Family Search for PF10577 (FAM171A1-2-B_N)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10577 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

XP_016871393 protein FAM171A1 isoform X2 from Homo sapiens
Aligns to 5:258 / 861 (29.5%), covers 100.0% of PF10577, 419.5 bits

• Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth.
  Rasila, The American journal of pathology 2019 (PubMed)
  • GeneRIF: APCN regulates the dynamics of the actin cytoskeletal and, thereby, the cell shape and invasive growth potential of tumor cells.
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

F1711_HUMAN / Q5VUB5 Protein FAM171A1; Astroprincin; APCN from Homo sapiens (Human) (see paper)
Aligns to 34:287 / 890 (28.5%), covers 100.0% of PF10577, 419.4 bits

• function: Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation.
  subunit: Interacts with ADAM10, NSG1 and OAZ1.
• Detection of N‑glycoprotein associated with IgA nephropathy in urine as a potential diagnostic biomarker using glycosylated proteomic analysis.
  Liu, Experimental and therapeutic medicine 2023
  • “...5 0 0 0 A9X9L1 DSC2 1.106x10 6 8.126x10 5 1.304x10 6 0 0 0 Q5VUB5 FAM171A1 1.556x10 5 4.516x10 4 2.113x10 4 0 0 0 C9J131 FAP 3.034x10 5 1.652x10 5 2.427x10 5 0 0 0 F5H3Z4 FOLR2 5.122x10 5 2.554x10 5 1.587x10 5 0...”
• Epigenetic virtues of chromodomains
  Blus, Critical reviews in biochemistry and molecular biology 2011
  • “...CPRK (Q8IWU2) DMXL2 (Q8TDJ6) LAMA4 (Q16363) LTC4 (P33527) MAP-1A (P78559) CHRD (Q9H2X0) VIP1 (Q6PFW1) FAM171A1 (Q5VUB5) BOC (Q9BWV1) AFTPH (Q6ULP2) KIF17 (Q9P2E2) BMP-1 (P13497) DHTKD1 (Q96HY7) EMILIN-4 (Q13201) ATP13A4 (Q4VNC1) GTSE-1 (Q9NYZ3) SAP-97 (Q12959) DPDE3 (Q08499) PRTG (Q2VWP7) ADB2 (Q13349) GABRG2 (P18507) CLASP2 (O75122) NRK (Q7Z2Y5)...”

Q9Y438 Uncharacterized protein DKFZp564A026 (Fragment) from Homo sapiens
Aligns to 36:289 / 892 (28.5%), covers 100.0% of PF10577, 418.6 bits

• DeepPhos: prediction of protein phosphorylation sites with deep learning.
  Luo, Bioinformatics (Oxford, England) 2019
  • “...Position Score Rank Protein Position Score 1 Q8N5F7 217 0.9916 11 Q9HBD4 1458 0.9400 2 Q9Y438 857 0.9786 12 O43526 476 0.9393 3 Q9NSI6 1822 0.9698 13 O14529 418 0.9391 4 Q9H987 788 0.9637 14 Q5CZC0 6583 0.9380 5 Q8N3T6 807 0.9598 15 Q8N3T6 557 0.9367...”

NP_940877 protein FAM171A2 precursor from Homo sapiens
Aligns to 41:295 / 826 (30.9%), covers 100.0% of PF10577, 402.4 bits

• The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases.
  Xu, Science advances 2020
  • GeneRIF: The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases.

F171B_MOUSE / Q14CH0 Protein FAM171B from Mus musculus (Mouse) (see paper)
Aligns to 84:334 / 825 (30.4%), covers 99.2% of PF10577, 214.2 bits

• Protective effects of Qing-Re-Huo-Xue formula on bleomycin-induced pulmonary fibrosis through the p53/IGFBP3 pathway
  Yang, Chinese medicine 2023
  • “...Slc29a3 Equilibrative nucleoside transporter 3 OS=Mus musculus OX=10,090 GN=Slc29a3 PE=1 SV=1 0.790 Down 1.251 Up Q14CH0 Fam171b Protein FAM171B OS=Mus musculus OX=10,090 GN=Fam171b PE=1 SV=2 0.830 Down 1.328 Up Q8K004 Spata2 Spermatogenesis-associated protein 2 OS=Mus musculus OX=10,090 GN=Spata2 PE=1 SV=1 0.819 Down 1.453 Up P02802 Mt1...”

