Family Search for PF11248 (DUF3046)

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PF11248 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Rv2738c hypothetical protein from Mycobacterium tuberculosis H37Rv
Aligns to 5:66 / 68 (91.2%), covers 98.4% of PF11248, 98.5 bits

• Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence
  Talwar, mSystems 2020
  • “...Conserved hypotheticals 100 Rv1893 Conserved hypotheticals 100 Rv1993c Conserved hypotheticals 100 Rv2548A Conserved hypotheticals 100 Rv2738c Conserved hypotheticals 100 Rv3440c Conserved hypotheticals 100 Rv0011c Cell wall and cell processes 60 Rv0431 Cell wall and cell processes 60 Rv1463 Cell wall and cell processes 60 Rv1973 Cell...”
• Bacterial EndoMS/NucS acts as a clamp-mediated mismatch endonuclease to prevent asymmetric accumulation of replication errors
  Takemoto, Nucleic acids research 2018
  • “...found in C. glutamicum . The C. glutamicum homologues of Rv2412 ( NCgl2261 ) and Rv2738c ( NCgl1806 ) were annotated as ribosomal protein and phage integrase, respectively, and were not analyzed further. We attempted to obtain a C. glutamicum in-frame deletion mutant strains with the...”
• The effect of growth rate on pyrazinamide activity in Mycobacterium tuberculosis - insights for early bactericidal activity?
  Pullan, BMC infectious diseases 2016
  • “...two. In contrast, four genes were up-regulated under fast growth between these phases: Rv2645 (uncharacterised), Rv2738c (uncharacterised), Rv3221 (biotynylated protein TB7.3), and Rv3018c (uncharacterised PPE family protein), (Additional file 1 : Table S1). Following this, comparisons were made between the pre-PZA phase and the recovery phases....”

ML0986 conserved hypothetical protein from Mycobacterium leprae TN
Aligns to 4:65 / 67 (92.5%), covers 98.4% of PF11248, 96.7 bits

• Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences
  Chandra, FEMS microbiology reviews 2014
  • “...), 5414 ( ML1176 ), 5493 ( ML1706 ), 5697 ( Tfu_0751 ), 5766 ( ML0986 ), 5866 ( ML1027 ), 6030 ( ML1041 ). One ( ML2428A ) was similar to SCO3327 , but did not give a reciprocal blastp best hit, and another (...”

PFCIRM129_04925 DUF3046 domain-containing protein from Propionibacterium freudenreichii subsp. freudenreichii
Aligns to 1:62 / 64 (96.9%), covers 98.4% of PF11248, 89.0 bits

• Mutation of the Surface Layer Protein SlpB Has Pleiotropic Effects in the Probiotic Propionibacterium freudenreichii CIRM-BIA 129
  do, Frontiers in microbiology 2018
  • “...biogenesis PFCIRM129_05460 489.2107 Surface protein with SLH domain 2.29 0.039 Posttranslational modification, protein turnover, chaperones PFCIRM129_04925 12.884 Hypothetical protein 2.29 0.028 Carbohydrate transport and metabolism PFCIRM129_10690 9.166 Protein of unknown function 2.37 0.049 Function unknown PFCIRM129_05620 65.4691 MscS transporter, small conductance mechanosensitive ion channel 2.43 0.044...”

Blon_0948 hypothetical protein from Bifidobacterium longum subsp. infantis ATCC 15697
Aligns to 23:84 / 99 (62.6%), covers 98.4% of PF11248, 86.1 bits

• Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response
  Kavanaugh, PloS one 2013
  • “...0.005 1.59 0.008 1.43 0.012 Blon_0947 helix-turn-helix domain protein 1.32 0.01 1.35 0.007 1.54 0.0002 Blon_0948 hypothetical protein 1.3 0.02 1.3 0.02 1.5 0.003 Blon_0992 hypothetical protein 1.43 0.021 1.98 0.004 2.47 0.002 Blon_1687 TfoX, C-terminal domain protein 1.56 0.009 1.93 0.0006 2.26 0.001 Blon_1688 transcription...”

