Family Search for PF10697 (DUF2502)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10697 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

YPO2981 putative exported protein from Yersinia pestis CO92
YPTB2704 putative exported protein from Yersinia pseudotuberculosis IP 32953
Aligns to 39:126 / 137 (64.2%), covers 100.0% of PF10697, 143.8 bits

• Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
  Rosso, BMC microbiology 2008
  • “...protein. flk 0.549 (0.008) YPTB2699 YPO2976 conserved hypothetical protein 4.448 (< 0.001) 1.458 (0.016) YPTB2704 YPO2981 putative exported protein 1.628 (0.015) YPTB2744 (yfeY) YPO3026 putative lipoprotein 1.604 (0.019) YPTB2753 YPO3031 putative acetyltransferase 1.391 (0.02) YPTB2750 or3477 hypothetical 0.688 (0.006) YPTB2787 YPO3066 hypothetical protein 1.504 (0.019) YPTB2822...”
• Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
  Rosso, BMC microbiology 2008
  • “...regulatory protein. flk 0.549 (0.008) YPTB2699 YPO2976 conserved hypothetical protein 4.448 (< 0.001) 1.458 (0.016) YPTB2704 YPO2981 putative exported protein 1.628 (0.015) YPTB2744 (yfeY) YPO3026 putative lipoprotein 1.604 (0.019) YPTB2753 YPO3031 putative acetyltransferase 1.391 (0.02) YPTB2750 or3477 hypothetical 0.688 (0.006) YPTB2787 YPO3066 hypothetical protein 1.504 (0.019)...”

YPTB2334 putative exported protein from Yersinia pseudotuberculosis IP 32953
Aligns to 23:128 / 151 (70.2%), covers 95.6% of PF10697, 120.9 bits

• Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
  Rosso, BMC microbiology 2008
  • “...putative acid shock protein 0.654 (0.022) YPTB2269 (pspB) YPO2350 phage shock protein B 1.983 (0.018) YPTB2334 YPO2426 putative exported protein 1.628 (0.015) YPTB2353 (yfeE) YPO2445 putative yfeABCD locus regulatoR 1.526 (0.008) YPTB2358 (pelY) YPO1723 periplasmic pectate lyase precursoR 2.081 (0.001) YPTB2363 YPO1718 putative exported protein 1.804...”

YPO2426 putative exported protein from Yersinia pestis CO92
Aligns to 23:129 / 152 (70.4%), covers 95.6% of PF10697, 120.7 bits

• Growth of Yersinia pseudotuberculosis in human plasma: impacts on virulence and metabolic gene expression
  Rosso, BMC microbiology 2008
  • “...acid shock protein 0.654 (0.022) YPTB2269 (pspB) YPO2350 phage shock protein B 1.983 (0.018) YPTB2334 YPO2426 putative exported protein 1.628 (0.015) YPTB2353 (yfeE) YPO2445 putative yfeABCD locus regulatoR 1.526 (0.008) YPTB2358 (pelY) YPO1723 periplasmic pectate lyase precursoR 2.081 (0.001) YPTB2363 YPO1718 putative exported protein 1.804 (0.038)...”

SMDB11_2817 DUF2502 domain-containing protein from Serratia marcescens subsp. marcescens Db11
Aligns to 28:120 / 136 (68.4%), covers 96.7% of PF10697, 103.6 bits

• The Short-chain Fatty Acid Propionic Acid Activates the Rcs Stress Response System Partially through Inhibition of d-Alanine Racemase
  Harshaw, mSphere 2023
  • “...-gfp 73 pMQ747 pMQ713 with SMDB11_1637 ( osmB ) promoter-l uxCDABE 29 pMQ748 pMQ713 with SMDB11_2817 promoter-l uxCDABE 29 pMQ749 pMQ713 with umoD promoter luxCDABE 29 pMQ802 pMQ414 with pHLuorin2 replacing tdtomato , codon optimized for S. marcescens This study pKD4 Source of kanamycin resistance marker...”
  • “...recently shown to activate Rcs in this strain ( 29 ). These promoters, namely, P SMDB11_2817 and P umoD , are also highly responsive to propionic acid in the WT background but are minimally or not activated in the rcsB mutant ( Fig.3 ). FIG3 Propionic...”
• Antibiotics Used in Empiric Treatment of Ocular Infections Trigger the Bacterial Rcs Stress Response System Independent of Antibiotic Susceptibility
  Harshaw, Antibiotics (Basel, Switzerland) 2021
  • “...vector ( Figure 2 A and Figure S1 ). The promoters were for the SMDB11_1637, SMDB11_2817, and SMDB11_1194 open reading frames. All of these previously uncharacterized open reading frames bear high similarity to Rcs-regulated genes in other bacteria. SMDB11_1637 is similar to osmotically inducible lipoprotein B...”
  • “...in P. mirabilis [ 27 ], as is its ortholog YPO1624 in Y. pseudotuberculosis . SMDB11_2817 has similarity to yaaX from E. coli with the DUF2502 domain of unknown function and was identified as an RcsB-regulated gene in E. coli [ 25 ]. In addition, the...”

