Family Search for PF10998 (DUF2838)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF10998 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
AFUA_3G08240 glycerophosphocholine acyltransferase from Aspergillus fumigatus Af293
Aligns to 202:312 / 561 (19.8%), covers 100.0% of PF10998, 154.2 bits
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_4G13500 0.649573592 YDR479C AFUA_2G01510 0.649340576 YLR307W AFUA_4G09940 0.641152119 YLL050C AFUA_5G10570 0.636927762 YMR011W AFUA_2G11520 0.631877767 YGR149W AFUA_3G08240 0.627253467 YKL125W AFUA_1G02590 0.626251676 YDL247W AFUA_3G01700 0.621782331 YHR165C AFUA_2G03030 0.616638486 YLR355C AFUA_3G14490 0.615946987 YLR307W AFUA_3G07210 0.615345397 YNL156C AFUA_4G07680 0.605449075 YOL157C AFUA_8G07070 0.600254438 YPL196W AFUA_3G08740 0.596649007 YOL156W AFUA_2G11520 0.589475104 YGL055W AFUA_7G05920...”
CNB04770 integral to membrane protein from Cryptococcus neoformans var. neoformans JEC21
Aligns to 146:256 / 513 (21.6%), covers 100.0% of PF10998, 151.6 bits
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...2.06 Membrane proteins CNE02570 CNAG_02288 Succinate/fumarate mitochondrial transporter 3.22 CNA07060 CNAG_00727 Cation transporter-like protein 2.62 CNB04770 CNAG_03991 GPCR 2.46 CNA00570 CNAG_00066 Membrane protein 2.39 CNL04850 CNAG_05137 Putative KDEL receptor 2.14 CNH00490 CNAG_07874 Sugar transporter 2.06 CNC00290 CNAG_03060 Multiple drug resistance protein 2.04 Cryptococcus can use inositol...”
CNAG_03991 integral membrane protein from Cryptococcus neoformans var. grubii H99
Aligns to 146:256 / 513 (21.6%), covers 100.0% of PF10998, 151.6 bits
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...CNAG_06561 Allantoate transporter XM_012193248.1 2.46 0.0000 45.7 254.0 CNAG_04981 Catalase XM_012191909.1 2.44 0.0000 16.3 89.7 CNAG_03991 Integral membrane protein XM_012193748.1 2.43 0.0000 5.3 28.9 CNAG_00883 Transcription factor XM_012192625.1 2.42 0.0000 1.3 7.0 CNAG_06932 Sugar transporter XM_012193344.1 2.39 0.0000 4.8 25.5 CNAG_05139 Solute carrier family 35 (UDP-sugar...”
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...Membrane proteins CNE02570 CNAG_02288 Succinate/fumarate mitochondrial transporter 3.22 CNA07060 CNAG_00727 Cation transporter-like protein 2.62 CNB04770 CNAG_03991 GPCR 2.46 CNA00570 CNAG_00066 Membrane protein 2.39 CNL04850 CNAG_05137 Putative KDEL receptor 2.14 CNH00490 CNAG_07874 Sugar transporter 2.06 CNC00290 CNAG_03060 Multiple drug resistance protein 2.04 Cryptococcus can use inositol as...”
GPC1_SCHPO / O94673 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 111:221 / 403 (27.5%), covers 100.0% of PF10998, 147.1 bits
- function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (By similarity). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (By similarity). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (By similarity). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (By similarity). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (By similarity).
catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA (RHEA:62104)
GPC1_YEAST / P48236 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
YGR149W Putative protein of unknown function; predicted to be an integal membrane protein from Saccharomyces cerevisiae
NP_011665 glycerophosphocholine acyltransferase from Saccharomyces cerevisiae S288C
Aligns to 112:222 / 432 (25.7%), covers 100.0% of PF10998, 143.7 bits
- function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:18430972, PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:18430972, PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859). Involved in postsynthetic PC remodeling that produces more saturated PC species (PubMed:30514764).
catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA (RHEA:62104)
catalytic activity: hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine (RHEA:56148)
catalytic activity: (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56152)
catalytic activity: (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3- phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56156)
catalytic activity: (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3- phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56164)
catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- octadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56168)
catalytic activity: 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn- glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3- phosphocholine + sn-glycero-3-phosphoethanolamine (RHEA:56236)
disruption phenotype: Decreases the levels of monounsaturated PC species and increased those of diunsaturated PC species. Does not significantly affect phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine profiles. - Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes
Yasukawa, Molecular biology of the cell 2024 (no snippet) - Phosphatidylcholine:diacylglycerol cholinephosphotransferase's unique regulation of castor bean oil quality
Demski, Plant physiology 2022 - “...S. cerevisiae ) mutated in ALE1 (lysophospholipid acyltransferase, YOR175C ) and overexpressing the GPC1 ( YGR149W ) gene (yeast GPC acyltransferase, GPCAT) ( Glab et al., 2016 ). The lipids were extracted into chloroform and LPC separated from other lipids on TLC in chloroform:methanol:acetic acid:water (85:15:10:3.5...”
- Cloning of Glycerophosphocholine Acyltransferase (GPCAT) from Fungi and Plants: A NOVEL ENZYME IN PHOSPHATIDYLCHOLINE SYNTHESIS
Głąb, The Journal of biological chemistry 2016 - “...not screened ( Fig. 2 B ). The identified strain bears a deletion in ORF YGR149W , here named GPC1 , which is annotated as a putative protein of unknown function in the Saccharomyces Genome Database. The gene was amplified, cloned into a pYES-based yeast vector,...”
- “...the deletion strain lacking GPCAT activity (within the hatched square ). C , complementation of YGR149W ( GPC1 ) in the gpc1 deletion strain. Empty vector as well as the deletion strain ( gpc1 ) are also included. Irrelevant lanes from the plate have been removed...”
- The yeast Hot1 transcription factor is critical for activating a single target gene, STL1
Bai, Molecular biology of the cell 2015 - “...name Fold change Gene name Fold change Gene name Fold change STL1 87.68 BAG7 4.02 YGR149W 2.45 RTC3 75.61 SPI1 3.97 PRX1 2.45 HSP12 47.21 YPK2 3.59 YNR066C 2.42 KDX1 26.33 ALD3 3.52 FLC2 2.42 GPD1 18.19 YMR103C 3.50 ERR1 2.39 CWP1 16.78 YPS3 3.47 RGS2...”
- An efficient algorithm to explore liquid association on a genome-wide scale
Gunderson, BMC bioinformatics 2014 - “...\usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} ${\hat {MLA}}$ \end{document} MLA ^ Wald p-value p-adj Model 1 SKN1 GAS2 YGR149W 1.335 0.417 49.050 2.501E-12 5.332E-05 F 2 YCRX13W YFL052W STL1 1.234 0.417 47.600 5.217E-12 5.332E-05 F 3 UBC5 RTG2 MLH2 -1.325 -0.471 46.720 8.194E-12 5.332E-05 F 4 RSM28 YLR281C PLB1...”
- A Whole Genome Screen for Minisatellite Stability Genes in Stationary-Phase Yeast Cells
Alver, G3 (Bethesda, Md.) 2013 - “...YGR031w AIM23 YJL131c LIP5 YOR196c SOL3 YHR163w YGR051C YGR051c ALR2 YFL050c MET22 YOL064c SPE1 YKL184w YGR149W YGR149w APM4 YOL062c MON1 YGL124c SPS22 YCL048w YGR176W YGR176w APS1 YLR170c MPC54 YOR177c SRN2 YLR119w YGR207C YGR207c ARN2 YHL047c MRM2 YGL136c SRX1 YKL086w YGR266W YGR266w ART5 YGR068c MRPL22 YNL177c SSH4...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...0.989224447 706505 chr07 YGR109W-B 0.964433838 0.990506548 707614 + chr07 YGR109W-A 0.964433838 0.990506548 707614 + chr07 YGR149W 0.957244122 0.960107682 789036 + chr07 YGR161W-B 0.958455297 0.972873884 811743 + chr07 YGR161W-A 0.958455297 0.9728739 811743 + chr07 YGR161C-D 0.9711882 0.974318881 823020 chr07 YGR161C-C 0.9711882 0.9743189 823020 chr07 YGR162W 0.967152562 0.972476532...”