Y274C_MYCTU / O33285 Putative envelope-preserving system protein Rv2742c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Rv2742c CONSERVED HYPOTHETICAL ARGININE RICH PROTEIN from Mycobacterium tuberculosis H37Rv
Aligns to 223:269 / 277 (17.0%), covers 66.1% of PF11248, 47.9 bits

• function: Involved in preservation of envelope integrity and tolerance to surface stress (PubMed:25899163). Reverses the inhibitory effect of PspA on ClgR activity (PubMed:25899163). Facilitates intracellular growth of M.tuberculosis (PubMed:25899163).
  subunit: Interacts with Rv2743c.
  disruption phenotype: The Rv2743c-Rv2742c double mutation reduces intracellular ATP levels under surface-stress conditions to less than 60% of wild-type levels.
• SigE: A master regulator of Mycobacterium tuberculosis
  Manganelli, Frontiers in microbiology 2023
  • “...PspA, until following surface stress, PspA releases it to bind the surface-associated proteins Rv2743c and Rv2742c through a partner-switching mechanism ( Manganelli and Gennaro, 2017 ). It is possible that in condition of low pH this mechanism is only mildly activated, with ClgR remaining inactive and...”
• Global-scale GWAS associates a subset of SNPs with animal-adapted variants in M. tuberculosis complex
  Brenner, BMC medical genomics 2023
  • “...membrane alanine valine and leucine rich protein Phe41Leu 3,055,922 0 0.997 4100 2250 9 8 Rv2742c Conserved hypothetical arginine rich protein Synonymous 3,140,153 0 0.998 4100 2250 9 4 Rv2833c UgpB Probable Sn-glycerol-3-phosphate-binding lipoprotein UgpB Ser111Ile 3,142,580 0 0.951 4100 2100 161 1 Rv2836c DinF Possible...”
• Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria
  Ravi, Antonie van Leeuwenhoek 2018
  • “...within the class Actinobacteria, whereas the constituent domain of PspN, a gene of unknown function (Rv2742c in M. tuberculosis H37Rv), is found in almost all the orders in the class ( Fig. 1 ). Other actinobacterial classes such as Coriobacteriia or Acidimicrobiia carry neither PspM nor...”
  • “...coli , M. tuberculosis , two copies from B. subtilis ); PspM (Rv2743c) and PspN (Rv2742c) (from M. tuberculosis ); PspB and PspC (from E. coli ); LiaI, LiaG, and LiaF (from B. subtilis ) were queried against all sequenced actinobacterial genomes (~450 of a total...”
• Protecting from Envelope Stress: Variations on the Phage-Shock-Protein Theme
  Manganelli, Trends in microbiology 2017
  • “...the transcriptional regulator clgR , pspA , and two genes of unknown function, rv2743c and rv2742c ( M. tuberculosis genes are numbered according to Cole et al. [ 46 ]) ( Figure 1C ). This four-gene operon, which is regulated by the envelope-stress-responsive accessory sigma factor...”
  • “...( Figure 1C ). It also appears that the multiprotein complex of PspA, Rv2743c and Rv2742c is targeted to the cell membrane, since the integral membrane protein Rv2743c can establish direct contacts with both PspA and Rv2742c [ 12 ]. Indeed, sub-cellular fractionation studies of M....”
• Rv2744c Is a PspA Ortholog That Regulates Lipid Droplet Homeostasis and Nonreplicating Persistence in Mycobacterium tuberculosis
  Armstrong, Journal of bacteriology 2016
  • “...Number 11 mologs of Rv2745c-Rv2744c-Rv2743c but that lacks Rv2742c (24). While the significance of this difference is unclear, the presence of Rv2742c in human...”
  • “...two determinants present in this operon, Rv2743c and Rv2742c. Both are conserved alanine-rich proteins, and Rv2743c is predicted to possess a transmembrane...”
• The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions
  Datta, Molecular microbiology 2015
  • “...Psp-like functions. We identified a four-gene set -- clgR , pspA ( rv2744c ), rv2743c, rv2742c that is regulated by clgR and in turn regulates ClgR activity. Regulatory and protein-protein interactions within the set and a requirement of the four genes for functions associated with envelope...”
  • “...signals during chronic infection, making the system uniquely suited to tuberculosis pathogenesis. clgR pspA rv2743c rv2742c actinobacteria The intracellular pathogen Mycobacterium tuberculosis responds to host-generated stress by extensive metabolic remodeling that leads to growth arrest and reduced susceptibility to host defenses and most antimicrobial agents. The...”
• PANDA2: protein function prediction using graph neural networks.
  Zhao, NAR genomics and bioinformatics 2022
  • “...from electronic annotation (IEA) that is not an experimental evidence code. Only the hypothetical protein O33285 (putative envelope-preserving system protein Rv2742c) in the third dataset was annotated with the GO:0005886 (plasma membrane) by high throughput direct assay (HDA) that was an experimental evidence code. Our deep...”
  • “...Table 5 shows the top 10 CCO terms predicted by PANDA2 for the hypothetical protein O33285, which is the only protein that we have found having been annotated with a GO term based on experimental evidence. The semantic similarities of predicted GO terms and the experimentally...”

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