Family Search for PF10572 (UPF0556)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10572 hits 15 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

MYDGF_MOUSE / Q9CPT4 Myeloid-derived growth factor; MYDGF from Mus musculus (Mouse) (see 2 papers)
Aligns to 33:164 / 166 (79.5%), covers 99.2% of PF10572, 168.6 bits

• function: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway.
  disruption phenotype: Mice show normal postnatal body mass gain, develop normally and are fertile. Show larger infarct collagen-rich scars and more severe heart contractile dysfunction compared to wild- type mice after ischemia and reperfusion (IR) injury.

MYDGF_HUMAN / Q969H8 Myeloid-derived growth factor; MYDGF from Homo sapiens (Human) (see 3 papers)
Aligns to 40:171 / 173 (76.3%), covers 99.2% of PF10572, 166.8 bits

• function: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).

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