Family Search for PF10574 (UPF0552)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF10574 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
ARPIN_DANRE / Q1LWJ6 Arpin from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 1:224 / 226 (99.1%), covers 100.0% of PF10574, 396.6 bits
- function: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors (By similarity). Involved in steering cell migration by controlling its directional persistence.
subunit: Associates with the Arp2/3 complex.
ARPIN_HUMAN / Q7Z6K5 Arpin; Arp2/3 inhibition protein from Homo sapiens (Human) (see paper)
NP_872422 arpin isoform 1 from Homo sapiens
Aligns to 1:224 / 226 (99.1%), covers 100.0% of PF10574, 373.5 bits
- function: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
subunit: Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1. - Nucleation, stabilization, and disassembly of branched actin networks.
Gautreau, Trends in cell biology 2022 - “...N-WASP (O00401); WHAMM (Q8TF30); JMY (Q8N9B5); Cortactin (Q14247); GMF (O60234); Cofilin (P23528); SPIN90 (Q9NZQ3); Arpin (Q7Z6K5); Gadkin (Q63HQ0); Coronin 1A (P31146); Coronin 2A (Q92828); Coronin 7 (P57737). Ribbon diagrams of determined structures of domains of these proteins are shown along with the PDB accession codes. In...”
- Molecular mechanism of Arp2/3 complex inhibition by Arpin.
Fregoso, Nature communications 2022 - “...of which contain C-terminal CA regions (UniProt accession codes: human N-WASP, O00401 and human Arpin, Q7Z6K5). b d Comparison of cryo-EM maps (and ribbon diagrams) low-pass filtered at the 5- resolution of Arp2/3 complex alone 15 ( b ) and with bound Arpin ( c )...”
- Effects of Growth Hormone Treatment and Rehabilitation in Incomplete Chronic Traumatic Spinal Cord Injury: Insight from Proteome Analysis.
Martin-Rojas, Journal of personalized medicine 2020 - “...division and differentiation/Response to cytokine and growth factor/Positive regulation of axonogenesis 1 0.72 1.75 0.999 Q7Z6K5 Arpin ARPIN Negative regulation of actin nucleation/Negative regulation of cell migration 1 1.65 1.31 1.000 Q6P0Q8 Microtubule-associated serine/threonine-protein kinase 2 MAST2 Cytoskeleton organization/Intracellular signal transduction/Regulation of interleukin-12 biosynthetic process 1...”
- Oral Glucose Mobilizes Triglyceride Stores From the Human Intestine
Xiao, Cellular and molecular gastroenterology and hepatology 2019 - “...a UBTF -6.2100 .0063 Transcription/RNA processing/translation Q8N8S7 Protein enabled homolog a ENAH -5.7620 .0007 Cytoskeleton Q7Z6K5 Arpin a ARPIN -5.7573 2.02E-19 Cytoskeleton Q9UQ35 Serine/arginine repetitive matrix protein 2 a SRRM2 -5.5687 .0002 Transcription/RNA processing/translation P49790 Nuclear pore complex protein Nup153 a NUP153 -5.1794 .0079 Transcription/RNA processing/translation...”
- Early targets of miR-34a in neuroblastoma.
De, Molecular & cellular proteomics : MCP 2014 - RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN.
Park, Molecules and cells 2023 - GeneRIF: RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells via ARPIN.
- Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
Simanov, International journal of molecular sciences 2021 - GeneRIF: Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
- Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus.
Jubrail, EMBO reports 2020 - GeneRIF: Arpin is critical for phagocytosis in macrophages and is targeted by human rhinovirus.
- Clinicopathological and prognostic significance of aberrant Arpin expression in gastric cancer.
Li, World journal of gastroenterology 2017 - GeneRIF: Low Arpin levels are associated with clinicopathological variables and a poor prognosis in gastric cancer patients
- Restoration of Arpin suppresses aggressive phenotype of breast cancer cells.
Li, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 (PubMed)- GeneRIF: ARPIN is down-regulated in breast cancer cells and predicts poor prognosis in breast cancer patients. Data suggest that restoration of ARPIN in breast cancer cells suppresses cell proliferation, colony formation, cell cycle distribution, invasion in vitro, and tumorigenesis in vivo (xenograft experiments in nude mice); Arpin acts as tumor suppressor in breast cancer and is associated with inhibition of Akt signaling.
- Aberrant expression of Arpin in human breast cancer and its clinical significance.
Liu, Journal of cellular and molecular medicine 2016 - GeneRIF: Arpin downregulation may contribute to the initiation and development of breast cancer metastasis.
- Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope.
Fetics, Structure (London, England : 1993) 2016 (PubMed)- GeneRIF: Data reveal that Arpin is comprised of an elongated globular core from which the C-terminal tail extends as a linear peptide, thus forming a primary epitope that is readily available to tether Arpin to interacting proteins.
- Arpin contributes to bacterial translocation and development of severe acute pancreatitis.
Deng, World journal of gastroenterology 2015 - GeneRIF: Arpin protein affects the expression of tight junction proteins and may have an impact on bacterial translocation in severe acute pancreatitis.
ARPIN_MOUSE / Q9D0A3 Arpin; Arp2/3 inhibition protein from Mus musculus (Mouse) (see paper)
Aligns to 1:224 / 226 (99.1%), covers 100.0% of PF10574, 372.5 bits
NP_001101000 arpin from Rattus norvegicus
Aligns to 1:224 / 226 (99.1%), covers 100.0% of PF10574, 371.0 bits
- Toxicokinetics of Arenobufagin and its Cardiotoxicity Mechanism Exploration Based on Lipidomics and Proteomics Approaches in Rats
Zhao, Frontiers in pharmacology 2021 - “...roles in exploring the mechanism of cardiotoxicity. These proteins were mainly NP_446,069 (Cpb2), NP_619,715 (Rabggtb), NP_001101000 (Arpin), NP_001101947 (Hnrnpul1), NP_001102181 (Snx6), NP_001034090 (Trap1), NP_445,943 (Plg), XP_017447177 (Xirp2) and NP_001178009 (Golga4). Combining the multi-layered network and bubble diagram ( Figures 6B,E,F ), the metabolic pathways involved in...”
ARPIN_DICDI / Q54F87 Arpin from Dictyostelium discoideum (Social amoeba) (see paper)
Aligns to 1:223 / 224 (99.6%), covers 93.3% of PF10574, 91.9 bits
- function: Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex (By similarity). Involved in steering cell migration by controlling its directional persistence.
subunit: Associates with the Arp2/3 complex.
Or search for genetic data about PF10574 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory