Family Search for PF10776 (DUF2600)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF10776 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

E6U1R5 tetraprenyl-beta-curcumene synthase (EC 4.2.3.130) from Evansella cellulosilytica (see paper)
Aligns to 20:348 / 353 (93.2%), covers 100.0% of PF10776, 517.0 bits

A8FGH3 tetraprenyl-beta-curcumene synthase (EC 4.2.3.130) from Bacillus pumilus (see paper)
Aligns to 20:348 / 359 (91.6%), covers 100.0% of PF10776, 513.6 bits

Npun_F0237 hypothetical protein from Nostoc punctiforme
Aligns to 44:372 / 381 (86.4%), covers 99.4% of PF10776, 509.2 bits

• A regulatory linkage between scytonemin production and hormogonia differentiation in Nostoc punctiforme
  Klicki, iScience 2022
  • “...type. While most of these genes were annotated as hypothetical, one contiguous cluster (Npun_F0198 to Npun_F0237) included a heat shock protein HSP20, UV damage endonuclease, and manganese-containing catalase among other general stress response genes ( FigureS2 ). These results would imply that scyTCR can act as...”

YTPB_BACSU / O34707 Tetraprenyl-beta-curcumene synthase; EC 4.2.3.130 from Bacillus subtilis (strain 168) (see paper)
O34707 tetraprenyl-beta-curcumene synthase (EC 4.2.3.130) from Priestia megaterium (see paper)
NP_390928 tetraprenyl-beta-curcumene synthase from Bacillus subtilis subsp. subtilis str. 168
Aligns to 20:348 / 367 (89.6%), covers 100.0% of PF10776, 508.7 bits

• function: Catalyzes the transformation of a linear C35 prenyl diphosphate chain to form tetraprenyl-beta-curcumene.
  catalytic activity: all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta- curcumene + diphosphate (RHEA:33123)
• Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter.
  Kingston, Molecular microbiology 2014
  • GeneRIF: Results show that in the abscence of YtpB, heptaprenyl diphosphate accumulates and antagonizes both enzymes BceAB and BcrC sensitizing the bacteria to bacitracin.
• Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases
  Rudolf, Natural product reports 2020
  • “...185 DmtA1 A0A343VTS1 Drimentines Type II - - 238 Large terpene synthase (PF010776/IPR019712) YtpB (BsuTS) O34707 Sporulenes Type I DxxDxxxD and DxxxDxxED - 242 BalTS A0A094YZ24 Large -prenes Type I DxxDxxxD and DxxxDxxED 5YO8 243 Non-canonical humulene synthase (no PFAM/no IPR) AsR6 A0A2U8U2L5 Xenovulene Type I...”

A0A0H3E5A4 tetraprenyl-beta-curcumene synthase (EC 4.2.3.130) from Bacillus atrophaeus (see paper)
Aligns to 20:348 / 359 (91.6%), covers 100.0% of PF10776, 503.3 bits

D5DN48 tetraprenyl-beta-curcumene synthase (EC 4.2.3.130) from Priestia megaterium (see paper)
Aligns to 20:348 / 352 (93.5%), covers 100.0% of PF10776, 496.0 bits

6looA / A0A094YZ24 Crystal structure of class ib terpene synthase bound with geranylcitronellyl diphosphate (see paper)
Aligns to 19:347 / 347 (94.8%), covers 100.0% of PF10776, 487.1 bits

• Ligands: phosphono [(3~{s},6~{e},10~{e})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate; phosphono [(3~{r},6~{e},10~{e})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate (6looA)

Q5WIP9 beta-geranylfarnesene synthase (EC 4.2.3.188) from Alkalihalobacillus clausii (see 2 papers)
Aligns to 21:348 / 352 (93.2%), covers 99.7% of PF10776, 446.2 bits

BCLTS_SHOCL / M5AW86 Trifunctional sesterterpene/triterpene/sesquarterpene synthase; Bcl-TS; Beta-geranylfarnesene synthase; EC 4.2.3.188 from Shouchella clausii (Alkalihalobacillus clausii) (see 2 papers)
Aligns to 21:348 / 352 (93.2%), covers 99.7% of PF10776, 441.0 bits

• function: Catalyzes the conversion of geranylfarnesyl diphosphate (GFPP) and hexaprenyl diphosphate (HexPP) into beta-geranylfarnesene and beta-hexaprene, respectively (PubMed:23554321, PubMed:25882275). Also produces beta-heptaprene from heptaprenyl diphosphate (HepPP) as a minor product (PubMed:25882275).
  catalytic activity: (2E,6E,10E,14E)-geranylfarnesyl diphosphate = beta- geranylfarnesene + diphosphate (RHEA:54500)
  catalytic activity: all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate (RHEA:54504)
  catalytic activity: all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate (RHEA:54508)

Or search for genetic data about PF10776 in the Fitness Browser