation of different cell types in tissue.
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MYDGF_HUMAN / Q969H8 Myeloid-derived growth factor; MYDGF from Homo sapiens (Human) (see 3 papers)
NP_061980 myeloid-derived growth factor precursor from Homo sapiens
Aligns to 40:171 / 173 (76.3%), covers 99.2% of PF10572, 166.8 bits
- function: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
- rhMYDGF Alleviates I/R-induced Kidney Injury by Inhibiting Inflammation and Apoptosis via the Akt Pathway.
Wang, Transplantation 2023 - GeneRIF: rhMYDGF Alleviates I/R-induced Kidney Injury by Inhibiting Inflammation and Apoptosis via the Akt Pathway.
- Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
Wang, Theranostics 2021 - GeneRIF: Hypoxia-induced myeloid derived growth factor promotes hepatocellular carcinoma progression through remodeling tumor microenvironment.
- Identification of the correlations between interleukin-27 (IL-27) and immune-inflammatory imbalance in preterm birth.
Ran, Bioengineered 2021 - GeneRIF: Identification of the correlations between interleukin-27 (IL-27) and immune-inflammatory imbalance in preterm birth.
- Altered peripheral B lymphocyte homeostasis and functions mediated by IL-27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis.
Tang, Clinical and experimental immunology 2021 - GeneRIF: Altered peripheral B lymphocyte homeostasis and functions mediated by IL-27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis.
- Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes.
Wang, Endocrinology 2020 (PubMed)- GeneRIF: maintains glucose homeostasis by inducing glucagon-like peptide-1 production and secretion
- Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair.
Ebenhoch, Nature communications 2019 - GeneRIF: MYDGF structure consists of a 10-stranded beta-sandwich with a folding topology showing no similarities to other cytokines or growth factors.X-ray structure of MYDGF identifies its functionally relevant receptor binding epitope.
- Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum.
Bortnov, Nature communications 2019 - GeneRIF: MYDGF complexed to the KDEL receptor binds cargo via its conserved residues for transport to the endoplasmic reticulum.
- Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction.
Korf-Klingebiel, Nature medicine 2015 (PubMed)- GeneRIF: Bone marrow-derived monocytes and macrophages produce this protein endogenously to protect and repair the heart after myocardial infarction.
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- ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data.
Durbin, Journal of proteome research 2023 - “...As a second example, we analyzed existing native spectra of myeloid-derived growth factor (MYDGF, UniProt Q969H8 ). A search revealed the proteoform as the full-length chain expected after cleavage of an annotated signal sequence ( Figure S6 ). The identified proteoform includes a disulfide bond between...”
- Integrated multi-omic analysis of low-grade ovarian serous carcinoma collected from short and long-term survivors
Wong, Journal of translational medicine 2022 - “...(Log2 fold-change) P02144 MYG_HUMAN Myoglobin MB 1.28 1.11 Q9Y617 SERC_HUMAN Phosphoserine aminotransferase PSAT1 0.93 1.66 Q969H8 MYDGF_HUMAN Myeloid-derived growth factor MYDGF 0.83 0.89 Q15645 PCH2_HUMAN Pachytene checkpoint protein 2 homolog TRIP13 0.66 1.14 Q9UBP6 TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase METTL1 0.56 0.76 Q9Y657 SPIN1_HUMAN Spindlin-1 SPIN1 0.49 0.56...”
- Extracellular Vesicles from Human Adipose-Derived Mesenchymal Stem Cells: A Review of Common Cargos.
Alonso-Alonso, Stem cell reviews and reports 2022 - “...Muscle, skeletal receptor tyrosine-protein kinase* MUSK_HUMAN O15146 MUSK [ 52 ] Myeloid-derived growth factor MYDGF_HUMAN Q969H8 MYDGF [ 57 ] Natriuretic peptides B* ANFB_HUMAN P16860 NPPB [ 52 ] Natural killer cell receptor 2B4* CD244_HUMAN Q9BZW8 CD244 [ 65 ] Neprilysin NEP_HUMAN P08473 MME [ 63...”
- Extracellular vesicles of human diabetic retinopathy retinal tissue and urine of diabetic retinopathy patients are enriched for the junction plakoglo bin protein.
Mighty, Frontiers in endocrinology 2022 - “...dehydrogenase 2 1.9E+07 1.3E+08 8.3E+07 PSMB1 P20618 Proteasome subunit beta type-1 1.9E+07 2.5E+08 2.4E+08 MYDGF Q969H8 UPF0556 protein C19orf10 1.8E+07 1.4E+08 SEC22B O75396 Vesicle-trafficking protein SEC22b 1.7E+07 1.9E+08 PSMA2 P25787 Proteasome subunit alpha type-2 1.7E+07 6.3E+08 6.3E+08 ATP2B4 P23634 Plasma membrane calcium-transporting ATPase 4 1.6E+07 4.1E+08...”
- Long-term in vivo survival of 3D-bioprinted human lipoaspirate-derived adipose tissue: proteomic signature and cellular content.
Säljö, Adipocyte 2022 - “...3 (HRP-3) Cell proliferation Q9Y3E1 Myeloid-derived growth factor (MYDGF and IL-25) Angiogenesis and cell proliferation Q969H8 Stromal/stem cell-derived factor 1 (SDF-1) Growth factor and chemokine activity P48061 Growth factor receptors Fibroblast growth factor receptor 1 (FGFR-1) Angiogenesis and differentiation P11362 Vascular endothelial growth factor receptor 1...”
- Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature
Khorami, Clinical proteomics 2021 - “...pathways 1.192E-02 13 P32119 PRDX2 0.276 0.551 0.500 Cellular response to external stimuli 5.214E-04 14 Q969H8 MYDGF 0.223 0.000 #### Cellular response to external stimuli 7.942E-05 15 Q01469 FABP5 0.128 0.346 0.369 Metabolic pathways 3.527E-02 16 P69891 HBG1 2.030 9.27 0.218 Blood coagulation 2.182E-03 17 P15090...”
- Quantitative proteomics analysis of glioblastoma cell lines after lncRNA HULC silencing.
Ye, Scientific reports 2021 - “...S100-A6 S100A6 10.18 0.829 0.00169719 Q6NYC1 Bifunctional arginine demethylase and lysyl-hydroxylaseJMJD6 JMJD6 46.461 0.827 0.0197959 Q969H8 Myeloid-derived growth factor MYDGF 18.795 0.824 0.000081223 P18827 Syndecan-1 SDC1 32.461 0.82 0.0032242 Q9H900 Protein zwilch homolog ZWILCH 67.213 0.817 0.007761 P53602 Diphosphomevalonate decarboxylase MVD 43.404 0.815 0.00033664 P48735 Isocitrate...”
- Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage.
Houseright, The Journal of cell biology 2021 - “...was generated in Jalview using the protein sequences of mature human MYDGF (UniProtKB accession no. Q969H8 ; residues V32-L173), mature zebrafish MYDGF (UniProtKB accession no. Q6DGL1 ; E27-L164; The UniProt Consortium, 2017 ), and the 22 seed sequences of MYDGF homologues provided in Pfam (Pfam accession...”
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M3UZ63 Myeloid derived growth factor from Sus scrofa
Aligns to 41:172 / 174 (75.9%), covers 99.2% of PF10572, 165.4 bits
P62248 Myeloid-derived growth factor from Bos taurus
Aligns to 41:172 / 174 (75.9%), covers 99.2% of PF10572, 165.1 bits
- Effects of Multispecies Probiotic on Intestinal Microbiota and Mucosal Barrier Function of Neonatal Calves Infected With E. coli K99.
Wu, Frontiers in microbiology 2021 - “...and 12 were downregulated in the other groups compared with group D. The proteins, Q3ZBF3, P62248, Q9XSC9, and Q3ZC02, in group D were significantly downregulated compared to those in C, and the proteins, Q3ZBF3, Q3ZC02, and Q9XSC9, in group P were significantly upregulated compared to those...”
- Profiling of proteins secreted in the bovine oviduct reveals diverse functions of this luminal microenvironment
Pillai, PloS one 2017 - “...8 P79255 Leukemia inhibitory factor Q27956 Macrophage migration inhibitory factor P80177 Myeloid derived growth factor P62248 Osteopontin P31096 Small inducible cytokine subfamily E, member 1 Q3ZBX5 Tumor necrosis factor ligand 1B E1BF06 * Exceptions: Proteins identified with only one unique peptide 10.1371/journal.pone.0188105.t002 Table 2 Proteases and...”
V4CF92 Myeloid-derived growth factor from Lottia gigantea
Aligns to 36:160 / 162 (77.2%), covers 99.2% of PF10572, 152.8 bits
B3RJH9 Myeloid-derived growth factor from Trichoplax adhaerens
Aligns to 31:151 / 152 (79.6%), covers 98.4% of PF10572, 143.7 bits
K1R980 UPF0556 protein C19orf10-like protein from Crassostrea gigas
Aligns to 11:134 / 136 (91.2%), covers 99.2% of PF10572, 142.2 bits
M0QYN0 Myeloid derived growth factor from Homo sapiens
Aligns to 40:156 / 189 (61.9%), covers 79.7% of PF10572, 141.2 bits
- Dcf1 induces glioblastoma cells apoptosis by blocking autophagy
Luo, Cancer medicine 2022 - “...13 P48201 ATP5G3 1.328 1 142 14.684 14 Q9H4I9 SMDT1 1.303 1 107 11.434 15 M0QYN0 MYDGF 1.278 1 189 20.375 16 Q8TD26 CHD6 1.248 1 2715 305.22 Note FC: expression fold change, the abundance ratio of DCF1 and EGFP. AA: the number of amino acid....”
W6ULY3 Uncharacterized protein from Echinococcus granulosus
Aligns to 30:157 / 160 (80.0%), covers 95.1% of PF10572, 132.2 bits
F2UTG5 Myeloid-derived growth factor from Salpingoeca rosetta (strain ATCC 50818 / BSB-021)
Aligns to 41:162 / 162 (75.3%), covers 95.9% of PF10572, 100.3 bits
L8H7H9 Myeloid-derived growth factor from Acanthamoeba castellanii (strain ATCC 30010 / Neff)
Aligns to 31:166 / 187 (72.7%), covers 99.2% of PF10572, 99.1 bits
M0R3V4 Myeloid-derived growth factor from Rattus norvegicus
Aligns to 70:154 / 156 (54.5%), covers 56.1% of PF10572, 83.0 bits
M0QXF7 Myeloid derived growth factor (Fragment) from Homo sapiens
Aligns to 1:77 / 84 (91.7%), covers 48.0% of PF10572, 71.8 bits
Or search for genetic data about PF10572 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory