Family Search for PF11326 (DUF3128)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF11326 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

AFUA_1G07360 conserved hypothetical protein from Aspergillus fumigatus Af293
Aligns to 114:195 / 227 (36.1%), covers 100.0% of PF11326, 97.5 bits

• Afu-Emi1 Contributes to Stress Adaptation and Voriconazole Susceptibility in Aspergillus fumigatus
  Tan, Microbiology spectrum 2023
  • “...of a protein with previously unknown function that is encoded by the gene designated Afu-emi1 (AFUA_1G07360). High-throughput gene replacement technology was applied to construct the knockout Afu-emi1 strain and a revertant strain. The MICs for azoles, including posaconazole, itraconazole, and voriconazole, were evaluated via the broth...”
  • “...and impede azole resistance. KEYWORDS Aspergillus fumigatus Afu-emi1 voriconazole cyp51A stress adaptation efflux pump azoles AFUA_1G07360 Natural Science Foundation of Fujian Province (Fujian Provincial Natural Science Foundation) https://doi.org/10.13039/501100003392 2021D031 Gao Lujuan Xiamen Municipal Bureau of Science and Technology (Xiamen Science and Technology Bureau) https://doi.org/10.13039/100010166 3502Z202114ZD1072 Gao...”

SPAC227.17c conserved protein (fungal and plant) from Schizosaccharomyces pombe
Aligns to 33:114 / 121 (67.8%), covers 98.8% of PF11326, 91.6 bits

• Exploring Genetic Interactions with Telomere Protection Gene pot1 in Fission Yeast
  Ueno, Biomolecules 2023
  • “...that pot1 has negative genetic interactome with atp10 and prz1 and positive genetic interaction with SPAC227.17c [ 86 ]. However, these interactions are not studied in detail. Further research will be necessary to understand the mechanism of these genetic interactions. Prokaryotes such as E. coli have...”

EMI1_YEAST / Q04406 Early meiotic induction protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
NP_010800 Emi1p from Saccharomyces cerevisiae S288C
YDR512C Emi1p from Saccharomyces cerevisiae
Aligns to 104:181 / 187 (41.7%), covers 100.0% of PF11326, 90.9 bits

• function: Involved in sporulation. Required for the full activation of the early meiotic inducer IME1.
• Systematic analysis of the twin cx(9)c protein family.
  Longen, Journal of molecular biology 2009 (PubMed)
  • GeneRIF: Loss of Mdm35, Emi1, and Mrp10 leads to abnormal mitochondrial morphology
• Gene-nutrient interaction markedly influences yeast chronological lifespan
  Smith, Experimental gerontology 2016
  • “...FATty acid transporter YBR128C ATG14 AuTophaGy related YBR281C DUG2 Deficient in Utilization of Glutathione YCR087W YDR512C EMU Early Meiotic Induction YEL033W MTC7 Maintenance of Telomere Capping YER005W YND1 Yeast Nucleoside Diphosphatase YFL033C RIM 15 Regulator of IME2 YGL045W RIM8 Regulator of IME2 YHL027W RIM 101 Regulator...”
• Global genetic determinants of mitochondrial DNA copy number
  Zhang, PloS one 2014
  • “...membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase YDR512C 640.157.3 * Molecular function unknown VMA21 2396.6394.4 * Vacuolar acidification PET309 428.167.4 * Required for stability and translation of COX1 mRNA MEF1 315.422.1 * Mitochondrial elongation factor G-like protein YLR091W...”
• The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria
  Osman, The Journal of cell biology 2009
  • “...CTK3 YML112w N, C GD PIF1 YML061c M, N GD PIH1 YHR034c N GD EMI1 YDR512c C GD C, cytosol; GD, growth defect associated with double mutant; IM, inner membrane; IMS, intermembrane space; M, mitochondria; MA, matrix; N, nucleus; ND, not determined; OM, outer membrane; SL,...”
• A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae
  Addinall, Genetics 2008
  • “...YFL001W YKR035W-A YGR227W YKL213C YDR206W YBL047C YKL048C YDR512C YMR015C [YML008C YER145C YPL262W YBL016W YIL097W YOR183W YMR307W YJR040W YGL020C YHL031C...”
• Ascospore formation in the yeast Saccharomyces cerevisiae
  Neiman, Microbiology and molecular biology reviews : MMBR 2005
  • “...YDL059c YDR076w YDR108w YDR138w YDR207c YDR255c YDR285w YDR512c YER095w YER179w YFL033c YFR048w YGL033c YGL175c YGL240w YGL249w YHL023c YHL024w YHL027w YHR004c...”
• Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae
  Enyenihi, Genetics 2003
  • “...YBR174C YCR105W YDL041W YDL151C YDR070C YDR126W YDR359C YDR512C YEL072W YFR048W YGL066W YGL218W YHL023C YHR116W YKL054C YKR089C YLR235C YML009W-B YMR158W-A...”