- “...YMR110C AFUA_4G13500 0.649573592 YDR479C AFUA_2G01510 0.649340576 YLR307W AFUA_4G09940 0.641152119 YLL050C AFUA_5G10570 0.636927762 YMR011W AFUA_2G11520 0.631877767 YGR149W AFUA_3G08240 0.627253467 YKL125W AFUA_1G02590 0.626251676 YDL247W AFUA_3G01700 0.621782331 YHR165C AFUA_2G03030 0.616638486 YLR355C AFUA_3G14490 0.615946987 YLR307W AFUA_3G07210 0.615345397 YNL156C AFUA_4G07680 0.605449075 YOL157C AFUA_8G07070 0.600254438 YPL196W AFUA_3G08740 0.596649007 YOL156W AFUA_2G11520 0.589475104 YGL055W...”
- Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A
Florio, BMC microbiology 2011 - “...2.05 03452 AFG1 AFG1 family mitochondrial ATPase - 2.16 05831 MMF1 Brt1 - 2.19 03991 YGR149W Integral to membrane protein - 2.39 02039 YPL264C Integral membrane protein - 2.46 02943 SLM1 Cytoplasm protein - 2.49 06668 AIM38 Mitochondrion protein - 2.61 00638 LSG1 GTPase - 2.89...”
- More
- Cloning of Glycerophosphocholine Acyltransferase (GPCAT) from Fungi and Plants: A NOVEL ENZYME IN PHOSPHATIDYLCHOLINE SYNTHESIS.
Głąb, The Journal of biological chemistry 2016 - GeneRIF: In vivo labeling studies confirm a role for Gpc1p in PC biosynthesis in yeast. It is postulated that GPCATs contribute to the maintenance of phosphatidylcholine (PC) homeostasis and also have specific functions in acyl editing of PC (e.g. in transferring acyl groups modified at the sn-2 position of PC to the sn-1 position of this molecule in plant cells).
- The acyltransferase Gpc1 is both a target and an effector of the unfolded protein response in Saccharomyces cerevisiae
Hrach, The Journal of biological chemistry 2023 - “...to known acyltransferases or transacylases and has been designated a new protein family (UniProtKB - P48236) ( 78 ). Gpc1 sequence homologs are lacking in vertebrates but are found in other organisms, including plants ( 22 ), and medically important pathogenic fungi such as C.albicans (...”
- TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids.
Reed, Nature chemical biology 2023 - “...(S.pneumoniae (Q8CYG1); B.subtilis (P25149)) and YpjA proteins (S.aureus (Q2FYH4); A.venificus (F2KNL0)), and GPC1 enzymes (S.cerevisiae (P48236); A.thaliana (Q9FJB4). In some cases, models were built with ColabFold implementation of AlphaFold2 ( http://github.com/sokrypton/ColabFold ). The alignment was displayed and analyzed with Jalview ( http://jalview.org ), showing the six...”
DDB_G0275521 hypothetical protein from Dictyostelium discoideum AX4
Aligns to 103:213 / 477 (23.3%), covers 100.0% of PF10998, 131.6 bits
GPC1_ARATH / Q9FJB4 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT5G35460 hypothetical protein from Arabidopsis thaliana
Aligns to 66:176 / 381 (29.1%), covers 99.1% of PF10998, 131.5 bits
- function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859).
catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- octadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56168) - TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids.
Reed, Nature chemical biology 2023 - “...B.subtilis (P25149)) and YpjA proteins (S.aureus (Q2FYH4); A.venificus (F2KNL0)), and GPC1 enzymes (S.cerevisiae (P48236); A.thaliana (Q9FJB4). In some cases, models were built with ColabFold implementation of AlphaFold2 ( http://github.com/sokrypton/ColabFold ). The alignment was displayed and analyzed with Jalview ( http://jalview.org ), showing the six blocks of...”
- RLPredictiOme, a Machine Learning-Derived Method for High-Throughput Prediction of Plant Receptor-like Proteins, Reveals Novel Classes of Transmembrane Receptors
Silva, International journal of molecular sciences 2022 - “...leaf senescence related protein, putative, expressed AT4G12250 0.0 0.33333333 1 4 UDP-glucuronate 4-epimerase, putative, expressed AT5G35460 0.0 0.33333333 1 4 integral membrane protein, putative, expressed AT1G16170 0.0 0.33333333 1 4 expressed protein AT5G03345 0.0 0.33333333 1 4 expressed protein AT1G47640 0.0 0.33333333 1 4 SSA2-2S albumin...”
