Family Search for PF11119 (DUF2633)

PF11119 hits 3 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

STM14_3071 YfgG family protein from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S
STM2506 putative inner membrane protein from Salmonella typhimurium LT2
Aligns to 7:49 / 63 (68.3%), covers 100.0% of PF11119, 101.4 bits

• L-Arabinose Transport and Metabolism in Salmonella Influences Biofilm Formation
  Vasicek, Frontiers in cellular and infection microbiology 2021
  • “...family, sn-glycerol-3-phosphate transport protein STM14_2886 3.53 putative transketolase ulaA_2 3.48 ascorbate-specific PTS system enzyme IIC STM14_3071 -3.51 putative inner membrane protein ygaP -3.52 putative rhodanese-like sulfurtransferase maf_2 -3.53 Maf-like protein folA -3.61 Dihydrofolate reductase otsB -3.7 trehalose-6-phosphate phosphatase yejG -3.86 hypothetical protein yqjI -3.87 putative transcriptional...”
• Ethanol Adaptation Strategies in Salmonella enterica Serovar Enteritidis Revealed by Global Proteomic and Mutagenic Analyses
  He, Applied and environmental microbiology 2019 (secret)

BWI76_RS21010 Negative regulator of nickel and cobalt uptake (YfgG) from Klebsiella michiganensis M5al
Aligns to 1:43 / 63 (68.3%), covers 100.0% of PF11119, 99.8 bits

• mutant phenotype: Specifically important in stress Nickel (II) chloride hexahydrate, and also important for cobalt stress. Similar to E.coli yfgG, which has similar phenotypes. Both orthologs have strong negative cofitness with the Mg/Ni/Co transporter corA (BWI76_RS01225). BWI76_RS21010 is a putative small membrane protein and might inhibit corA or reduce its abundance (by analogy to the magnesium transporter MtgE and the small membrane protein MtgS that binds and stabilizes MtgS).

b2504 Negative regulator of nickel and cobalt uptake (YfgG) from Escherichia coli BW25113
YfgG / b2504 nickel/cobalt stress response protein YfgG from Escherichia coli K-12 substr. MG1655 (see 3 papers)
YFGG_ECOLI / P64545 Protein YfgG from Escherichia coli (strain K12) (see paper)
b2504 hypothetical protein from Escherichia coli str. K-12 substr. MG1655
Aligns to 7:49 / 63 (68.3%), covers 100.0% of PF11119, 98.2 bits

• mutant phenotype: YfgG is important for resisting cobalt and nickel stress, as is its ortholog in Klebsiella (BWI76_RS21010). Furthermore, overexpression of yfgG confers increased resistance to cobalt (PMID:30659179). YfgG has strong negative cofitness with the Mg/Ni/Co transporter corA, as does its ortholog in Klebsiella. YfgG is a small putative membrane protein and might bind corA to inhibit it or reduce its abundance (by analogy to the magnesium transporter MtgE and the small membrane protein MtgS that binds and stabilizes MtgS.)
• A comparative genomics approach to prediction of new members of regulons
  Tan, Genome research 2001
  • “...20.88 20.17 20.93 14.99 Category I b1674-b1673-b1672b1671-ydhU-b1669 b2503 b2504 cydAB narXL ung yciCB yciD yehDCBA yfiD Listed are predictions from category I....”

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