Family Search for PF11028 (DUF2723)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF11028 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BF0076 Hypothetical protein from Bacteroides fragilis YCH46
Aligns to 35:214 / 1119 (16.1%), covers 97.8% of PF11028, 260.1 bits

• Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice
  Donaldson, Nature microbiology 2020
  • “...in the lumen ( Fig. 2f , Supplementary Table 6 ). Ribonuclease P (RNase P, BF0076 or BF9343_RS00335), the ribozyme that cleaves the precursor RNA on tRNAs to form mature tRNAs, was also up-regulated in both the mucus and tissue ( Fig. 2f ). Additionally, a...”

Aasi_1844 hypothetical protein from Candidatus Amoebophilus asiaticus 5a2
Aligns to 43:223 / 1005 (18.0%), covers 99.4% of PF11028, 210.2 bits

• A bacterial genome in transition--an exceptional enrichment of IS elements but lack of evidence for recent transposition in the symbiont Amoebophilus asiaticus
  Schmitz-Esser, BMC evolutionary biology 2011
  • “...A. asiaticus likely play an important role (Additional file 2 , Table S3). For example, Aasi_1844 is an uncharacterized membrane protein conserved among most Bacteroidetes and Chlorobi ; Aasi_1118 contains six TPR/SEL1 repeats, eukaryotic domains that can be involved in host cell interaction [ 75 ],...”

TM260_HUMAN / Q9NX78 Protein O-mannosyl-transferase TMEM260; Transmembrane protein 260; EC 2.4.1.109 from Homo sapiens (Human) (see 3 papers)
Aligns to 52:215 / 707 (23.2%), covers 97.8% of PF11028, 136.9 bits

• function: O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins (PubMed:37186866). Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON (PubMed:37186866). TMEM260- mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified (PubMed:37186866).
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) (RHEA:17377)
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) (RHEA:53396)

TM260_MOUSE / Q8BMD6 Protein O-mannosyl-transferase TMEM260; Transmembrane protein 260; EC 2.4.1.109 from Mus musculus (Mouse) (see paper)
Aligns to 48:211 / 703 (23.3%), covers 97.8% of PF11028, 132.6 bits

• function: O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins. Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON. TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3- O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) (RHEA:17377)
  catalytic activity: a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+) (RHEA:53396)
  disruption phenotype: Receptor maturation defects and abnormal epithelial morphogenesis.

XP_013409033 transmembrane protein 260-like from Lingula anatina
Aligns to 87:249 / 736 (22.1%), covers 97.8% of PF11028, 114.4 bits

• Horizontal gene transfer is not a hallmark of the human genome
  Salzberg, Genome biology 2017
  • “...protein ID Bit score New HGT index ENSG00000070269 C14orf101 337 Protist B4LPG6 37 Lingula anatina XP_013409033 566 192 ENSG00000102805 Ceroid-lipofuscinosis, neuronal 5 84 Protist E3MZU2 39 Lottia gigantea XP_009059770 338 215 ENSG00000116721 PRAME family member 1 72 Protist a A8MVS2 44 No hits ENSG00000157358 PRAME family...”

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