CV039_MOUSE / Q3U595 Synaptic plasticity regulator PANTS; Plasticity-associated neural transcript short from Mus musculus (Mouse) (see 2 papers)
Aligns to 10:88 / 105 (75.2%), covers 98.8% of PF11326, 59.2 bits

• function: Negatively regulates long-term potentiation and modulates adult synaptic plasticity (PubMed:35771867). Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites (PubMed:35771867). Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses (PubMed:35771867).
  subunit: Interacts with RTN4 isoform A/Nogo-A; the interaction results in enhanced RTN4-mediated inhibition of AMPA receptor clustering (PubMed:35771867). Also interacts with NCAM1, RANBP2 and CCT8 (PubMed:35771867).
• The central nervous system can directly regulate breast cancer progression and blockage by quercetin.
  Luo, Annals of translational medicine 2021
  • “...Krt5 0.6096 0.0480 Q6IFX2 Krt42 0.5902 0.0192 Q61781 Krt14 0.5115 0.0245 Q9D845 Tex9 0.5061 0.0073 Q3U595 UPF0545 protein C22orf39 homolog 0.5006 0.0246 CRS, chronic restraint stress. Table 4 Proteins upregulated by the Xiaoyao pill after CRS (CRS + Xiaoyao pill vs. CRS) Accession Gene name/description CRS...”

AT4G25315 Expressed protein from Arabidopsis thaliana
Aligns to 45:115 / 127 (55.9%), covers 80.0% of PF11326, 53.7 bits

• Identification of imprinted genes subject to parent-of-origin specific expression in Arabidopsis thaliana seeds
  McKeown, BMC plant biology 2011
  • “...replicates was used. The following genes did not have probes: At1g12420, At1g55320, At2g45315, At3g21465, At4g01000, At4g25315, At5g04895, At5g35737 and At5g40240. Probes for At4g37530 and At1g14880 also matched another gene so were omitted from the analysis due to the possibility of ambiguous results. LCM Siliques of emasculated...”

CG15908 uncharacterized protein from Drosophila melanogaster
Aligns to 25:108 / 156 (53.8%), covers 98.8% of PF11326, 52.9 bits

• Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control
  Maurer, PLoS genetics 2020
  • “...a decrease in locomotor activity, with unchanged or increased sleep amount. Nervous system-specific knockdown of CG15908 ( C22orf39 ), gonadal ( DGCR6L ), or slgA ( PRODH ) increased the total amount of sleep exhibited by males, while only the knockdown of CG3711 , the Drosophila...”
• Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms
  Guna, Journal of neurodevelopmental disorders 2015
  • “...KO MRPL40 mrpl-40 30 KD mRpL40 40 KO, KD mrpl40 50 Mrpl40 75 KO C22orf39 CG15908 32 KO, KD si:ch211..51 h9.6 49 2510002D24Rik 72 KO UFD1L ufd-1 41 KD Ufd1-like 56 KO, KD ufd1l 87 KO Ufd1l 99 KO CDC45 evl-18 29 KO, KD CDC45L 39...”
• Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions
  Yin, PloS one 2013
  • “...LOF HOF p value Modulator of FBpp0087838 CG8696 Mal-A1 0.730.10 0.680.05 <0.05 Notch signaling FBpp0085448 CG15908 CG15908 0.530.05 0.650.03 <0.05 calcium signaling FBpp0261451 CG33950 CG33950 1.300.12 1.350.09 <0.05 calcium signaling FBpp0079400 CG3747 Eaat1 1.530.15 1.550.12 <0.05 ND FBpp0082514 CG4264 Hsc70-4 1.350.06 1.430.08 <0.05 Notch signaling FBpp0076522...”

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