t0450 conserved hypothetical protein from Salmonella enterica subsp. enterica serovar Typhi Ty2
STM2407 putative periplasmic protein from Salmonella typhimurium LT2
T_RS02280 DUF2502 domain-containing protein YpeC from Salmonella enterica subsp. enterica serovar Typhi str. Ty2
Aligns to 23:106 / 108 (77.8%), covers 100.0% of PF10697, 95.8 bits

• Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue
  Nickerson, EBioMedicine 2018
  • “...protein SsaG T_RS19490 t3831 2.71975 0.0499517 Hypothetical protein T_RS16450 t3244 2.68263 0.011345 Glutamine amidotransferase T_RS02280 t0450 2.67886 0.0466588 Hypothetical protein T_RS09750 t1914 2.67E+00 0.0006626 Methyltransferase T_RS23210 t4563 2.66886 0.0212746 Membrane protein T_RS23145 t4550 2.6688 0.0477512 SAM-dependent methyltransferase T_RS08510 t1671 2.64519 0.0003457 Nitrate reductase molybdenum cofactor assembly...”
• Genome expression analyses revealing the modulation of the Salmonella Rcs regulon by the attenuator IgaA
  Mariscotti, Journal of bacteriology 2009
  • “...55 30, 55 STM2118 wza 5.1 0.7 0.7 5.1 0.2 23, 55 STM2407 STM2801 STM4100 STM4105 ypeC ygaC metB metF 2.2 3.0 2.4 2.5 0.7 1.5 0.2 0.5 0.6 2.3 0.5 0.2 0.02 0.4...”
• Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal Tissue
  Nickerson, EBioMedicine 2018
  • “...needle protein SsaG T_RS19490 t3831 2.71975 0.0499517 Hypothetical protein T_RS16450 t3244 2.68263 0.011345 Glutamine amidotransferase T_RS02280 t0450 2.67886 0.0466588 Hypothetical protein T_RS09750 t1914 2.67E+00 0.0006626 Methyltransferase T_RS23210 t4563 2.66886 0.0212746 Membrane protein T_RS23145 t4550 2.6688 0.0477512 SAM-dependent methyltransferase T_RS08510 t1671 2.64519 0.0003457 Nitrate reductase molybdenum cofactor...”

YpeC / b2390 DUF2502 domain-containing protein YpeC from Escherichia coli K-12 substr. MG1655 (see paper)
ECs3270 hypothetical protein from Escherichia coli O157:H7 str. Sakai
b2390 hypothetical protein from Escherichia coli str. K-12 substr. MG1655
Z3656 orf, hypothetical protein from Escherichia coli O157:H7 EDL933
Aligns to 23:108 / 108 (79.6%), covers 100.0% of PF10697, 85.4 bits