Q6P995 Protein FAM171B from Homo sapiens
KIAA1946, NP_803237 protein FAM171B precursor from Homo sapiens
Aligns to 83:334 / 826 (30.5%), covers 98.4% of PF10577, 212.5 bits

• Mitochondria-derived vesicles and their potential roles in kidney stone disease.
  Chaiyarit, Journal of translational medicine 2023
  • “...homolog 1 (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) 181 FAM171B Q6P995 Protein FAM171B 182 FAM181B A6NEQ2 Protein FAM181B 183 FAM234A Q9H0X4 Protein FAM234A (Protein ITFG3) 184 FAM83F Q8NEG4 Protein FAM83F 185 JARID2 Q92833 Protein Jumonji (Jumonji/ARID domain-containing protein 2) 186 CCDC58...”
• Exploration of potential novel drug targets and biomarkers for small cell lung cancer by plasma proteome screening.
  Wu, Frontiers in pharmacology 2023
  • “...Q9Y2I2; X5DNW2; B4DKF0 rs115668827 C 0.81 (0.74, 0.90) 4.60E-05 17.45 315.52 Sun et al FAM171B Q6P995 rs10931256 C 1.40 (1.21, 1.62) 4.42E-06 7.46 127.88 Sun et al OR: odds ratio, per standard deviation increase in plasma protein levels. PVE: proportion of variance explained. In the external...”
• The Stress Response of the Holothurian Central Nervous System: A Transcriptomic Analysis.
  Cruz-González, International journal of molecular sciences 2022
  • “...glutamate receptor binding Upregulated LZIC Q8WZA0 Beta-catenin binding Downregulated NRL P54846 Transcriptional regulator Upregulated FAM171B Q6P995 Integral component of membrane Downregulated Note: All genes have an adjusted p -value of <0.05. ijms-23-13393-t002_Table 2 Table 2 Apoptosis-related genes in the RNC transcriptome. Gene Gene Function Pattern of...”
• Predicting Functions of Uncharacterized Human Proteins: From Canonical to Proteoforms.
  Poverennaya, Genes 2020
  • “...the top). * denotes the following set of proteins: O00193, O15481, Q53RE8, Q5THK1, Q68CR1, Q6P1M9, Q6P995, Q86X40, Q8IV32, Q8IW50, Q8N7X4, Q8NCJ5, Q8NCT3, Q8NCU4, Q8TBZ0, Q8TDY8, Q8WUB2, Q96BQ5, Q96GQ5, Q9BVG4, Q9H106, Q9H5V9, Q9H910, Q9Y546. Figure 3 Functional prediction of molecular functions for 60 uPE1 proteins. Figure 4...”
  • “...Q8TD91-2, Q9H741, Q9HA90, Q9NWQ9. ** denotes the following set of proteins: Q0P6D6, Q2M3V2, Q53LP3, Q68CR1, Q6P995, Q6ZRI6-2, Q86X40, Q8IV32, Q8IW50, Q8N6V9, Q8NCJ5, Q8NCT3, Q8NCU4, Q8NEF3, Q8TBZ0, Q8WUB2, Q96BQ5, Q96GQ5, Q96MY1, Q9H106, Q9H693. Figure 5 The largest connected component of the obtained PPI network showing canonical proteins...”
• Massive peptide sharing between viral and human proteomes
  Kanduc, Peptides 2008
  • “...HES6_HUMAN; Q5JUU8; UTP20_HUMAN; TLR4_HUMAN; Q9UL85; Q496H8; HV2A_HUMAN; Q86VK9; Q8IV74; HXA9_HUMAN; Q68CS5; Q8TEH7; Q6ZNW8; TRPV1_HUMAN; Q8N3Q9; Q6P995; Q6EF02; FA47B_HUMAN; CI055_HUMAN; BAD_HUMAN; Q5T7E5; Q6LET9; Q5T6F2; Q5VWV2; PCD16_HUMAN; 3BHS7_HUMAN; CB013_HUMAN; Q59FA6; Q9H901; Q8N1Y8; Q9BVY2; Q6ZSI0; MYOTI_HUMAN; Q6P0L0; Q8IYC2; Q5SWJ3; SPDYA_HUMAN; Q9Y569; Q2QD09; Q6NXR2; Q5T3L7; Q8N2D3; Q5JR95; Q5TYV8 Sequence similarity...”
• FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
  Hu, Journal of experimental & clinical cancer research : CR 2023
  • GeneRIF: FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
• FAM171B is a novel polyglutamine protein widely expressed in the mammalian brain.
  Tran, Brain research 2021 (PubMed)
  • GeneRIF: FAM171B is a novel polyglutamine protein widely expressed in the mammalian brain.
• MiR-483-3p regulates oxaliplatin resistance by targeting FAM171B in human colorectal cancer cells.
  Liang, Artificial cells, nanomedicine, and biotechnology 2019 (PubMed)
  • GeneRIF: FAM171B expression is up-regulated in oxaliplatin-resistant colorectal cancer cell line. Transfection of miR-483-3p mimics markedly decreases the levels of FAM171B and restores oxaliplatin responsiveness, and this alteration enhances cell apoptosis and weakens cell migration. Knockdown of FAM171B in oxaliplatin-resistant colorectal cancer cell line sensitizes its reaction of the treatment with oxaliplatin.
• Glycoproteomics in neurodegenerative diseases
  Hwang, Mass spectrometry reviews 2010
  • “...N ITVDYLYNK Y Y IPI00844348.1 PON2 39 kDa protein HTNM N LTQLK Y Y IPI00845399.1 KIAA1946 Isoform 2 of UPF0560 protein KIAA1946 precursor QYLSQAVVEVFV N YTK Y Y IPI00847414.1 DPP10 dipeptidyl peptidase 10 isoform short WI N DTDVVYK Y Y IPI00847635.1 SERPINA3 Isoform 1 of Alpha-1-antichymotrypsin...”

