Family Search for PF10759 (BPA)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

Running HMMer for PF10759

PF10759 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

BPA_MYCS2 / A0R5Z0 Bacterial proteasome activator from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
Aligns to 19:175 / 175 (89.7%), covers 97.5% of PF10759, 269.5 bits

• function: Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif) (PubMed:25469515). Interaction of Bpa with the proteasome stimulates proteasomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction (By similarity).
  subunit: Forms a homooligomeric, either hexameric or heptameric, ring- like structure which stacks co-axially with the proteasomal alpha- rings.

BPA_MYCTU / P9WKX3 Bacterial proteasome activator from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 24:174 / 174 (86.8%), covers 86.9% of PF10759, 263.7 bits

• function: Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteasomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.
  subunit: Forms a homooligomeric, either hexameric or heptameric, ring- like structure which stacks co-axially with the proteasomal alpha- rings.

Or search for genetic data about PF10759 in the Fitness Browser