• Gene expression induced in Escherichia coli O157:H7 upon exposure to model apple juice
  Bergholz, Applied and environmental microbiology 2009
  • “...ECs2737 ECs2758 ECs2759 ECs2987 ECs3105 ECs3264 ECs3267 ECs3270 ECs3355 ECs3358 ECs3426 ECs3441 ECs3485 ECs3526 ECs3529 ECs3531 ECs3643 ECs3692 ECs3779 ECs3780...”
• The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli
  Zoetendal, Applied and environmental microbiology 2008
  • “...27.6 22.5 b1532 b1530 marB marR 2.6 2.6 21.5 27.4 b0005 b2390 b0618 b3687 b3686 b3238 b2675 yaaX ypeC citC ibpA ibpB yhcN nrdE 4.9 2.8 34.6 6.9 9.5 3.1 26.8...”
• Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli
  Nishino, Journal of bacteriology 2003
  • “...None b0812 b3512 b0867 b1597 b2359 b1492 b2390 b0897 b0329 b2358 b3514 b0485 b4242 b2371 Adaptation (starvation) Regulation Metabolism Adaptation (stress)...”
• DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli
  DeLisa, Journal of bacteriology 2001
  • “...3.9 b2390 ................................................................................... 3.9 b2511...”
• Disruption of rcsB by a duplicated sequence in a curli-producing Escherichia coli O157:H7 results in differential gene expression in relation to biofilm formation, stress responses and metabolism
  Sharma, BMC microbiology 2017
  • “...+2.36 0.04 Z2893 Unknown 1.61 0.01 rcnB Z3275 Putative nickel/cobalt efflux protein 1.61 0.02 ypeC Z3656 Unknown 23.74 1.9E-17 ypfG Z3722 Unknown 4.58 9.0E-09 Z3965 Unknown 2.33 1.5E-03 Z4126 Unknown 4.31 3.0E-04 Z4151 Unknown 3.84 7.4E-07 Z4267 Unknown +5.52 2.3E-03 Z4268 Unknown +4.92 4.3E-06 yggG Z4280...”

KP1_3995 hypothetical protein from Klebsiella pneumoniae NTUH-K2044
KPN_02742 hypothetical protein from Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Aligns to 23:114 / 119 (77.3%), covers 93.3% of PF10697, 60.8 bits

• YjcC, a c-di-GMP phosphodiesterase protein, regulates the oxidative stress response and virulence of Klebsiella pneumoniae CG43
  Huang, PloS one 2013
  • “...mglB 4.2 KP1_3815 Putative ABC transport system component 4.6 KP1_3175 Molybdate ABC transporter system 4.4 KP1_3995 Maltose/maltodextrin transporter ATP binding protein malK 4.2 KP1_0276 Sugar ABC transport system permease component 4.1 KP1_1424 Putative ABC transporter mocB 3.7 KP1_1423 Putative rhizopine uptake ABC transporter proY 3.7 KP1_1422...”
• Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578
  Huang, BMC research notes 2014
  • “...0.0012 7.62 KPN_01568 Hypothetical 7.46 10.07 0.0085 6.10 KPN_01977 Lysozyme inhibitor 9.57 12.45 0.0007 7.34 KPN_02742 Hypothetical 8.95 11.38 0.0057 5.40 KPN_03160 Hypothetical 11.17 13.82 0.0028 6.30 KPN_04221 Periplasmic repressor CpxP 10.08 12.49 0.0044 5.32 KPN_04433 Putative stress-response protein 9.46 11.81 0.0083 5.09 KPN_04512 a N-glycosyl-transferase...”

S0005 hypothetical protein from Shigella flexneri 2a str. 2457T
Aligns to 22:94 / 95 (76.8%), covers 67.8% of PF10697, 52.5 bits

• A multi-omic assessment of the mechanisms of intestinal microbes used to treat diarrhea in early-weaned lambs
  Guo, mSystems 2024 (no snippet)
• Temporal Variations in the Gut Microbiota of the Globally Endangered Sichuan Partridge (Arborophila rufipectus): Implications for Adaptation to Seasonal Dietary Change and Conservation
  Tang, Applied and environmental microbiology 2023 (secret)
• Possible beneficial interactions of ciliated protozoans with coral health and resilience
  Ravindran, Applied and environmental microbiology 2023 (secret)
• Genome Analysis of Enterobacter asburiae and Lelliottia spp. Proliferating in Oligotrophic Drinking Water Reservoirs and Lakes
  Leister, Applied and environmental microbiology 2022 (secret)

Z0005 orf, hypothetical protein from Escherichia coli O157:H7 EDL933
Aligns to 25:97 / 98 (74.5%), covers 98.9% of PF10697, 52.3 bits

