Family Search for PF10951 (DUF2776)

PF10951 hits 8 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CPE2059 hypothetical protein from Clostridium perfringens str. 13
Aligns to 1:350 / 351 (99.7%), covers 100.0% of PF10951, 540.3 bits

• The yhiM gene codes for an inner membrane protein involved in GABA export in Escherichia coli
  Tramonti, AIMS microbiology 2017
  • “...E. coli is rather different from that found in Clostridium perfringens str.13, where the gene CPE2059 coding for a 351 amino acid-long protein homologous to E. coli YhiM, is located in between the genes CPE2060 and CPE2058 , coding for the homologs of E. coli GadC...”
• Biochemical and spectroscopic properties of Brucella microti glutamate decarboxylase, a key component of the glutamate-dependent acid resistance system
  Grassini, FEBS open bio 2015
  • “...Notably C. perfringens possesses both gadB (CPE2058) and gadC (CPE2060) genes, separated by the gene CPE2059 likely involved in the protection from acid stress [1] . In light of a possible involvement of C. perfringens Gad in GDAR and in the successful colonization of the gut,...”
• Comparative transcription analysis and toxin production of two fluoroquinolone-resistant mutants of Clostridium perfringens
  Park, BMC microbiology 2013
  • “...CPE0492 CPF_0465 capsular polysaccharide biosynthesis protein 6.5 1.9 CPE0495 CPF_0468 UDP-glucose/GDP-mannose dehydrogenase family 3.5 2.4 CPE2059 CPF_2316 putative membrane protein 7.1 3.2 CPE2079 CPF_2336 putative membrane protein 14.2 2.1 CPE0785 CPF_0787 putative membrane protein 2.3 2.1 Energy metabolism CPE2186 CPF_2451 ( atpE ) ATP synthase epsilon...”

CPF_2316 hypothetical protein from Clostridium perfringens ATCC 13124
Aligns to 1:350 / 351 (99.7%), covers 100.0% of PF10951, 537.7 bits

• Comparative transcription analysis and toxin production of two fluoroquinolone-resistant mutants of Clostridium perfringens
  Park, BMC microbiology 2013
  • “...CPF_0465 capsular polysaccharide biosynthesis protein 6.5 1.9 CPE0495 CPF_0468 UDP-glucose/GDP-mannose dehydrogenase family 3.5 2.4 CPE2059 CPF_2316 putative membrane protein 7.1 3.2 CPE2079 CPF_2336 putative membrane protein 14.2 2.1 CPE0785 CPF_0787 putative membrane protein 2.3 2.1 Energy metabolism CPE2186 CPF_2451 ( atpE ) ATP synthase epsilon subunit...”

DC23_22785 DUF2776 domain-containing protein from Escherichia coli O145:H28 str. 4865/96
Aligns to 1:348 / 350 (99.4%), covers 99.7% of PF10951, 522.3 bits

• Comparative Transcriptomics of Shiga Toxin-Producing and Commensal Escherichia coli and Cytokine Responses in Colonic Epithelial Cell Culture Infections
  Harrison, Frontiers in cellular and infection microbiology 2020
  • “...2.12 2.84 DA88_15545 DC23_10065 wcaK colanic acid biosynthesis pyruvyl transferase 122.26 15.65 3.55 2.16 DA88_18555 DC23_22785 yhiM environmental stress response 9.71 57.85 11.76 4.73 DA88_20255 DC23_11075 yahM function unknown 2.52 8.11 3.72 9.13 DA88_26845 DC23_21615 CAAX protease 13.35 4.23 5.82 3.42 DA88_27945 DC23_14280 diguanylate cyclase 2.35...”

YhiM / b3491 inner membrane protein YhiM from Escherichia coli K-12 substr. MG1655 (see 5 papers)
P37630 Inner membrane protein YhiM from Escherichia coli (strain K12)
NP_417948 inner membrane protein YhiM from Escherichia coli str. K-12 substr. MG1655
b3491 conserved inner membrane protein from Escherichia coli str. K-12 substr. MG1655
DA88_18555, SSON53G_RS20815 DUF2776 domain-containing protein from Escherichia coli
Aligns to 1:348 / 350 (99.4%), covers 99.7% of PF10951, 521.0 bits