- Cloning of Glycerophosphocholine Acyltransferase (GPCAT) from Fungi and Plants: A NOVEL ENZYME IN PHOSPHATIDYLCHOLINE SYNTHESIS
Głąb, The Journal of biological chemistry 2016 - “...WT in GPCAT assays. The genes encoding GPCAT from yeast ( YGR149W ) and Arabidopsis (At5g35460) were amplified by PCR, whereas the genes from castor bean (XM_002514040) and oilseed rape (BnaA04g07370D) were ordered synthetically (GenScript) by using known sequence information. The Gateway system was used to...”
- Identification of conserved drought-adaptive genes using a cross-species meta-analysis approach
Shaar-Moshe, BMC plant biology 2015 - “...(AT3G51520, diacylglycerol acyltransferase family), loc_os06g49990 (AT3G51130) Unclassified loc_os10g32680 (AT1G07040), loc_os11g37560 (AT3G55760), loc_os01g46600 (PM41), loc_os03g51350, loc_os01g40280 (AT5G35460), loc_os09g20930, loc_os03g45280 (dehydrin), loc_os04g34610 (AT1G43245), loc_os03g48380 (AT1G27150), loc_os08g33640 (AT1G23110), loc_os01g58114 (AT4G27020), loc_os05g33820 (AT1G10740), loc_os02g48630 (AT5G48020), loc_os05g48230 (AT4G13400), loc_os09g04100 (AT4G31830), loc_os01g26920 (AT2G39080) loc_os02g38240 (AT4G24750), loc_os07g12730 (AT5G01750) To compare the CSA:Drought results...”
- Presence-absence variation in A. thaliana is primarily associated with genomic signatures consistent with relaxed selective constraints
Bush, Molecular biology and evolution 2014 - “...D < 2 and only 2 have D > 2 (AT1G12180, D = 2.17, and AT5G35460, D = 2.05, both of which are functionally uncharacterized). Among CDS-PAV genes, only seven have D < 2 and none have D > 2. Compared with the set of intact...”
- Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression
Ma, Genome biology 2007 - “...(C3HC4-type RING finger) family protein; AT2G32800, protein kinase family protein, contains dual protein kinase domains; AT5G35460, expressed protein; AT2G32510, protein kinase family protein, contains protein kinase domain; AT1G07870, protein kinase family protein, contains protein kinase domain; AT1G43160, encodes a member of the ERF (ethylene response factor)...”
GPC1_RICCO / B9RK42 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Ricinus communis (Castor bean) (see paper)
Aligns to 69:179 / 391 (28.4%), covers 99.1% of PF10998, 131.0 bits
- function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859).
catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a monoacyl-sn- glycero-3-phosphocholine + CoA (RHEA:58460)
catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
catalytic activity: hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine (RHEA:56148)
catalytic activity: (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- hexadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56228)
catalytic activity: (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56152)
catalytic activity: (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3- phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56156)
catalytic activity: (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3- phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3- phosphocholine + CoA (RHEA:56164)
catalytic activity: (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z- octadecenoyl)-sn-glycero-3-phosphocholine + CoA (RHEA:56168)
GPC1_BRANA / A0A078H868 Glycerophosphocholine acyltransferase 1; GPCAT; EC 2.3.1.- from Brassica napus (Rape) (see paper)
Aligns to 70:180 / 387 (28.7%), covers 99.1% of PF10998, 130.0 bits
- function: Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859).
catalytic activity: an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn- glycero-3-phosphocholine + CoA (RHEA:58476)
catalytic activity: an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl- sn-glycero-3-phosphoethanolamine + CoA (RHEA:62108)
EHI_109690 hypothetical protein, conserved from Entamoeba histolytica HM-1:IMSS
Aligns to 77:190 / 391 (29.2%), covers 100.0% of PF10998, 119.8 bits
Or search for genetic data about PF10998 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory