Family Search for PF11630 (DUF3254)

PF11630.8 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

XP_027206930 anti-lipopolysaccharide factor-like from Penaeus vannamei
Aligns to 23:122 / 122 (82.0%), covers 100.0% of PF11630, 151.0 bits

• Identification of an anti-lipopolysaccharide factor AV-R isoform (LvALF AV-R) related to Vp_PirAB-like toxin resistance in Litopenaeus vannamei.
  Tinwongger, Fish & shellfish immunology 2019 (PubMed)
  • GeneRIF: LvALF AV-R expression was induced in the hepatopancreas of shrimp in response to the presence of Vibrio parahaemolyticus Vp_PirAB-like toxin, although other factors might also be involved in the resistance mechanism.

ALPS_SCYSE / B5TTX7 Anti-lipopolysaccharide factor; SsALF from Scylla serrata (Mud crab) (see 2 papers)
Aligns to 24:122 / 123 (80.5%), covers 100.0% of PF11630, 140.6 bits

• function: Binds to bacterial LPS and may specifically inhibit the LPS- mediated activation of the hemolymph coagulation. It has a strong antibacterial effect especially on the growth of Gram-negative bacteria.

P07087 Anti-lipopolysaccharide factor from Tachypleus tridentatus
Aligns to 1:99 / 102 (97.1%), covers 99.0% of PF11630, 140.3 bits

• Functional divergence in shrimp anti-lipopolysaccharide factors (ALFs): from recognition of cell wall components to antimicrobial activity
  Rosa, PloS one 2013
  • “...performed with ALF sequences from penaeid shrimp and from the horseshoe crabs T. tridentatus (TACTR_ALF: P07087; TACTR2_ALF: AAK00651), L. polyphemus (LIMPO_ALF: P07086) and Carcinoscorpius rotundicauda (CARRO_ALF: CK086627). A total of 42 sequences were analyzed. A phylogenetic tree was generated from the sequence alignments with scygonadins [34]...”
  • “...AGH32549; Litsty ALF-D1: AAY33769); (ii) Horseshoe crab ALFs : Chinese horseshoe crab Tachypleus tridentatus (TACTR_ALF: P07087; TACTR2_ALF: AAK00651), Atlantic horseshoe crab Limulus polyphemus (LIMPO_ALF: P07086) and Southeast Asian horseshoe crab Carcinoscorpius rotundicauda (CARRO_ALF: CK086627); (iii) Scygonadins (outgroup): giant mud crab Scylla serrata ( S serrata scygonadin:...”
• Antilipopolysaccharide factor interferes with white spot syndrome virus replication in vitro and in vivo in the crayfish Pacifastacus leniusculus
  Liu, Journal of virology 2006
  • “...from Tachypleus tridentatus (GenBank accession no. P07087), Limulus polyphemus (GenBank accession no. P07086), Litopenaeus stylirostris (GenBank accession no....”

ALPS_PORTR / C0KJQ4 Anti-lipopolysaccharide factor; PtALF from Portunus trituberculatus (Swimming crab) (Neptunus trituberculatus) (see 2 papers)
Aligns to 24:122 / 123 (80.5%), covers 100.0% of PF11630, 135.3 bits

• function: May bind to bacterial LPS and thus specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect especially on the growth of Gram-negative bacteria (By similarity).

P07086 Anti-lipopolysaccharide factor from Limulus polyphemus
Aligns to 1:98 / 101 (97.0%), covers 96.0% of PF11630, 132.9 bits

• Functional divergence in shrimp anti-lipopolysaccharide factors (ALFs): from recognition of cell wall components to antimicrobial activity
  Rosa, PloS one 2013
  • “...shrimp and from the horseshoe crabs T. tridentatus (TACTR_ALF: P07087; TACTR2_ALF: AAK00651), L. polyphemus (LIMPO_ALF: P07086) and Carcinoscorpius rotundicauda (CARRO_ALF: CK086627). A total of 42 sequences were analyzed. A phylogenetic tree was generated from the sequence alignments with scygonadins [34] , another two cysteine-containing AMP family...”
  • “...Chinese horseshoe crab Tachypleus tridentatus (TACTR_ALF: P07087; TACTR2_ALF: AAK00651), Atlantic horseshoe crab Limulus polyphemus (LIMPO_ALF: P07086) and Southeast Asian horseshoe crab Carcinoscorpius rotundicauda (CARRO_ALF: CK086627); (iii) Scygonadins (outgroup): giant mud crab Scylla serrata ( S serrata scygonadin: AAW57403; S serrata scygonadin-2: ABI96918; S serrata SSAP: ABM05493)...”
• Anti-lipopolysaccharide factors in the American lobster Homarus americanus: molecular characterization and transcriptional response to Vibrio fluvialis challenge
  Beale, Comparative biochemistry and physiology. Part D, Genomics & proteomics 2008
  • “...Japanese horseshoe crab Tachypleus tridentatus ( AF227150 ) and Atlantic horseshoe crab Limulus polyphemus ( P07086 ). Arrows indicate conserved cysteine residues participating in a disulfide bridge that forms a cationic loop in the protein. Figure 6 Neighbor-joining tree of representative arthropod anti-lipopolysaccharide protein sequences based...”
• Antilipopolysaccharide factor interferes with white spot syndrome virus replication in vitro and in vivo in the crayfish Pacifastacus leniusculus
  Liu, Journal of virology 2006
  • “...P07087), Limulus polyphemus (GenBank accession no. P07086), Litopenaeus stylirostris (GenBank accession no. AAY33769), Penaeus monodon, and Pacifastacus...”

AMP1_SCYSE / A1YV58 Antimicrobial protein 1 from Scylla serrata (Mud crab) (see paper)
Aligns to 23:124 / 126 (81.0%), covers 99.0% of PF11630, 113.4 bits

• function: Has antibacterial activity against the Gram-positive bacteria E.coli (MIC<50 ug/ml) and P.aeruginosa (MIC<25 ug/ml), and the Gram- negative bacteria S.aureus (MIC<100 ug/ml) and S.pyogenes (MIC<50 ug/ml).

SCYG_SCYSE / Q5D710 Scygonadin from Scylla serrata (Mud crab) (see paper)
Aligns to 23:124 / 126 (81.0%), covers 99.0% of PF11630, 102.5 bits

• function: Has antibacterial activity against the Gram-positive bacterium M.luteus with an IC(90) of 125ug/ml. Has weak antibacterial activity against the Gram-negative bacterium A.hydrophila.

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