• Rationally seeded computational protein design of ɑ-helical barrels
  Albanese, Nature chemical biology 2024
  • “...6XR1) 73 and the putative inner membrane protein from E. coli , YhiM (UniProt ID, P37630) 55 , 69 , 74 (Fig. 5 and Supplementary Tables 39 46 ). This model, based on five central helices, has the most striking similarity to the parallel -helical barrel...”
• The yhiM gene codes for an inner membrane protein involved in GABA export in Escherichia coli
  Tramonti, AIMS microbiology 2017
  • “...kDa and a theoretical pI 8.2. A BLAST [41] search, using E. coli YhiM (Swiss-Prot: P37630) as query sequence, retrieved as best scoring sequences (>45% identity) those from members of a protein family (pfam10951: DUF2776) for which a biochemical function has not been assigned yet. The...”
• The inner membrane protein YhiM is necessary for Escherichia coli growth at high temperatures and low osmolarity.
  Anderson, Archives of microbiology 2017 (PubMed)
  • GeneRIF: YhiM is important in protecting the cells from changes in temperature and osmolarity.
• Comparative Analysis of Transcriptomic Response of Escherichia coli K-12 MG1655 to Nine Representative Classes of Antibiotics
  Bie, Microbiology spectrum 2023
  • “...15.34 16.53 9.79 76.36 40.98 74.41 26.08 10.07 Sulfite reductase, flavoprotein subunit complex Sulfur metabolism b3491 yhiM 242.66 18.38 18.48 64.46 67.48 33.71 3.04 9.90 38.44 Inner membrane protein Acid stress response b3990 thiH 10.10 8.77 4.85 4.22 12.70 1.93 3.10 9.28 11.33 2-Iminoacetate synthase Sulfur...”
• The yhiM gene codes for an inner membrane protein involved in GABA export in Escherichia coli
  Tramonti, AIMS microbiology 2017
  • “...( Figure 1A ). In the E. coli K12 reference strain MG1655 the yhiM gene (b3491) is located in between the divergently oriented yhiL and yhiN genes ( Figure 1B ), thus suggesting that its transcript is monocistronic. The genomic context in E. coli is rather...”
• Evolutionary dynamics of small RNAs in 27 Escherichia coli and Shigella genomes
  Skippington, Genome biology and evolution 2012
  • “...fhlA b2731 oxyS 24 Variable Incongruent No yobF b1824 oxyS 18 Variable Congruent No yhiM b3491 oxyS 19 Variable Incongruent No gadB b1493 oxyS 27 Core Incongruent No uhpT b3666 oxyS 27 Core Incongruent No wrbA b1004 oxyS 21 Variable Incongruent No ybaY b0453 oxyS 25...”
• The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction
  Oberto, PloS one 2009
  • “...1.98 1.01 2.99 1 2.12 2.62 1.99 1 1.47 1.46 0.86 a hypothetical protein yhiM b3491 yhiM 1 3.03 1.24 4.03 1 0.69 1.71 0.11 1 1.63 2.38 0.36 g conserved inner membrane protein slp b3506 slp-dctR 1 0.24 1.08 0.88 1 1.42 8.6 0.64 1...”
• Gene expression profiling of the pH response in Escherichia coli
  Tucker, Journal of bacteriology 2002
  • “...b3510 hdeAc b0329 yahO b1003 yccJ b1597 asrc b1724 b1836 b3491 b1004 b2885 b4186 b0485 b0486 b0897 b1493 b3517 b3507 b3512 b3515 c ydiZ yebV yhiMc wrbA ygfRc...”
• Escherichia coli gene expression responsive to levels of the response regulator EvgA
  Masuda, Journal of bacteriology 2002
  • “...b2369 yegR emrK evgA b2371 b2372 b2373 b2374 b2375 b3238 b3491 b3506 yfdE yfdV yfdU yfdW yfdX yhcN yhiM slp b3507 b3508 b3509 b3510 b3511 b3512 b3513 b3514...”
• Comparative Transcriptomics of Shiga Toxin-Producing and Commensal Escherichia coli and Cytokine Responses in Colonic Epithelial Cell Culture Infections
  Harrison, Frontiers in cellular and infection microbiology 2020
  • “...2.57 2.12 2.84 DA88_15545 DC23_10065 wcaK colanic acid biosynthesis pyruvyl transferase 122.26 15.65 3.55 2.16 DA88_18555 DC23_22785 yhiM environmental stress response 9.71 57.85 11.76 4.73 DA88_20255 DC23_11075 yahM function unknown 2.52 8.11 3.72 9.13 DA88_26845 DC23_21615 CAAX protease 13.35 4.23 5.82 3.42 DA88_27945 DC23_14280 diguanylate cyclase...”
• Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence
  Torraca, PLoS pathogens 2019
  • “...suhB, katE, SSON53G_RS31575 (mcbA-like), hdeD, gadB_1, gadB_2, yohC, gadE, hdeB, SSON53G_RS09595 (narU-like), yegP, ycgB, hdeA, SSON53G_RS20815 (yhiM-like), fadB, yafH, fadA, dadA, artJ, argC, ygjG, argI, yjbJ, aceA, narZ, trxC, aceB_1, argA, modA, ybaT, ybaA, modB, phoH, rmf. From top to bottom, genes represented in E are:...”