D3ZTG3 Family with sequence similarity 171, member B from Rattus norvegicus
Aligns to 80:330 / 823 (30.5%), covers 99.2% of PF10577, 208.2 bits

• Translational proteomic study to address host protein changes during aspergillosis
  Desoubeaux, PloS one 2018
  • “...42.5 9.42 GW7_16137 cell organization and biogenesis; transport Family with sequence similarity 171, member B D3ZTG3 5.011 1.973684211 1 760 84.8 7.9 Fam171b membrane Uncharacterized protein DUF4706 G5BQI7 4.778 12.34567901 2 243 27.3 5.16 GW7_00817 Apoptosis-stimulating of p53 protein 1 A0A091DHP4 4.649 1.705029838 1 1173 128.3...”

LOC582269 uncharacterized protein LOC582269 from Strongylocentrotus purpuratus
Aligns to 397:538 / 724 (19.6%), covers 53.5% of PF10577, 48.4 bits

• The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth
  Alvares, Connective tissue research 2018
  • “...24 kDa Predicted uncharacterized protein LOC577267 ( Sp ) 79 95 kDa Predicted uncharacterized protein LOC582269 ( Sp ) 78 86 kDa Predicted uncharacterized protein LOC585121( Sp ) 63 47 kDa Predicted uncharacterized protein LOC100888382 ( Sp )* 75 50 kDa Predicted uncharacterized protein LOC579383 (...”

Or search for genetic data about PF10577 in the Fitness Browser