• Genome mining of novel rubiginones from Streptomyces sp. CB02414 and characterization of the post-PKS modification steps in rubiginone biosynthesis
  Zhang, Microbial cell factories 2021
  • “...by in-frame deletion [ 26 ], to generate mutant strains Z0004 (i.e., CB02414 rubN1 ), Z0005 (i.e., CB02414 rubN2 ), and Z0008 (i.e., CB02414 rubM4 ) (Additional file 1 : Fig. S53). The respective genes were cloned into the pSET152 plasmid under the ermE * promoter...”
  • “...that RubN1 is responsible for the introduction of the -hydroxyl group at C-2. Similarly, the Z0005 mutant only produced compounds 3 , 6 , and 7 , which lack the C-4 hydroxyl group, and the production of the other five compounds (rubiginones J, K, A 2...”
• Disruption of rcsB by a duplicated sequence in a curli-producing Escherichia coli O157:H7 results in differential gene expression in relation to biofilm formation, stress responses and metabolism
  Sharma, BMC microbiology 2017
  • “...protein +2.83 0.04 Z3305 Bacteriophage CP-933V encoded protein 1.62 0.01 Z4330 Transposase +1.94 0.03 Hypothetical Z0005 Unknown 7.49 4.7E-08 yagU Z0353 Putative acid resistance 2.29 0.004 yagY Z0359 Predicted pilus chaperone (cryptic) 2.13 0.04 yagZ Z0360 Predicted pilus major subunit 2.83 0.001 yaiY Z0475 Predicted inner...”

AAF13_RS18930 DUF2502 domain-containing protein from Escherichia coli O104:H4 str. C227-11
Aligns to 25:97 / 98 (74.5%), covers 67.8% of PF10697, 52.0 bits

• Broad time-dependent transcriptional activity of metabolic genes of E. coli O104:H4 strain C227/11Φcu in a soil microenvironment at low temperature
  Detert, Environmental microbiology reports 2023
  • “...Gene name Description Log 2 FC a 1week 4weeks AAF13_RS15145 YbgSlike family protein n.d.e 5.16 AAF13_RS18930 DUF2502 domaincontaining protein n.d.e 5.36 AAF13_RS19105 DUF1328 domaincontaining protein 2.20 5.39 AAF13_RS19690 Nacetylmannosamine6phosphate 2epimerase 3.03 5.32 AAF13_RS31850 DUF1471 domaincontaining protein n.d.e 6.20 actP Cation/acetate symporter ActP 6.73 2.17 araD Lribulose5phosphate...”

YaaX / b0005 DUF2502 domain-containing protein YaaX from Escherichia coli K-12 substr. MG1655 (see paper)
b0005 hypothetical protein from Escherichia coli str. K-12 substr. MG1655
Aligns to 25:97 / 98 (74.5%), covers 67.8% of PF10697, 51.8 bits

• Global analysis of extracytoplasmic stress signaling in Escherichia coli
  Bury-Moné, PLoS genetics 2009
  • “...H wcaB H b2062-58 Colanic acid biosynthesis and secretion 1.6; -; 1.9; -; - yaaX b0005 Putative periplasmic protein protein 1.9 wcaC F H wcaD F H wcaE F H wcaF FH gmd F fcl F nudD F H wcaI FH cpsB H cpsG H wcaJ...”
• The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli
  Zoetendal, Applied and environmental microbiology 2008
  • “...15.3 27.6 22.5 b1532 b1530 marB marR 2.6 2.6 21.5 27.4 b0005 b2390 b0618 b3687 b3686 b3238 b2675 yaaX ypeC citC ibpA ibpB yhcN nrdE 4.9 2.8 34.6 6.9 9.5 3.1...”
• A functional update of the Escherichia coli K-12 genome
  Serres, Genome biology 2001
  • “...leader peptide b0050 ec_0078 apaG o Conserved protein b0081 ec_0123 mraZ o Conserved hypothetical protein b0005 ec_G0005 yaaX o Unknown CDS * Gene product type: c, carrier; e, enzyme; f, factor; h, extrachromosomal origin; l, leader peptide; m, membrane component; n, RNA; o, ORF of unknown...”
• Web-based visualization tools for bacterial genome alignments
  Florea, Nucleic acids research 2000
  • “...same, contiguous fragment from the other genome. For example, the gene b0005 (at ~5 kb in ECO) is simply deleted from STM. A blue vertical stripe at the end of...”

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