EC042_RS20090 DUF2776 domain-containing protein from Escherichia coli 042
Aligns to 1:348 / 350 (99.4%), covers 99.7% of PF10951, 519.2 bits

• Overexpression of the third H-NS paralogue H-NS2 compensates fitness loss in hns mutants of the enteroaggregative Escherichia coli strain 042
  Prieto, Scientific reports 2020
  • “...WcaF) 581.7 9.8 EC042_RS12260 (GDP-L-fucose synthase WcaG) 505.7 5.4 EC042_RS24025 (cadaverine/lysine antiporter CadB) 492.4 7.0 EC042_RS20090 (hypothetical protein membrane protein) 438.8 14.0 EC042_RS12275 (colanic acid biosynthesis glycosyltransferase WcaE) 427.6 7.4 EC042_RS08585 (glutamate decarboxylase) 371.1 4.3 EC042_RS17480 (thymidylate kinase) 364.7 4.7 EC042_RS12255 (GDP-mannose mannosyl hydrolase) 352.9 6.1...”
  • “...187.9 EC042_RS06770 (tRNA-Tyr) 14.8 EC042_RS04580 (hypothetical protein) 14.5 13.5 EC042_RS01720 (putative fimbrial protein) 14.2 157.9 EC042_RS20090 (hypothetical protein membrane protein) 14.0 438.8 EC042_RS07750 (type I toxin-antitoxin Iar) 13.9 EC042_RS01270 (hypothetical protein) 13.6 88.2 EC042_RS24770 (tRNA-Gly) 13.5 EC042_RS09275 (hypothetical protein) 13.3 EC042_RS01065 (tRNA-Ala) 12.8 EC042_RS18940 (tRNA-Ala) 12.8...”

Z4890 orf, hypothetical protein from Escherichia coli O157:H7 EDL933
Aligns to 34:381 / 383 (90.9%), covers 99.4% of PF10951, 517.9 bits

• Disruption of rcsB by a duplicated sequence in a curli-producing Escherichia coli O157:H7 results in differential gene expression in relation to biofilm formation, stress responses and metabolism
  Sharma, BMC microbiology 2017
  • “...gadB Z2215 Glutamate decarboxylase 14.41 3.0E-03 xasA Z2216 Acid sensitivity protein GadC 17.72 7.5E-05 yhiM Z4890 Inner membrane protein 14.43 0.01 yhiD Z4920 Mg 2+ transport ATPase 12.48 0.01 hdeD Z4923 Acid-resistance membrane protein 13.47 5.0E-03 gadA Z4930 Glutamate decarboxylase 13.99 0.01 Oxidative stress ybjW Z1107...”
• Comparison of strand-specific transcriptomes of enterohemorrhagic Escherichia coli O157:H7 EDL933 (EHEC) under eleven different environmental conditions including radish sprouts and cattle feces
  Landstorfer, BMC genomics 2014
  • “...(3) 0.0 (0) 0.0 (0) 4.2 (4) 4.6 (9) 6.6 (36) 3.9 (5) 0.0 (0) Z4890 hypothetical protein spinach 1 (17) 2.1 (45) 0.4 (2) 3.9 (230) 4.9 (500) 0.7 (3) 2.1 (1) 4.7 (286) 5.6 (485) 2.1 (42) 0.8 (5) Z4909 hypothetical protein spinach 1...”
• RcsB contributes to the distinct stress fitness among Escherichia coli O157:H7 curli variants of the 1993 hamburger-associated outbreak strains
  Carter, Applied and environmental microbiology 2012
  • “...gadC yhiM yhiD hdeB hdeA hdeD gadA Z2216 Z4890 Z4920 Z4921 Z4922 Z4923 Z4930 Acid sensitivity protein Hypothetical protein related to acid resistance Putative...”

c4289 Hypothetical protein yhiM from Escherichia coli CFT073
Aligns to 5:352 / 354 (98.3%), covers 99.7% of PF10951, 512.8 bits

• The inner membrane protein YhiM links copper and CpxAR envelope stress responses in uropathogenic E. coli
  Saenkham-Huntsinger, mBio 2024
  • “...focD c1242 F1C fimbrial usher Outer membrane cusC c0658 Outer membrane channel Outer membrane yhiM c4289 Hypothetical protein Inner membrane cpxA c4863 Sensor histidine kinase Inner membrane c4545 Hypothetical protein Inner membrane c5041 Putative transport sensor protein Inner membrane c4502 Putative antiporter Inner membrane waaH c4441...”
• A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress
  Casanova-Hampton, Metallomics : integrated biometal science 2021
  • “...a transposon mutant in uropathogenic E. coli strain CFT073 that has a Tn5 inserted in c4289 encoding a predicted inner membrane protein (YhiM, Supplementary TableS1 ). This mutant exhibits a high level of Cu resistance compared to parental strain CFT073, and this phenotype could be reversed...”

EC958_3887 DUF2776 family protein from Escherichia coli O25b:H4-ST131
Aligns to 1:348 / 350 (99.4%), covers 99.7% of PF10951, 512.2 bits

• Sequential Acquisition of Virulence and Fluoroquinolone Resistance Has Shaped the Evolution of Escherichia coli ST131
  Ben, mBio 2016
  • “...39 yhaK Hypothetical protein 3921426 G G G G G G G G A KR EC958_3887 78 yhiM Hypothetical protein 2536291 C C C C C T C C T ND EC958_2567 87 gyrA DNA gyrase subunit A 1504736 C C C C C C C...”

Or search for genetic data about PF10951 in the Fitness Browser